Novel Zn2+-binding sites in human transthyretin: Implications for amyloidogenesis and retinol-binding protein recognition

Journal of Biological Chemistry

Volumn 285, Issue 41, 2010, Pages 31731-31741

  De Palmieri, Leonardo C ^a   Lima, Luis Mauricio T R ^a   Freire, Juliana B B ^a   Bleicher, Lucas ^b   Polikarpov, Igor ^b   Almeida, Fabio C L ^a   Foguel, Debora ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC PH; AMINO ACID RESIDUES; AMYLOID FIBRIL; AMYLOIDOGENESIS; EX-VIVO; HUMAN TRANSTHYRETIN; IN-VITRO; RETINOL-BINDING PROTEIN; STRUCTURAL FLEXIBILITIES; STRUCTURAL PERTURBATION; TETRAMER STABILITY; TETRAMERS; VITAMIN A;

AMINO ACIDS; BINDING ENERGY; BINDING SITES; BIOCHEMISTRY; CRYSTAL STRUCTURE; MONOMERS; PROTEINS;

ZINC;

PREALBUMIN; RECOMBINANT PROTEIN; RETINOL BINDING PROTEIN; ZINC ION; RETINOL; ZINC;

ALPHA HELIX; AMYLOIDOSIS; ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; EX VIVO STUDY; HOMEOSTASIS; IN VITRO STUDY; NUCLEAR MAGNETIC RESONANCE; PH; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SEQUENCE ALIGNMENT; THERMOSTABILITY; WILD TYPE; CHEMISTRY; HUMAN; METABOLISM; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; PROTEIN SECONDARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

TETRA;

AMYLOIDOSIS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROGEN-ION CONCENTRATION; PREALBUMIN; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; RETINOL-BINDING PROTEINS; VITAMIN A; ZINC;

EID: 77957766617     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.157206     Document Type: Article

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