Why has methicillin-resistant staphylococcus aureus become such a successful pathogen in adults?

Infectious Diseases in Clinical Practice

Volumn 18, Issue 5, 2010, Pages 286-291

  Moellering, Robert C ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

methicillin resistance; pathogenicity; Staphylococcus aureus; USA300

Indexed keywords

ALPHA HEMOLYSIN; PANTON VALENTINE LEUKOCIDIN;

ANTIBIOTIC RESISTANCE; BACTERIAL ARTHRITIS; BACTERIAL GENOME; BACTERIAL STRAIN; BACTERIAL VIRULENCE; COMMUNICABLE DISEASE; COMMUNITY HOSPITAL; EPIDEMIC MENINGITIS; GENE CASSETTE; HOSPITAL INFECTION; HOSPITALIZATION; HUMAN; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MORTALITY; NECROTIZING FASCIITIS; NONHUMAN; NURSING HOME; OSTEOMYELITIS; PELVIS ABSCESS; PNEUMONIA; REVIEW; STAPHYLOCOCCAL SKIN INFECTION; THROMBOPHLEBITIS; UNITED STATES;

EID: 77957759717     PISSN: 10569103     EISSN: None     Source Type: Journal    
DOI: 10.1097/IPC.0b013e3181efebca     Document Type: Review

References (26)

1. Chambers HF. Community-associated MRSA-resistance and virulence converge. N Engl J Med. 2005;352(14):1485-1487.
2. Kazakova SV, Hageman JC, Matava M, et al. A clone of methicillin- resistant Staphylococcus aureus among professional football players. N Engl J Med. 2005;352(5):468-475.
3. Miller LG, Perdreau-Remington F, Rieg G, et al. Necrotizing fasciitis caused by community-acquired methicillin-resistant Staphylococcus aureus in Los Angeles. N Engl J Med. 2005;352(14):1445-1453.
4. Montgomery CP, Boyle-Vavra S, Adem PV, et al. Comparison of virulence in community-associated methicillin-resistant Staphylococcus aureus pulsotypes USA300 and USA400 in a rat model of pneumonia. J Infect Dis. 2008;198(4):561-570.
5. Wardenburg BJ, Bae T, Otto M, et al. Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia. Nat Med. 2007;13(12):1405-1406.
6. Diep BA, Stone GG, Basuino L, et al. The arginine catabolic mobile element and staphylococcal chromosomal cassette mec linkage: convergence ofvirulence and resistance in the USA300 clone of methicillin-resistant Staphylococcus aureus. J Infect Dis. 2008;197(11):1523-1530.
7. Kuroda M, Ohta T, Uchiyama I, et al. Whole genome sequencing ofmethicillin-resistant Staphylococcus aureus. Lancet. 2001;357(9264):1225-1240.
8. Zhang K, Mc Clure JA, Elsayed S, et al. Coexistence ofPanton-Valentine leukocidin-positive and-negative community-associated methicillin-resistant Staphylococcus aureus USA400 sibling strains in a large Canadian health-care region. J Infect Dis. 2008;197(2):195-204.
9. Baba T, Takeuchi F, Kuroda M, et al. Genome and virulence determinants ofhigh virulence community-acquired MRSA. Lancet. 2002;359(9320):1819-1827.
10. Chongtrakool P, Ito T, Ma XX, et al. Staphylococcal cassette chromosome mec (SCCmec) typing of methicillin-resistant Staphylococcus aureus strains isolated in 11 Asian countries: a proposal for a new nomenclature for SCCmec elements. Antimicrob Agents Chemother. 2006;50(3):1001-1012.
11. Westh H, Jarløv JO, Kjersem H, et al. The disappearance of multiresistant Staphylococcus aureus in Denmark: changes in strains of the 83A complex between 1969 and 1989. Clin Infect Dis. 1992;14(6):1186-1194.
12. Chambers HF. Methicillin resistance in staphylococci: molecular and biochemical basis and clinical implications. Clin Microbiol Rev. 1997;10(4):781-791.
13. Bradley SF Methicillin-resistant Staphylococcus aureus: long-term care concerns. Am J Med. 1999;106(5A):2S-10S.
14. National Nosocomial Infections Surveillance System (NNIS). http://www.cdc.gov/ncidod/dhqp/pdf/ar/ICU-RESTrend1995-2004.pdf. Accessed July 28, 2010.
15. Bradley SF, Terpenning MS, Ramsey MA, et al. Methicillin-resistant Staphylococcus aureus: colonization and infection in a long-term care facility. Ann Intern Med. 1991;115(6):417-422.
16. Groom AV, Wolsey DH, Naimi TS, et al. Community-acquired methicillin-resistant Staphylococcus aureus in a rural American Indian community. JAMA. 2001;286(10):1201-1205.
17. Ma XX, Ito T, Tiensasitorn C, et al. Novel type ofstaphylococcal cassette chromosome mec identified in community-acquired methicillin-resistant Staphylococcus aureus strains. Antimicrob Agents Chemother. 2002;46(4):1147- 1152.
18. Moellering RC Jr. The growing menace ofcommunity-acquired methicillin-resistant Staphylococcus aureus. Ann Intern Med. 2006;144(5):368-370.
19. Kaplan SL, Hulten KG, Gonzalez BE, et al. Three-year surveillance of community-acquired Staphylococcus aureus infections in children. Clin Infect Dis. 2005;40(12):1785-1791.
20. King MD, Humphrey BJ, Wang YF, et al. Emergence of community-acquired methicillin-resistant Staphylococcus aureus USA300 clone as the predominant cause of skin and soft-tissue infections. Ann Intern Med. 2006;144(5):309-317.
21. Moran GJ, Krishnadasan A, Gorwitz RJ, et al. Methicillin-resistant S. aureus infections among patients in the emergency department. N Engl J Med. 2006;355(7):666-674.
22. Okuma K, Iwakawa K, Turnidge JD, et al. Dissemination of new methicillin-resistant Staphylococcus aureus clones in the community. J Clin Microbiol. 2002;40(11):4289-4294.
23. Klein E, Smith DL, Laxminarayan R. Hospitalizations and deaths caused by methicillin-resistant Staphylococcus aureus, United States, 1999-2005. Emerg Infect Dis. 2007;13(12):1840-1846.
24. Popovich KJ, Weinstein RA, Hota B. Are community-associated methicillin-resistant Staphylococcus aureus (MRSA) strains replacing traditional nosocomial MRSA strains? Clin Infect Dis. 2008;46(6):787-794.
25. Liu C, Graber CJ, Karr M, et al. A population-based study of the incidence and molecular epidemiology of methicillin-resistant Staphylococcus aureus disease in San Francisco, 2004-2005. Clin Infect Dis. 2008;46(11):1637-1646.
26. D'Agata EM, Webb GF, Horn MA, et al. Modeling the invasion of community-acquired methicillin-resistant Staphylococcus aureus into hospitals. Clin Infect Dis. 2009;48(3):274-284.