Erroneous determination of hyperphosphatemia ('pseudohyperphosphatemia') in sera of patients that have been treated with liposomal amphotericin B (AmBisome)

Clinica Chimica Acta

Volumn 411, Issue 23-24, 2010, Pages 1900-1905

  Jensen, Gerard M ^a   Bunch, Tarquinus H ^a   Wolf, Steven ^b   Laybourne, Stefanie ^b  

^a GILEAD SCIENCES   (United States)

^b BECKMAN COULTER INC   (United States)

Author keywords

AmBisome; Amphotericin; Hyperphosphatemia; Liposome; Phosphorous; Pseudohyperphosphatemia

Indexed keywords

AMPHOTERICIN B LIPID COMPLEX; PHOSPHATE; PLACEBO;

ANALYTICAL ERROR; ARTICLE; CONTROLLED STUDY; HUMAN; HYPERPHOSPHATEMIA; MAXIMUM PLASMA CONCENTRATION; PHOSPHATE BLOOD LEVEL; PRIORITY JOURNAL; ULTRAFILTRATION;

AMPHOTERICIN B; ARTIFACTS; BLOOD CHEMICAL ANALYSIS; DIAGNOSTIC ERRORS; HUMANS; HYPERPHOSPHATEMIA; PHOSPHORUS;

EID: 77957754744     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2010.07.017     Document Type: Article

References (10)

1. Bailey H.L., Chan E.M. L-AmB interferes with the phosphorus assay on the Synchron LX 20 analyzer. Clin Chem 2007, 53:795-796.
2. Bekersky I., Fielding R.M., Dressler D.E., Lee J.W., Buell D.N., Walsh T.J. Pharmacokinetics, excretion, and mass balance of L-AmB (L-AmB) and amphotericin B deoxycholate in humans. Antimicrob Agents Chemother 2002, 46:828-833.
3. Dryer R.L., Routh J.I. Determination of serum inorganic phosphorus. Clin Chem 1963, 4:191-195.
4. Fiske C.H., Subbarow Y. The colorimetric determination of phosphorous. J Biol Chem 1925, 66:375-400.
5. Jain A., Butani L. Severe hyperphosphatemia resulting from high-dose liposomal amphotericin in a child with leukemia. J Pediatr Hematol/Oncol 2003, 25:324-326.
6. Larner A.J. Pseudohyperphosphatemia. Clin Biochem 1995, 28:391-393.
7. Lane J.W., Rehak N.N., Hortin G.L., Zaoutis T., Krause P.R., Walsh T.J. Pseudohyperphosphatemia associated with high-dose L-AmB therapy. Clin Chim Acta 2008, 387:145-149.
8. Mendoza D., Connors S., Lane C., Strehnach S. L-AmB as a cause of pseudohyperphosphatemia. Clin Infect Dis 2008, 46:645-646.
9. Sutherland S.M., Hong D.K., Balagtas J., Gutierrez K., Dvorak C.C., Sarwal M. L-AmB associated with severe hyperphosphatemia. Pediatr Infect Dis J 2008, 1:77-79.
10. McCoy M.T., Aguanno J.J., Ritzmann S.E. Interferences of mannitol with phosphate determination. Am J Clin Pathol 1982, 77:468-470.