Activity of a new hydrogen sulfide-releasing aspirin (ACS14) on pathological cardiovascular alterations induced by glutathione depletion in rats

European Journal of Pharmacology

Volumn 648, Issue 1-3, 2010, Pages 139-145

  Rossoni, Giuseppe ^a   Manfredi, Barbara ^a   Tazzari, Valerio ^a   Sparatore, Anna ^a   Trivulzio, Silvio ^a   Del Soldato, Piero ^b   Berti, Ferruccio ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b CTG Pharma   (Italy)

Author keywords

Glutathione depletion; H2S releasing aspirin; Hypertension; Ischemia reperfusion; Metabolic syndrome

Indexed keywords

1,2 DITHIOLE 3 THIONE DERIVATIVE; 2 ACETYLOXYBENZOIC ACID 4 (3 THIOXO 3H 1,2 DITHIOL 5 YL)PHENYL ESTER; 2 HYDROXYBENZOIC ACID 4 (3 THIOXO 3H 1,2 DITHIOL 5 YL)PHENYL ESTER; 5 (4 HYDROXYPHENYL) 3H 1,2 DITHIOL 3 THIONE; 6 OXOPROSTAGLANDIN F2 ALPHA; 8 ISOPROSTANE; ACETYLSALICYLIC ACID; ACETYLSALICYLIC ACID DERIVATIVE; ACS 14; ACS 21; BUTHIONINE SULFOXIMINE; CREATINE KINASE; GLUCOSE; GLUTATHIONE; HYDROGEN SULFIDE; INSULIN; LACTATE DEHYDROGENASE; PROSTAGLANDIN F2 ALPHA; SALICYLIC ACID; THROMBOXANE B2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVITY; FATTY ACID BLOOD LEVEL; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART RATE; HYPERTENSION; IN VIVO STUDY; ISOLATED HEART; MALE; METABOLIC SYNDROME X; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; RAT; STOMACH MUCOSA LESION; SYSTOLIC BLOOD PRESSURE;

ANIMALS; AORTA; ASPIRIN; BLOOD PRESSURE; CONSCIOUSNESS; CREATINE KINASE; ENDOTHELIUM, VASCULAR; GASTRIC MUCOSA; GLUTATHIONE; HEART; HEART RATE; HYDROGEN SULFIDE; L-LACTATE DEHYDROGENASE; MALE; MALONDIALDEHYDE; METABOLIC SYNDROME X; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; OXIDATIVE STRESS; RATS; RATS, WISTAR; VASODILATION;

EID: 77957752179     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.08.039     Document Type: Article

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