Sub-chronic hepatotoxicity of Anacardium occidentale (Anacardiaceae) inner stem bark extract in rats

Indian Journal of Pharmaceutical Sciences

Volumn 72, Issue 3, 2010, Pages 353-357

  Okonkwo, T J N ^a   Okorie, O ^a   Okonta, J M ^b   Okonkwo, C J ^c  

^a UNIVERSITY OF PORT HARCOURT   (Nigeria)

^b UNIVERSITY OF NIGERIA   (Nigeria)

^c Novena University   (Nigeria)

Author keywords

Anacardium occidantale; Anti nutrients; heavy metals; Liver function indices

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ANACARDIUM OCCIDANTALE EXTRACT; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CADMIUM; CYANIDE; HEAVY METAL; IRON; LEAD; METHANOL; OXALIC ACID DERIVATIVE; PHYTATE; PLANT EXTRACT; PROTEIN; SAPONIN DERIVATIVE; TANNIN DERIVATIVE; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CASHEW NUT; CONTROLLED STUDY; FEMALE; LD 50; LIVER CELL; LIVER FUNCTION; LIVER INJURY; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PHYTOCHEMISTRY; PLANT STEM; PROTEIN BLOOD LEVEL; RAT;

EID: 77957737121     PISSN: 0250474X     EISSN: 19983743     Source Type: Journal    
DOI: 10.4103/0250-474X.70482     Document Type: Article

References (30)

1. Chan TY. Monitoring the safety of herbal medicines. Drug Safety 1997;17:209-15.
2. Patro C, Behera RN. Cashew helps to fix sand dumes in Orissa. Indian Farming 1979;28:31-2.
3. Mota ML. Anti-inflammatory actions of tannins isolated from the bark of Anacardium occidentale. J. Ethnopharmacol 1985;13:289-300.
4. Esimone CO, Okonta JM, Ezugwu CO. Blood sugar lowering effect of Anacardum occidentale leaf extract in experimental rabbit model. J Nat Remed 2001;1:60-3.
5. Kubo J. Anti-Helicobacter pylori agents from the cashew apple. J Agric Food Chem 1999;47:533-7.
6. Laurens A. Study of antimicrobial activity of Anacardium occidentale. L. Ann Pharm Fr 1982;40:143-6.
7. Kudi AC. Screening of some Nigerian medicinal plants for antibacterial activity J Ethnopharmacol 1999;67:225-8.
8. Akinpelu DA. Antimicrobial activity of Anacadium occidentale bark. Fitoterapia 2001;72:286-7.
9. Kamtchoury P. Protective role of Anacardium occidentale extract against streptozotocin-induced diabetes in rats. J Ethnopharrmacol 1998;62:95-9.
10. Mendes NM. Molluscacide activity of a mixuture of 6-n-alkyl salicylic acid (anacardic acid). Rev Soc Bras Med Trop 1990;23:217-24.
11. Pak E, Esrason KT, Wu VH. Hepato-toxicity of herbal remedies: An emerging dilemma. Prog Transplant 2004;14:91-6.
12. Okafor PN, Ezeigwe DO. Toxicity evaluation of the cyanogens of a Nigerian local legume (Vigna species) in Rabbits. Bioresearch 2005;3:21-4.
13. Akueshi EU, Sabo AE, Ogugbuaja, VO. Micronutrient and trace content of calyx and bud of Bomboax buonopozenes (P. Beauv.) Bioresearch 2005;3:43-65.
14. th ed. London: J and A Churchill; 1983. p. 507-15.
15. rd ed. London: Thompson Science; 1998. p. 107-50.
16. Lorke DA. New Approach to practical Acute Toxicity Testing. Arch Toxicol 1983;54:275-87.
17. Gornall AG, Bardawill CS, David MM. Determination of serum protein by means of biuret reaction. J Biol Chem 1949;177:751-66.
18. The committee on enzymes of the Scandinavan Society for Clinical Chemistry and Clinical Physiology Recommended methods for determination of four enzymes in blood. Invest Scand J Clin Lab 1974;33:291-306.
19. Ahmed M, Khater MR. Evaluation of the protective effect of Ambrosia maritime extract on acetaminophen-induced liver damage. J Ethnopharm 2001;75:169-74.
20. Pearson D. The Chemical Analysis of Foods. 7th ed. Edinburgh: Churchill Livingstone; 1976.
21. Haslam E. Plant polyphenols. Cambridge: Cambridge University Press; 1989. p. 137.
22. Hemingway RW, Karchesy JJ. editors. Chemistry and significance of condensed tannins. New York: Plenum Press; 1989. p. 362.
23. Oke OL. Oxalic acid in plants and in nutrition, In: Bourne GH. editors, World Review of Nutrition and Dietetics. Vol. 10, Basel: S. Karger; 1966. p. 262-303.
24. Graf E, Empson KL, Eaton JW. Phytic acid a natural antioxidant. J Biol Chem 1987;262:11647-50.
25. Graf E, Eaton JW. Antioxidant functions of phytic acid. Free Rad Biol Med 1990;8:61-9.
26. Montgomery RD. The medical significance of cyanogens in plant foodstuff. Am J Clin Nutr 1965;17:103-13.
27. Okafor PN, Okoronkwo CO, Maduagwu EN. Occupational and dietary exposure of humans to cyanide poisoning from large scale cassava processing and ingestion of cassava food. Food Chem Toxicol 2002;40:1001-5.
28. Cross CE, Halliwell B, Borish ET, Pryor WA, Ames BN, Saul RL, et al. Oxygen and human disease. Ann Int Med 1987;107:526-45.
29. Pitter MH, Ernest E. Systemic Review: hepatotoxic events associated with herbal medicinal products. Aliment Pharmacol Ther 2003;18:451-71.
30. Bukar BB, Uguru MO, Edache PJ, Wannang NN, Dayon BW. Subchronic hepato-toxicity evaluations of the aqueous extract of the leaves of Xylopia parviflora (Benth) in rats. Nig J Pharm Res 2005;4:55-9.