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Volumn 38, Issue 4, 2010, Pages 1413-1427

Combined inhibitory effects of celecoxib and fluvastatin on the growth of human hepatocellular carcinoma xenografts in nude mice

Author keywords

Celecoxib; COX 2 inhibitors; Fluvastatin; Hepatocellular carcinoma; Nude mice; Signalling pathway; Statins

Indexed keywords

CELECOXIB; CYCLIN DEPENDENT KINASE INHIBITOR 1; FLUINDOSTATIN; PROTEIN KINASE B; PROTEIN MCL 1; SURVIVIN;

EID: 77957730454     PISSN: 03000605     EISSN: None     Source Type: Journal    
DOI: 10.1177/147323001003800423     Document Type: Article
Times cited : (28)

References (75)
  • 1
    • 0035888074 scopus 로고    scopus 로고
    • Estimating the world cancer burden: Globocan 2000
    • Parkin DM, Bray F, Ferlay J, et al: Estimating the world cancer burden: Globocan 2000. Int J Cancer 2001; 94: 153-156.
    • (2001) Int J Cancer , vol.94 , pp. 153-156
    • Parkin, D.M.1    Bray, F.2    Ferlay, J.3
  • 2
    • 0024421391 scopus 로고
    • Prevalence of antibodies to hepatitis C virus in Spanish patients with hepato-cellular carcinoma and hepatic cirrhosis
    • Bruix J, Barrera JM, Calvet X, et al: Prevalence of antibodies to hepatitis C virus in Spanish patients with hepato-cellular carcinoma and hepatic cirrhosis. Lancet 1989; 2: 1004-1006.
    • (1989) Lancet , vol.2 , pp. 1004-1006
    • Bruix, J.1    Barrera, J.M.2    Calvet, X.3
  • 3
    • 0032742183 scopus 로고    scopus 로고
    • Intention-to-treat analysis of surgical treatment for early hepato-cellular carcinoma: Resection versus transplantation
    • Llovet JM, Fuster J, Bruix J: Intention-to-treat analysis of surgical treatment for early hepato-cellular carcinoma: resection versus transplantation. Hepatology 1999; 30: 1434-1440.
    • (1999) Hepatology , vol.30 , pp. 1434-1440
    • Llovet, J.M.1    Fuster, J.2    Bruix, J.3
  • 4
    • 27244453396 scopus 로고    scopus 로고
    • Liver transplantation for adult patients with hepato-cellular carcinoma in Korea: Comparison between cadaveric donor and living donor liver transplantations
    • Hwang S, Lee SG, Joh JW, et al: Liver transplantation for adult patients with hepato-cellular carcinoma in Korea: comparison between cadaveric donor and living donor liver transplantations. Liver Transpl 2005; 11: 1265-1272.
    • (2005) Liver Transpl , vol.11 , pp. 1265-1272
    • Hwang, S.1    Lee, S.G.2    Joh, J.W.3
  • 5
    • 41949113329 scopus 로고    scopus 로고
    • Transcatheter arterial chemoembolization (TACE) in hepato-cellular carcinoma (HCC): The role of angiogenesis and invasiveness
    • Sergio A, Cristofori C, Cardin R, et al: Transcatheter arterial chemoembolization (TACE) in hepato-cellular carcinoma (HCC): the role of angiogenesis and invasiveness. Am J Gastroenterol 2008; 103: 914-921.
    • (2008) Am J Gastroenterol , vol.103 , pp. 914-921
    • Sergio, A.1    Cristofori, C.2    Cardin, R.3
  • 6
    • 0033848847 scopus 로고    scopus 로고
    • Radiofrequency ablation of hepato-cellular cancer in 110 patients with cirrhosis
    • Curley SA, Izzo F, Ellis LM, et al: Radiofrequency ablation of hepato-cellular cancer in 110 patients with cirrhosis. Ann Surg 2000; 232: 381-391.
    • (2000) Ann Surg , vol.232 , pp. 381-391
    • Curley, S.A.1    Izzo, F.2    Ellis, L.M.3
  • 7
    • 0034991518 scopus 로고    scopus 로고
    • Liver transplantation for hepato-cellular carcinoma: Expansion of the tumor size limits does not adversely impact survival
    • Yao FY, Ferrell L, Bass NM, et al: Liver transplantation for hepato-cellular carcinoma: expansion of the tumor size limits does not adversely impact survival. Hepatology 2001; 33: 1394-1403.
    • (2001) Hepatology , vol.33 , pp. 1394-1403
    • Yao, F.Y.1    Ferrell, L.2    Bass, N.M.3
  • 8
    • 0036157485 scopus 로고    scopus 로고
    • Many actions of cyclooxygenase-2 in cellular dynamics and in cancer
    • Cao Y, Prescott SM: Many actions of cyclooxygenase-2 in cellular dynamics and in cancer. J Cell Physiol 2002; 190: 279-286.
    • (2002) J Cell Physiol , vol.190 , pp. 279-286
    • Cao, Y.1    Prescott, S.M.2
  • 10
    • 0035173913 scopus 로고    scopus 로고
    • Specific inhibition of cyclooxygenase-2 results in inhibition of proliferation of oral cancer cell lines via suppression of prostaglandin E2 production
    • Sumitani K, Kamijo R, Toyoshima T, et al: Specific inhibition of cyclooxygenase-2 results in inhibition of proliferation of oral cancer cell lines via suppression of prostaglandin E2 production. J Oral Pathol Med 2001; 30: 41-47.
    • (2001) J Oral Pathol Med , vol.30 , pp. 41-47
    • Sumitani, K.1    Kamijo, R.2    Toyoshima, T.3
  • 11
    • 0031984810 scopus 로고    scopus 로고
    • Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells
    • Sheng H, Shao J, Morrow JD, et al: Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells. Cancer Res 1998; 58: 362-366.
    • (1998) Cancer Res , vol.58 , pp. 362-366
    • Sheng, H.1    Shao, J.2    Morrow, J.D.3
  • 12
    • 0033063736 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression in hepato-cellular carcinoma
    • Shiota G, Okubo M, Noumi T, et al: Cyclooxygenase-2 expression in hepato-cellular carcinoma. Hepato-gastroenterology 1999; 46: 407-412.
    • (1999) Hepato-gastroenterology , vol.46 , pp. 407-412
    • Shiota, G.1    Okubo, M.2    Noumi, T.3
  • 13
    • 0033106051 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer
    • Tucker ON, Dannenberg AJ, Yang EK, et al: Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer. Cancer Res 1999; 59: 987-990.
    • (1999) Cancer Res , vol.59 , pp. 987-990
    • Tucker, O.N.1    Dannenberg, A.J.2    Yang, E.K.3
  • 14
    • 0032170955 scopus 로고    scopus 로고
    • Increased expression of cyclooxygenase-2 occurs frequently in human lung cancers, specifically in adenocarcinomas
    • Hida T, Yatabe Y, Achiwa H, et al: Increased expression of cyclooxygenase-2 occurs frequently in human lung cancers, specifically in adenocarcinomas. Cancer Res 1998; 58: 3761-3764.
    • (1998) Cancer Res , vol.58 , pp. 3761-3764
    • Hida, T.1    Yatabe, Y.2    Achiwa, H.3
  • 15
    • 0033988665 scopus 로고    scopus 로고
    • Over-expression of cyclooxygenase-2 in human prostate adenocarcinoma
    • Gupta S, Srivastava M, Ahmad N, et al: Over-expression of cyclooxygenase-2 in human prostate adenocarcinoma. Prostate 2000; 42: 73-78.
    • (2000) Prostate , vol.42 , pp. 73-78
    • Gupta, S.1    Srivastava, M.2    Ahmad, N.3
  • 16
    • 0036120432 scopus 로고    scopus 로고
    • Over-expression of cyclooxygenase-2 correlates with advanced stages of colorectal cancer
    • Zhang H, Sun XF: Over-expression of cyclooxygenase-2 correlates with advanced stages of colorectal cancer. Am J Gastroenterol 2002; 97: 1037-1041.
    • (2002) Am J Gastroenterol , vol.97 , pp. 1037-1041
    • Zhang, H.1    Sun, X.F.2
  • 17
    • 61349185227 scopus 로고    scopus 로고
    • In vitro and in vivo inhibitory effect evaluation of cyclooxygenase-2 inhibitors, antisense cyclooxygenase-2 cDNA, and their combination on the growth of human bladder cancer cells
    • Qin J, Yuan J, Li L, et al: In vitro and in vivo inhibitory effect evaluation of cyclooxygenase-2 inhibitors, antisense cyclooxygenase-2 cDNA, and their combination on the growth of human bladder cancer cells. Biomed Pharmacother 2009; 63: 241-248.
    • (2009) Biomed Pharmacother , vol.63 , pp. 241-248
    • Qin, J.1    Yuan, J.2    Li, L.3
  • 18
    • 48149084823 scopus 로고    scopus 로고
    • Selective inhibition of cyclooxygenase-2 suppresses the growth of pancreatic cancer cells in vitro and in vivo
    • Xu XF, Xie CG, Wang XP, et al: Selective inhibition of cyclooxygenase-2 suppresses the growth of pancreatic cancer cells in vitro and in vivo. Tohoku J Exp Med 2008; 215: 149-157.
    • (2008) Tohoku J Exp Med , vol.215 , pp. 149-157
    • Xu, X.F.1    Xie, C.G.2    Wang, X.P.3
  • 19
    • 28144445331 scopus 로고    scopus 로고
    • In vitro and in vivo effects and mechanisms of celecoxib-induced growth inhibition of human hepato-cellular carcinoma cells
    • Cui W, Yu CH, Hu KQ: In vitro and in vivo effects and mechanisms of celecoxib-induced growth inhibition of human hepato-cellular carcinoma cells. Clin Cancer Res 2005; 11: 8213-8221.
    • (2005) Clin Cancer Res , vol.11 , pp. 8213-8221
    • Cui, W.1    Yu, C.H.2    Hu, K.Q.3
  • 20
    • 34547855113 scopus 로고    scopus 로고
    • Inhibitory effect of meloxicam, a selective cyclooxygenase-2 inhibitor, and ciglitazone, a peroxisome proliferator-activated receptor γ ligand, on the growth of human ovarian cancers
    • Xin B, Yokoyama Y, Shigeto T, et al: Inhibitory effect of meloxicam, a selective cyclooxygenase-2 inhibitor, and ciglitazone, a peroxisome proliferator-activated receptor γ ligand, on the growth of human ovarian cancers. Cancer 2007; 110: 791-800.
    • (2007) Cancer , vol.110 , pp. 791-800
    • Xin, B.1    Yokoyama, Y.2    Shigeto, T.3
  • 21
    • 33645006930 scopus 로고    scopus 로고
    • Risk of cardiovascular events and celecoxib: A systematic review and meta-analysis
    • Caldwell B, Aldington S, Weatherall M, et al: Risk of cardiovascular events and celecoxib: a systematic review and meta-analysis. J R Soc Med 2006; 99: 132-140.
    • (2006) J R Soc Med , vol.99 , pp. 132-140
    • Caldwell, B.1    Aldington, S.2    Weatherall, M.3
  • 22
    • 0029947184 scopus 로고    scopus 로고
    • Fluvastatin: A review of its pharmacology and use in the management of hypercholesterolaemia
    • Plosker GL, Wagstaff AJ: Fluvastatin: a review of its pharmacology and use in the management of hypercholesterolaemia. Drugs 1996; 51: 433-459.
    • (1996) Drugs , vol.51 , pp. 433-459
    • Plosker, G.L.1    Wagstaff, A.J.2
  • 23
    • 0025120211 scopus 로고
    • Regulation of the mevalonate pathway
    • Goldstein JL, Brown MS: Regulation of the mevalonate pathway. Nature 1990; 343: 425-430.
    • (1990) Nature , vol.343 , pp. 425-430
    • Goldstein, J.L.1    Brown, M.S.2
  • 24
    • 0035992581 scopus 로고    scopus 로고
    • 3-Hydroxy-3-methylglutaryl coenzyme A reductase activity and low-density lipoprotein receptor expression in diffuse-type and intestinal-type human gastric cancer
    • Caruso MG, Notarnicola M, Cavallini A, et al: 3-Hydroxy-3-methylglutaryl coenzyme A reductase activity and low-density lipoprotein receptor expression in diffuse-type and intestinal-type human gastric cancer. J Gastroenterol 2002; 33: 504-508.
    • (2002) J Gastroenterol , vol.33 , pp. 504-508
    • Caruso, M.G.1    Notarnicola, M.2    Cavallini, A.3
  • 25
    • 0025291799 scopus 로고
    • Increase in active form of 3-hydroxy-3-methylglutaryl coenzyme A reductase in human hepato-cellular carcinoma: Possible mechanism for alteration of cholesterol biosynthesis
    • Kawata S, Takaishi K, Nagase T, et al: Increase in active form of 3-hydroxy-3-methylglutaryl coenzyme A reductase in human hepato-cellular carcinoma: possible mechanism for alteration of cholesterol biosynthesis. Cancer Res 1990; 50: 3270-3273.
    • (1990) Cancer Res , vol.50 , pp. 3270-3273
    • Kawata, S.1    Takaishi, K.2    Nagase, T.3
  • 26
    • 26844513586 scopus 로고    scopus 로고
    • Statin therapy is associated with improved cardiovascular outcomes and levels of inflammatory markers in patients with heart failure
    • Sola S, Mir MQ, Rajagopalan S, et al: Statin therapy is associated with improved cardiovascular outcomes and levels of inflammatory markers in patients with heart failure. J Card Fail 2005; 11: 607-612.
    • (2005) J Card Fail , vol.11 , pp. 607-612
    • Sola, S.1    Mir, M.Q.2    Rajagopalan, S.3
  • 27
    • 26244457184 scopus 로고    scopus 로고
    • Cell cycle arrest and apoptosis induction in hepato-cellular carcinoma cells by HMG-CoA reductase inhibitors. Synergistic anti-proliferative action with ligands of the peripheral benzodiazepine receptor
    • Sutter AP, Maaser K, Höpfner M, et al: Cell cycle arrest and apoptosis induction in hepato-cellular carcinoma cells by HMG-CoA reductase inhibitors. Synergistic anti-proliferative action with ligands of the peripheral benzodiazepine receptor. J Hepatol 2005; 43: 808-816.
    • (2005) J Hepatol , vol.43 , pp. 808-816
    • Sutter, A.P.1    Maaser, K.2    Höpfner, M.3
  • 28
    • 34848893709 scopus 로고    scopus 로고
    • Atorvastatin and celecoxib inhibit prostate PC-3 tumors in immunodeficient mice
    • Zheng X, Cui XX, Avila GE, et al: Atorvastatin and celecoxib inhibit prostate PC-3 tumors in immunodeficient mice. Clin Cancer Res 2007; 13: 5480-5487.
    • (2007) Clin Cancer Res , vol.13 , pp. 5480-5487
    • Zheng, X.1    Cui, X.X.2    Avila, G.E.3
  • 29
    • 33746872856 scopus 로고    scopus 로고
    • Chemoprevention of familial adenomatous polyposis by low doses of atorvastatin and celecoxib given individually and in combination to APCMin mice
    • Swamy MV, Patlolla JM, Steele VE, et al: Chemoprevention of familial adenomatous polyposis by low doses of atorvastatin and celecoxib given individually and in combination to APCMin mice. Cancer Res 2006; 66: 7370-7377.
    • (2006) Cancer Res , vol.66 , pp. 7370-7377
    • Swamy, M.V.1    Patlolla, J.M.2    Steele, V.E.3
  • 30
    • 33749040295 scopus 로고    scopus 로고
    • Breast cancer growth prevention by statins
    • Campbell MJ, Esserman LJ, Zhou Y, et al: Breast cancer growth prevention by statins. Cancer Res 2006; 66: 8707-8714.
    • (2006) Cancer Res , vol.66 , pp. 8707-8714
    • Campbell, M.J.1    Esserman, L.J.2    Zhou, Y.3
  • 31
    • 0024354304 scopus 로고
    • Determination of subcutaneous tumor size in athymic (nude) mice
    • Tomayko MM, Reynolds CP: Determination of subcutaneous tumor size in athymic (nude) mice. Cancer Chemother Pharm 1989; 24: 148-154.
    • (1989) Cancer Chemother Pharm , vol.24 , pp. 148-154
    • Tomayko, M.M.1    Reynolds, C.P.2
  • 32
    • 0029328266 scopus 로고
    • Intratumor microvessel density as a prognostic factor in cancer
    • Weidner N: Intratumor microvessel density as a prognostic factor in cancer. Am J Pathol 1995; 147: 9-19.
    • (1995) Am J Pathol , vol.147 , pp. 9-19
    • Weidner, N.1
  • 33
    • 33846812600 scopus 로고    scopus 로고
    • Xenografts of human hepato-cellular carcinoma: A useful model for testing drugs
    • Huynh H, Soo KC, Chow PK, et al: Xenografts of human hepato-cellular carcinoma: a useful model for testing drugs. Clin Cancer Res 2006; 12: 4306-4314.
    • (2006) Clin Cancer Res , vol.12 , pp. 4306-4314
    • Huynh, H.1    Soo, K.C.2    Chow, P.K.3
  • 34
    • 1242271219 scopus 로고    scopus 로고
    • Cyclo-oxygenase-2 promotes human cholangio-carcinoma growth: Evidence for cyclooxygenase-2-independent mechanism in celecoxib-mediated induction of p21waf1/cip1 and p27kip1 and cell cycle arrest
    • Han C, Leng J, Demetris AJ, et al: Cyclo-oxygenase-2 promotes human cholangio-carcinoma growth: evidence for cyclooxygenase-2-independent mechanism in celecoxib-mediated induction of p21waf1/cip1 and p27kip1 and cell cycle arrest. Cancer Res 2004; 64: 1369-1376.
    • (2004) Cancer Res , vol.64 , pp. 1369-1376
    • Han, C.1    Leng, J.2    Demetris, A.J.3
  • 35
    • 0041833663 scopus 로고    scopus 로고
    • Suppression of N-methyl-N-nitrosourea/ testosterone-induced rat prostate cancer growth by celecoxib: Effects on cyclooxygenase-2, cell cycle regulation, and apoptosis mechanism(s)
    • Narayana BA, Condon MS, Bosland MC, et al: Suppression of N-methyl-N-nitrosourea/ testosterone-induced rat prostate cancer growth by celecoxib: effects on cyclooxygenase-2, cell cycle regulation, and apoptosis mechanism(s). Clin Cancer Res 2003; 9: 3503-3513.
    • (2003) Clin Cancer Res , vol.9 , pp. 3503-3513
    • Narayana, B.A.1    Condon, M.S.2    Bosland, M.C.3
  • 36
    • 38849106752 scopus 로고    scopus 로고
    • Statin induces apoptosis and cell growth arrest in prostate cancer cells
    • Hoque A, Chen H, Xu XC: Statin induces apoptosis and cell growth arrest in prostate cancer cells. Cancer Epidemiol Biomarkers Prev 2008; 17: 88-94.
    • (2008) Cancer Epidemiol Biomarkers Prev , vol.17 , pp. 88-94
    • Hoque, A.1    Chen, H.2    Xu, X.C.3
  • 37
    • 40849114654 scopus 로고    scopus 로고
    • Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells
    • Saito A, Saito N, Mol W, et al: Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells. Melanoma Res 2008; 18: 85-94.
    • (2008) Melanoma Res , vol.18 , pp. 85-94
    • Saito, A.1    Saito, N.2    Mol, W.3
  • 38
    • 34248352031 scopus 로고    scopus 로고
    • Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation
    • Dai Y, Khanna P, Chen S, et al: Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation. Blood 2007; 109: 4415-4423.
    • (2007) Blood , vol.109 , pp. 4415-4423
    • Dai, Y.1    Khanna, P.2    Chen, S.3
  • 39
    • 41849115563 scopus 로고    scopus 로고
    • Statins inhibit proliferation and induce apoptosis in Barrett's esophageal adenocarcinoma cells
    • Ogunwobi OO, Beales IL: Statins inhibit proliferation and induce apoptosis in Barrett's esophageal adenocarcinoma cells. Am J Gastroenterol 2008; 103: 825-837.
    • (2008) Am J Gastroenterol , vol.103 , pp. 825-837
    • Ogunwobi, O.O.1    Beales, I.L.2
  • 40
    • 33746896137 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibition induces apoptosis signaling via death receptors and mitochondria in hepato-cellular carcinoma
    • Kern MA, Haugg AM, Koch AF, et al: Cyclooxygenase-2 inhibition induces apoptosis signaling via death receptors and mitochondria in hepato-cellular carcinoma. Cancer Res 2006; 66: 7059-7066.
    • (2006) Cancer Res , vol.66 , pp. 7059-7066
    • Kern, M.A.1    Haugg, A.M.2    Koch, A.F.3
  • 41
    • 10744230216 scopus 로고    scopus 로고
    • Octreotide acts as an antitumor angiogenesis compound and suppresses tumor growth in nude mice bearing human hepato-cellular carcinoma xenografts
    • Jia WD, Xu GL, Xu RN, et al: Octreotide acts as an antitumor angiogenesis compound and suppresses tumor growth in nude mice bearing human hepato-cellular carcinoma xenografts. J Cancer Res Clin Oncol 2003; 129: 327-334.
    • (2003) J Cancer Res Clin Oncol , vol.129 , pp. 327-334
    • Jia, W.D.1    Xu, G.L.2    Xu, R.N.3
  • 42
    • 75149149835 scopus 로고    scopus 로고
    • Chitosan nanoparticles inhibit the growth of human hepato-cellular carcinoma xenografts through an antiangiogenic mechanism
    • Xu Y, Wen Z, Xu Z: Chitosan nanoparticles inhibit the growth of human hepato-cellular carcinoma xenografts through an antiangiogenic mechanism. Anticancer Res 2009; 29: 5103-5109.
    • (2009) Anticancer Res , vol.29 , pp. 5103-5109
    • Xu, Y.1    Wen, Z.2    Xu, Z.3
  • 43
    • 0037023634 scopus 로고    scopus 로고
    • Doubleedged role of statins in angiogenesis signaling
    • Urbich C, Dernbach E, Zeiher AM, et al: Doubleedged role of statins in angiogenesis signaling. Circ Res 2002; 90: 737-744.
    • (2002) Circ Res , vol.90 , pp. 737-744
    • Urbich, C.1    Dernbach, E.2    Zeiher, A.M.3
  • 44
    • 68249097560 scopus 로고    scopus 로고
    • Statins and angiogenesis: Is it about connections?
    • Khaidakov M, Wang W, Khan JA, et al: Statins and angiogenesis: is it about connections? Biochem Biophys Res Commun 2009; 387: 543-547.
    • (2009) Biochem Biophys Res Commun , vol.387 , pp. 543-547
    • Khaidakov, M.1    Wang, W.2    Khan, J.A.3
  • 45
    • 67349105662 scopus 로고    scopus 로고
    • Synergistic antitumor efficacy of lovastatin and protein kinase C-beta inhibitor in hepato-cellular carcinoma
    • Kim W, Yoon JH, Kim JR, et al: Synergistic antitumor efficacy of lovastatin and protein kinase C-beta inhibitor in hepato-cellular carcinoma. Cancer Chemother Pharmacol 2009; 64: 497-507.
    • (2009) Cancer Chemother Pharmacol , vol.64 , pp. 497-507
    • Kim, W.1    Yoon, J.H.2    Kim, J.R.3
  • 46
    • 33644513730 scopus 로고    scopus 로고
    • Beyond PTEN mutations: The PI3K pathway as an integrator of multiple inputs during tumorigenesis
    • Cully M, You H, Levine AJ, et al: Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer 2006; 6: 184-192.
    • (2006) Nat Rev Cancer , vol.6 , pp. 184-192
    • Cully, M.1    You, H.2    Levine, A.J.3
  • 47
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navigating downstream
    • Manning BD, Cantley LC: AKT/PKB signaling: navigating downstream. Cell 2007; 129: 1261-1274.
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 48
    • 31344479312 scopus 로고    scopus 로고
    • Phosphorylated Akt Over-expression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis
    • Tang JM, He QY, Guo RX, et al: Phosphorylated Akt Over-expression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis. Lung Cancer 2006; 51: 181-191.
    • (2006) Lung Cancer , vol.51 , pp. 181-191
    • Tang, J.M.1    He, Q.Y.2    Guo, R.X.3
  • 49
    • 11144354317 scopus 로고    scopus 로고
    • Prognostic significance of activated Akt expression in pancreatic ductal adeno-carcinoma
    • Yamamoto S, Tomita Y, Hoshida Y, et al: Prognostic significance of activated Akt expression in pancreatic ductal adeno-carcinoma. Clin Cancer Res 2004; 10: 2846-2850.
    • (2004) Clin Cancer Res , vol.10 , pp. 2846-2850
    • Yamamoto, S.1    Tomita, Y.2    Hoshida, Y.3
  • 50
    • 5144228549 scopus 로고    scopus 로고
    • High levels of phosphorylated form of Akt-1 in prostate cancer and non-neoplastic prostate tissues are strong predictors of biochemical recurrence
    • Ayala G, Thompson T, Yang G, et al: High levels of phosphorylated form of Akt-1 in prostate cancer and non-neoplastic prostate tissues are strong predictors of biochemical recurrence. Clin Cancer Res 2004; 10: 6572-6578.
    • (2004) Clin Cancer Res , vol.10 , pp. 6572-6578
    • Ayala, G.1    Thompson, T.2    Yang, G.3
  • 51
    • 12344289067 scopus 로고    scopus 로고
    • Akt phosphorylation is a risk factor for early disease recurrence and poor prognosis in hepato-cellular carcinoma
    • Nakanishi K, Sakamoto M, Yamasaki S, et al: Akt phosphorylation is a risk factor for early disease recurrence and poor prognosis in hepato-cellular carcinoma. Cancer 2005; 103: 307-312.
    • (2005) Cancer , vol.103 , pp. 307-312
    • Nakanishi, K.1    Sakamoto, M.2    Yamasaki, S.3
  • 52
    • 36549013178 scopus 로고    scopus 로고
    • Activation of the ERK and AKT signaling pathway predicts poor prognosis in hepato-cellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection
    • Schmitz KJ, Wohlschlaeger J, Lang H, et al: Activation of the ERK and AKT signaling pathway predicts poor prognosis in hepato-cellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection. J Hepatol 2008; 48: 83-90.
    • (2008) J Hepatol , vol.48 , pp. 83-90
    • Schmitz, K.J.1    Wohlschlaeger, J.2    Lang, H.3
  • 53
    • 1242271208 scopus 로고    scopus 로고
    • 3-Phosphoinositide-dependent protein kinase-1/Akt signaling represents a major cyclooxygenase-2-independent target for celecoxib in prostate cancer cells
    • Kulp SK, Yang YT, Hung CC: 3-Phosphoinositide-dependent protein kinase-1/Akt signaling represents a major cyclooxygenase-2-independent target for celecoxib in prostate cancer cells. Cancer Res 2004; 64: 1444-1451.
    • (2004) Cancer Res , vol.64 , pp. 1444-1451
    • Kulp, S.K.1    Yang, Y.T.2    Hung, C.C.3
  • 54
    • 0034908652 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI3-kinase/Akt pathway
    • Dimmeler S, Aicher A, Vasa M, et al: HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI3-kinase/Akt pathway. J Clin Invest 2001; 108: 391-397.
    • (2001) J Clin Invest , vol.108 , pp. 391-397
    • Dimmeler, S.1    Aicher, A.2    Vasa, M.3
  • 55
    • 33845218255 scopus 로고    scopus 로고
    • Statins induce mammalian target of rapamycin (mTOR)-mediated inhibition of Akt signaling and sensitize p53-deficient cells to cytostatic drugs
    • Roudier E, Mistafa O, Stenius U: Statins induce mammalian target of rapamycin (mTOR)-mediated inhibition of Akt signaling and sensitize p53-deficient cells to cytostatic drugs. Mol Cancer Ther 2006; 5: 2706-2715.
    • (2006) Mol Cancer Ther , vol.5 , pp. 2706-2715
    • Roudier, E.1    Mistafa, O.2    Stenius, U.3
  • 56
    • 70249093582 scopus 로고    scopus 로고
    • Statins inhibit Akt/PKB signaling via P2X7 receptor in pancreatic cancer cells
    • Mistafa O, Stenius U: Statins inhibit Akt/PKB signaling via P2X7 receptor in pancreatic cancer cells. Biochem Pharmacol 2009; 78: 1115-1126.
    • (2009) Biochem Pharmacol , vol.78 , pp. 1115-1126
    • Mistafa, O.1    Stenius, U.2
  • 57
    • 1842584647 scopus 로고    scopus 로고
    • Celecoxib-induced apoptosis in rat cholangiocarcinoma cells mediated by Akt inactivation and Bax translocation
    • Zhang Z, Lai GH, Sirica AE: Celecoxib-induced apoptosis in rat cholangiocarcinoma cells mediated by Akt inactivation and Bax translocation. Hepatology 2004; 39: 1028-1037.
    • (2004) Hepatology , vol.39 , pp. 1028-1037
    • Zhang, Z.1    Lai, G.H.2    Sirica, A.E.3
  • 58
    • 40749156343 scopus 로고    scopus 로고
    • Combination of atorvastatin and celecoxib synergistically induces cell cycle arrest and apoptosis in colon cancer cells
    • Xiao H, Zhang Q, Lin Y, et al: Combination of atorvastatin and celecoxib synergistically induces cell cycle arrest and apoptosis in colon cancer cells. Int J Cancer 2008; 122: 2115-2124.
    • (2008) Int J Cancer , vol.122 , pp. 2115-2124
    • Xiao, H.1    Zhang, Q.2    Lin, Y.3
  • 59
    • 42049088710 scopus 로고    scopus 로고
    • Statins increase p21 through inhibition of histone deacetylase activity and release of promoter-associated HDAC1/2
    • Lin YC, Lin JH, Chou CW, et al: Statins increase p21 through inhibition of histone deacetylase activity and release of promoter-associated HDAC1/2. Cancer Res 2008; 68: 2375-2383.
    • (2008) Cancer Res , vol.68 , pp. 2375-2383
    • Lin, Y.C.1    Lin, J.H.2    Chou, C.W.3
  • 60
    • 28844437366 scopus 로고    scopus 로고
    • Mcl-1 Over-expression in hepato-cellular carcinoma: A potential target for antisense therapy
    • Sieghart W, Losert D, Strommer S, et al: Mcl-1 Over-expression in hepato-cellular carcinoma: a potential target for antisense therapy. J Hepatol 2006; 44: 151-157.
    • (2006) J Hepatol , vol.44 , pp. 151-157
    • Sieghart, W.1    Losert, D.2    Strommer, S.3
  • 61
    • 33846212284 scopus 로고    scopus 로고
    • Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepato-cellular carcinoma model PLC/PRF/5
    • Liu L, Cao Y, Chen C, et al: Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepato-cellular carcinoma model PLC/PRF/5. Cancer Res 2006; 66: 11851-11858.
    • (2006) Cancer Res , vol.66 , pp. 11851-11858
    • Liu, L.1    Cao, Y.2    Chen, C.3
  • 62
    • 33644798945 scopus 로고    scopus 로고
    • Mcl-1 is an antiapoptotic factor for human hepato-cellular carcinoma
    • Fleischer B, Schulze-Bergkamen H, Schuchmann M, et al: Mcl-1 is an antiapoptotic factor for human hepato-cellular carcinoma. Int J Oncol 2006; 28: 25-32.
    • (2006) Int J Oncol , vol.28 , pp. 25-32
    • Fleischer, B.1    Schulze-Bergkamen, H.2    Schuchmann, M.3
  • 63
    • 0142245593 scopus 로고    scopus 로고
    • Inhibition of protein geranylgeranylation induces apoptosis in myeloma plasma cells by reducing Mcl-1 protein levels
    • van de Donk NW, Kamphuis MM, van Kessel B, et al: Inhibition of protein geranylgeranylation induces apoptosis in myeloma plasma cells by reducing Mcl-1 protein levels. Blood 2003; 102: 3354-3362.
    • (2003) Blood , vol.102 , pp. 3354-3362
    • van de Donk, N.W.1    Kamphuis, M.M.2    van Kessel, B.3
  • 64
    • 51049115143 scopus 로고    scopus 로고
    • Synergistic inhibition of lung tumorigenesis by a combination of green tea polyphenols and atorvastatin
    • Lu G, Xiao H, You H, et al: Synergistic inhibition of lung tumorigenesis by a combination of green tea polyphenols and atorvastatin. Clin Cancer Res 2008; 14: 4981-4988.
    • (2008) Clin Cancer Res , vol.14 , pp. 4981-4988
    • Lu, G.1    Xiao, H.2    You, H.3
  • 65
    • 0035969963 scopus 로고    scopus 로고
    • An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and caspase-7
    • Shin S, Sung BJ, Cho YS, et al: An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and caspase-7. Biochemistry 2001; 40: 1117-1123.
    • (2001) Biochemistry , vol.40 , pp. 1117-1123
    • Shin, S.1    Sung, B.J.2    Cho, Y.S.3
  • 66
    • 25844451103 scopus 로고    scopus 로고
    • Hepatitis B virus X protein upregulates survivin expression in hepatoma tissues
    • Zhang X, Dong N, Yin L, et al: Hepatitis B virus X protein upregulates survivin expression in hepatoma tissues. J Med Virol 2005; 77: 374-381.
    • (2005) J Med Virol , vol.77 , pp. 374-381
    • Zhang, X.1    Dong, N.2    Yin, L.3
  • 67
    • 2542502542 scopus 로고    scopus 로고
    • HPV DNA and survivin expression in epithelial oral carcinogenesis: A relationship?
    • Lo Muzio L, Campisi G, Giovannelli L, et al: HPV DNA and survivin expression in epithelial oral carcinogenesis: a relationship? Oral Oncol 2004; 40: 736-741.
    • (2004) Oral Oncol , vol.40 , pp. 736-741
    • Lo Muzio, L.1    Campisi, G.2    Giovannelli, L.3
  • 68
    • 0034806033 scopus 로고    scopus 로고
    • Vitamin C augments chemotherapeutic response of cervical carcinoma HeLa cells by stabilizing P53
    • Reddy VG, Khanna N, Singh N: Vitamin C augments chemotherapeutic response of cervical carcinoma HeLa cells by stabilizing P53. Biochem Biophys Res Commun 2001; 282: 409-415.
    • (2001) Biochem Biophys Res Commun , vol.282 , pp. 409-415
    • Reddy, V.G.1    Khanna, N.2    Singh, N.3
  • 69
    • 0037267333 scopus 로고    scopus 로고
    • Validating survivin as a cancer therapeutic target
    • Altieri DC: Validating survivin as a cancer therapeutic target. Nat Rev Cancer 2003; 3: 46-54.
    • (2003) Nat Rev Cancer , vol.3 , pp. 46-54
    • Altieri, D.C.1
  • 70
    • 4844227693 scopus 로고    scopus 로고
    • Survivin as a therapeutic target for radiation sensitization in lung
    • Lu B, Mu Y, Cao C, et al: Survivin as a therapeutic target for radiation sensitization in lung. Cancer Res 2004; 64: 2840-2845.
    • (2004) Cancer Res , vol.64 , pp. 2840-2845
    • Lu, B.1    Mu, Y.2    Cao, C.3
  • 71
    • 77957728274 scopus 로고    scopus 로고
    • Celecoxib inhibits the expression of survivin via the suppression of promoter activity in human colon cancer cells
    • Sakoguchi-Okada N, Takahashi-Yanaga F, Fukada K, et al: Celecoxib inhibits the expression of survivin via the suppression of promoter activity in human colon cancer cells. Biochem Biophys Res Commun 2007; 357: 1166-1171.
    • (2007) Biochem Biophys Res Commun , vol.357 , pp. 1166-1171
    • Sakoguchi-Okada, N.1    Takahashi-Yanaga, F.2    Fukada, K.3
  • 72
    • 46749097472 scopus 로고    scopus 로고
    • Statins activate a mitochondria-operated pathway of apoptosis in breast tumor cells by a mechanism regulated by ErbB2 and dependent on the prenylation of proteins
    • Herrero-Martin G, López-Rivas A: Statins activate a mitochondria-operated pathway of apoptosis in breast tumor cells by a mechanism regulated by ErbB2 and dependent on the prenylation of proteins. FEBS Lett 2008; 582: 2589-2594.
    • (2008) FEBS Lett , vol.582 , pp. 2589-2594
    • Herrero-Martin, G.1    López-Rivas, A.2
  • 73
    • 33745238704 scopus 로고    scopus 로고
    • Cyclooxygenase-2 independent anticarcino-genic effects of selective COX-2 inhibitors
    • Grösch S, Maier TJ, Schiffmann S, et al: Cyclooxygenase-2 independent anticarcino-genic effects of selective COX-2 inhibitors. J Natl Cancer Inst 2006; 98: 736-747.
    • (2006) J Natl Cancer Inst , vol.98 , pp. 736-747
    • Grösch, S.1    Maier, T.J.2    Schiffmann, S.3
  • 74
    • 1642407595 scopus 로고    scopus 로고
    • Cyclooxygenase-2 (COX-2)-dependent and-independent anticarcinogenic effects of celecoxib in human colon carcinoma cells
    • Maier TJ, Schilling K, Schmidt R, et al: Cyclooxygenase-2 (COX-2)-dependent and-independent anticarcinogenic effects of celecoxib in human colon carcinoma cells. Biochem Pharmacol 2004; 67: 1469-1478.
    • (2004) Biochem Pharmacol , vol.67 , pp. 1469-1478
    • Maier, T.J.1    Schilling, K.2    Schmidt, R.3
  • 75
    • 74049089011 scopus 로고    scopus 로고
    • Synergistic actions of atorvastatin with gamma-tocotrienol and celecoxib against human colon cancer HT29 and HCT116 cells
    • Yang Z, Xiao H, Jin H, et al: Synergistic actions of atorvastatin with gamma-tocotrienol and celecoxib against human colon cancer HT29 and HCT116 cells. Int J Cancer 2010; 126: 852-863.
    • (2010) Int J Cancer , vol.126 , pp. 852-863
    • Yang, Z.1    Xiao, H.2    Jin, H.3


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