Substrate affinity of photosensitizers derived from chlorophyll-a: The ABCG2 transporter affects the phototoxic response of side population stem cell-like cancer cells to photodynamic therapy

Molecular Pharmaceutics

Volumn 7, Issue 5, 2010, Pages 1789-1804

  Morgan, Janet ^a   Jackson, Jennifer D ^a   Zheng, Xiang ^a   Pandey, Suresh K ^a   Pandey, Ravindra K ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

ABCG2; cancer stem cells; HPPH; photodynamic therapy; photosensitizer; resistance; side population; tetrapyrrole; tyrosine kinase inhibitor

Indexed keywords

2 (1 HEXYLOXYETHYL) 2 DEVINYLPYROPHEOPHORBIDE A; 2 (1 HEXYLOXYETHYL) 2 DEVINYLPYROPHEOPHORBIDE A GALACTOSE CONJUGATE; 3 HYDROXYMETHYL N HEXYLPURPURINIMIDE DERIVATIVE; ALKYL GROUP; BREAST CANCER RESISTANCE PROTEIN; CARBOHYDRATE; CHLOROPHYLL A; DACTINOMYCIN; FUMITREMORGIN C; IMATINIB; IODOBENZENE; MACROCYCLIC COMPOUND; MONOSACCHARIDE; N HEXYLPURPURINIMIDE DERIVATIVE; PHEOPHORBIDE; PHOTOSENSITIZING AGENT; PROTEIN TYROSINE KINASE INHIBITOR; TETRAPYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER RESISTANCE; CELL STRAIN HEK293; CONJUGATION; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PHOTODYNAMIC THERAPY; PHOTOTOXICITY; PRIORITY JOURNAL; PROTEIN BINDING; STEM CELL; STRUCTURE ACTIVITY RELATION;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CELL LINE, TUMOR; CHLOROPHYLL; DRUG DESIGN; FEMALE; HEK293 CELLS; HELA CELLS; HUMANS; MICE; MICE, INBRED BALB C; MOLECULAR STRUCTURE; NEOPLASM PROTEINS; NEOPLASTIC STEM CELLS; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; SIDE-POPULATION CELLS;

EID: 77957723627     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp100154j     Document Type: Article

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