Etiopathogenesis of Behçet's disease with emphasison the role of immunological aberrations

Clinical Rheumatology

Volumn 29, Issue 11, 2010, Pages 1211-1216

  Kapsimali, Violetta D ^a   Kanakis, Meletios A ^b   Vaiopoulos, George A ^b   Kaklamanis, Phaedon G ^c  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b UNIVERSITY OF ATHENS   (Greece)

^c ATHENS MEDICAL CENTER   (Greece)

Author keywords

Beh et's disease; Genetic; Immunologic; Inflammatory mediators; Pathophysiology; Thrombophilic factors

Indexed keywords

AUTOANTIBODY; CYTOKINE; HEAT SHOCK PROTEIN;

ARTICLE; AUTOIMMUNE DISEASE; BEHCET DISEASE; CYTOKINE PRODUCTION; ENDOTHELIUM; ENVIRONMENTAL FACTOR; HEREDITY; HUMAN; IMMUNE SYSTEM; IMMUNOGENETICS; IMMUNOPATHOGENESIS; INFECTION; INFLAMMATION; NEUTROPHILIA; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

AUTOANTIBODIES; BEHCET SYNDROME; ENDOTHELIUM; ENVIRONMENT; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HEAT-SHOCK PROTEINS; HELICOBACTER PYLORI; HUMANS; IMMUNE SYSTEM; INFLAMMATION; MALE; NEUTROPHILS; T-LYMPHOCYTES; THROMBOPHILIA;

EID: 77957722519     PISSN: 07703198     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10067-010-1491-6     Document Type: Article

References (57)

1. VG Kaklamani G Vaiopoulos P Kaklamanis 1998 Behçet's disease Semin Arthritis Rheum 27 197 217 1:STN:280:DyaK1c7ntlSmuw%3D%3D 10.1016/S0049- 0172(98)80001-2 9514126
2. KT Calamia FC Wilson M Icen CS Crowson SE Gabriel HM Kremers 2009 Epidemiology and clinical characteristics of Behçet's disease in the United States: a population-based study Arthritis Rheum 61 600 604 10.1002/art.24423 19405011
3. G Azizlerli AA Kose R Sarica A Gul IT Tutkun M Kylac, et al. 2003 Prevalence of Behçet's disease in Instanbul, Turkey Int J Dermatol 42 803 806 10.1046/j.1365-4362.2003.01893.x 14521694
4. CC Zouboulis T May 2003 Pathogenesis of Adamantiades-Behçet's disease Med Microbiol Immunol 192 149 155 1:CAS:528:DC%2BD3sXmtl2lt7k%3D 10.1007/s00430-002-0167-5 12684757
5. A Gul 2001 Behçet's disease: an update on the pathogenesis Clin Exp Rheumatol 19 Suppl 24 S6 S12 1:STN:280:DC%2BD38%2FjsV2kuw%3D%3D 11760403
6. AD Protogerou PP Sfikakis KS Stamatelopoulos C Papamichael K Aznaouridis E Karatzis, et al. 2007 Interrelated modulation of endothelial function in Behçet's disease by clinical activity and corticosteroid treatment Arthritis Res Ther 9 R90 10.1186/ar2289 17845731
7. G Hatemi I Fresko K Tascilar H Yazici 2008 Increased enthesopathy among Behçet's syndrome patients with acne and arthritis: an ultrasonography study Arthritis Rheum 58 1539 1545 10.1002/art.23450 18438817
8. H Yazici I Fresko 2005 Behçet's disease and other autoinflammatory conditions: what's in a name? Clin Exp Rheumatol 23 suppl 38 S1 S2 16273757
9. K Aksu Y Kabasakal A Sayiner G Keser F Oksel A Bilgic, et al. 1999 Prevalence of hepatitis A, B, C and E viruses in Behçet's disease Rheumatology 38 1279 1281 1:STN:280:DC%2BD3c%2Fls1CgsA%3D%3D 10.1093/rheumatology/38.12.1279 10587560
10. T Lehner 1997 The role of heat shock protein, microbial and autiimmune agents in the aetiology of Behçet's disease Int Rev Immun 14 21 32 1:STN:280:DyaK2szks1KjtQ%3D%3D
11. EB Baskan E Yilmaz H Saricaoglu G Alkan I Ercan R Mistik, et al. 2007 Detection of parvovirus B19 DNA in the lesional skin of patients with Behçet's disease Clin Exp Dermatol 32 186 190 1:STN:280: DC%2BD2s7gslyitw%3D%3D 10.1111/j.1365-2230.2006.02330.x 17250756
12. O Ersoy R Ersoy O Yayar H Demirci S Tatlican 2007 H. pylori infections in patients with Behçet's disease World J Gastroenterol 13 2983 2985 17589951
13. E Ayaslioglu N Duzgun E Erkek A Inal 2004 Evidence of chronic Chlamydia pneumoniae infection in patients with Behçet's disease Scand J Infect Dis 36 428 430 10.1080/00365540410020730 15307562
14. F Kaneko N Oyama A Nishibu 1997 Streptococcal infection in the pathogenesis of Behçet's disease and clinical effects of minocycline on the disease symptoms Yonsei Med J 38 444 454 1:CAS:528:DyaK1cXhvVeiurw%3D 9509915
15. E Isogai M Hirata H Isogai K Matuo K Kimura K Yokota, et al. 2003 Antimicrobial activity of synthetic human CAP 18 peptides to Streptococcus sanguis isolated from patients with Behcet's disease Adv Exp Med Biol 528 195 200 1:CAS:528:DC%2BD3sXnsFersro%3D 10.1007/0-306-48382-3-38 12918689
16. M Mochizuki N Suzuki M Takeno H Nagafuchi T Harada H Kaneoka, et al. 1994 Fine antigen specificity of human gamma delta T cell lines (V gamma 9+) established by repetitive stimulation with a serotype (KTH-1) of a gram positive bacterium Streptococcus sanguis Eur J Immunol 24 1536 1543 1:CAS:528: DyaK2cXltlWrtrc%3D 10.1002/eji.1830240712 7517873
17. U Karacayli G Mumcu I Simsek S Pay O Kose H Erdem, et al. 2009 The close association between dental and periodontal treatments and oral ulcers course in Behçet's disease: a perspective clinical study J Oral Pathol Med 38 410 415 10.1111/j.1600-0714.2009.00765.x 19320802
18. I Krause Y Monselise G Milo A Weinberger 2002 Anti-Saccharomyces cerevisiae antibodies-a novel serologic marker of Behçet's disease Clin Exp Rheumatol 20 suppl.26 S-21 S-24 1:STN:280:DC%2BD38nhsVKgtQ%3D%3D
19. L Filik I Biyikoglu 2008 Differentiation of Behcet's disease from inflammatory bowel diseases: anti-Saccharomyces cerevisiae antibody and anti-neutrophilic cytoplasmic antibody World J Gastroenterol 14 7271 10.3748/wjg.14.7271 19084948
20. T Ergun U Ince E Eksioglu-Demiralp H Direskeneli O Gurbuz L Gurses, et al. 2001 HSP60 expression in mucocutaneous lesions of Behçet's disease J Am Acad Dermatol 45 904 909 1:STN:280:DC%2BD3MnovFegtg%3D%3D 10.1067/mjd.2001.117728 11712037
21. K Pervin A Childerstone T Shinnick Y Mizushima R van der Zee A Hasan R Vaughan T Lehner 1993 T cell epitope expression of mycobacterial and homologous human 65-kilodalton heat shock protein peptides in short term cell lines from patients with Behçet's disease J Immunol 151 2273 2282 1:CAS:528:DyaK2cXms1Wm 7688396
22. H Direskeneli G Saruhan-Direskeneli 2003 The role of heat shock proteins in Behçet's disease Clin Exp Rheumatol 21 S44 S48 1:STN:280: DC%2BD2c%2FivVWksg%3D%3D 14727460
23. E Birtas-Atesoglu N Inanc S Yavuz T Ergun H Direskeneli 2008 Serum levels of free heat shock protein 70 and anti-HSP70 and elevated in Behçet's disease Clin Exp Rheumatol 26 suppl 50 S96 S98 1:STN:280:DC%2BD1cjmtVCiuw%3D%3D 19026123
24. G Triolo A Accardo-Palumbo F Dieli F Ciccia A Ferrante E Giardina CD Sano G Licata 2003 Vgamma9/Vdelta2 T lymphocytes in Italian patients with Behçet's disease-evidence for expansion and tumor necrosis factor receptor II and interleukin-12 receptor beta1 expression in active disease Arthritis Res Ther 5 R262 R268 1:CAS:528:DC%2BD3sXmtVeqsLY%3D 10.1186/ar785 12932289
25. I Bank M Duvdevani A Livneh 2003 Expansion of gammadelta T cells in Behçet's disease: role of disease activity and microbial flora in oral ulcers J Lab Clin Med 141 33 40 1:CAS:528:DC%2BD3sXmt1WntQ%3D%3D 10.1067/mlc.2003.1 12518166
26. K Hamzaoui A Hamzaoui F Hentati A Kahan K Ayed A Chabbou M Ben Hamida M Hamza 1994 Phenotype and functional profile of T cells expressing gammadelta receptor patients with active Behçet's disease J Rheumatol 21 2301 2306 1:STN:280:DyaK2M3htl2qtA%3D%3D 7699633
27. H Yasuoka Y Yamaguchi N Mizuki T Nishida Y Kawakami M Kuwana 2008 Preferential activation of circulating CD8+ and gammadelta T cells in patients with active Behçet's disease and HLA-B51 Clin Exp Rheumatol 26 suppl 50 S59 S63 1:STN:280:DC%2BD1cjmtVCitw%3D%3D 19026117
28. E Eksioglu-Demiralp H Direskeneli A Kibaroglu S Yavuz T Ergun T Akoglu 2001 Neutrophil activation in Behçet's disease Clin Exp Rheumatol 19 Suppl 24 S19 S24 1:STN:280:DC%2BD38%2FjsV2luw%3D%3D 11760393
29. S Pay I Simşek H Erdem A Dinç 2007 Immunopathogenesis of Behçet's disease with special emphasize on the possible role of antigen presenting cells Rheumatol Int 27 417 424 1:CAS:528:DC%2BD2sXhvVeitr0%3D 10.1007/s00296-006-0281-6 17171346
30. A Carletto ML Pacor D Biasi P Caramaschi S Zeminian P Bellavite LM Bambara 1997 Changes of neutrophil migration without modification of in vitro metabolism and adhesion in Behçet's disease J Rheumatol 24 1332 1336 1:STN:280:DyaK2szntFylug%3D%3D 9228133
31. CC Zouboulis J Katsantonis R Ketteler R Treudler E Kaklamani S Hornemann P Kaklamanis CE Orfanos 2000 Adamantiades-Behçet's disease: interleukin-8 is increased in serum of patients with active oral and neurological manifestations and is secreted by small vessel endothelial cells Arch Dermatol Res 292 279 284 1:CAS:528:DC%2BD3cXls1OqtLY%3D 10.1007/s004030000128 10929768
32. J Katsantonis Y Adler CE Orfanos CC Zouboulis 2000 Adamantiades- Behçet's disease: serum IL-8 is a more reliable marker for disease activity than C-reactive protein and erythrocyte sedimentation rate Dermatology 201 37 39 1:CAS:528:DC%2BD3cXmvV2hsL4%3D 10.1159/000018426 10971057
33. MA Frassanito R Dammacco P Cafforio F Dammacco 1999 Th1 polarization of the immune response in Behçet's disease Arthritis Rheum 42 1967 1974 1:CAS:528:DyaK1MXmsl2msLY%3D 10.1002/1529-0131(199909)42:9<1967::AID- ANR24>3.0.CO;2-Z 10513814
34. M Ben Ahmed H Houman M Miled K Dellagi H Louzir 2004 Involvement of chemokines and Th1 cytokines in the pathogenesis of mucocutaneous lesions of Behçet's disease Arthritis Rheum 50 7 2291 2295 1:CAS:528: DC%2BD2cXmsVantr8%3D 10.1002/art.20334 15248229
35. A Protogerou J Lekakis K Stamatelopoulos K Aznaouridis E Karatzis I Ikonomidis, et al. 2003 Arterial wall characteristics in patients with Adamantiades-Behcet's disease Adv Exp Med Biol 528 399 404 1:STN:280: DC%2BD3szot1KgsA%3D%3D 10.1007/0-306-48382-3-82 12918733
36. R Ozdemir I Barutcu AT Sezgin N Acikgoz N Ermis A Metin, et al. 2004 Vascular endothelial function and plasma homocysteine levels in Behcet's disease Am J Cardiol 94 522 525 1:CAS:528:DC%2BD2cXmvFCqsLY%3D 10.1016/j.amjcard.2004. 04.073 15325946
37. M Leiba Y Sidi H Gur A Leiba M Ehrenfeld 2001 Behçet's disease and thrombophilia Ann Rheum Dis 60 1081 1085 1:CAS:528:DC%2BD38XitFeksw%3D%3D 10.1136/ard.60.12.1081 11709446
38. GP Fadini S Tognon L Rodriguez E Boscaro I Baesso A Avogaro, et al. 2009 Low levels of endothelial progenitor cells correlate with disease duration and activity in patients with Behçet's disease Clin Exp Rheumatol 27 814 821 1:STN:280:DC%2BD1MjmtlKqtw%3D%3D 19917165
39. G Espinosa J Font D Tassies A Viddaler R Deulofeu A Lopez-Soto 2002 Vascular involvement in Behçet's disease: relation with thrombophilic factors, coagulation activation and thrombomodulin Am J Med 112 37 43 1:CAS:528:DC%2BD38Xms1GksA%3D%3D 10.1016/S0002-9343(01)01048-8 11812405
40. S Menashi B Tribout C Dosquet P Le Toumelin JC Piette B Wechsler, et al. 2008 Strong association between plasma thrombomodulin and pathergy test in Behçet's disease Ann Rheumatol Dis 67 892 893 1:STN:280: DC%2BD1czhtFOnsw%3D%3D 10.1136/ard.2007.075143
41. Y Ozkan S Yardim-Akaydin A Sepici B Engin V Sepici B Simsek 2007 Assessement of homocysteine, neopterin and nitric oxide levels in Behçet's disease Clin Chem Lab Med 45 73 77 1:CAS:528: DC%2BD2sXhsFKisbk%3D 10.1515/CCLM.2007.018 17243919
42. A Dinc T Takafuta D Jiang M Melikoglu G Saruhan-Direskeneli SS Shapiro 2003 Antiendothelial cell antibodies in Behçet's disease Clin Exp Rheumatol 21 suppl 30 S27 S30 1:STN:280:DC%2BD2c%2FivVWltw%3D%3D 14727455
43. KH Lee HS Chung HS Kim SH Oh MK Ha JH Baik, et al. 2003 Human alpha-enolase from endothelial cells as a target antigen of anti-endothelial cell antibody in Behçet's disease Arthritis Rheum 46 2025 2035 10.1002/art.11074
44. A Kalayciyan C Zouboulis 2007 An update on Behçet's disease J Eur Acad Dermatol Venereol 21 1 10 1:STN:280:DC%2BD2s%2FhtFaktA%3D%3D 10.1111/j.1468-3083.2006.01863.x 17207160
45. U Musabak O Baylan T Cetin Z Yesilova A Sengul K Saglam, et al. 2005 Lipid profile and anticardiolipin antibodies in Behçet's disease Arch Med Res 36 387 392 1:CAS:528:DC%2BD2MXltFakur4%3D 10.1016/j.arcmed.2005.03.019 15950080
46. L Kandolf-Sekulovic MD Pavlovic B Glisic M Petronijevic G Ristic Z Mijuskovic, et al. 2005 Adamantiades-Behçet's disease, deep venous thrombosis and anticardiolipin antibodies: report of two cases J Eur Acad Dermatol Venereol 19 484 488 1:STN:280:DC%2BD2Mzjs1KntQ%3D%3D 10.1111/j.1468-3083.2005.01193.x 15987300
47. SA Al Mutawa SM Hegab 2004 Behçet's disease Clin Exp Med 4 103 131 1:CAS:528:DC%2BD2cXhtVKrurnI 10.1007/s10238-004-0045-0 15599660
48. F Mor A Weinberger IR Cohen 2002 Identification of alpha tropomyosin as a target self-antigen in Behçet's syndrome Eur J Immunol 32 356 365 1:CAS:528:DC%2BD38XhvVehtrk%3D 10.1002/1521-4141(200202)32:2<356::AID- IMMU356>3.0.CO;2-9 11807775
49. Y Lu P Ye SL Chen EM Ten EK Chen 2005 Identification of kinektin as a novel Behçet's disease autoantigen Arthritis Res Ther 7 R1133 R1139 1:CAS:528:DC%2BD2MXpvFOguro%3D 10.1186/ar1798 16207330
50. J Zervas G Vayopoulos N Sakellaropoulos P Kaklamanis P Fessas 1988 HLA antigens and Adamantiades-Behçet's disease (ABD) in Greeks Clin Exp Rheumatol 6 277 280 1:STN:280:DyaL1M%2FivFegtw%3D%3D 3180547
51. TI Kaya H Dur U Tursen A Gurler 2002 Association of class I HLA antigens with the clinical manifestations of Turkish patients with Behçet's disease Clin Exp Dermatol 27 498 501 1:STN:280:DC%2BD38nhsFGjsQ%3D%3D 10.1046/j.1365-2230.2002.01060.x 12372094
52. N Mizuki K Yabuki M Ota Y Katsuyama H Ando E Nomura, et al. 2002 Microsatellite polymorhism around the HLA-B locus in Iranian patients with Behçet's disease Tissue Antigens 60 396 399 1:CAS:528: DC%2BD3sXkslWlsQ%3D%3D 10.1034/j.1399-0039.2002.600506.x 12492815
53. Meguro A, Inoko H, Ota M, Katsuyama Y, Oka A, Okada E, et al (2010) Genetics of Behçet's disease inside and outside the MHC. Ann Rheum Dis 69:747-754
54. K Durrani GN Papaliodis 2008 The genetics of Adamantiades Behçet's disease Semin Ophthalmol 23 73 79 1:STN:280:DC%2BD1c%2Fmtlaltw%3D%3D 10.1080/08820530701745264 18214795
55. H Direskeneli 2001 Behçet's disease: infectious aetiology, new autoantigens and HLA-B51 Ann Rheum Dis 60 996 1002 1:CAS:528: DC%2BD3MXotlGiur4%3D 10.1136/ard.60.11.996 11602462
56. T Ahmad GR Wallace T James M Neville M Bunce K Mulcahy-Hawes, et al. 2003 Mapping of the HLA association in Behçet's disease. A role for tumor necrosis factor polymorphisms? Arthritis Rheum 48 807 813 1:CAS:528: DC%2BD3sXislKgurs%3D 10.1002/art.10815 12632436
57. N Mizuki A Meguro I Tohnai A Gul S Ohno N Mizuki 2007 Association of major histocompatibility complex class I chain-related gene A and HLA-B alleles with Behçet's disease in Turkey Jpn J Ophthalmol 51 431 436 10.1007/s10384-007-0473-y 18158593