Quercetin permeability across blood-brain barrier and its effect on the viability of U251 cells

Journal of Sichuan University (Medical Science)

Volumn 41, Issue 5, 2010, Pages

  Ren, Si Chong ^a   Suo, Qi Feng ^a   Du, Wen Ting ^a   Pan, Hong ^a   Yang, Ming Ming ^a   Wang, Ruo Han ^a   Liu, Ji ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Blood brain barrier; Glioblastoma; HPLC; Quercetin; SCGE

Indexed keywords

EID: 77957717811     PISSN: 1672173X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Pardridge WM. The blood-brain barrier: bottleneck in brain drug development. Neuro RX, 2005; 2(1): 3-14.
2. Eyal S, Hsiao P, Unadkat JD. Drug interactions at the bloodbrain barrier: fact or fantasy. Pharmacology & Therapeutics, 2009;123 ( 1 ) : 80-104.
3. Boots AW, Haenen GRMM, Bast A. Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol, 2008); 585(2-3): 325-337.
4. Iwase Y, Takemura Y, Jurichi M, et al. Inhibitory effect of flavonoid derivatives on Epstein-Barr virus activation and twostage carcinogenesis of skin tumor. Cancer Lett, 2001;173(2) : 105-109.
5. Kim WK, Bang MH, Kim IS, et al. Quercetin decreases the expression of ErbB2 and ErbB3 proteins in HT-29 human colon cancer cells. J Nutr Biochem,2005;16(3): 115-162.
6. Lim JC, Wolpaw AJ, Caldwell MA, et al. Neural precursor cell influences on blood-brain barrier characteristics in rat brain endothelial cells. Brain Res, 2007; 1159(23): 67-76.
7. Murakami A, Ashida H, Terao J. Multitargeted cancer prevention by quercetin. Cancer Lett, 2008; 269(2): 315-325.
8. Youdim KA, Qaiser MZ, Begley DJ, et al. Flavonoid permeability across an in situ model of the blood-brain barrier. Free Radical Bio Med, 2004; 36(5): 592-604.
9. Hurst RD, Fritz LB. Properties of an immortalized vascular endothelial/ glioma cell co-culture model of the blood-brain barrier.J Cell Physiol,1996; 167(1): 81-88.
10. Lee DH, Szczepansk M, Lee YJ. Role of Bax in quercetininduced apoptosis in human prostate cancer cells. Biochem Pharmacol, 2008; 75(12): 2345-2355.
11. Mertens-Talcott SU, Percival SS. Ellagic acid and quercetin interact synergistically with resveratrol in the induction of apoptosis and cause transientcell cycle arrest in human leukemia cells. Cancer Lett, 2005; 218(2): 141-151.