The combination of a histone deacetylase inhibitor with the BH3-mimetic GX15-070 has synergistic antileukemia activity by activating both apoptosis and autophagy

Autophagy

Volumn 6, Issue 7, 2010, Pages 976-978

  Wei, Yue ^a   Kadia, Tapan ^a   Tong, Weigang ^a   Zhang, Ming ^a   Jia, Yu ^a   Yang, Hui ^a   Hu, Yumin ^a   Viallet, Jean ^b   O'Brien, Susan ^a   Garcia Manero, Guillermo ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b Gemin X Pharmaceuticals   (United States)

Author keywords

Apoptosis; Autophagy; GX15 070; Histone deacetylase inhibitor; Leukemia

Indexed keywords

CALPAIN; CASPASE; N (2 AMINOPHENYL) 4 [4 (3 PYRIDINYL) 2 PYRIMIDINYLAMINOMETHYL]BENZAMIDE; OBATOCLAX; VORINOSTAT;

ACUTE GRANULOCYTIC LEUKEMIA; APOPTOSIS; AUTOPHAGY; CANCER CELL CULTURE; CELL VIABILITY; CYTOTOXICITY; DRUG POTENTIATION; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; SHORT SURVEY;

EID: 77957688352     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.6.7.13117     Document Type: Short Survey

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