The fate of irreparable DNA double-strand breaks and eroded telomeres at the nuclear periphery

Nucleus

Volumn 1, Issue 2, 2010, Pages

  Lisby, Michael ^a   Teixeira, Teresa ^b   Gilson, Eric ^b   Géli, Vincent ^c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITÉ DE LYON   (France)

^c CNRS   (France)

Author keywords

Cdc13; DNA damage; Homologous recombination; Nuclear pore complex; Rad52; Replication protein A; Telomeres

Indexed keywords

DOUBLE STRANDED DNA; TELOMERASE;

ARTICLE; CHROMATIN STRUCTURE; ENZYME ACTIVITY; GENE EXPRESSION; NUCLEAR PORE COMPLEX; SUMOYLATION; TELOMERE;

EID: 77957686732     PISSN: 19491034     EISSN: 19491042     Source Type: Journal    
DOI: 10.4161/nucl.11173     Document Type: Article

References (31)

1. Longhese MP. DNA damage response at functional and dysfunctional telomeres. Genes Dev 2008; 22:125-40.
2. McEachern MJ, Krauskopf A, Blackburn EH. Telomeres and their control. Annu Rev Genet 2000; 34:331-58.
3. Larrivee M, LeBel C, Wellinger RJ. The generation of proper constitutive G-tails on yeast telomeres is dependent on the MRX complex. Genes Dev 2004; 18:1391-6.
4. Conrad MN, Wright JH, Wolf AJ, Zakian VA. RAP1 protein interacts with yeast telomeres in vivo: overproduction alters telomere structure and decreases chromosome stability. Cell 1990; 63:739-50.
5. Linger BR, Price CM. Conservation of telomere protein complexes: shuffling through evolution. Crit Rev Biochem Mol Biol 2009; 44:434-46.
6. Bianchi A, Shore D. How telomerase reaches its end: mechanism of telomerase regulation by the telomeric complex. Mol Cell 2008; 31:153-65.
7. Bonetti D, Martina M, Clerici M, Lucchini G, Longhese MP. Multiple pathways regulate 3' overhang generation at S. cerevisiae telomeres. Mol Cell 2009; 35:70-81.
8. Sabourin M, Zakian VA. ATM-like kinases and regulation of telomerase: lessons from yeast and mammals. Trends Cell Biol 2008; 18:337-46.
9. Negrini S, Ribaud V, Bianchi A, Shore D. DNA breaks are masked by multiple Rap1 binding in yeast: implications for telomere capping and telomerase regulation. Genes Dev 2007; 21:292-302.
10. Teixeira MT, Arneric M, Sperisen P, Lingner J. Telomere length homeostasis is achieved via a switch between telomerase-extendible and -nonextendible states. Cell 2004; 117:323-35.
11. Lisby M, Rothstein R. Choreography of recombination proteins during the DNA damage response. DNA Repair (Amst) 2009; 8:1068-76.
12. AS IJ, Greider CW. Short telomeres induce a DNA damage response in Saccharomyces cerevisiae. Mol Biol Cell 2003; 14:987-1001.
13. Gilson E, Geli V. How telomeres are replicated. Nat Rev Mol Cell Biol 2007; 8:825-38.
14. Makovets S, Herskowitz I, Blackburn EH. Anatomy and dynamics of DNA replication fork movement in yeast telomeric regions. Mol Cell Biol 2004; 24:4019-31.
15. Miller KM, Rog O, Cooper JP. Semi-conservative DNA replication through telomeres requires Taz1. Nature 2006; 440:824-8.
16. Chang M, Arneric M, Lingner J. Telomerase repeat addition processivity is increased at critically short telomeres in a Tel1-dependent manner in Saccharomyces cerevisiae. Genes Dev 2007; 21:2485-94.
17. Khadaroo B, Teixeira MT, Luciano P, Eckert-Boulet N, Germann SM, Simon MN, et al. The DNA damage response at eroded telomeres and tethering to the nuclear pore complex. Nat Cell Biol 2009; 11:980-7.
18. Hediger F, Neumann FR, Van Houwe G, Dubrana K, Gasser SM. Live imaging of telomeres: yKu and Sir proteins define redundant telomere-anchoring pathways in yeast. Curr Biol 2002; 12:2076-89.
19. Taddei A, Hediger F, Neumann FR, Bauer C, Gasser SM. Separation of silencing from perinuclear anchoring functions in yeast Ku80, Sir4 and Esc1 proteins. EMBO J 2004; 23:1301-12.
20. Schober H, Ferreira H, Kalck V, Gehlen LR, Gasser SM. Yeast telomerase and the SUN domain protein Mps3 anchor telomeres and repress subtelomeric recombination. Genes Dev 2009; 23:928-38.
21. Oza P, Jaspersen SL, Miele A, Dekker J, Peterson CL. Mechanisms that regulate localization of a DNA double-strand break to the nuclear periphery. Genes Dev 2009; 23:912-27.
22. Kalocsay M, Hiller NJ, Jentsch S. Chromosome-wide Rad51 spreading and SUMO-H2A.Z-dependent chromosome fixation in response to a persistent DNA double-strand break. Mol Cell 2009; 33:335-43.
23. Nagai S, Dubrana K, Tsai-Pflugfelder M, Davidson MB, Roberts TM, Brown GW, et al. Functional targeting of DNA damage to a nuclear pore-associated SUMO-dependent ubiquitin ligase. Science 2008; 322:597-602.
24. Dubrana K, van Attikum H, Hediger F, Gasser SM. The processing of double-strand breaks and binding of single-strand-binding proteins RPA and Rad51 modulate the formation of ATR-kinase foci in yeast. J Cell Sci 2007; 120:4209-20.
25. Abdallah P, Luciano P, Runge KW, Lisby M, Geli V, Gilson E, et al. A two-step model for senescence triggered by a single critically short telomere. Nat Cell Biol 2009; 11:988-93.
26. Evans SK, Lundblad V. Est1 and Cdc13 as comediators of telomerase access. Science 1999; 286:117-20.
27. Peterson SE, Stellwagen AE, Diede SJ, Singer MS, Haimberger ZW, Johnson CO, et al. The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku. Nat Genet 2001; 27:64-7.
28. Loeillet S, Palancade B, Cartron M, Thierry A, Richard GF, Dujon B, et al. Genetic network interactions among replication, repair and nuclear pore deficiencies in yeast. DNA Repair (Amst) 2005; 4:459-68.
29. Therizols P, Fairhead C, Cabal GG, Genovesio A, Olivo-Marin JC, Dujon B, et al. Telomere tethering at the nuclear periphery is essential for efficient DNA double strand break repair in subtelomeric region. J Cell Biol 2006; 172:189-99.
30. Palancade B, Doye V. Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties? Trends Cell Biol 2008; 18:174-83.
31. Gartenberg MR. Life on the edge: telomeres and persistent DNA breaks converge at the nuclear periphery. Genes Dev 2009; 23:1027-31.