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Volumn 67, Issue 14, 2010, Pages 1157-1164

Vernakalant: A novel agent for the termination of atrial fibrillation

Author keywords

Atrial fibrillation; Cardiac drugs; Mechanism of action; Pharmacokinetics; Toxicity; Vernakalant

Indexed keywords

AMIODARONE; DOFETILIDE; FLECAINIDE; IBUTILIDE; PLACEBO; PROPAFENONE; SOTALOL; VERNAKALANT; ANISOLE DERIVATIVE; ANTIARRHYTHMIC AGENT; POTASSIUM CHANNEL BLOCKING AGENT; PYRROLIDINE DERIVATIVE; SODIUM CHANNEL BLOCKING AGENT;

EID: 77957686713     PISSN: 10792082     EISSN: 15352900     Source Type: Journal    
DOI: 10.2146/ajhp080501     Document Type: Review
Times cited : (10)

References (47)
  • 1
    • 36549087247 scopus 로고    scopus 로고
    • Status of the Epidemiology of Atrial Fibrillation
    • DOI 10.1016/j.mcna.2007.09.002, PII S0025712507001307, Atrial Fibrillation
    • Kannel WB, Benjamin EJ. Status of the epidemiology of atrial fibrillation. Med Clin North Am. 2008; 92:17-40. (Pubitemid 350182405)
    • (2008) Medical Clinics of North America , vol.92 , Issue.1 , pp. 17-40
    • Kannel, W.B.1    Benjamin, E.J.2
  • 2
    • 37349082433 scopus 로고    scopus 로고
    • Increasing US emergency department visit rates and subsequent hospital admissions for atrial fibrillation from 1993 to 2004
    • McDonald AJ, Pelletier AJ, Ellinor PT et al. Increasing US emergency department visit rates and subsequent hospital admissions for atrial fibrillation from 1993 to 2004. Ann Emerg Med. 2008; 51:58-65.
    • (2008) Ann Emerg Med , vol.51 , pp. 58-65
    • McDonald, A.J.1    Pelletier, A.J.2    Ellinor, P.T.3
  • 3
    • 0035832261 scopus 로고    scopus 로고
    • Prevalence of diagnosed atrial fibrillation in adults: National implications for rhythm management and stroke prevention: The anticoagulation and risk factors in atrial fibrillation (ATRIA) study
    • Go AS, Hylek EM, Phillips KA et al. Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors In Atrial Fibrillation (ATRIA) Study. JAMA. 2001; 285:2370-5. (Pubitemid 32424106)
    • (2001) Journal of the American Medical Association , vol.285 , Issue.18 , pp. 2370-2375
    • Go, A.S.1    Hylek, E.M.2    Phillips, K.A.3    Chang, Y.C.4    Henault, L.E.5    Selby, J.V.6    Singer, D.E.7
  • 4
    • 33747052359 scopus 로고    scopus 로고
    • Secular trends in incidence of atrial fibrillation in Olmsted County, Minnesota, 1980 to 2000, and implications on the projections for future prevalence
    • Miyasaka Y, Barnes ME, Gersh BJ et al. Secular trends in incidence of atrial fibrillation in Olmsted County, Minnesota, 1980 to 2000, and implications on the projections for future prevalence. Circulation. 2006; 114:119-25.
    • (2006) Circulation , vol.114 , pp. 119-125
    • Miyasaka, Y.1    Barnes, M.E.2    Gersh, B.J.3
  • 5
    • 0346613575 scopus 로고    scopus 로고
    • Prevalence, incidence, prognosis and predisposing conditions for atrial fibrillation: Population based estimates
    • Kannel WB, Wolf PA, Benjamin EJ et al. Prevalence, incidence, prognosis and predisposing conditions for atrial fibrillation: population based estimates. Am J Cardiol. 1998; 82:2N-9N.
    • (1998) Am J Cardiol , vol.82
    • Kannel, W.B.1    Wolf, P.A.2    Benjamin, E.J.3
  • 6
    • 0034745254 scopus 로고    scopus 로고
    • Atrial fibrillation and stroke: Concepts and controversies
    • Hart RG, Halperin JL. Atrial fibrillation and stroke: concepts and controversies. Stroke. 2001; 32:803-8.
    • (2001) Stroke , vol.32 , pp. 803-808
    • Hart, R.G.1    Halperin, J.L.2
  • 8
    • 0025779484 scopus 로고
    • Atrial fibrillation as an independent risk factor for stroke: The Framingham Study
    • Wolf PA, Abbott RD, Kannel WB. Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. Stroke. 1991; 22:983-8.
    • (1991) Stroke , vol.22 , pp. 983-988
    • Wolf, P.A.1    Abbott, R.D.2    Kannel, W.B.3
  • 9
    • 0023625745 scopus 로고
    • Atrial fibrillation: A major contributor to stroke in the elderly. The Framingham study
    • DOI 10.1001/archinte.147.9.1561
    • Wolf PA, Abbott RD, Kannel WB. Atrial fibrillation: a major contributor to stroke in the elderly: the Framingham Study. Arch Intern Med. 1987; 147:1561-4. (Pubitemid 17138836)
    • (1987) Archives of Internal Medicine , vol.147 , Issue.9 , pp. 1561-1564
    • Wolf, P.A.1    Abbott, R.D.2    Kannel, W.B.3
  • 10
    • 0028244264 scopus 로고
    • Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation: Analysis of pooled data from five randomized controlled trials
    • Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation: analysis of pooled data from five randomized controlled trials. Arch Intern Med. 1994; 154:1449-57.
    • (1994) Arch Intern Med , vol.154 , pp. 1449-1457
  • 11
    • 0028921708 scopus 로고
    • Prevalence, age distribution, and gender of patients with atrial fibrillation: Analysis and implications
    • Feinberg WM, Blackshear JL, Laupacis A et al. Prevalence, age distribution, and gender of patients with atrial fibrillation: analysis and implications. Arch Intern Med. 1995; 155:469-73.
    • (1995) Arch Intern Med , vol.155 , pp. 469-473
    • Feinberg, W.M.1    Blackshear, J.L.2    Laupacis, A.3
  • 12
    • 2342605426 scopus 로고    scopus 로고
    • Blockers of the Kv1.5 channel for the treatment of atrial arrhythmias
    • Brendel J, Peukert S. Blockers of the Kv1.5 channel for the treatment of atrial arrhythmias. Curr Med Chem. 2003; 1:273-87.
    • (2003) Curr Med Chem , vol.1 , pp. 273-287
    • Brendel, J.1    Peukert, S.2
  • 13
    • 34147105609 scopus 로고    scopus 로고
    • Vernakalant (RSD1235): A novel, atrial-selective antifibrillatory agent
    • DOI 10.1517/13543784.16.4.519
    • Fedida D. Vernakalant (RSD1235): a novel, atrial-selective antifibrillatory agent. Expert Opin Investig Drugs. 2007; 16:519-32. (Pubitemid 46554469)
    • (2007) Expert Opinion on Investigational Drugs , vol.16 , Issue.4 , pp. 519-532
    • Fedida, D.1
  • 15
    • 0030069247 scopus 로고    scopus 로고
    • Differences between outward currents of human atrial and subepicardial ventricular myocytes
    • Amos GJ, Wettwer E, Metzger F et al. Differences between outward currents of human atrial and subepicardial ventricular myocytes. J Physiol (Lond). 1996; 491:31-50. (Pubitemid 26059547)
    • (1996) Journal of Physiology , vol.491 , Issue.1 , pp. 31-50
    • Amos, G.J.1    Wettwer, E.2    Metzger, F.3    Li, Q.4    Himmel, H.M.5    Ravens, U.6
  • 16
    • 0025261315 scopus 로고
    • Three different potassium channels in human atrium
    • Heidbüchel H, Vereecke J, Carmeliet E. Three different potassium channels in human atrium. Circ Res. 1990; 66:1277-86.
    • (1990) Circ Res , vol.66 , pp. 1277-1286
    • Heidbüchel, H.1    Vereecke, J.2    Carmeliet, E.3
  • 17
    • 0037967287 scopus 로고    scopus 로고
    • The AFFIRM first antiarrhythmic drug substudy investigators. Maintenance of sinus rhythm in patients with atrial fibrillation
    • The AFFIRM first antiarrhythmic drug substudy investigators. Maintenance of sinus rhythm in patients with atrial fibrillation. J Am Coll Cardiol. 2003; 42:20-9.
    • (2003) J Am Coll Cardiol , vol.42 , pp. 20-29
  • 18
    • 0027990339 scopus 로고
    • The treatment of atrial fibrillation. An evaluation of drug therapy, electrical modalities, and therapeutic considerations
    • Nattel S, Hadjis T, Talajic M. The treatment of atrial fibrillation. An evaluation of drug therapy, electrical modalities, and therapeutic considerations. Drugs. 1994; 48:345-71.
    • (1994) Drugs , vol.48 , pp. 345-371
    • Nattel, S.1    Hadjis, T.2    Talajic, M.3
  • 19
    • 0023272292 scopus 로고
    • Risk factors for the development of proarrhythmic events
    • Morganroth J. Risk factors for the development of proarrhythmic events. Am J Cardiol. 1987; 59:32E-37E.
    • (1987) Am J Cardiol , vol.59
    • Morganroth, J.1
  • 20
    • 0025542167 scopus 로고
    • Efficacy and safety of quinidine therapy for maintenance of sinus rhythm after cardioversion
    • Coplen SE, Antman EM, Berlin JA et al. Efficacy and safety of quinidine therapy for maintenance of sinus rhythm after cardioversion. Circulation. 1990; 82:1106-16.
    • (1990) Circulation , vol.82 , pp. 1106-1116
    • Coplen, S.E.1    Antman, E.M.2    Berlin, J.A.3
  • 21
    • 33645729137 scopus 로고    scopus 로고
    • Antiarrhythmic drugs for maintaining sinus rhythm after cardioversion of atrial fibrillation
    • Lafuente C, Mouly S, Longas-Tejero MA et al. Antiarrhythmic drugs for maintaining sinus rhythm after cardioversion of atrial fibrillation. Arch Intern Med. 2006; 166:719-28.
    • (2006) Arch Intern Med , vol.166 , pp. 719-728
    • Lafuente, C.1    Mouly, S.2    Longas-Tejero, M.A.3
  • 22
    • 0014240798 scopus 로고
    • Long-term results of DC reversion of atrial fibrillation
    • Radford MD, Evans DW. Long-term results of DC reversion of atrial fibrillation. Br Heart J. 1968; 30:91-6.
    • (1968) Br Heart J , vol.30 , pp. 91-96
    • Radford, M.D.1    Evans, D.W.2
  • 23
    • 0026011647 scopus 로고
    • Mortality and morbidity in patients receiving encainide, flecainide, or placebo
    • The Cardiac Arrhythmia Suppression Trial
    • Echt DS, Liebson PR, Mitchell LB et al. Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial. N Engl J Med. 1991; 324:781-8.
    • (1991) N Engl J Med , vol.324 , pp. 781-788
    • Echt, D.S.1    Liebson, P.R.2    Mitchell, L.B.3
  • 24
    • 0027202609 scopus 로고
    • A comparison of seven antiarrhythmic drugs in patients with ventricular tachyarrhythmias
    • DOI 10.1056/NEJM199308123290702
    • Mason JW. A comparison of seven antiarrhythmic drugs in patients with ventricular tachyarrhythmias. N Engl J Med. 1993; 329:452-8. (Pubitemid 23222330)
    • (1993) New England Journal of Medicine , vol.329 , Issue.7 , pp. 452-458
    • Mason, J.W.1
  • 25
    • 0345761995 scopus 로고    scopus 로고
    • Clinical experience with dofetilide in the treatment of patients with atrial fibrillation
    • Prystowsky EN, Freeland S, Branyas NA et al. Clinical experience with dofetilide in the treatment of patients with atrial fibrillation. J Cardiovasc Electrophysiol. 2003; 14:S287-90.
    • (2003) J Cardiovasc Electrophysiol , vol.14
    • Prystowsky, E.N.1    Freeland, S.2    Branyas, N.A.3
  • 26
    • 8944234858 scopus 로고    scopus 로고
    • Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction
    • Waldo AL, Camm AJ, deRuyter H et al. Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. Lancet. 1996; 348:7-12.
    • (1996) Lancet , vol.348 , pp. 7-12
    • Waldo, A.L.1    Camm, A.J.2    DeRuyter, H.3
  • 27
    • 0034619437 scopus 로고    scopus 로고
    • Efficacy and safety of oral dofetilide in converting to and maintaining sinus rhythm in patients with chronic atrial fibrillation or atrial flutter: The Symptomatic Atrial Fibrillation Investigative Research on Dofetilide (SAFIRE-D) Study
    • Singh S, Zoble RG, Yellen L et al. Efficacy and safety of oral dofetilide in converting to and maintaining sinus rhythm in patients with chronic atrial fibrillation or atrial flutter: the Symptomatic Atrial Fibrillation Investigative Research on Dofetilide (SAFIRE-D) Study. Circulation. 2000; 102:2385-90.
    • (2000) Circulation , vol.102 , pp. 2385-2390
    • Singh, S.1    Zoble, R.G.2    Yellen, L.3
  • 28
    • 0029778315 scopus 로고    scopus 로고
    • Efficacy and safety of repeated intravenous doses of ibutilide for rapid conversion of atrial flutter or fibrillation
    • Stambler BS, Wood MA, Ellenbogen KA et al. Efficacy and safety of repeated intravenous doses of ibutilide for rapid conversion of atrial flutter or fibrillation. Circulation. 1996; 94:1613-21. (Pubitemid 26320266)
    • (1996) Circulation , vol.94 , Issue.7 , pp. 1613-1621
    • Stambler, B.S.1    Wood, M.A.2    Ellenbogen, K.A.3    Perry, K.T.4    Wakefield, L.K.5    VanderLugt, J.T.6
  • 30
    • 35548991523 scopus 로고    scopus 로고
    • New antiarrhythmic drugs for establishing sinus rhythm in atrial fibrillation: What are our therapies likely to be by 2010 and beyond?
    • Morrow JP, Cannon CP, Reiffel JA. New antiarrhythmic drugs for establishing sinus rhythm in atrial fibrillation: what are our therapies likely to be by 2010 and beyond? Am Heart J. 2007; 154:824-9.
    • (2007) Am Heart J , vol.154 , pp. 824-829
    • Morrow, J.P.1    Cannon, C.P.2    Reiffel, J.A.3
  • 31
    • 33644810948 scopus 로고    scopus 로고
    • The mechanism of atrial antiarrhythmic action of RSD1235
    • Fedida D, Orth P, Chen J et al. The mechanism of atrial antiarrhythmic action of RSD1235. J Cardiovasc Electrophysiol. 2005; 16:1227-38.
    • (2005) J Cardiovasc Electrophysiol , vol.16 , pp. 1227-1238
    • Fedida, D.1    Orth, P.2    Chen, J.3
  • 32
    • 33646533304 scopus 로고    scopus 로고
    • Electrophysiological properties of an atrial selective antiarrhythmic agent, RSD1235, in humans
    • Dorian P, Mangat I, Korley V et al. Electrophysiological properties of an atrial selective antiarrhythmic agent, RSD1235, in humans. Can J Cardiol. 2004; 20:198D.
    • (2004) Can J Cardiol , vol.20
    • Dorian, P.1    Mangat, I.2    Korley, V.3
  • 33
    • 34547666917 scopus 로고    scopus 로고
    • The effect of vernakalant (RSD1235), an investigational antiarrhythmic agent, on atrial electrophysiology in humans
    • DOI 10.1097/FJC.0b013e3180547553, PII 0000534420070700000006
    • Dorian P, Pinter A, Mangat I et al. The effect of vernakalant (RSD1235), an investigational antiarrhythmic agent, on atrial electrophysiology in humans. J Cardiovasc Pharmacol. 2007; 50:35-40. (Pubitemid 47220444)
    • (2007) Journal of Cardiovascular Pharmacology , vol.50 , Issue.1 , pp. 35-40
    • Dorian, P.1    Pinter, A.2    Mangat, I.3    Korley, V.4    Cvitkovic, S.S.5    Beatch, G.N.6
  • 34
    • 10644238491 scopus 로고    scopus 로고
    • A dose-ranging study of RSD1235, a novel antiarrhythmic agent, in healthy volunteers
    • Abstract
    • Ezrin AM, Grant SM, Bell G et al. A dose-ranging study of RSD1235, a novel antiarrhythmic agent, in healthy volunteers. Pharmacologist. 2002; 44(suppl 1):A15. Abstract.
    • (2002) Pharmacologist , vol.44 , Issue.SUPPL. 1
    • Ezrin, A.M.1    Grant, S.M.2    Bell, G.3
  • 36
    • 79955982965 scopus 로고    scopus 로고
    • Astellas Pharma US, Inc. NDA 22-034. accessed 2008 Sep 4
    • Astellas Pharma US, Inc. Kynapid, vernakalant hydrochloride injection. NDA 22-034. www.fda.gov/ohrms/dockets/ac/07/briefing/2007-4327b1-01- astellasbackgrounder. pdf (accessed 2008 Sep 4).
    • Kynapid, Vernakalant Hydrochloride Injection
  • 37
    • 58149194828 scopus 로고    scopus 로고
    • Pharmacokinetics of novel atrial-selective antiarrhythmic agent vernakalant hydrochloride injection (RSD1235): Influence of CYP2D6 expression on other factors
    • Mao ZL, Wheeler JJ, Clohs L et al. Pharmacokinetics of novel atrial-selective antiarrhythmic agent vernakalant hydrochloride injection (RSD1235): influence of CYP2D6 expression on other factors. J Clin Pharmacol. 2009; 49:17-29.
    • (2009) J Clin Pharmacol , vol.49 , pp. 17-29
    • Mao, Z.L.1    Wheeler, J.J.2    Clohs, L.3
  • 38
    • 41149179489 scopus 로고    scopus 로고
    • Vernakalant hydrochloride for rapid conversion of atrial fibrillation
    • Roy D, Pratt C, Torp-Pedersen C et al. Vernakalant hydrochloride for rapid conversion of atrial fibrillation. Circulation. 2008; 117:1518-25.
    • (2008) Circulation , vol.117 , pp. 1518-1525
    • Roy, D.1    Pratt, C.2    Torp-Pedersen, C.3
  • 39
    • 79955992698 scopus 로고    scopus 로고
    • accessed 2008 Dec 30
    • Cardiome Pharma Corp. Vernakalant (intravenous). www.cardiome.com/ vernakalantIntravenous.php (accessed 2008 Dec 30).
    • Vernakalant (Intravenous)
  • 40
    • 34147127491 scopus 로고    scopus 로고
    • RSD1235 in the treatment of recent onset atrial fibrillation in ACT I (Atrial arrhythmia Conversion Trial I) - Effect of age, sex, and prior rate control medications
    • Abstract
    • Stiell IG, Rowe BH, Roy D. RSD1235 in the treatment of recent onset atrial fibrillation in ACT I (Atrial arrhythmia Conversion Trial I) - effect of age, sex, and prior rate control medications. Ann Emerg Med. 2005; 46:S115. Abstract.
    • (2005) Ann Emerg Med , vol.46
    • Stiell, I.G.1    Rowe, B.H.2    Roy, D.3
  • 41
    • 42049112346 scopus 로고    scopus 로고
    • Efficacy and safety of vernakalant hydrochloride injection for the treatment of atrial fibrillation after valvular or coronary artery bypass surgery
    • Abstract
    • Kowey PR, Roy D, Pratt CM et al. Efficacy and safety of vernakalant hydrochloride injection for the treatment of atrial fibrillation after valvular or coronary artery bypass surgery. Circulation. 2007; 116:II636-7. Abstract.
    • (2007) Circulation , vol.116
    • Kowey, P.R.1    Roy, D.2    Pratt, C.M.3
  • 42
    • 33747437950 scopus 로고    scopus 로고
    • ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients with Atrial Fibrillation)
    • Fuster V, Ryden LE, Cannom DS et al. ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation). Circulation. 2006; 114:e257-354.
    • (2006) Circulation , vol.114
    • Fuster, V.1    Ryden, L.E.2    Cannom, D.S.3
  • 43
    • 0037722720 scopus 로고    scopus 로고
    • Amiodarone for pharmacological cardioversion of recent-onset atrial fibrillation
    • DOI 10.1016/S0167-5273(02)00477-1
    • Khan IA, Mehta JH, Gowda RM. Amiodarone for pharmacological cardioversion of recent-onset atrial fibrillation. Int J Cardiol. 2003; 89:239-48. (Pubitemid 36588945)
    • (2003) International Journal of Cardiology , vol.89 , Issue.2-3 , pp. 239-248
    • Khan, I.A.1    Mehta, N.J.2    Gowda, R.M.3
  • 44
    • 0037307438 scopus 로고    scopus 로고
    • Oral loading single dose flecainide for pharmacological cardioversion of recent-onset atrial fibrillation
    • DOI 10.1016/S0167-5273(02)00467-9, PII S0167527302004679
    • Khan IA. Oral loading single dose flecainide for pharmacological cardioversion of recent-onset atrial fibrillation. Int J Cardiol. 2003; 87:121-8. (Pubitemid 36135964)
    • (2003) International Journal of Cardiology , vol.87 , Issue.2-3 , pp. 121-128
    • Khan, I.A.1
  • 45
    • 9444256916 scopus 로고    scopus 로고
    • Efficacy of intravenous ibutilide for rapid termination of atrial fibrillation
    • Ellenbogen KA, Stambler BS, Wood MA et al. Efficacy of intravenous ibutilide for rapid termination of atrial fibrillation. J Am Coll Cardiol. 1996; 28:130-6.
    • (1996) J Am Coll Cardiol , vol.28 , pp. 130-136
    • Ellenbogen, K.A.1    Stambler, B.S.2    Wood, M.A.3
  • 46
    • 0029778315 scopus 로고    scopus 로고
    • Efficacy and safety of repeated intravenous doses of ibutilide for rapid conversion of atrial flutter or fibrillation
    • Stambler BS, Wood MA, Ellenbogen KA et al. Efficacy and safety of repeated intravenous doses of ibutilide for rapid conversion of atrial flutter or fibrillation. Circulation. 1996; 94:1613-21. (Pubitemid 26320266)
    • (1996) Circulation , vol.94 , Issue.7 , pp. 1613-1621
    • Stambler, B.S.1    Wood, M.A.2    Ellenbogen, K.A.3    Perry, K.T.4    Wakefield, L.K.5    VanderLugt, J.T.6
  • 47
    • 0035137975 scopus 로고    scopus 로고
    • Single oral loading dose of propafenone for pharmacological cardioversion of recent-onset atrial fibrillation
    • Khan IA. Single oral loading dose of propafenone for pharmacological cardioversion of recent-onset atrial fibrillation. J Am Coll Cardiol. 2001; 37:542-7.
    • (2001) J Am Coll Cardiol , vol.37 , pp. 542-547
    • Khan, I.A.1


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