Comparison of the effectiveness of vitamin C vaginal tablet with metronidazole vaginal gel in the treatment of bacterial vaginosis

African Journal of Pharmacy and Pharmacology

Volumn 4, Issue 7, 2010, Pages 484-489

  Zahra, Abbaspoor ^a   Fateme, Goodarzy ^b   Mohamadreza, Abbaspoor ^a  

^a AHVAZ JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b Minab Health Center   (Iran)

Author keywords

Bacterial vaginosis; Metronidazole; Vitamin C

Indexed keywords

ASCORBIC ACID; METRONIDAZOLE;

ADOLESCENT; ADULT; ARTICLE; BEDTIME DOSAGE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEMOGRAPHY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; EDUCATIONAL STATUS; FEMALE; GEL; HUMAN; IRAN; MAJOR CLINICAL STUDY; PH MEASUREMENT; RANDOMIZED CONTROLLED TRIAL; TABLET; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT; VAGINA DISCHARGE; VAGINITIS;

EID: 77957681243     PISSN: None     EISSN: 19960816     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Amsel R, Totten PA, Spiegel CA, Chen KC, Eschenbach D, Holmes KK (1983).Nonspecific vaginitis: Diagnostic criteria and microbial and epidemiological associations. Am. J. Med., 74: 14-22.
2. Andersch B, Forssman L, Lincoln K, Torstensson P (1986). Treatment of bacterial vaginosis with an acid cream: A comparison between the effect of lactate-gel and metronidazole. Gynecol. Obstet. Invest., 21: 19-25.
3. Aroutcheva A, Gariti D, Simon M, Shott S, Faro J, Simoes JA, Gurguis A, Faro S (2001). Defence factors of vaginal lactobacilli. Am. J. Obstet. Gynecol., 185: 375-379.
4. Barlett JG, Onderdonk AB, Drude E, Goldstein C, Anderka M, Alpert S, McCormack WM (1977). Quantitative bacteriology of the vaginal flora. J. Infect. Dis., 136: 271-277.
5. thEdition. pp. 298-299.
6. Boris S, Barbes C (2000). Role played by lactobacilli in controlling the population of vaginal pathogens. Microbes. Infect., 2: 543-546.
7. Boskey E, Telsch K, Whaley K, Moench T, Cone R (1999). Acid production by vaginal flora in vitro is consistent with the rate and extent of vaginal acidification, infection, and immunity. Infect. Immune. 67: 5170-5175.
8. Brand JM, Galask RP (1986). Trimethylamine: The substance mainly responsible for the fishy odor often associated with bacterial vaginosis. Obstet. Gynecol., 68: 682-785.
9. Bro F (1990). Metronidazole pessaries compared with placebo in the treatment of bacterial vaginosis. Scand J. Prim. Health Care, 8: 216-23.
10. Chaudhuric M, Chatte RB (1996). Pathogenic potential of Gardenerella vaginalis on female urogenital system. J. Indian. Med. Assoc., 94: 311-316.
11. Chen KC, Amsel R, Eschenbach DA (1982). Biochmical diagnosis of vaginitis;determination of diamines in vaginal fluid. J. Infect. Dis., 145: 337-345.
12. CU-Uvin S, Hogan J, Caliend A, Harwell J, Mayer KH (2001). Association between bacterial vaginosis and expression of human immunodeficiency virus type IRNA in female genital tract. Clin. Infect. Dis., 33: 896.
13. Ditas C, Decena D, Jenifer T, Recardo M, Manalastas J (2006). Metronidazole with lactic acid vaginal gel in bacterial vaginosis. Obstet. Gynecol., 32: 243-5.
14. th. St. Louis, MO: Mosby, 362.
15. Gutman RE, Peipert JF, Weitzen S, Blume J (2005). Evaluation of clinical method for diagnosing bacterial vaginosis Obstet. Gynecol., 105: 551-6.
16. Halzman C, Levental MJ (2001). Factors linked to bacterial vaginosis in non pregnant women. Acta. Obestet. Gynecol., 191(10): 1664-70.
17. Harmanli O, Cheng G, Nyirjesy P (2000). Urinary tract infections in women with bacterial vaginosis. Obestet.Gynecol., 95: 710-712.
18. Jacobsson B, Prnevi P, Chidekel L, Jorgen J, Christensen P (2002). Bacterial vaginosis in early pregnancy may predispose for preterm birth and postpartum endometritis. Acta. Obestet. Gynecol., 81(11): 1006-10.
19. Livengood CH, Soper DE, Sheendan KL, Fenner DM, Mastens MG, Nelson AJ (1999). Comparison of once daily and twice daily dosing of 0.75% metronidazol gel in the treatment of bacterial vaginosis. Sex. Transm. Dis., 26(3): 137-42.
20. Peterson EE, Magnany P (2004). Efficacy and safety of vitamin C vaginal tablets in the treatment of non specific vaginitis. Obstet. Gynecol., 117: 70-5.
21. Robert HL, Holly RE,. Edward VR, Pair Lisa MSN, Jane SR (2004). A randomized double-blind clinical trial of vaginal acidification versus placebo for the treatment of symptomatic bacterial vaginosis. Sex Transm. Dis., 31(4): 236-8.
22. Ryan KJ, Berkwitz RS,. Barbieri RL, Dunaif A (1999). Kistner's Gynaecology and women's health. Seventh edition, pp: 565-575.
23. Simos JA, Bahamondes LG, Camorgo R, Alves V, Zaneveld L, Waller D (2006). A pilot clinical trial comparing an acid-buffering formulation (ACID FORM gel) with metronidazole. BJCP, 61: 211-7.
24. nd edn. London, UK: Blackwell Science Inc., 270-277.