Cholesterol toxicity in pancreatic islets from LDL receptor-deficient mice

Diabetologia

Volumn 53, Issue 11, 2010, Pages 2461-2462

  De Souza, J C ^a   De Oliveira, C A M ^a   Carneiro, E M ^a   Boschero, A C ^a   De Oliveira, H C F ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Beta cell function; Cholesterol; Insulin secretion; LDL receptor; Pancreatic islets

Indexed keywords

ABC TRANSPORTER A1; CHOLESTEROL; GLUCOSE; INSULIN; LOW DENSITY LIPOPROTEIN RECEPTOR;

CELL LEVEL; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; GLUCOSE HOMEOSTASIS; GLUCOSE OXIDATION; GLUCOSE TOLERANCE; GLUCOSE TRANSPORT; HYPERCHOLESTEROLEMIA; INSULIN RELEASE; LETTER; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; PROTEIN FUNCTION;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CELL LINE, TUMOR; CELLS, CULTURED; CHOLESTEROL; DIABETES MELLITUS, EXPERIMENTAL; HYPERCHOLESTEROLEMIA; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; MICE; MICE, KNOCKOUT; RECEPTORS, LDL;

EID: 77957676479     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-010-1868-8     Document Type: Letter

References (3)

1. JK Kruit PHC Kremer L Dai, et al. 2010 Cholesterol efflux via ATP-binding cassette transporter A1 (ABCA1) and cholesterol uptake via the LDL receptor influences cholesterol-induced impairment of beta cell function in mice Diabetologia 53 1110 1119 1:CAS:528:DC%2BC3cXlt1Oms70%3D 10.1007/s00125-010- 1691-2 20229095
2. ML Bonfleur EC Vanzela RA Ribeiro, et al. 2010 Primary hypercholesterolaemia impairs glucose homeostasis and insulin secretion in low-density lipoprotein receptor knockout mice independently of high-fat diet and obesity Biochim Biophys Acta 1801 183 190 1:CAS:528:DC%2BC3cXjtlOgtA%3D%3D 19913637
3. M Cnop 2008 Fatty acids and glucolipotoxicity in the pathogenesis of type 2 diabetes Biochem Soc Trans 36 348 52 1:CAS:528:DC%2BD1cXmtVKlsLs%3D 10.1042/BST0360348 18481955 (Pubitemid 351839329)