Characterization of the membrane-coating nup84 complex: Paradigm for the nuclear pore complex structure

Nucleus

Volumn 1, Issue 2, 2010, Pages 150-157

  Debler, Erik W ^a   Hsia, Kuo Chiang ^a   Nagy, Vivien ^a   Seo, Hyuk Soo ^a   Hoelz, André ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Binding promiscuity; Coat protein complex; Coatomer; Crystallography; Dynamic interaction; Electron microscopy; Macromolecular assembly; Nucleocytoplasmic transport; Nucleoporin; Vesicle coats

Indexed keywords

ARTICLE; CONFORMATION; MOLECULAR DYNAMICS; NUCLEAR PORE COMPLEX; PROTEIN BINDING; PROTEIN TRANSPORT;

EID: 77957672516     PISSN: 19491034     EISSN: 19491042     Source Type: Journal    
DOI: 10.4161/nucl.1.2.11120     Document Type: Article

References (53)

1. Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. Molecular biology of the cell. New York: Garland Science 2008.
2. Green NM. The nuclear pore-a biological grommet? Nature 1982; 297:287-8.
3. Suntharalingam M, Wente SR. Peering through the pore: nuclear pore complex structure, assembly and function. Dev Cell 2003; 4:775-89.
4. Vlcek S, Foisner R. Lamins and lamin-associated proteins in aging and disease. Curr Opin Cell Biol 2007; 19:298-304.
5. Burke B, Stewart CL. The laminopathies: the functional architecture of the nucleus and its contribution to disease. Annu Rev Genomics Hum Genet 2006; 7:369-405.
6. Razafsky D, Hodzic D. Bringing KASH under the SUN: the many faces of nucleo-cytoskeletal connections. J Cell Biol 2009; 186:461-72.
7. Starr DA. A nuclear-envelope bridge positions nuclei and moves chromosomes. J Cell Sci 2009; 122:577-86.
8. Akhtar A, Gasser SM. The nuclear envelope and transcriptional control. Nat Rev Genet 2007; 8:507-17.
9. Galy V, Olivo-Marin JC, Scherthan H, Doye V, Rascalou N, Nehrbass U. Nuclear pore complexes in the organization of silent telomeric chromatin. Nature 2000; 403:108-12.
10. Nagai S, Dubrana K, Tsai-Pflugfelder M, Davidson MB, Roberts TM, Brown GW, et al. Functional targeting of DNA damage to a nuclear pore-associated SUMO-dependent ubiquitin ligase. Science 2008; 322:597-602.
11. Khadaroo B, Teixeira MT, Luciano P, Eckert-Boulet N, Germann SM, Simon MN, et al. The DNA damage response at eroded telomeres and tethering to the nuclear pore complex. Nat Cell Biol 2009; 11:980-7.
12. Towbin BD, Meister P, Gasser SM. The nuclear envelope-a scaffold for silencing? Curr Opin Genet Dev 2009; 19:180-6.
13. Reichelt R, Holzenburg A, Buhle EL Jr, Jarnik M, Engel A, Aebi U. Correlation between structure and mass distribution of the nuclear pore complex and of distinct pore complex components. J Cell Biol 1990; 110:883-94.
14. Rout MP, Aitchison JD, Suprapto A, Hjertaas K, Zhao Y, Chait BT. The yeast nuclear pore complex: composition, architecture, and transport mechanism. J Cell Biol 2000; 148:635-51.
15. Cronshaw JM, Krutchinsky AN, Zhang W, Chait BT, Matunis MJ. Proteomic analysis of the mammalian nuclear pore complex. J Cell Biol 2002; 158:915-27.
16. Yang Q, Rout MP, Akey CW. Three-dimensional architecture of the isolated yeast nuclear pore complex: functional and evolutionary implications. Mol Cell 1998; 1:223-34.
17. Alber F, Dokudovskaya S, Veenhoff LM, Zhang W, Kipper J, Devos D, et al. The molecular architecture of the nuclear pore complex. Nature 2007; 450:695-701.
18. Chook YM, Blobel G. Karyopherins and nuclear import. Curr Opin Struct Biol 2001; 11:703-15.
19. Hoelz A, Blobel G. Cell biology: popping out of the nucleus. Nature 2004; 432:815-6.
20. Cook A, Bono F, Jinek M, Conti E. Structural biology of nucleocytoplasmic transport. Annu Rev Biochem 2007; 76:647-71.
21. Debler EW, Blobel G, Hoelz A. Nuclear transport comes full circle. Nat Struct Mol Biol 2009; 16:457-9.
22. Kiseleva E, Goldberg MW, Allen TD, Akey CW. Active nuclear pore complexes in Chironomus: visualization of transporter configurations related to mRNP export. J Cell Sci 1998; 111:223-36.
23. Pante N, Kann M. Nuclear pore complex is able to transport macromolecules with diameters of about 39 nm. Mol Biol Cell 2002; 13:425-34.
24. King MC, Lusk CP, Blobel G. Karyopherin-mediated import of integral inner nuclear membrane proteins. Nature 2006; 442:1003-7.
25. Saksena S, Summers MD, Burks JK, Johnson AE, Braunagel SC. Importin-alpha-16 is a transloconassociated protein involved in sorting membrane proteins to the nuclear envelope. Nat Struct Mol Biol 2006; 13:500-8.
26. Beck M, Lucic V, Forster F, Baumeister W, Medalia O. Snapshots of nuclear pore complexes in action captured by cryo-electron tomography. Nature 2007; 449:611-5.
27. Akey CW. Structural plasticity of the nuclear pore complex. J Mol Biol 1995; 248:273-93.
28. Bhattacharya A. Protein structures: Structures of desire. Nature 2009; 459:24-7.
29. Siniossoglou S, Lutzmann M, Santos-Rosa H, Leonard K, Mueller S, Aebi U, et al. Structure and assembly of the Nup84p complex. J Cell Biol 2000; 149:41-54.
30. Allen NP, Huang L, Burlingame A, Rexach M. Proteomic analysis of nucleoporin interacting proteins. J Biol Chem 2001; 276:29268-74.
31. Lutzmann M, Kunze R, Buerer A, Aebi U, Hurt E. Modular self-assembly of a Y-shaped multiprotein complex from seven nucleoporins. EMBO J 2002; 21:387-97.
32. Berke IC, Boehmer T, Blobel G, Schwartz TU. Structural and functional analysis of Nup133 domains reveals modular building blocks of the nuclear pore complex. J Cell Biol 2004; 167:591-7.
33. Boehmer T, Jeudy S, Berke IC, Schwartz TU. Structural and functional studies of Nup107/Nup133 interaction and its implications for the architecture of the nuclear pore complex. Mol Cell 2008; 30:721-31.
34. Hsia KC, Stavropoulos P, Blobel G, Hoelz A. Architecture of a coat for the nuclear pore membrane. Cell 2007; 131:1313-26.
35. Debler EW, Ma Y, Seo HS, Hsia KC, Noriega TR, Blobel G, et al. A fence-like coat for the nuclear pore membrane. Mol Cell 2008; 32:815-26.
36. Brohawn SG, Leksa NC, Spear ED, Rajashankar KR, Schwartz TU. Structural evidence for common ancestry of the nuclear pore complex and vesicle coats. Science 2008; 322:1369-73.
37. Nagy V, Hsia KC, Debler EW, Kampmann M, Davenport AM, Blobel G, et al. Structure of a trimeric nucleoporin complex reveals alternate oligomerization states. Proc Natl Acad Sci USA 2009; 106:17693-8.
38. Seo HS, Ma Y, Debler EW, Wacker D, Kutik S, Blobel G, et al. Structural and functional analysis of Nup120 suggests ring formation of the Nup84 complex. Proc Natl Acad Sci USA 2009; 106:14281-6.
39. Leksa NC, Brohawn SG, Schwartz TU. The structure of the scaffold nucleoporin Nup120 reveals a new and unexpected domain architecture. Structure 2009; 17:1082-91.
40. Kampmann M, Blobel G. Three-dimensional structure and flexibility of a membrane-coating module of the nuclear pore complex. Nat Struct Mol Biol 2009; 16:782-8.
41. Brohawn SG, Partridge JR, Whittle JR, Schwartz TU. The nuclear pore complex has entered the atomic age. Structure 2009; 17:1156-68.
42. Melcák I, Hoelz A, Blobel G. Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular sliding. Science 2007; 315:1729-32.
43. Fath S, Mancias JD, Bi X, Goldberg J. Structure and organization of coat proteins in the COPII cage. Cell 2007; 129:1325-36.
44. Devos D, Dokudovskaya S, Williams R, Alber F, Eswar N, Chait BT, et al. Simple fold composition and modular architecture of the nuclear pore complex. Proc Natl Acad Sci USA 2006; 103:2172-7.
45. Kirchhausen T. Three ways to make a vesicle. Nat Rev Mol Cell Biol 2000; 1:187-98.
46. Devos D, Dokudovskaya S, Alber F, Williams R, Chait BT, Sali A, et al. Components of coated vesicles and nuclear pore complexes share a common molecular architecture. PLoS Biol 2004; 2:380.
47. Stagg SM, LaPointe P, Balch WE. Structural design of cage and coat scaffolds that direct membrane traffic. Curr Opin Struct Biol 2007; 17:221-8.
48. Stagg SM, Gurkan C, Fowler DM, LaPointe P, Foss TR, Potter CS, et al. Structure of the Sec13/31 COPII coat cage. Nature 2006; 439:234-8.
49. Stagg SM, LaPointe P, Razvi A, Gurkan C, Potter CS, Carragher B, et al. Structural basis for cargo regulation of COPII coat assembly. Cell 2008; 134:474-84.
50. Caspar DL, Klug A. Physical principles in the construction of regular viruses. Cold Spring Harb Symp Quant Biol 1962; 27:1-24.
51. Bamford DH, Gilbert RJ, Grimes JM, Stuart DI. Macromolecular assemblies: greater than their parts. Curr Opin Struct Biol 2001; 11:107-13.
52. Byeon IJ, Meng X, Jung J, Zhao G, Yang R, Ahn J, et al. Structural convergence between Cryo-EM and NMR reveals intersubunit interactions critical for HIV-1 capsid function. Cell 2009; 139:780-90.
53. Fahrenkrog B, Koser J, Aebi U. The nuclear pore complex: a jack of all trades? Trends Biochem Sci 2004; 29:175-82.