메뉴 건너뛰기




Volumn 44, Issue 10, 2010, Pages 1572-1578

Efavirenz plasma concentrations and cytochrome 2B6 polymorphisms

Author keywords

Cytochrome 2B6 polymorphisms; Efavirenz

Indexed keywords

CYTOCHROME 2B6; CYTOCHROME B6; EFAVIRENZ; UNCLASSIFIED DRUG;

EID: 77957670817     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1P141     Document Type: Article
Times cited : (16)

References (19)
  • 2
    • 0032589627 scopus 로고    scopus 로고
    • Identification and characterization of efavirenz metabolites by liquid chromatography/mass spectrometry and high field NMR: Species differences in the metabolism of efavirenz
    • Mutlib AE, Chen H, Nemeth GA, Gan LS, Christ D. Identification and characterization of efavirenz metabolites by liquid chromatography/mass spectrometry and high field NMR: species differences in the metabolism of efavirenz. Drug Metab Dispos 1999;27:1319-33.
    • (1999) Drug Metab Dispos , vol.27 , pp. 1319-1333
    • Mutlib, A.E.1    Chen, H.2    Nemeth, G.A.3    Gan, L.S.4    Christ, D.5
  • 3
    • 34250764311 scopus 로고    scopus 로고
    • Impact of CYP2B6 polymorphism on hepatic efavirenz metabolism in vitro
    • Desta Z, Saussele T, Ward B, et al. Impact of CYP2B6 polymorphism on hepatic efavirenz metabolism in vitro. Pharmacogenomics 2007;8:547-58.
    • (2007) Pharmacogenomics , vol.8 , pp. 547-558
    • Desta, Z.1    Saussele, T.2    Ward, B.3
  • 4
    • 0038002981 scopus 로고    scopus 로고
    • The cytochrome p450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: Implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity
    • Ward BA, Gorski JC, Jones DR, Hall SD, Flockhart DA, Desta Z. The cytochrome p450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity. J Pharmacol Exp Ther 2003;306:287-300.
    • (2003) J Pharmacol Exp Ther , vol.306 , pp. 287-300
    • Ward, B.A.1    Gorski, J.C.2    Jones, D.R.3    Hall, S.D.4    Flockhart, D.A.5    Desta, Z.6
  • 5
    • 33745268491 scopus 로고    scopus 로고
    • Metabolism of efavirenz and 8-hydroxyefavirenz by P450 2B6 leads to inactivation by two distinct mechanisms
    • Bumpus NN, Kent UM, Hollenberg PF. Metabolism of efavirenz and 8-hydroxyefavirenz by P450 2B6 leads to inactivation by two distinct mechanisms. J Pharmacol Exp Ther 2006;318:345-51.
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 345-351
    • Bumpus, N.N.1    Kent, U.M.2    Hollenberg, P.F.3
  • 6
    • 33644910426 scopus 로고    scopus 로고
    • Interpatient variability in the pharmacokinetics of the HIV non-nucleoside reverse transcriptase inhibitor efavirenz: The effect of gender, race, and CYP2B6 polymorphism
    • Burger D, van der Heiden I, La Porte C, et al. Interpatient variability in the pharmacokinetics of the HIV non-nucleoside reverse transcriptase inhibitor efavirenz: the effect of gender, race, and CYP2B6 polymorphism. Br J Clin Pharmacol 2005;61:148-54.
    • (2005) Br J Clin Pharmacol , vol.61 , pp. 148-154
    • Burger, D.1    Van Der Heiden, I.2    La Porte, C.3
  • 7
    • 4644349582 scopus 로고    scopus 로고
    • Multiple novel nonsynonymous CYP2B6 gene polymorphisms in Caucasians: Demonstration of phenotypic null alleles
    • Lang T, Klein K, Richter T, et al. Multiple novel nonsynonymous CYP2B6 gene polymorphisms in Caucasians: demonstration of phenotypic null alleles. J Pharmacol Exp Ther 2004;311:34-43.
    • (2004) J Pharmacol Exp Ther , vol.311 , pp. 34-43
    • Lang, T.1    Klein, K.2    Richter, T.3
  • 8
    • 40049092364 scopus 로고    scopus 로고
    • High prevalence of the CYP2B6 516 G→T (*6) variant and effect on the population pharmacokinetics of efavirenz in HIV/AIDS outpatients in Zimbabwe
    • Nyakutira C, Roshammar D, Chigutsa E, et al. High prevalence of the CYP2B6 516 G→T (*6) variant and effect on the population pharmacokinetics of efavirenz in HIV/AIDS outpatients in Zimbabwe. Eur J Clin Pharmacol 2008;64:357-65.
    • (2008) Eur J Clin Pharmacol , vol.64 , pp. 357-365
    • Nyakutira, C.1    Roshammar, D.2    Chigutsa, E.3
  • 9
    • 33645683551 scopus 로고    scopus 로고
    • Prevalence of CYP2B6 alleles in malaria-endemic populations of West Africa and Papua New Guinea
    • Mehlotra RK, Ziats MN, Bockarie MJ, Zimmerman PA. Prevalence of CYP2B6 alleles in malaria-endemic populations of West Africa and Papua New Guinea. Eur J Clin Pharmacol 2006;62:267-75.
    • (2006) Eur J Clin Pharmacol , vol.62 , pp. 267-275
    • Mehlotra, R.K.1    Ziats, M.N.2    Bockarie, M.J.3    Zimmerman, P.A.4
  • 10
    • 34248998418 scopus 로고    scopus 로고
    • Genetic variability of CYP2B6 polymorphisms in four southern Chinese populations
    • Xu BY, Guo LP, Lee SS, et al. Genetic variability of CYP2B6 polymorphisms in four southern Chinese populations. World J Gastroenterol 2007;13:2100-3.
    • (2007) World J Gastroenterol , vol.13 , pp. 2100-2103
    • Xu, B.Y.1    Guo, L.P.2    Lee, S.S.3
  • 11
    • 19944428456 scopus 로고    scopus 로고
    • Pharmacogenetics of efavirenz and central nervous system side effects: An Adult AIDS Clinical Trials Group study
    • Haas DW, Ribaudo HJ, Kim RB, et al. Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study. AIDS 2004;18:2391-2400.
    • (2004) AIDS , vol.18 , pp. 2391-2400
    • Haas, D.W.1    Ribaudo, H.J.2    Kim, R.B.3
  • 12
    • 0035808574 scopus 로고    scopus 로고
    • Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients
    • DOI 10.1097/00002030-200101050-00011
    • Marzolini C, Telenti A, Decosterd LA, Greub G, Biollaz J, Buclin T. Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients. AIDS 2001;15:71-75. (Pubitemid 32055781)
    • (2001) AIDS , vol.15 , Issue.1 , pp. 71-75
    • Marzolini, C.1    Telenti, A.2    Decosterd, L.A.3    Greub, G.4    Biollaz, J.5    Buclin, T.6
  • 13
    • 35649024497 scopus 로고    scopus 로고
    • accessed 2010 May 20
    • USA QuickFacts. US Census Bureau. http://quickfacts.census.gov/qfd/ states/00000.html (accessed 2010 May 20).
    • USA QuickFacts
  • 14
    • 48749117983 scopus 로고    scopus 로고
    • Estimation of HIV incidence in the United States
    • Hall HI, Song R, Rhodes P, et al. Estimation of HIV incidence in the United States. JAMA 2008;300:520-9.
    • (2008) JAMA , vol.300 , pp. 520-529
    • Hall, H.I.1    Song, R.2    Rhodes, P.3
  • 15
    • 10744221053 scopus 로고    scopus 로고
    • Hepatic CYP2B6 expression: Gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression
    • Lamba V, Lamba J, Yasuda K, et al. Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression. J Pharmacol Exp Ther 2003;307:906-22.
    • (2003) J Pharmacol Exp Ther , vol.307 , pp. 906-922
    • Lamba, V.1    Lamba, J.2    Yasuda, K.3
  • 16
    • 0030872838 scopus 로고    scopus 로고
    • PolyPhred: Automating the detection and genotyping of single nucleotide substitutions using fluorescence-based resequencing
    • Nickerson DA, Tobe VO, Taylor SL. PolyPhred: automating the detection and genotyping of single nucleotide substitutions using fluorescence-based resequencing. Nucleic Acids Res 1997;25:2745-51.
    • (1997) Nucleic Acids Res , vol.25 , pp. 2745-2751
    • Nickerson, D.A.1    Tobe, V.O.2    Taylor, S.L.3
  • 17
    • 0024389366 scopus 로고
    • The Pittsburgh Sleep Quality Index: A new instrument for psychiatric practice and research
    • Buysse DJ, Reynolds CF, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 1989;28:193-213.
    • (1989) Psychiatry Res , vol.28 , pp. 193-213
    • Buysse, D.J.1    Reynolds, C.F.2    Monk, T.H.3    Berman, S.R.4    Kupfer, D.J.5
  • 18
    • 35348923463 scopus 로고    scopus 로고
    • Successful efavirenz dose reduction in HIV type-1 infected individuals with cytochrome p4502B6*6 and *6
    • Gatanaga H, Hayashida T, Tsuchiya K, et al. Successful efavirenz dose reduction in HIV type-1 infected individuals with cytochrome p4502B6*6 and *6. Clin Infect Dis 2007;45:1230-7.
    • (2007) Clin Infect Dis , vol.45 , pp. 1230-1237
    • Gatanaga, H.1    Hayashida, T.2    Tsuchiya, K.3
  • 19
    • 33947382259 scopus 로고    scopus 로고
    • Predictive value of known and novel alleles of CYP2B6 for efavirenz plasma concentrations in HIV-infected individuals
    • Rotger M, Tegude H, Colombo S, et al. Predictive value of known and novel alleles of CYP2B6 for efavirenz plasma concentrations in HIV-infected individuals. Clin Pharmacol Ther 2007;81:557-66.
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 557-566
    • Rotger, M.1    Tegude, H.2    Colombo, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.