Mutations of an antibody binding energy hot spot on domain III of the dengue 2 envelope glycoprotein exploited for neutralization escape

Virology

Volumn 407, Issue 2, 2010, Pages 237-246

  Gromowski, Gregory D ^a   Roehrig, John T ^b   Diamond, Michael S ^c   Lee, J Ching ^a   Pitcher, Trevor J ^a   Barrett, Alan D T ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b NATIONAL CENTER FOR EMERGING AND ZOONOTIC INFECTIOUS DISEASES   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Dengue; Envelope protein domain 3; Monoclonal antibodies; Neutralization

Indexed keywords

MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 1A1D 2; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN; EPITOPE; NEUTRALIZING ANTIBODY; VIRUS ANTIBODY;

AMINO ACID SEQUENCE; ANIMAL CELL; ANTIGEN BINDING; ARTICLE; BINDING SITE; DENGUE VIRUS 2; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; VIRUS NEUTRALIZATION; AMINO ACID SUBSTITUTION; ANIMAL; ANTIBODY AFFINITY; CHEMICAL STRUCTURE; CHEMISTRY; CHLOROCEBUS AETHIOPS; DENGUE VIRUS; EPITOPE MAPPING; GENETICS; IMMUNOLOGY; METABOLISM; PROTEIN TERTIARY STRUCTURE; SERODIAGNOSIS; VERO CELL LINE;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; ANTIBODY AFFINITY; CERCOPITHECUS AETHIOPS; DENGUE VIRUS; EPITOPE MAPPING; EPITOPES; MODELS, MOLECULAR; NEUTRALIZATION TESTS; PROTEIN STRUCTURE, TERTIARY; VERO CELLS; VIRAL ENVELOPE PROTEINS;

DENGUE VIRUS;

EID: 77957665570     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2010.06.044     Document Type: Article

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