Notch signaling is required for the generation of hair cells and supporting cells in the mammalian inner ear

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 36, 2010, Pages 15798-15803

  Pan, Wei ^a   Jin, Ying ^a   Stanger, Ben ^b   Kiernan, Amy E ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Development; JAG1; NICD; SOX2; Tet On

Indexed keywords

JAGGED1; NOTCH1 RECEPTOR; DOXYCYCLINE; NOTCH RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CELL REGENERATION; COCHLEA; CONTROLLED STUDY; HAIR CELL; INNER EAR; LOSS OF FUNCTION MUTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; VESTIBULE; ANIMAL; CELL LINEAGE; CYTOLOGY; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; METABOLISM; MOUSE MUTANT; SIGNAL TRANSDUCTION;

MAMMALIA;

ANIMALS; CELL LINEAGE; DOXYCYCLINE; EAR, INNER; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MICE; MICE, KNOCKOUT; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION;

EID: 77957663412     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1003089107     Document Type: Article

References (38)

1. Fekete DM, Muthukumar S, Karagogeos D (1998) Hair cells and supporting cells share a common progenitor in the avian inner ear. J Neurosci 18:7811-7821. (Pubitemid 28441021)
2. Satoh T, Fekete DM (2005) Clonal analysis of the relationships between mechanosensory cells and the neurons that innervate them in the chicken ear. Development 132:1687-1697.
3. Lewis J (1991) Rules for the production of sensory cells. Ciba Found Symp 160:25-39, discussion 40-53.
4. Corwin JT, Jones JE, Katayama A, Kelley MW, Warchol ME (1991) Hair cell regeneration: The identities of progenitor cells, potential triggers and instructive cues. Ciba Found Symp 160:103-120, discussion 120-130.
5. Lanford PJ, et al. (1999) Notch signaling pathway mediates hair cell development in mammalian cochlea. Nat Genet 21:289-292.
6. Kiernan AE, Cordes R, Kopan R, Gossler A, Gridley T (2005) The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear. Development 132:4353-4362.
7. Riley BB, Chiang M, Farmer L, Heck R (1999) The deltaA gene of zebrafish mediates lateral inhibition of hair cells in the inner ear and is regulated by pax2.1. Development 126:5669-5678. (Pubitemid 30035015)
8. Raft S, et al. (2007) Cross-regulation of Ngn1 and Math1 coordinates the production of neurons and sensory hair cells during inner ear development. Development 134:4405-4415.
9. Kiernan AE, et al. (2005) Sox2 is required for sensory organ development in the mammalian inner ear. Nature 434:1031-1035.
10. Puligilla C, Dabdoub A, Brenowitz SD, Kelley MW (2010) Sox2 induces neuronal formation in the developing mammalian cochlea. J Neurosci 30:714-722.
11. Stevens CB, Davies AL, Battista S, Lewis JH, Fekete DM (2003) Forced activation of Wnt signaling alters morphogenesis and sensory organ identity in the chicken inner ear. Dev Biol 261:149-164.
12. Chang W, et al. (2008) Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements. PLoS Genet 4:e1000050.
13. Pirvola U, et al. (2002) FGFR1 is required for the development of the auditory sensory epithelium. Neuron 35:671-680.
14. Pauley S, et al. (2003) Expression and function of FGF10 in mammalian inner ear development. Dev Dyn 227:203-215.
15. Hayashi T, Ray CA, Bermingham-McDonogh O (2008) Fgf20 is required for sensory epithelial specification in the developing cochlea. J Neurosci 28:5991-5999.
16. Daudet N, Ariza-McNaughton L, Lewis J (2007) Notch signalling is needed to maintain, but not to initiate, the formation of prosensory patches in the chick inner ear. Development 134:2369-2378.
17. Daudet N, Lewis J (2005) Two contrasting roles for Notch activity in chick inner ear development: Specification of prosensory patches and lateral inhibition of hair-cell differentiation. Development 132:541-551. (Pubitemid 40277694)
18. Brooker R, Hozumi K, Lewis J (2006) Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear. Development 133:1277-1286.
19. Kiernan AE, Xu J, Gridley T (2006) The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear. PLoS Genet 2:e4.
20. Jayasena CS, Ohyama T, Segil N, Groves AK (2008) Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode. Development 135:2251-2261.
21. Morrison A, Hodgetts C, Gossler A, Hrabé de Angelis M, Lewis J (1999) Expression of Delta1 and Serrate1 (Jagged1) in the mouse inner ear. Mech Dev 84:169-172.
22. Morsli H, Choo D, Ryan A, Johnson R, Wu DK (1998) Development of the mouse inner ear and origin of its sensory organs. J Neurosci 18:3327-3335.
23. Leimeister C, Externbrink A, Klamt B, Gessler M (1999) Hey genes: A novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis. Mech Dev 85:173-177.
24. Ghai K, Zelinka C, Fischer AJ (2010) Notch signaling influences neuroprotective and proliferative properties of mature Müller glia. J Neurosci 30:3101-3112.
25. Gering M, Patient R (2010) Notch signalling and haematopoietic stem cell formation during embryogenesis. J Cell Physiol 222:11-16.
26. Purow BW, et al. (2005) Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation. Cancer Res 65:2353-2363.
27. Ma Q, Chen Z, del Barco Barrantes I, de la Pompa JL, Anderson DJ (1998) neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia. Neuron 20:469-482. (Pubitemid 28153078)
28. Ovchinnikov DA, Deng JM, Ogunrinu G, Behringer RR (2000) Col2a1-directed expression of Cre recombinase in differentiating chondrocytes in transgenic mice. Genesis 26:145-146.
29. Hébert JM, McConnell SK (2000) Targeting of cre to the Foxg1 (BF-1) locus mediates loxP recombination in the telencephalon and other developing head structures. Dev Biol 222:296-306.
30. Chang W, Brigande JV, Fekete DM, Wu DK (2004) The development of semicircular canals in the inner ear: Role of FGFs in sensory cristae. Development 131:4201-4211.
31. Haddon C, Jiang YJ, Smithers L, Lewis J (1998) Delta-Notch signalling and the patterning of sensory cell differentiation in the zebrafish ear: Evidence from the mind bomb mutant. Development 125:4637-4644. (Pubitemid 29027194)
32. Xue Y, et al. (1999) Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1. Hum Mol Genet 8:723-730.
33. Mao X, Fujiwara Y, Orkin SH (1999) Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice. Proc Natl Acad Sci USA 96:5037-5042. (Pubitemid 29214531)
34. Murtaugh LC, Stanger BZ, Kwan KM, Melton DA (2003) Notch signaling controls multiple steps of pancreatic differentiation. Proc Natl Acad Sci USA 100:14920-14925.
35. Belteki G, et al. (2005) Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction. Nucleic Acids Res 33:e51.
36. Stanger BZ, Datar R, Murtaugh LC, Melton DA (2005) Direct regulation of intestinal fate by Notch. Proc Natl Acad Sci USA 102:12443-12448.
37. Jiang R, Lan Y, Norton CR, Sundberg JP, Gridley T (1998) The Slug gene is not essential for mesoderm or neural crest development in mice. Dev Biol 198:277-285. (Pubitemid 28304444)
38. Gubbels SP, Woessner DW, Mitchell JC, Ricci AJ, Brigande JV (2008) Functional auditory hair cells produced in the mammalian cochlea by in utero gene transfer. Nature 455:537-541.