Design and synthesis of selective and potent orally active S1P5 agonists

ChemMedChem

Volumn 5, Issue 10, 2010, Pages 1693-1696

  Mattes, Henri ^a   Dev, Kumlesh Kumar ^a,b   Bouhelal, Rochdi ^a   Barske, Carmen ^a   Gasparini, Fabrizio ^a   Guerini, Danilo ^a   Mir, Anis Khusro ^a   Orain, David ^a   Osinde, Maribel ^a   Picard, Anne ^a   Dubois, Celine ^a   Tasdelen, Engin ^a   Haessig, Samuel ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Agonists; FTY720; Myelination; Oligodendrocytes; Receptors; Sphingosine

Indexed keywords

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; BENZAMIDE; FINGOLIMOD; FINGOLIMOD PHOSPHATE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE 5 RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM MOBILIZATION; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; HUMAN; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; COMPUTER SIMULATION; DRUG DESIGN; MOLECULAR SEQUENCE DATA; MYELIN BASIC PROTEINS; OLIGODENDROGLIA; PHTHALAZINES; PROPYLENE GLYCOLS; RATS; RECEPTORS, LYSOSPHINGOLIPID; SPHINGOSINE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77957660978     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000253     Document Type: Article

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