3D-QSAR CoMFA study of benzoxazepine derivatives as mGluR5 positive allosteric modulators

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 19, 2010, Pages 5922-5924

  Lowe Jr , Edward W ^a   Ferrebee, Alysia ^b   Rodriguez, Alice L ^a   Conn, P Jeffrey ^a   Meiler, Jens ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HOWARD UNIVERSITY   (United States)

Author keywords

Allosteric; Metabotropic; mGluR5; QSAR

Indexed keywords

DIBENZOXAZEPINE DERIVATIVE; GLUTAMIC ACID; METABOTROPIC RECEPTOR 5;

ALLOSTERISM; ARTICLE; CELL CULTURE; CHEMICAL STRUCTURE; COMPARATIVE MOLECULAR FIELD ANALYSIS; CORRELATION COEFFICIENT; DRUG ACTIVITY; DRUG BINDING; MOLECULAR MODEL; NONHUMAN; PREDICTIVE VALIDITY; PROTEIN EXPRESSION; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ALLOSTERIC REGULATION; BENZOXAZINES; DRUG DESIGN; MODELS, CHEMICAL; MODELS, MOLECULAR; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECEPTORS, METABOTROPIC GLUTAMATE; STATIC ELECTRICITY;

EID: 77957606217     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.07.061     Document Type: Article

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