Mutagenicity of two species of the genus Alchornea measured by Salmonella microsome assay and micronucleus test;Mutagenicidade de duas espécies do gěnero Alchornea avaliadas através de ensaios com Salmonella microssomo e teste do micronúcleo

Revista Brasileira de Farmacognosia

Volumn 20, Issue 3, 2010, Pages 382-389

  dos Santos, Fabio V ^a   Calvo, Tamara R ^a   Cólus, Ilce Mara S ^b   Vilegas, Wagner ^a   Varanda, Eliana A ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b STATE UNIVERSITY OF LONDRINA   (Brazil)

Author keywords

Alchornea; Ames assay; Medicinal plant; Micronucleus; Mutagenicity

Indexed keywords

CHLOROFORM EXTRACT; CYCLOPHOSPHAMIDE; METHANOLIC EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ALCHORNEA; ALCHORNEA CASTANEAEFOLIA; ALCHORNEA GLANDULOSA; AMES ASSAY; ANIMAL EXPERIMENT; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG SCREENING; EUPHORBIA; FEMALE; MALE; MICRONUCLEUS TEST; MOUSE; MUTAGEN TESTING; MUTAGENICITY; NONHUMAN; PLANT LEAF; SALMONELLA MICROSOME ASSAY; SALMONELLA TYPHIMURIUM;

EID: 77957604792     PISSN: 0102695X     EISSN: None     Source Type: Journal    
DOI: 10.1590/s0102-695x2010000300015     Document Type: Article

References (36)

1. Abo KA, Ashidi JS 1999. Antimicrobial screening of Bridelia micrantha, Alchornea cordifolia and Boerhavia diffusa. Afr J Medicine Med Sci 28: 167-169.
2. Ayisi NK, Nyadedzor C 2003. Comparative in vitro effects of AZT and extracts of Ocimum gratissimum, Ficus polita, Clausena anisata, Alchornea cordifolia and Elaeophorbia drupifera against HIV-1 and HIV-2 infections. Antiviral Res 58: 25-33.
3. Awad AB, Fink CS 2000. Phytosterols as anticancer dietary components: Evidence and mechanism of action. J Nutr 130: 2127-2130.
4. Calvo TR, Lima ZP, Silva JS, Ballesteros KVR, Pellizzon CH, Hiruma-Lima CA, Tamashiro J, Souza-Brito A.M, Takahira RK, Vilegas W 2007. Constituents and antiulcer effect of Alchornea glandulosa: activation of cell proliferation in gastric mucosa during the healing process. Biol Pharm Bull 30: 451-459.
5. Cardoso CRP, Cólus IMS, Bernardi CC, Sannomiya M, Vilegas W, Varanda EA 2006. Mutagenic activity promoted by amentoflavone and methanolic extract of Byrsonima crassa Niedenzu. Toxicology 225: 55-63.
6. Chen SC, Chung KT 2000. Mutagenicity and antimutagenicity studies of tannic acid and its related compounds. Food Chem Toxicol 38: 1-5.
7. Conegero LS, Ide RM, Nazari AS, Sarragiotto MH, Filho, BPD, Nakamura CV, Carvalho JE, Foglio MA 2003.Constituintes químicos de Alchornea glandulosa (Euphorbiaceae). Quim Nova 26: 825-827.
8. Duke J, Vasquez R 1994. Amazonian ethnobotanical dictionary. CRC Press Inc, Boca Raton, p. 677.
9. Dunstan CA, Noreen Y, Serrano G, Cox PA, Pereira P, Bohlin L 1997. Evaluation of some Peruvian medicinal plants by prostaglandin biosynthesis and rat ear edema assays. J Ethnopharmacol 57: 35-56.
10. Ebi GC 2001. Antimicrobial activities of Alchornea cordifolia. Fitoterapia 72: 69-72.
11. Farombi EO, Ogundipe OO, Uhunwangho ES, Adeyanju MA, Moody JO 2003. Antioxidant properties of extracts from Alchornea laxiflora (Benth) Pax and Hoffman. Phytotherapy Res 17: 713-716.
12. Gaspar J, Laires A, Monteiro M, Laureano O, Ramos E, Rueff J 1993. Quercetin and the mutagenicity of wines. Mutagenesis 8: 51-55.
13. Hayashi M, Morita T, Kodama Y, Sofuni T, Ishidate Jr M 1990. The micronucleus assay with mouse peripheral blood reticulocytes using acridine orange-coated slides. MutatRes 245: 245-249.
14. Heim KE, Tagliaferro AR, Bobilya DJ 2002. Flavonoid antioxidants: Chemistry, metabolism and structureactivity relationships. J Nutr Biochem 13: 572-584.
15. Hiruma-Lima CA, Calvo TR, Rodrigues CM, Andrade FDP, Vilegas W, Souza-Brito ARM 2006. Antiulcerogenic activity of Alchornea castaneaefolia: Effects on somatostatin, gastrin and prostaglandin. J Ethnopharmacol 104: 215-224.
16. Jurado J, Alejandre-Durán E, Alonso-Moraga A, Pueyo C 1991. Study on the mutagenic activity of 13 bioflavonoids with the Salmonella ara test. Mutagenesis 6: 289-295.
17. Kinoshita S, Inoue Y, Nakama S, Ichiba T, Aniya Y 2007. Antioxidant and hepatoprotective actions of medicinal herb, Terminalia catappa L. from Okinawa Island and its tannin corilagin. Phytomedicine 14: 755-762.
18. Kritchevsk D, Chen SC 2005. Phytosterols - health benefits and potential concerns: A review. Nutr Res 25: 413-428.
19. Labieniec M, Gabryelak T, Falcioni G 2003. Antioxidant and pro-oxidant effects of tannins in digestive cells of the freshwater mussel unio tumidus. Mutat Res 539: 19-28.
20. Lamikanra A, Ogundaini AO, Ogungbamila FO 1990. Antibacterial constituents of Alchornea cordifolia leaves. Phytotherapy Res 4: 198-200.
21. Lopes FC, Calvo TR, Vilegas W, Carlos IZ 2005. Inhibition of hydrogen peroxide, nitric oxide and TNF-α production in peritoneal macrophages by ethyl acetate fraction from Alchornea glandulosa. Biol Pharm Bull 28: 1726-1730.
22. Lorenzi H 2002. Árvores Brasileiras: Manual de identificação e cultivo de plantas arbóreas nativas do Brasil. Instituto Plantarum, Nova Odessa, p. 352
23. MacGregor JT 1986. Mutagenic and carcinogenic effects of flavonoids. In: Cody V, Middlenton E, Harbone B (Eds.), Plant Flavonoids in Biology and Medicine. Biochemical Pharmacological and Structure-Activity Relationships, Alan R. Liss, New York, pp. 411-424.
24. Maron DM, Ames BN 1983. Revised methods for the Salmonella mutagenicity test. Mutat Res 113: 173-215.
25. Martínez A, Urios A, Blanco M 2000. Mutagenicity of 80 chemicals in Escherichia coli tester strains IC203, deficient in oxyR, and its oxyRQ parent WP2 uvra/pkm101: Detection of 31 oxidative mutagens. Mutat Res 467: 41-53.
26. Mavar-Manga H, Chapon D, Hoet S, Block S, Pauw-Gillet M, Quetin-Leclercq J 2006. N1,N2,N3-Trisisopentenyl guanidine and N1,N2-diisopentenyl guanidine, two cytotoxic alkaloids from Alchornea cordifolia (Schumach.& Thonn.) Müll. Arg. (Euphorbiaceae) root barks. Nat Prod Comm 12: 1097-1100.
27. Mortelmans K, Zeiger E 2000. The Ames Salmonella/microsome mutagenicity assay. Mutat Res 455: 29-60.
28. Olfert ED, Cross, BM, McWilliam AA 1993. The Guide to the Care and Use of Experimental Animals. V. 1. Canadian Council on Animal Care, Ontario.
29. Osadebe PO, Okoye EC 2003. Anti-inflammatory effects of crude methanolic extract and fractions of Alchornea cordifolia. J Ethnopharmacol 89: 19-24.
30. Santos FV, Tubaldini,F., Cólus IMS, Andreo MA, Bauab TM, Leite CQ., Vilegas W, Varanda EA 2008. Mutagenicity of Mouriri pusa Gardner and Mouriri elliptica Martius. Food Chem Toxicol 46: 2721-2727.
31. Schwontkowski D 1993. Herbs of the amazon: traditional and common uses. Science Student Brain Trust Publishing, Utah, p. 26.
32. Setzer WN, Shen X, Bates R., Burns JR, Mcclure KJ, Zhang P, Moriarity DM, Lawton RO 2000. A phytochemical investigation of Alchornea latifolia. Fitoterapia 71: 195-198.
33. Silva JD, Herrmann SM, Heuser V, Peres W, Marronid NP, González-Gallego J, Erdtmann B 2002. Evaluation of the genotoxic effect of rutin and quercetin by comet assay and micronucleus test. Food Chem Toxicol 40: 941-947.
34. Uddin Q, Malik A, Azam S, Hadi N, Azmi AS, Parveen N, Khan NU, Hadi SM 2004. The biflavonoid, amentoflavone degrades DNA in the presence of copper ions. Toxicology in Vitro18: 435-440.
35. Varella SD, Pozetti GL, Vilegas W, Varanda EA 2004. Mutagenic activity in waste from an aluminum products factory in Salmonella/microsome assay. Toxicol in Vitro 18: 895-900.
36. Wolfreys AM, Hepburn PA 2002. Safety evaluation of phytosterol esters. Part 7. Assessment of mutagenic activity of phytosterols, phytosterol esters and the cholesterol derivative, 4-cholesten-3-one. Food Chem Toxicol 40: 461-470.