Diversity in CD8+ T cell function and epitope breadth among persons with genital herpes

Journal of Clinical Immunology

Volumn 30, Issue 5, 2010, Pages 703-722

  Laing, Kerry J ^a   Magaret, Amalia S ^a,b   Mueller, Dawn E ^a   Zhao, Lin ^a   Johnston, Christine ^b   De Rosa, Stephen C ^a,b   Koelle, David M ^a,b,c   Wald, Anna ^a,b   Corey, Lawrence ^a,b  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c BENAROYA RESEARCH INSTITUTE   (United States)

Author keywords

antigens peptides epitopes; HSV 2; T cells; virus

Indexed keywords

CYTOKINE; EPITOPE; GRANZYME B; PERFORIN;

ADULT; AGED; ARTICLE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; ENZYME LINKED IMMUNOSPOT ASSAY; EX VIVO STUDY; FEMALE; FLOW CYTOMETRY; GENITAL HERPES; HERPES SIMPLEX VIRUS 2; HUMAN; HUMAN CELL; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; MAJOR CLINICAL STUDY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; VIRUS REACTIVATION;

ADULT; AGED; ANTIGENIC VARIATION; ANTIGENS, VIRAL; CD8-POSITIVE T-LYMPHOCYTES; CELL DEGRANULATION; CELL PROLIFERATION; CELLS, CULTURED; CYTOKINES; EPITOPE MAPPING; EPITOPES, T-LYMPHOCYTE; FEMALE; HERPES GENITALIS; HERPESVIRUS 2, HUMAN; HUMANS; MALE; MIDDLE AGED;

EID: 77957594058     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-010-9441-2     Document Type: Article

References (43)

1. A Wald K Link 2002 Risk of human immunodeficiency virus infection in herpes simplex virus type 2-seropositive persons: a meta-analysis J Infect Dis 185 45 52 10.1086/338231 11756980 (Pubitemid 34043015)
2. EE Freeman HA Weiss JR Glynn PL Cross JA Whitworth RJ Hayes 2006 Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and meta-analysis of longitudinal studies AIDS 20 73 83 10.1097/01.aids.0000198081.09337.a7 16327322
3. DM Koelle CM Posavad GR Barnum ML Johnson JM Frank L Corey 1998 Clearance of HSV-2 from recurrent genital lesions correlates with infiltration of HSV-specific cytotoxic T lymphocytes J Clin Invest 101 1500 1508 10.1172/JCI1758 9525993 1:CAS:528:DyaK1cXitleksbs%3D
4. + T cells J Virol 81 8157 8164 10.1128/JVI.00474-07 17522198 1:CAS:528:DC%2BD2sXnvFyit7c%3D (Pubitemid 47101502)
5. J Zhu DM Koelle J Cao J Vazquez ML Huang F Hladik A Wald L Corey 2007 Virus-specific CD8+ T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation J Exp Med 204 595 603 10.1084/jem.20061792 17325200 1:CAS:528:DC%2BD2sXjsVyqsrw%3D (Pubitemid 46457082)
6. ME Dobbs JE Strasser CF Chu C Chalk GN Milligan 2005 Clearance of herpes simplex virus type 2 by CD8+ T cells requires gamma interferon and either perforin- or Fas-mediated cytolytic mechanisms J Virol 79 14546 14554 10.1128/JVI.79.23.14546-14554.2005 16282454 1:CAS:528:DC%2BD2MXht1Cgsb7J (Pubitemid 41636253)
7. N Hosken P McGowan A Meier DM Koelle P Sleath F Wagener M Elliott K Grabstein C Posavad L Corey 2006 Diversity of the CD8+ T-cell response to herpes simplex virus type 2 proteins among persons with genital herpes J Virol 80 5509 5515 10.1128/JVI.02659-05 16699031 1:CAS:528:DC%2BD28XlsVGnurs%3D
8. DM Koelle Z Liu CL McClurkan RC Cevallos J Vieira NA Hosken CA Meseda DC Snow A Wald L Corey 2003 Immunodominance among herpes simplex virus-specific CD8 T cells expressing a tissue-specific homing receptor Proc Natl Acad Sci USA 100 12899 12904 10.1073/pnas.2131705100 14566059 1:CAS:528:DC%2BD3sXoslKnu70%3D (Pubitemid 37339997)
9. AA Chentoufi X Zhang K Lamberth G Dasgupta I Bettahi A Nguyen M Wu X Zhu A Mohebbi S Buus SL Wechsler AB Nesburn L BenMohamed 2008 HLA-A 0201-restricted CD8+ cytotoxic T lymphocyte epitopes identified from herpes simplex virus glycoprotein D J Immunol 180 426 437 18097044 1:CAS:528:DC%2BD2sXhsVGjur%2FF
10. H Horton EP Thomas JA Stucky I Frank Z Moodie Y Huang YL Chiu MJ McElrath SC De Rosa 2007 Optimization and validation of an 8-color intracellular cytokine staining (ICS) assay to quantify antigen-specific T cells induced by vaccination J Immunol Methods 323 39 54 10.1016/j.jim.2007.03.002 17451739 1:CAS:528:DC%2BD2sXlt1ShtLw%3D (Pubitemid 46722712)
11. WJ Muller L Dong A Vilalta B Byrd KM Wilhelm CL McClurkan M Margalith C Liu D Kaslow J Sidney A Sette DM Koelle 2009 Herpes simplex virus type 2 tegument proteins contain subdominant T-cell epitopes detectable in BALB/c mice after DNA immunization and infection J Gen Virol 90 1153 1163 10.1099/vir.0.008771-0 19264627 1:CAS:528:DC%2BD1MXmtV2ltLw%3D
12. RL Ashley J Militoni F Lee A Nahmias L Corey 1988 Comparison of Western blot (immunoblot) and glycoprotein G-specific immunodot enzyme assay for detecting antibodies to herpes simplex virus types 1 and 2 in human sera J Clin Microbiol 26 662 667 2835389 1:STN:280:DyaL1c3htlKjsQ%3D%3D
13. JA Hanley A Negassa MD Edwardes JE Forrester 2003 Statistical analysis of correlated data using generalized estimating equations: an orientation Am J Epidemiol 157 364 375 10.1093/aje/kwf215 12578807 (Pubitemid 36196757)
14. ML Precopio MR Betts J Parrino DA Price E Gostick DR Ambrozak TE Asher DC Douek A Harari G Pantaleo R Bailer BS Graham M Roederer RA Koup 2007 Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8(+) T cell responses J Exp Med 204 1405 1416 10.1084/jem.20062363 17535971 1:CAS:528:DC%2BD2sXms1aktL8%3D (Pubitemid 46919878)
15. SI Mannering JS Morris KP Jensen AW Purcell MC Honeyman PM van Endert LC Harrison 2003 A sensitive method for detecting proliferation of rare autoantigen-specific human T cells J Immunol Methods 283 173 183 10.1016/j.jim.2003.09.004 14659909 1:CAS:528:DC%2BD3sXptlOksrw%3D (Pubitemid 37501068)
16. J Sidney E Assarsson C Moore S Ngo C Pinilla A Sette B Peters 2008 Quantitative peptide binding motifs for 19 human and mouse MHC class I molecules derived using positional scanning combinatorial peptide libraries Immunome Res 4 2 10.1186/1745-7580-4-2 18221540 1:CAS:528:DC%2BD1cXjvVWrtL0%3D (Pubitemid 351278399)
17. MR Betts MC Nason SM West SC De Rosa SA Migueles J Abraham MM Lederman JM Benito PA Goepfert M Connors M Roederer RA Koup 2006 HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells Blood 107 4781 4789 10.1182/blood-2005-12-4818 16467198 1:CAS:528:DC%2BD28XlvFCgtrg%3D (Pubitemid 43882629)
18. JR Almeida DA Price L Papagno ZA Arkoub D Sauce E Bornstein TE Asher A Samri A Schnuriger I Theodorou D Costagliola C Rouzioux H Agut AG Marcelin D Douek B Autran V Appay 2007 Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover J Exp Med 204 2473 2485 10.1084/jem.20070784 17893201 1:CAS:528:DC%2BD2sXhtFCntrbE (Pubitemid 47529331)
19. RA Seder PA Darrah M Roederer 2008 T-cell quality in memory and protection: implications for vaccine design Nat Rev Immunol 8 247 258 10.1038/nri2274 18323851 1:CAS:528:DC%2BD1cXjs1antLk%3D (Pubitemid 351432801)
20. PV Suneetha V Schlaphoff C Wang KA Stegmann P Fytili SK Sarin MP Manns M Cornberg H Wedemeyer 2009 Effect of peptide pools on effector functions of antigen-specific CD8+ T cells J Immunol Methods 342 33 48 10.1016/j.jim.2008.11. 020 19135447 1:CAS:528:DC%2BD1MXitVCntL8%3D
21. L Banks D Pim M Thomas 2003 Viruses and the 26 S proteasome: hacking into destruction Trends Biochem Sci 28 452 459 10.1016/S0968-0004(03)00141-5 12932734 1:CAS:528:DC%2BD3sXmsVGqsLc%3D (Pubitemid 36976748)
22. I Rezuchova M Kudelova V Durmanova A Vojvodova J Kosovsky J Rajcani 2003 Transcription at early stages of herpes simplex virus 1 infection and during reactivation Intervirology 46 25 34 10.1159/000068121 12566696 1:CAS:528:DC%2BD3sXovFagsw%3D%3D (Pubitemid 36173474)
23. SN Mueller CM Jones W Chen Y Kawaoka MR Castrucci WR Heath FR Carbone 2003 The early expression of glycoprotein B from herpes simplex virus can be detected by antigen-specific CD8+ T cells J Virol 77 2445 2451 10.1128/JVI.77.4.2445-2451.2003 12551982 1:CAS:528:DC%2BD3sXpvVGntg%3D%3D (Pubitemid 36222768)
24. TJ Manley L Luy T Jones M Boeckh H Mutimer SR Riddell 2004 Immune evasion proteins of human cytomegalovirus do not prevent a diverse CD8+ cytotoxic T-cell response in natural infection Blood 104 1075 1082 10.1182/blood-2003-06- 1937 15039282 1:CAS:528:DC%2BD2cXmslKgsLw%3D (Pubitemid 39038028)
25. AW Sylwester BL Mitchell JB Edgar C Taormina C Pelte F Ruchti PR Sleath KH Grabstein NA Hosken F Kern JA Nelson LJ Picker 2005 Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects J Exp Med 202 673 685 10.1084/jem.20050882 16147978 1:CAS:528:DC%2BD2MXhtVSjs7zE (Pubitemid 41248418)
26. L Neumann W Kraas S Uebel G Jung R Tampe 1997 The active domain of the herpes simplex virus protein ICP47: a potent inhibitor of the transporter associated with antigen processing J Mol Biol 272 484 492 10.1006/jmbi.1997.1282 9325106 1:CAS:528:DyaK2sXms1Sntrw%3D (Pubitemid 27429836)
27. R Tomazin NE van Schoot K Goldsmith P Jugovic P Sempe K Fruh DC Johnson 1998 Herpes simplex virus type 2 ICP47 inhibits human TAP but not mouse TAP J Virol 72 2560 2563 9499125 1:CAS:528:DyaK1cXhtFKiu7c%3D
28. X Paliard B Doe MJ Selby K Hartog AY Lee RL Burke CM Walker 2001 Induction of herpes simplex virus gB-specific cytotoxic T lymphocytes in TAP1-deficient mice by genetic immunization but not HSV infection Virology 282 56 64 10.1006/viro.2000.0829 11259190 1:CAS:528:DC%2BD3MXhvFKjtbc%3D (Pubitemid 32881775)
29. G Mouzakitis J McLauchlan C Barreca L Kueltzo P O'Hare 2005 Characterization of VP22 in herpes simplex virus-infected cells J Virol 79 12185 12198 10.1128/JVI.79.19.12185-12198.2005 16160145 1:CAS:528:DC%2BD2MXhtVGls7nK (Pubitemid 41346080)
30. BL Trus WW Newcomb N Cheng G Cardone L Marekov FL Homa JC Brown AC Steven 2007 Allosteric signaling and a nuclear exit strategy: binding of UL25/UL17 heterodimers to DNA-Filled HSV-1 capsids Mol Cell 26 479 489 10.1016/j.molcel.2007.04.010 17531807 1:CAS:528:DC%2BD2sXmsVWksLs%3D (Pubitemid 46765180)
31. BR Bowman RL Welschhans H Jayaram ND Stow VG Preston FA Quiocho 2006 Structural characterization of the UL25 DNA-packaging protein from herpes simplex virus type 1 J Virol 80 2309 2317 10.1128/JVI.80.5.2309-2317.2006 16474137 1:CAS:528:DC%2BD28XhvFyht78%3D (Pubitemid 43271536)
32. DS McNabb RJ Courtney 1992 Identification and characterization of the herpes simplex virus type 1 virion protein encoded by the UL35 open reading frame J Virol 66 2653 2663 1313892 1:CAS:528:DyaK38XisFWrs7k%3D
33. ND Stow 2001 Packaging of genomic and amplicon DNA by the herpes simplex virus type 1 UL25-null mutant KUL25NS J Virol 75 10755 10765 10.1128/JVI.75.22.10755-10765.2001 11602717 1:CAS:528:DC%2BD3MXnvVeltr4%3D (Pubitemid 33031545)
34. MA Ali B Forghani EM Cantin 1996 Characterization of an essential HSV-1 protein encoded by the UL25 gene reported to be involved in virus penetration and capsid assembly Virology 216 278 283 10.1006/viro.1996.0061 8615003 1:CAS:528:DyaK28XpsVChsg%3D%3D (Pubitemid 26075575)
35. DM Koelle HB Chen MA Gavin A Wald WW Kwok L Corey 2001 CD8 CTL from genital herpes simplex lesions: recognition of viral tegument and immediate early proteins and lysis of infected cutaneous cells J Immunol 166 4049 4058 11238653 1:CAS:528:DC%2BD3MXitVGmsLw%3D
36. RP Braun LG Payne L Dong 2006 Characterization of the IFN-gamma T-cell responses to immediate early antigens in humans with genital herpes Virol J 3 54 10.1186/1743-422X-3-54 16822314 1:CAS:528:DC%2BD28Xns1Cjsrg%3D (Pubitemid 44214750)
37. HH Bui J Sidney K Dinh S Southwood MJ Newman A Sette 2006 Predicting population coverage of T-cell epitope-based diagnostics and vaccines BMC Bioinform 7 153 10.1186/1471-2105-7-153 1:CAS:528:DC%2BD28XkvV2qtLY%3D (Pubitemid 44082046)
38. H Shin EJ Wherry 2007 CD8 T cell dysfunction during chronic viral infection Curr Opin Immunol 19 408 415 10.1016/j.coi.2007.06.004 17656078 1:CAS:528:DC%2BD2sXpsFKktrk%3D (Pubitemid 47284857)
39. G Makedonas MR Betts 2006 Polyfunctional analysis of human t cell responses: importance in vaccine immunogenicity and natural infection Springer Semin Immunopathol 28 209 219 10.1007/s00281-006-0025-4 16932955 (Pubitemid 44764277)
40. M Feldmann FM Brennan MJ Elliott RO Williams RN Maini 1995 TNF alpha is an effective therapeutic target for rheumatoid arthritis Ann NY Acad Sci 766 272 278 10.1111/j.1749-6632.1995.tb26675.x 7486670 1:CAS:528:DyaK28XkvVWltw%3D%3D (Pubitemid 26169107)
41. LG Guidotti FV Chisari 2001 Noncytolytic control of viral infections by the innate and adaptive immune response Annu Rev Immunol 19 65 91 10.1146/annurev.immunol.19.1.65 11244031 1:CAS:528:DC%2BD3MXivFKgtb0%3D (Pubitemid 32368030)
42. JE Knickelbein KM Khanna MB Yee CJ Baty PR Kinchington RL Hendricks 2008 Noncytotoxic lytic granule-mediated CD8+ T cell inhibition of HSV-1 reactivation from neuronal latency Science 322 268 271 10.1126/science.1164164 18845757 1:CAS:528:DC%2BD1cXht1Slu7%2FI
43. C Cellerai M Perreau V Rozot FB Enders G Pantaleo A Harari 2010 Proliferation capacity and cytotoxic activity are mediated by functionally and phenotypically distinct virus-specific CD8 T cells defined by interleukin-7R{alpha} (CD127) and perforin expression J Virol 84 3868 3878 10.1128/JVI.02565-09 20130059 1:CAS:528:DC%2BC3cXkvVyqs7g%3D