The role of serum pepsinogen in the detection of gastric cancer

Gut and Liver

Volumn 4, Issue 3, 2010, Pages 307-319

  Kim, Nayoung ^a,b   Jung, Hyun Chae ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Seoul National University Bundang Hospital   (South Korea)

Author keywords

Atrophic gastritis; Gastric cancer; Helicobacter pylori; Pepsinogen

Indexed keywords

PEPSINOGEN I; PEPSINOGEN II; TUMOR MARKER;

ATROPHIC GASTRITIS; BLOOD LEVEL; CANCER DIAGNOSIS; CANCER INVASION; CANCER LOCALIZATION; CANCER RISK; GROUPS BY AGE; HELICOBACTER INFECTION; HISTOPATHOLOGY; HUMAN; INTESTINE METAPLASIA; LABORATORY TEST; NONHUMAN; PEPSINOGEN TEST; REVIEW; SEROPREVALENCE; SEX DIFFERENCE; STOMACH CANCER;

EID: 77957587129     PISSN: 19762283     EISSN: None     Source Type: Journal    
DOI: 10.5009/gnl.2010.4.3.307     Document Type: Review

References (79)

1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005;55:74-108.
2. Shin HR, Won YJ, Jung KW, et al. Nationwide cancer incidence in Korea, 1999~2001; first result using the national cancer incidence database. Cancer Res Treat 2005; 37:325-331.
3. Nomura K, ed. Cancer statistics in Japan 2005. Tokyo: Foundation for Promotion Cancer Research, 2006.
4. Correa P, Piazuelo MB, Camargo MC. The future of gastric cancer prevention. Gastric Cancer 2004;7:9-16.
5. Fuchs CS, Mayer RJ. Gastric carcinoma. N Engl J Med 1995;333:32-41.
6. Hill MJ. Salt and gastric cancer. Eur J Cancer Prev 1998; 7:173-175.
7. Sandor J, Kiss I, Farkas O, Ember I. Association between gastric cancer mortality and nitrate content of drinking water: ecological study on small area inequalities. Eur J Epidemiol 2001;17:443-447.
8. Serafini M, Bellocco R, Wolk A, Ekström AM. Total antioxidant potential of fruit and vegetables and risk of gastric cancer. Gastroenterology 2002;123:985-991.
9. Terry P, Nyrén O, Yuen J. Protective effect of fruits and vegetables on stomach cancer in a cohort of Swedish twins. Int J Cancer 1998;76:35-37.
10. Shin CM, Kim N, Yang HJ, et al. Stomach cancer risk in gastric cancer relatives: interaction between Helicobacter pylori infection and family history of gastric cancer for the risk of stomach cancer. J Clin Gastroenterol 2010;44:e34-e39.
11. Kikuchi S, Katada N, Sakuramoto S, et al. Survival after surgical treatment of early gastric cancer: surgical techniques and long-term survival. Langenbecks Arch Surg 2004;389:69-74.
12. Onodera H, Tokunaga A, Yoshiyuki T, et al. Surgical outcome of 483 patients with gastric cancer: prognosis, postoperative morbidity and mortality, and gastric remnant cancer. Hepatogastroenterology 2004;51:82-85.
13. Gotoda T. Endoscopic resection of early gastric cancer. Gastric Cancer 2007;10:1-11.
14. Kim JP, Nam SJ, Yang HK, Chung M. Clinical analysis of early gastric cancer. Korean J Gastroenterol 1991;23:428-435.
15. Choi IJ. Gastric cancer screening and diagnosis. Korean J Gastroenterol 2009;54:67-76.
16. Hamashima C, Shibuya D, Yamazaki H, et al. The Japanese guidelines for gastric cancer screening. Jpn J Clin Oncol 2008;38:259-267.
17. Liu CY, Wu CY, Lin JT, Lee YC, Yen AM, Chen TH. Multistate and multifactorial progression of gastric cancer: results from community-based mass screening for gastric cancer. J Med Screen 2006;13 Suppl 1:S2-S5.
18. Parsonnet J, Samloff IM, Nelson LM, et al. Helicobacter pylori, pepsinogen, and risk of gastric adenocarcinoma. Cancer Epidemiol Biomarkers Prev 1993;2:461-466.
19. Kimura K. Chronological transition of the fundic-pyloric border determined by stepwise biopsy of the lesser and greater curvatures of the stomach. Gastroenterology 1972;63:584-592.
20. Kuipers EJ. Review article: relationship between Helicobacter pylori, atrophic gastritis and gastric cancer. Aliment Pharmacol Ther 1998;12 Suppl 1:25-36.
21. Miki K, Ichinose M, Kawamura N, et al. The significance of low serum pepsinogen levels to detect stomach cancer associated with extensive chronic gastritis in Japanese subjects. Jpn J Cancer Res 1989;80:111-114.
22. Samloff IM, Varis K, Ihamaki T, Siurala M, Rotter JI. Relationships among serum pepsinogen I, serum pepsinogen II, and gastric mucosal histology. A study in relatives of patients with pernicious anemia. Gastroenterology 1982;83(1 Pt 2):204-209.
23. Aromaa A, Kosunen TU, Knekt P, et al. Circulating anti-Helicobacter pylori immunoglobulin A antibodies and low serum pepsinogen I level are associated with increased risk of gastric cancer. Am J Epidemiol 1996;144:142-149.
24. Watanabe Y, Kurata JH, Mizuno S, et al. Helicobacter pylori infection and gastric cancer. A nested case-control study in a rural area of Japan. Dig Dis Sci 1997;42:1383-1387.
25. Kitahara F, Kobayashi K, Sato T, Kojima Y, Araki T, Fujino MA. Accuracy of screening for gastric cancer using serum pepsinogen concentrations. Gut 1999;44:693-697.
26. Ohata H, Kitauchi S, Yoshimura N, et al. Progression of chronic atrophic gastritis asssociated with Helicobacter pylori infection increases risk of gastric cancer. Int J Cancer 2004;109:138-143.
27. Watabe H, Mitsushima T, Yamaji Y, et al. Predicting the development of gastric cancer from combining Helicobacter pylori antibodies and serum pepsinogen status: a prospective endoscopic cohort study. Gut 2005;54:764-768.
28. Normura AM, Kolonel LN, Miki K, et al. Helicobacter pylori, pepsinogen, and gastric adenocarcinoma in Hawaii. J Infect Dis 2005;191:2075-2081.
29. Sasazuki S, Inoue M, Iwasaki M, et al. Effect of Helicobacter pylori infection combined with CagA and pepsinogen status on gastric cancer development among Japanese men and women: a nested case-control study. Cancer Epidemiol Biomarkers Prev 2006;15:1341-1347.
30. Yamada S, Matsuhisa T, Makonkawkeyoon L, et al. Helicobacter pylori infection in combination with the serum pepsinogen I/II ratio and interleukin-1beta-511 polymorphisms are independent risk factors for gastric cancer in Thais. J Gastroenterol 2006;41:1169-1177.
31. Oishi Y, Kiyohara Y, Kubo M, et al. The serum pepsinogen test as a predictor of gastric cancer. The Hisayama study. Am J Epidemiol 2006;163:629-637.
32. Kang JM, Kim N, Yoo JY, et al. The role of serum pepsinogen and gastrin test for the detection of gastric cancer in Korea. Helicobacter 2008;13:146-156.
33. Miki K, Morita M, Sasajima M, Hoshina R, Kanda E, Urita Y. Usefulness of gastric cancer screening using the serum pepsinogen test method. Am J Gastroenterol 2003;98:735-739.
34. Miki K. Gastric cancer screening using the serum pepsinogen test method. Gastric Cancer 2006;9:245-253.
35. Ang TL, Fock KM, Dhamodaran S, Teo EK, Tan J. Racial differences in Helicobacter pylori, serum pepsinogen and gastric cancer incidence in an urban Asian population. J Gastroenterol Hepatol 2005;20:1603-1609.
36. Huang SC, Miki K, Sano J, et al. Pepsinogens I and II in gastric cancer: an immunohistochemical study using monoclonal antibodies. Jpn J Cancer Res 1988;79:1139-1146.
37. Samloff IM. Cellular localization of group I pepsinogens in human gastric mucosa by immunofluorescence. Gastroenterology 1971;61:185-188.
38. Miki K, Ichinose M, Shimizu A, et al. Serum pepsinogens as a screening test of extensive chronic gastritis. Gastroenterology Jpn 1987;22:133-141.
39. Feldman M, Richardson CT, Lam SK, Samloff IM. Comparison of gastric acid secretion rates and serum pepsinogen I and II concentrations in occidental and oriental duodenal ulcer patients. Gastroenterology 1988;95:630-635.
40. Kinoshita Y, Kawanami C, Kishi K, Nakata H, Seino Y, Chiba T. Helicobacter pyloriin dependent chronological change in gastric acid secretion in the Japanese. Gut 1997;41:452-458.
41. Yasunaga Y, Shinomura Y, Kanayama S. Serum pepsinogen I levels and acid secretion in Helicobacter pylori associated enlarged fold gastritis. Ital J Gastroenterol 1996;28:457-461.
42. Iijima K, Sekine H, Koike T, Imatani A, Ohara S, Shimosegawa T. Serum pepsinogen concentrations as a measure of gastric acid secretion in Helicobacter pylori-negative and -positive Japanese subjects. J Gastroenterol 2005;40:938-944.
43. Kim HY, Kim N, Kang JM, et al. Clinical meaning of pepsinogen test and Helicobacter pylori serology in the health check-up population in Korea. Eur J Gastroenterol Hepatol 2009;21:606-612.
44. Wagner S, Haruma K, Gladziwa U, et al. Helicobacter pylori infection and serum pepsinogen A, pepsinogen C, and gastrin in gastritis and peptic ulcer: significance of inflammation and effect of bacterial eradication. Am J Gastroenterol 1994;89:1211-1218.
45. Asaka M, Kimura T, Kudo M, et al. Relationship of Helicobacter pylori to serum pepsinogens in asymptomatic Japanese population. Gastroenterology 1992;102:760-766.
46. Cave TR, Cave DR. Helicobacter pylori stimulates pepsin secretion from isolated rabbit gastric glands. Scand J Gastroenterol 1991;181 Suppl:9-14.
47. Young GO, Stemmet N, Lastovica A, et al. Helicobacter pylori lipopolysaccharide stimulates gastric mucosal pepsinogen secretion. Aliment Pharmacol Ther 1992;6:169-177.
48. Gisbert JP, Boixeda D, Al-Mostafa A, et al. Basal and stimulated gastrin and pepsinogen levels after eradication of Helicobacter pylori: a 1-year follow-up study. Eur J Gastroenterol Hepatol 1999;11:189-200.
49. Knight T, Greaves S, Wilson A, et al. Variability in serum pepsinogen levels in an asymptomatic population. Eur J Gastroenterol Hepatol 1995;7:647-654.
50. Kikuchi S, Inaba Y, Wada O, et al. The association of smoking and drinking habits with serum pepsinogens. Int J Epidemiol 1995;24:346-353.
51. Denda K, Fujibayashi S, Seko C, Nakamura K, Ehata Y, Yagami T. Relationship between factors examined at health examination and serum pepsinogen levels in healthy adults. Physical measurements, blood chemical tests, drinking and smoking. Nippon Koshu Eisei Zasshi 1998;45:336-342.
52. Hokkanen S, Kosunen TU, Sarna S, et al. Normal serum pepsinogen I levels in adults: a population-based study with special reference to Helicobacter pylori infection and parietal cell antibodies. Scand J Clin Lab Invest 2005;65:291-299.
53. Ichinose M, Miki K, Furihata C, et al. Radioimmunoassay of serum group I and group II pepsinogens in normal controls and patients with various disorders. Clin Chim Acta 1982;126:183-191.
54. Samloff IM. Pepsinogen I and II: purification from gastric mucosa and radioimmunoassay in serum. Gastroenterology 1982;82:26-33.
55. Mukoubayashi C, Yanaoka K, Ohata H, et al. Serum pepsinogen and gastric cancer screening. Intern Med 2007;46:261-266.
56. Ren JS, Kamangar F, Qiao YL, et al. Serum pepsinogens and risk of gastric and oesophgeal cancers in the General Population Nutrition Intervention Trial Cohort. Gut 2009;58:636-642.
57. Ijima K, Abe Y, Kikuchi R, et al. Serum biomarker tests are useful in delineating between patients with gastric atrophy and normal, healthy stomach. World J Gastroenterol 2009;15:853-859.
58. Correa P. Helicobacter pylori and gastric carcinogenesis. Am J Surg Pathol 1995;19 Suppl 1:S37-S43.
59. Kim N, Park YS, Cho SI, et al. Prevalence and risk factors of atrophic gastritis and intestinal metaplasia in a Korean population without significant gastroduodenal disease. Helicobacter 2008;13:245-255.
60. Sipponen P, Kekki M, Haapakoski J, Ihamäki T, Siurala M. Gastric cancer risk in chronic atrophic gastritis: statistical calculations of cross-sectional data. Int J Cancer 1985;35:173-177.
61. Bodger K, Wyatt JI, Heatley RV. Variation in serum pepsinogens with severity and topography of Helicobacter pylori- associated chronic gastritis in dyspeptic patients referred for endoscopy. Helicobacter 2001;6:216-224.
62. Broutet N, Plebani M, Sakarovitch C, Sipponen P, Megraud F. Pepsinogen A, pepsinogen C, and gastrin as markers of atrophic chronic gastritis in European dyspeptics. Br J Cancer 2003;88:1239-1247.
63. Ricci C, Vakil N, Rugge M, et al. Serological markers for gastric atrophy in asymptomatic patients infected with Helicobacter pylori. Am J Gastroenterol 2004;99:1910-1915.
64. Shin CM, Kim N, Lee HS, et al. Validation of diagnostic tests for Helicobacter pylori with regard to grade of atrophic gastritis and/or intestinal metaplasia. Helicobacter 2009;14:512-519.
65. Lee JH, Kim N, Chung JI, et al. Long-term follow-up of Helicobacter pylori IgG serology after eradication and reinfection rate of H. pylori in South Korea. Helicobacter 2008;13:288-294.
66. Kang HY, Kim N, Park YS, et al. Progression of atrophic gastritis and intestinal metaplasia drives Helicobacter pylori out of the gastric mucosa. Dig Dis Sci 2006;51:2310-2315.
67. Webb PM, Hengels KJ, Moller H, et al. The epidemiology of low serum pepsinogen A levels and an international association with gastric cancer rates. EUROGAST Study Group. Gastroenterology 1994;107:1335-1344.
68. Yoshihara M, Sumii K, Haruma K, et al. Correlation of ratio of serum pepsinogen I and II with prevalence of gastric cancer and adenoma in Japanese subjects. Am J Gastroenterol 1998;93:1090-1096.
69. Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand 1965;64:31-49.
70. Seoane A, Bessa X, Balleste B, et al. Helicobacter pylori and gastric cancer: relationship with histological subtype and tumor location. Gastroenterol Hepatol 2005;28:60-64.
71. Trajkov D, Stardelova K, Dimitrova M, Mishevski J, Serafimoski V. Helicobacter pylori and gastric carcinoma. Prilozi 2007;28:39-46.
72. Nardone G. Reveiw article: molecular basis of gastric carcinogenesis. Aliment Pharmacol Ther 2003;17 Suppl 2:75-81.
73. Fujishiro M, Oka M, Yahagi N, et al. Correlation of serum pepsinogens and gross appearances combined with histology in early gastric cancer. J Exp Clin Cancer Res 2006;25:207-212.
74. Hansen S, Vollset SE, Derakhshan MH, et al. Two distinct aetiologies of cardia cancer: evidence from premorbid serological markers of gastric atrophy and Helicobacter pylori status. Gut 2007;56:918-925.
75. Kokkola A, Louhimo J, Puolakkainen P, Alfthan H, Haglund C, Rautelin H. Helicobacter pylori infection and low serum pepsinogen I level as risk factors for gastric carcinoma. World J Gastroenterol 2005;11:1032-1036.
76. Kitahara F, Shimazaki R, Sato T, Kojima Y, Morozumi A, Fujino MA. Severe atrophic gastritis with Helicobacter pylori infection and gastric cancer. Gastric Cancer 1998;1:118-124.
77. Kiyohira K, Yoshihara M, Ito M, Haruma K, Tanaka S, Chayama K. Serum pepsinogen concentration as a marker of Helicobacter pylori infection and the histologic grade of gastritis; evaluation of gastric mucosa by serum pepsinogen levels. J Gastroenterol 2003;38:332-338.
78. Yamagata H, Kiyohara Y, Aoyagi K, et al. Impact of Helicobacter pylori infection on gastric cancer incidence in a general Japanese population: the Hisayama study. Arch Intern Med 2000;160:1962-1968.
79. Yim JY, Kim N, Choi SH, et al. Seroprevalence of Helicobacter pylori in South Korea. Helicobacter 2007;12:333-340.