Cellular changes after photodynamic therapy on HEp-2 cells using the new ZnPcBr8 phthalocyanine

Photomedicine and Laser Surgery

Volumn 28, Issue SUPPL. 1, 2010, Pages

  Machado, Aline Helena Araujo ^a   Moraes, Karen C M ^b   Soares, Cristina Pacheco ^a   Beltrame Jr , Milton ^a   Da Silva, Newton Soares ^a  

^a INSTITUTO DE PESQUISA E DESENVOLVIMENTO   (Brazil)

^b FEDERAL UNIVERSITY OF OURO PRETO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL STUDIES; CELLULAR CHANGES; CELLULAR DEATH; CELLULAR ORGANELLES; CYTOSKELETONS; DIODE LASERS; MULTINUCLEATION; PERINUCLEAR REGION; SELECTIVE TREATMENT; STANDARD CONDITIONS; THERAPEUTIC METHOD; VISIBLE LIGHT; ZINC PHTHALOCYANINES;

BROMINE COMPOUNDS; FLUORESCENCE MICROSCOPY; MITOCHONDRIA; MOLECULAR OXYGEN; NITROGEN COMPOUNDS; PHOTOSENSITIZERS; PLASMONS; PRESSURE EFFECTS; ZINC COMPOUNDS;

PHOTODYNAMIC THERAPY;

OCTAL BROMIDE ZINC PHTHALOCYANINE; OCTAL-BROMIDE ZINC PHTHALOCYANINE; ORGANOMETALLIC COMPOUND; PHOTOSENSITIZING AGENT; ZINC;

ARTICLE; CELL NUCLEUS; CELL STRAIN HEPG2; CELL SURVIVAL; CYTOSKELETON; DRUG EFFECT; HUMAN; METHODOLOGY; PHOTOCHEMOTHERAPY;

CELL NUCLEUS; CELL SURVIVAL; CYTOSKELETON; HEP G2 CELLS; HUMANS; ORGANOMETALLIC COMPOUNDS; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; ZINC;

EID: 77957577235     PISSN: 15495418     EISSN: None     Source Type: Journal    
DOI: 10.1089/pho.2009.2561     Document Type: Article

References (32)

1. Castano, A.P., Demidova, T.N., and Hamblin, M.R. (2005). Mechanisms in photodynamic therapy: part two, cellular signaling, cell metabolism and modes of cell death. Photodiagn. Photodiagnosis Ther. 2, 1-23.
2. Campo, M.A., Gabriel, D., Kucera, P., Gurny, R., and Lange, N (2007). Polymeric photosensitizer prodrugs for photodynamic therapy. Photochem. Photobiol. 83, 958-965.
3. 4. Lasers Med. Sci. 18, 207-212.
4. Ribeiro, J.N., Silva, A.R., Pelegrino, A.C., Tedesco, A.C., and Jorge, R.A. (2005). Evaluation of photodynamic activity of octaethylporphyrin and vanadyl octaethylporphyrin. Applied Cancer Res. 25, 142-150.
5. Zhu, T.C., Finlay, J.C., and Hahn, S.M. (2005). Determination of the distribution of light, optical properties, drug concentration, and tissue oxygenation in-vivo in human prostate during motexafin lutetium-mediated photodynamic therapy. J. Photochem. Photobiol. B. Biol. 79, 231-241.
6. Laloi, C., Stachowiak, M., Pers-Kamczyc, E., Warzych, E., Murgia, I., and Apel, K. (2007). Cross-talk between singlet oxygen- and hydrogen peroxide-dependent signaling of stress responses in Arabidopsis thaliana. Proc. Natl. Acad. Sci. U. S. A. 104, 672-677.
7. Oleinick, N.L., Morris, R.L., and Belichenko, I. (2002). The role of apoptosis in response to photodynamic therapy: what, where, why and how. Photochem. Photobiol. Sci. 1, 1-21.
8. Cauchon, N., Tian, H., and Langlois, R., et al. (2005). Structure-photodynamic activity relationships of substituted zinc trisulfophthalocyanines. Bioconjug. Chem. 16, 80-89.
9. Machado, A.H.A., Pacheco-Soares, C., Da-Silva, N.S, and Moraes, K.C.M. (2009). Cellular and molecular studies of the initial process of the photodynamic therapy in HEp-2 cells using LED light source and two different photosensitizers. Cell Biol. Int. May 3 [Epub ahead of print].
10. Machado, A.H.A., Braga, F.M.P., Pacheco-Soares, C., Pelisson, M.M.M., Beltrame Jr, M., and Da-Silva, N.S. (2007). Photodynamic therapy with a new photosensitizing agent. Photomed. Laser Surg. 25, 220-228.
11. Tapajós, E.C.C., Longo, J.P., Simioni, A.R., et al. (2008). In vitro photodynamic therapy on human oral keratinocytes using chloroaluminum-phthalocyanine. Oral Oncol. 44, 1073-1079.
12. Maftoum-Costa, M., Naves, K.T., Oliveira, A.L., Tedesco, A.C., Da-Silva, N.S., and Pacheco-Soares, C. (2008). Mitochondria, endoplasmic reticulum and actin filament behavior after PDT with chloroaluminum phthalocyanine liposomal in HeLa cells. Cell Biol. Int. 32, 1024-1028.
13. Allison, R.R., Downie, G.H., Cuenca, R., Hu, X.H., Childs, C.J.H., and Sibata, C.H. (2004). Photosensitizers in clinical PDT. Photodiagnosis Photodyn. Ther. 1, 27-42.
14. Machado, A.H.A., Pacheco-Soares, C., Beltrame-Jr, M., Pacheco, M.T.T., and Da-Silva, N.S. (2008). Cytotoxicity of octal-bromide zinc phthalocyanine after photodynamic therapy with different light sources. Photomed. Laser Surg, 26, 455-159.
15. 4. Photomed. Laser Surg. 25, 175-179.
16. Zamzami, N., and Kroemer, G. (2003). Apoptosis: mitochondrial membrane permeabilization: the whole story? Curr. Biol. 13, R71-R73.
17. Green, D.R. (2005). Apoptotic pathways: ten minutes to dead. Cell 121, 671-674.
18. Dougherty, T.J., Gomer, C.J., Henderson, B.W., et al. (1997). Review: photodynamic therapy. J. Natl. Cancer Inst. 90, 889-905.
19. Kolárová, H., Mosinger, J., Lenobel, R., Kejlová, K., Jírová, D., and Strnad, M. (2003). In vitro toxicity testing of supramolecular sensitizers for photodynamic therapy. Toxicol. In Vitro 17, 775-778.
20. Bortoletto, R., Da-Silva, N.S., Zângaro, R.A., Pacheco, M.T.T., Da-Matta, R.A., and Pacheco-Soares, C. (2004). Mitochondrial membrane potential after low-power laser irradiation. Lasers Med. Sci. 18, 204-206.
21. Ahmad, N., Feyes, D.K., Agarwal, R., and Mukhtar, H. (1998). Photodynamic therapy results in induction of WAF1/CIP1/P21 leading to cell cycle arrest and apoptosis. Proc. Natl. Acad. Sci. U. S. A. 95, 6977-6982.
22. Huang, B., Wang, G.C, Zeng, C.K., and Li, Z.G. (2002). The experimental research of R-phycoerythrin subunits on cancer treatment: a new photosensitizer in PDT. Cancer Biother. Radiopharm. 17, 35-42.
23. Fernandez, M.G., Troiano, L., Moretti, L., et al. (2002). Early changes in intramitochondrial cardiolipin distribution during apoptosis. Cell Growth Differ. 13, 449-455.
24. Kriska, T., Korytowski, W., and Girotti., A.W. (2005). Role of mitochondrial cardiolipin peroxidation in apoptotic photokilling of 5-aminolevulinate-treated tumor cells. Arch. Biochem. Biophys. 433, 435-446.
25. Nomura, K., Imai, H., Koumura, T., Kobayashi, T., and Nakagawa, Y. (2000). Mitochondrial phospholipid hydroperoxide glutathione peroxidase inhibits the release of cytochrome c from mitochondria by suppressing the peroxidation of cardiolipin in hypoglycaemia-induced apoptosis. Biochem. J. 351, 183-193.
26. Morgan, J., and Oseroff, A.R. (2001). Mitochondria-based photodynamic anti-cancer therapy. Adv. Drug Deliv. Rev. 49, 71-86.
27. Morris, R.L., Azizuddin, K., Lam, M., et al. (2003). Fluorescence resonance energy transfer reveals a binding site of a photosensitizer for photodynamic therapy. Cancer Res. 63, 5194-5197.
28. Berg, K., and Moan, J. (1997). Lysosomes and microtubules as targets for photochemotherapy of cancer. Photochem. Photobiol. 65, 403-109.
29. Juarranz, A., Espada, J., Stockert, J.C., et al. (2001). Photodamage induced by zinc(II)-phthalocyanine to microtubules, actin, α-actinin and keratin of HeLa cells. Photochem. Photobiol. 73, 283-289.
30. Bursch, W., Hochegger, K., Török, L., Marian, B., Ellinger, A., and Hermann, R.S. (2000). Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments. J. Cell Sci. 113, 1189-1198.
31. Canti, G., Lattuada, D., Nicolin, A., Taroni, P., Valentini, G., and Cubeddu, R. Antitumour immunity induced by photodynamic therapy with aluminum disulfonated phthalocyanine and laser light. Anticancer Drugs 5, 443-447.
32. Caruso, J.A., Mathieu, P.A., and Reiners, J.J.Jr. (2005). Sphingomyelins suppress the targeted disruption of lysosomes /endosomes by the photosensitizer NPe6 during photodynamic therapy. Biochem. J. 392, 325-334.