-
1
-
-
33644954235
-
Genetic recombination in Streptomyces aureofaciens
-
Jarai M. Genetic recombination in Streptomyces aureofaciens. Acta Microbiol Acad Sci Hungary 1961; 8:73-9.
-
(1961)
Acta Microbiol Acad Sci Hungary
, vol.8
, pp. 73-79
-
-
Jarai, M.1
-
2
-
-
33644959406
-
Genetic recombination in the actinomycete breeding
-
In: Sermonti G, Alacevic M, eds., Zagreb: Yugoslav Academy of Sciences and Arts
-
Mindlin SZ. Genetic recombination in the actinomycete breeding. In: Sermonti G, Alacevic M, eds. Genetics and Breeding of Streptomyces. Zagreb: Yugoslav Academy of Sciences and Arts 1969; 147-59.
-
(1969)
Genetics and Breeding of Streptomyces
, pp. 147-159
-
-
Mindlin, S.Z.1
-
3
-
-
0026807020
-
A combined genetic and physical map of the Streptomyces coelicolor A3(2) chromosome
-
Kieser HM, Kieser T, Hopwood DA. A combined genetic and physical map of the Streptomyces coelicolor A3(2) chromosome. J Bacteriol 1992; 174:5496-507.
-
(1992)
J Bacteriol
, vol.174
, pp. 5496-5507
-
-
Kieser, H.M.1
Kieser, T.2
Hopwood, D.A.3
-
4
-
-
0020565069
-
Genetic recombination in Micromonospora rosaria by protoplast fusion
-
Ryu DDY, Kim KS, Cho NY, Pai HS. Genetic recombination in Micromonospora rosaria by protoplast fusion. Appl Environ Microbiol 1983; 45:1854-8.
-
(1983)
Appl Environ Microbiol
, vol.45
, pp. 1854-1858
-
-
Ryu, D.D.Y.1
Kim, K.S.2
Cho, N.Y.3
Pai, H.S.4
-
5
-
-
0018856611
-
Increased production of extracellular enzymes by the synergistic effect of genes introduced into Bacillus subtilis by stepwise transformation
-
Yoneda Y. Increased production of extracellular enzymes by the synergistic effect of genes introduced into Bacillus subtilis by stepwise transformation. Appl Environ Microbiol 1980; 39:274-6.
-
(1980)
Appl Environ Microbiol
, vol.39
, pp. 274-276
-
-
Yoneda, Y.1
-
6
-
-
0036161274
-
A novel methodology employing Corynebacterium glutamicum genome information to generate a new L-lysine-producing mutant
-
Ohnishi J, Mitsuhashi S, Hayashi M, Ando S, Yokoi H, Ochiai K, et al. A novel methodology employing Corynebacterium glutamicum genome information to generate a new L-lysine-producing mutant. Appl Microbiol Biotechnol 2002; 58:217-23.
-
(2002)
Appl Microbiol Biotechnol
, vol.58
, pp. 217-223
-
-
Ohnishi, J.1
Mitsuhashi, S.2
Hayashi, M.3
Ando, S.4
Yokoi, H.5
Ochiai, K.6
-
7
-
-
0032600888
-
Metabolic fluxes and metabolic engineering
-
Stephanopoulos G. Metabolic fluxes and metabolic engineering. Metab Eng 1999; 1:1-11.
-
(1999)
Metab Eng
, vol.1
, pp. 1-11
-
-
Stephanopoulos, G.1
-
9
-
-
0002188159
-
Quantifying and directing metabolic flux: Application to amino acid overproduction
-
Eggeling L, Sahm H, de Graaf AA. Quantifying and directing metabolic flux: application to amino acid overproduction. Adv Biochem Eng Biotechnol 1996; 54:1-30.
-
(1996)
Adv Biochem Eng Biotechnol
, vol.54
, pp. 1-30
-
-
Eggeling, L.1
Sahm, H.2
de Graaf, A.A.3
-
10
-
-
0033782932
-
Pathway analysis and metabolic engineering in Corynebacterium glutamicum
-
Sahm H, Eggeling L, de Graaf AA. Pathway analysis and metabolic engineering in Corynebacterium glutamicum. Biol Chem 2000; 381:899-910.
-
(2000)
Biol Chem
, vol.381
, pp. 899-910
-
-
Sahm, H.1
Eggeling, L.2
de Graaf, A.A.3
-
11
-
-
43049136820
-
Combinatorial engineering of microbes for optimizing cellular phenotype
-
Santos CSS, Stephanopoulos G. Combinatorial engineering of microbes for optimizing cellular phenotype. Curr Opin Chem Biol 2008; 12:168-76.
-
(2008)
Curr Opin Chem Biol
, vol.12
, pp. 168-176
-
-
Santos, C.S.S.1
Stephanopoulos, G.2
-
12
-
-
0030571217
-
Inverse metabolic engineering: A strategy for directed genetic engineering of useful phenotypes
-
Bailey JE, Sburlati A, Hatzimanikatis V, Lee K, Renner WA, Tsai PS. Inverse metabolic engineering: a strategy for directed genetic engineering of useful phenotypes. Biotechnol Bioeng 1996; 52:109-21.
-
(1996)
Biotechnol Bioeng
, vol.52
, pp. 109-121
-
-
Bailey, J.E.1
Sburlati, A.2
Hatzimanikatis, V.3
Lee, K.4
Renner, W.A.5
Tsai, P.S.6
-
14
-
-
0030754926
-
Optimization of DNA shuffling for high fidelity recombination
-
Zhao H, Arnold FH. Optimization of DNA shuffling for high fidelity recombination. Nucl Acids Res 1997; 25:1307-8.
-
(1997)
Nucl Acids Res
, vol.25
, pp. 1307-1308
-
-
Zhao, H.1
Arnold, F.H.2
-
16
-
-
0037034007
-
Genome shuffling leads to rapid phenotypic improvement in bacteria
-
Zhang YX, Perry K, Vinci VA, Powell K, Stemmer WP, del Cardayre SB. Genome shuffling leads to rapid phenotypic improvement in bacteria. Nature 2002; 415:644-6.
-
(2002)
Nature
, vol.415
, pp. 644-646
-
-
Zhang, Y.X.1
Perry, K.2
Vinci, V.A.3
Powell, K.4
Stemmer, W.P.5
del Cardayre, S.B.6
-
17
-
-
65049084532
-
Novel methods of genome shuffling in Saccharomyces cerevisiae
-
Hou L. Novel methods of genome shuffling in Saccharomyces cerevisiae. Biotechnol Lett 2009; 31:671-7.
-
(2009)
Biotechnol Lett
, vol.31
, pp. 671-677
-
-
Hou, L.1
-
18
-
-
28344455644
-
Biotechnological production of amino acids and derivatives: Current status and prospects
-
Leuchtenberger W, Huthmacher K, Drauz K. Biotechnological production of amino acids and derivatives: current status and prospects. Appl Microbiol Biotechnol 2005; 69:1-8.
-
(2005)
Appl Microbiol Biotechnol
, vol.69
, pp. 1-8
-
-
Leuchtenberger, W.1
Huthmacher, K.2
Drauz, K.3
-
19
-
-
36048992161
-
The business of biotechnology
-
Demain AL. The business of biotechnology. Indust Biotechnol 2007; 3:269-83.
-
(2007)
Indust Biotechnol
, vol.3
, pp. 269-283
-
-
Demain, A.L.1
-
20
-
-
0041429497
-
Tools for genetic engineering in the amino acid-producing bacterium Corynebacterium glutamicum
-
Kirchner O, Tauch AJ. Tools for genetic engineering in the amino acid-producing bacterium Corynebacterium glutamicum. J Biotechnol 2003; 104:287-99.
-
(2003)
J Biotechnol
, vol.104
, pp. 287-299
-
-
Kirchner, O.1
Tauch, A.J.2
-
21
-
-
0042162924
-
The Corynebacterium glutamicum genome: Features and impacts on biotechnological processes
-
Ikeda M, Nakagawa S. The Corynebacterium glutamicum genome: features and impacts on biotechnological processes. Appl Microbiol Biotechnol 2003; 62:99-109.
-
(2003)
Appl Microbiol Biotechnol
, vol.62
, pp. 99-109
-
-
Ikeda, M.1
Nakagawa, S.2
-
22
-
-
12444259324
-
The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins
-
Kalinowski J, Bathe B, Bartels D, Bischoff N, Bott M, Burkowski A, et al. The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins. J Biotechnol 2003; 104:5-25.
-
(2003)
J Biotechnol
, vol.104
, pp. 5-25
-
-
Kalinowski, J.1
Bathe, B.2
Bartels, D.3
Bischoff, N.4
Bott, M.5
Burkowski, A.6
-
23
-
-
0037810546
-
Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens
-
Nishio Y, Nakamura Y, Kawarabayashi Y, Usuda Y, Kimura E, Sugimoto S, et al. Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens. Genome Res 2003; 13:1572-9.
-
(2003)
Genome Res
, vol.13
, pp. 1572-1579
-
-
Nishio, Y.1
Nakamura, Y.2
Kawarabayashi, Y.3
Usuda, Y.4
Kimura, E.5
Sugimoto, S.6
-
24
-
-
38049185013
-
Microbial production of L-glutamate and L-glutamine by recombinant Corynebacterium glutamicum harboring Vitreoscilla hemoglobin gene vgb
-
Liu Q, Zhang J, Wei XX, Ouyang SP, Wu Q, Chen GQ. Microbial production of L-glutamate and L-glutamine by recombinant Corynebacterium glutamicum harboring Vitreoscilla hemoglobin gene vgb. Appl Microbiol Biotechnol 2008; 77:1297-304.
-
(2008)
Appl Microbiol Biotechnol
, vol.77
, pp. 1297-1304
-
-
Liu, Q.1
Zhang, J.2
Wei, X.X.3
Ouyang, S.P.4
Wu, Q.5
Chen, G.Q.6
-
25
-
-
34047252012
-
Innovative metabolic pathway design for efficient L-glutamate production by suppreassing CO2 emission
-
Chinen A, Kozlov YI, Hara Y, Izui H, Yasueda H. Innovative metabolic pathway design for efficient L-glutamate production by suppreassing CO2 emission. J Biosci Bioeng 2007; 103:262-9.
-
(2007)
J Biosci Bioeng
, vol.103
, pp. 262-269
-
-
Chinen, A.1
Kozlov, Y.I.2
Hara, Y.3
Izui, H.4
Yasueda, H.5
-
26
-
-
34548050175
-
The three tricarboxylate synthase activities of Corynebacterium glutamicum and increase of L-lysine synthesis
-
Radmacher E, Eggeling L. The three tricarboxylate synthase activities of Corynebacterium glutamicum and increase of L-lysine synthesis. Appl Microbiol Biotechnol 2007; 76:587-95.
-
(2007)
Appl Microbiol Biotechnol
, vol.76
, pp. 587-595
-
-
Radmacher, E.1
Eggeling, L.2
-
27
-
-
34548021634
-
Effect of pyruvate dehydrogenase complex deficiency on L-lysine production with Corynebacterium glutamicum
-
Blombach B, Schreiner ME, Moch M, Oldiges M, Eikmanns BJ. Effect of pyruvate dehydrogenase complex deficiency on L-lysine production with Corynebacterium glutamicum. Appl Microbiol Biotechnol 2007; 76:615-23.
-
(2007)
Appl Microbiol Biotechnol
, vol.76
, pp. 615-623
-
-
Blombach, B.1
Schreiner, M.E.2
Moch, M.3
Oldiges, M.4
Eikmanns, B.J.5
-
28
-
-
34548043216
-
Improving lysine production by Corynebacterium glutamicum through DNA microarray-based identification of novel target genes
-
Sindelar G, Wendisch VF. Improving lysine production by Corynebacterium glutamicum through DNA microarray-based identification of novel target genes. Appl Microbiol Biotechnol 2007; 76:677-89.
-
(2007)
Appl Microbiol Biotechnol
, vol.76
, pp. 677-689
-
-
Sindelar, G.1
Wendisch, V.F.2
-
29
-
-
0018579738
-
Transductional construction of a threonine-producing strain of Serratia marcescens
-
Komatsubara S, Kisumi M, Chibata I. Transductional construction of a threonine-producing strain of Serratia marcescens. Appl Environ Microbiol 1979; 38:1045-51.
-
(1979)
Appl Environ Microbiol
, vol.38
, pp. 1045-1051
-
-
Komatsubara, S.1
Kisumi, M.2
Chibata, I.3
-
30
-
-
0020619548
-
Transductional construction of a threonine-hyperproducing strain of Serratia marcescens: Lack of feedback controls of three aspartokinases and two homoserine dehydrogenases
-
Komatsubara S, Kisumi M, Chibata I. Transductional construction of a threonine-hyperproducing strain of Serratia marcescens: lack of feedback controls of three aspartokinases and two homoserine dehydrogenases. Appl Environ Microbiol 1983; 45:1445-52.
-
(1983)
Appl Environ Microbiol
, vol.45
, pp. 1445-1452
-
-
Komatsubara, S.1
Kisumi, M.2
Chibata, I.3
-
31
-
-
0043205398
-
Construction of a threonine-hyperproducing strain of Serratia marcescens by amplifying the phosphoenolpyruvate carboxylase gene
-
Sugita T, Komatsubara S. Construction of a threonine-hyperproducing strain of Serratia marcescens by amplifying the phosphoenolpyruvate carboxylase gene. Appl Microbiol Biotechnol 1989; 30:290-3.
-
(1989)
Appl Microbiol Biotechnol
, vol.30
, pp. 290-293
-
-
Sugita, T.1
Komatsubara, S.2
-
33
-
-
85007989254
-
Factors improving L-threonine production by a three L-threonine biosynthetic genes-amplified recombinant strain of Brevibacterium lactofermentum
-
Ishida M, Kawashima H, Sato K, Hashiguchi K, Ito H, Enei H, et al. Factors improving L-threonine production by a three L-threonine biosynthetic genes-amplified recombinant strain of Brevibacterium lactofermentum. Biosci Biotechnol Biochem 1994; 58:768-70.
-
(1994)
Biosci Biotechnol Biochem
, vol.58
, pp. 768-770
-
-
Ishida, M.1
Kawashima, H.2
Sato, K.3
Hashiguchi, K.4
Ito, H.5
Enei, H.6
-
34
-
-
0001474927
-
Amino acid production: Principles of metabolic engineering
-
In: Lee SY, Papoutsakis ET, eds., New York: Marcel Dekker
-
Eggeling L, Sahm H. Amino acid production: principles of metabolic engineering. In: Lee SY, Papoutsakis ET, eds. Metabolic Engineering. New York: Marcel Dekker 1999; 153-76.
-
(1999)
Metabolic Engineering
, pp. 153-176
-
-
Eggeling, L.1
Sahm, H.2
-
35
-
-
0036314932
-
Influence of threonine exporters on threonine production in Escherichia coli
-
Kruse D, Kraemer R, Eggeling L, Rieping M, Pfefferle W, Tchieu JH, et al. Influence of threonine exporters on threonine production in Escherichia coli. Appl Microb Biotechnol 2002; 59:205-10.
-
(2002)
Appl Microb Biotechnol
, vol.59
, pp. 205-210
-
-
Kruse, D.1
Kraemer, R.2
Eggeling, L.3
Rieping, M.4
Pfefferle, W.5
Tchieu, J.H.6
-
36
-
-
0037883611
-
Global expression profiling and physiological characterization of Corynebacterium glutamicum grown in the presence of L-valine
-
Lange C, Rittmann D, Wendisch VF, Bott M, Sahm H. Global expression profiling and physiological characterization of Corynebacterium glutamicum grown in the presence of L-valine. Appl Environ Microbiol 2003; 69:2521-32.
-
(2003)
Appl Environ Microbiol
, vol.69
, pp. 2521-2532
-
-
Lange, C.1
Rittmann, D.2
Wendisch, V.F.3
Bott, M.4
Sahm, H.5
-
37
-
-
0033014686
-
Expression of the Escherichia coli catabolic threonine dehydratase in Corynebacterium glutamicum and its effect on isoleucine production
-
Guillouet S, Rodal AA, An G-H, Lessard PA, Sinskey AJ. Expression of the Escherichia coli catabolic threonine dehydratase in Corynebacterium glutamicum and its effect on isoleucine production. Appl Environ Microbiol 1999; 65:3100-7.
-
(1999)
Appl Environ Microbiol
, vol.65
, pp. 3100-3107
-
-
Guillouet, S.1
Rodal, A.A.2
An, G-H.3
Lessard, P.A.4
Sinskey, A.J.5
-
38
-
-
0029860181
-
L-Isoleucine production with Corynebacterium glutamicum: Further flux increase and limitation of export
-
Morbach S, Sahm H, Eggeling L. L-Isoleucine production with Corynebacterium glutamicum: further flux increase and limitation of export. Appl Environ Microbiol 1996; 62:4345-51.
-
(1996)
Appl Environ Microbiol
, vol.62
, pp. 4345-4351
-
-
Morbach, S.1
Sahm, H.2
Eggeling, L.3
-
40
-
-
0029080712
-
Production of isoleucine by overexpression of ilvA in Corynebacterium lactofermentum threonine producer
-
Colon GE, Nguyen TT, Jetten MSM, Sinskey A, Stephanopoulos G. Production of isoleucine by overexpression of ilvA in Corynebacterium lactofermentum threonine producer. Appl Microbiol Biotechnol 1995; 43:482-8.
-
(1995)
Appl Microbiol Biotechnol
, vol.43
, pp. 482-488
-
-
Colon, G.E.1
Nguyen, T.T.2
Jetten, M.S.M.3
Sinskey, A.4
Stephanopoulos, G.5
-
41
-
-
3843134039
-
Aerobic production of alanine by Escherichia coli aceF IdhA mutants expressing the Bacillus sphaericus alaD gene
-
Lee M, Smith GM, Eiteman MA, Altman E. Aerobic production of alanine by Escherichia coli aceF IdhA mutants expressing the Bacillus sphaericus alaD gene. Appl Microbiol Biotechnol 2004; 65:56-60.
-
(2004)
Appl Microbiol Biotechnol
, vol.65
, pp. 56-60
-
-
Lee, M.1
Smith, G.M.2
Eiteman, M.A.3
Altman, E.4
-
42
-
-
0021949984
-
Proline production by regulatory mutants of Serratia marcescens
-
Sugiura M, Takagi T, Kisumu M. Proline production by regulatory mutants of Serratia marcescens. Appl Microbiol Biotechnol 1985; 21:213-39.
-
(1985)
Appl Microbiol Biotechnol
, vol.21
, pp. 213-239
-
-
Sugiura, M.1
Takagi, T.2
Kisumu, M.3
-
43
-
-
0022377661
-
Improvement of a proline-producing strain of Serratia marcescens by subcloning of a mutant allele of the proline gene
-
Sugiura M, Imai Y, Takagi T, Kisumi M. Improvement of a proline-producing strain of Serratia marcescens by subcloning of a mutant allele of the proline gene. J Biotechnol 1985; 3:47-58.
-
(1985)
J Biotechnol
, vol.3
, pp. 47-58
-
-
Sugiura, M.1
Imai, Y.2
Takagi, T.3
Kisumi, M.4
-
44
-
-
0027768557
-
Improvement of culture conditions for L-proline production by a recombinant strain of Serratia marcescens
-
Masuda M, Takamatu S, Nishimura N, Komatsubara S, Tosa T. Improvement of culture conditions for L-proline production by a recombinant strain of Serratia marcescens. Appl Biochem Biotechnol 1993; 43:189-97.
-
(1993)
Appl Biochem Biotechnol
, vol.43
, pp. 189-197
-
-
Masuda, M.1
Takamatu, S.2
Nishimura, N.3
Komatsubara, S.4
Tosa, T.5
-
45
-
-
0034319243
-
Construction of a novel hydroxyproline-producing recombinant Escherichia coli by introducing a proline 4-hydroxylase gene
-
Shibasaki T, Hashimoto S, Mori H, Ozaki A. Construction of a novel hydroxyproline-producing recombinant Escherichia coli by introducing a proline 4-hydroxylase gene. J Biosci Bioeng 2000; 90:522-5.
-
(2000)
J Biosci Bioeng
, vol.90
, pp. 522-525
-
-
Shibasaki, T.1
Hashimoto, S.2
Mori, H.3
Ozaki, A.4
-
46
-
-
0035209901
-
Metabolic engineering for microbial production of aromatic amino acids and derived compounds
-
Bongaerts J, Kraemer M, Mueller U, Raeven L, Wubbolts M. Metabolic engineering for microbial production of aromatic amino acids and derived compounds. Metab Eng 2001; 3:289-300.
-
(2001)
Metab Eng
, vol.3
, pp. 289-300
-
-
Bongaerts, J.1
Kraemer, M.2
Mueller, U.3
Raeven, L.4
Wubbolts, M.5
-
47
-
-
0033009718
-
Hyperproduction of tryptophan by Corynebacterium glutamicum with the modified pentose pathway
-
Ikeda M, Katsumata R. Hyperproduction of tryptophan by Corynebacterium glutamicum with the modified pentose pathway. Appl Environ Microbiol 1999; 65:2497-502.
-
(1999)
Appl Environ Microbiol
, vol.65
, pp. 2497-2502
-
-
Ikeda, M.1
Katsumata, R.2
-
48
-
-
0028406892
-
Fermentative production of tryptophan by a stable recombinant strain of Corynebacterium glutamicum with a modified serine-biosynthetic pathway
-
Ikeda M, Nakanishi K, Kino K, Katsumata R. Fermentative production of tryptophan by a stable recombinant strain of Corynebacterium glutamicum with a modified serine-biosynthetic pathway. Biosci Biotechnol Biochem 1994; 58:674-8.
-
(1994)
Biosci Biotechnol Biochem
, vol.58
, pp. 674-678
-
-
Ikeda, M.1
Nakanishi, K.2
Kino, K.3
Katsumata, R.4
-
49
-
-
0023906397
-
Stabilization of an Escherichia coli plasmid by a mini-F fragment of DNA
-
Yukawa H, Kurusu Y, Shimazu M, Yamagata H, Teresawa M. Stabilization of an Escherichia coli plasmid by a mini-F fragment of DNA. J Indust Microbiol 1988; 2:323-8.
-
(1988)
J Indust Microbiol
, vol.2
, pp. 323-328
-
-
Yukawa, H.1
Kurusu, Y.2
Shimazu, M.3
Yamagata, H.4
Teresawa, M.5
-
50
-
-
0023259834
-
Hyperproduction of phenylalanine by Escherichia coli: Application of a temperature-controllable expression vector carrying the repressor-promotor system of bacteriophage lambda
-
Sugimoto S, Yabuta M, Kato N, Seki T, Yoshida T, Taguchi H. Hyperproduction of phenylalanine by Escherichia coli: application of a temperature-controllable expression vector carrying the repressor-promotor system of bacteriophage lambda. J Biotechnol 1987; 5:237-53.
-
(1987)
J Biotechnol
, vol.5
, pp. 237-253
-
-
Sugimoto, S.1
Yabuta, M.2
Kato, N.3
Seki, T.4
Yoshida, T.5
Taguchi, H.6
-
51
-
-
0027112179
-
Knowledge-based control of fermentation processes
-
Konstantinov KB, Yoshida T. Knowledge-based control of fermentation processes. Biotechnol Bioeng 1992; 39:479-86.
-
(1992)
Biotechnol Bioeng
, vol.39
, pp. 479-486
-
-
Konstantinov, K.B.1
Yoshida, T.2
-
52
-
-
0025122901
-
Genetic engineering of metabolic pathways applied to the production of phenylalanine
-
Backman K, O'Connor MJ, Maruya A, Rudd E, McKay D, Balakrishnan R, et al. Genetic engineering of metabolic pathways applied to the production of phenylalanine. Ann NY Acad Sci 1990; 589:16-24.
-
(1990)
Ann NY Acad Sci
, vol.589
, pp. 16-24
-
-
Backman, K.1
O'Connor, M.J.2
Maruya, A.3
Rudd, E.4
McKay, D.5
Balakrishnan, R.6
-
53
-
-
0026588574
-
Metabolic engineering to produce tyrosine or phenylalanine in a tryptophan-producing Corynebacterium glutamicum strain
-
Ikeda M, Katsumata R. Metabolic engineering to produce tyrosine or phenylalanine in a tryptophan-producing Corynebacterium glutamicum strain. Appl Environ Microbiol 1992; 58:781-5.
-
(1992)
Appl Environ Microbiol
, vol.58
, pp. 781-785
-
-
Ikeda, M.1
Katsumata, R.2
-
54
-
-
0027479515
-
Biotin biosyntheric pathway in a recombinant strain of Escherichia coli overexpressing bio genes: Evidence for a limiting step upstream from KAPA
-
Levy-Schil S, Debussche L, Rigault S, Soubrier F, Bacchette F, Lagneaux D, et al. Biotin biosyntheric pathway in a recombinant strain of Escherichia coli overexpressing bio genes: evidence for a limiting step upstream from KAPA. Appl Microbiol Biotechnol 1993; 38:755-62.
-
(1993)
Appl Microbiol Biotechnol
, vol.38
, pp. 755-762
-
-
Levy-Schil, S.1
Debussche, L.2
Rigault, S.3
Soubrier, F.4
Bacchette, F.5
Lagneaux, D.6
-
55
-
-
0027935616
-
Improvement of a D-biotin-hyperproducing recombinant strain of Serratia marcescens
-
Sakurai N, Imai Y, Masuda M, Komatsubara S, Tosa T. Improvement of a D-biotin-hyperproducing recombinant strain of Serratia marcescens. J Biotechnol 1994; 36:63-73.
-
(1994)
J Biotechnol
, vol.36
, pp. 63-73
-
-
Sakurai, N.1
Imai, Y.2
Masuda, M.3
Komatsubara, S.4
Tosa, T.5
-
56
-
-
0028874079
-
Further improvement of D-biotin production by a recombinant strain of Serratia marcescens
-
Masuda M, Takahashi K, Sakurai N, Yanagiya K, Komatsubara S, Tosa T. Further improvement of D-biotin production by a recombinant strain of Serratia marcescens. Proc Biochem 1995; 30:553-62.
-
(1995)
Proc Biochem
, vol.30
, pp. 553-562
-
-
Masuda, M.1
Takahashi, K.2
Sakurai, N.3
Yanagiya, K.4
Komatsubara, S.5
Tosa, T.6
-
58
-
-
0003100229
-
Biosynthesis of riboflavin, biotin, folic acid, and cobalamin
-
In: Sonenshein AL, Hoch JA, Losick R, eds., Washington, DC: ASM Press
-
Perkins JB, Pero J. Biosynthesis of riboflavin, biotin, folic acid, and cobalamin. In: Sonenshein AL, Hoch JA, Losick R, eds. Bacillus subtilis and Other Gram Positive Bacteria: Biochemistry, Physiology and Molecular Genetics. Washington, DC: ASM Press 1993; 319:34.
-
(1993)
Bacillus subtilis and Other Gram Positive Bacteria: Biochemistry, Physiology and Molecular Genetics
, vol.319
, pp. 34
-
-
Perkins, J.B.1
Pero, J.2
-
59
-
-
0032993682
-
Genetic engineering of Bacillus subtilis for the commercial production of riboflavin
-
Perkins JB, Sloma A, Hermann T, Theriault K, Zachgo E, Erdenberger T, et al. Genetic engineering of Bacillus subtilis for the commercial production of riboflavin. J Indust Microbiol Biotechnol 1999; 22:8-18.
-
(1999)
J Indust Microbiol Biotechnol
, vol.22
, pp. 8-18
-
-
Perkins, J.B.1
Sloma, A.2
Hermann, T.3
Theriault, K.4
Zachgo, E.5
Erdenberger, T.6
-
60
-
-
0034130561
-
Gene expression analysis by massively parallel signature sequencing (MPSS) on microbead arrays
-
Brenner S, Johnson M, Bridgham J, Golda G, Lloyd DH, Johnson D, et al. Gene expression analysis by massively parallel signature sequencing (MPSS) on microbead arrays. Nat Biotechnol 2000; 18:630-4.
-
(2000)
Nat Biotechnol
, vol.18
, pp. 630-634
-
-
Brenner, S.1
Johnson, M.2
Bridgham, J.3
Golda, G.4
Lloyd, D.H.5
Johnson, D.6
-
61
-
-
4544372921
-
A genome wide transcription analysis of a fungal rivoflavin overproducer
-
Karos M, Vilarino C, Bollschweiler C, Revuelta JL. A genome wide transcription analysis of a fungal rivoflavin overproducer. J Biotechnol 2004; 113:69-76.
-
(2004)
J Biotechnol
, vol.113
, pp. 69-76
-
-
Karos, M.1
Vilarino, C.2
Bollschweiler, C.3
Revuelta, J.L.4
-
62
-
-
0022372833
-
Production of 2-keto-L-gulonate: An intermediate in L-ascorbate synthesis by a genetically modified Erwinia herbicola
-
Anderson S, Marks CB, Lazarus R, Miller J, Stafford K, Seymour J, et al. Production of 2-keto-L-gulonate: an intermediate in L-ascorbate synthesis by a genetically modified Erwinia herbicola. Science 1985; 230:144-9.
-
(1985)
Science
, vol.230
, pp. 144-149
-
-
Anderson, S.1
Marks, C.B.2
Lazarus, R.3
Miller, J.4
Stafford, K.5
Seymour, J.6
-
63
-
-
0023762137
-
Conversion of glucose to 2-keto-L-gulonate, an intermediate in L-ascorbate synthesis by a recombinant strain of Erwinia citreus
-
Grindley JF, Payton MA, van de Pol H, Hardy KG. Conversion of glucose to 2-keto-L-gulonate, an intermediate in L-ascorbate synthesis by a recombinant strain of Erwinia citreus. Appl Environ Microbiol 1988; 54:1770-5.
-
(1988)
Appl Environ Microbiol
, vol.54
, pp. 1770-1775
-
-
Grindley, J.F.1
Payton, M.A.2
van de Pol, H.3
Hardy, K.G.4
-
64
-
-
0030894636
-
Cloning of genes coding for L-sorbose and L-sorbosone dehydrogenases from Gluconobacter oxydans and microbial production of 2-keto-gulonate, a precursor of L-ascorbic acid, in a recombinant G. oxydans strain
-
Saito Y, Ishii Y, Hayashi H, Imao Y, Akashi T, Yoshikawa K, et al. Cloning of genes coding for L-sorbose and L-sorbosone dehydrogenases from Gluconobacter oxydans and microbial production of 2-keto-gulonate, a precursor of L-ascorbic acid, in a recombinant G. oxydans strain. Appl Environ Microbiol 1997; 63:454-60.
-
(1997)
Appl Environ Microbiol
, vol.63
, pp. 454-460
-
-
Saito, Y.1
Ishii, Y.2
Hayashi, H.3
Imao, Y.4
Akashi, T.5
Yoshikawa, K.6
-
66
-
-
66149134426
-
Metabolic regulation and overproduction of primary metabolites
-
Sanchez S, Demain AL. Metabolic regulation and overproduction of primary metabolites. Microb Biotechnol 2008; 1:283-319.
-
(2008)
Microb Biotechnol
, vol.1
, pp. 283-319
-
-
Sanchez, S.1
Demain, A.L.2
-
67
-
-
33746913914
-
Metabolic engineering of Escherichia coli and Corynebacterium glutamicum fot biotechnological production of organic acids and amino acids
-
Wendisch VF, Bott M, Eikmanns BJ. Metabolic engineering of Escherichia coli and Corynebacterium glutamicum fot biotechnological production of organic acids and amino acids. Curr Opin Microbiol 2006; 9:268-74.
-
(2006)
Curr Opin Microbiol
, vol.9
, pp. 268-274
-
-
Wendisch, V.F.1
Bott, M.2
Eikmanns, B.J.3
-
68
-
-
0037417864
-
Engineering the metabolism of Escherichia coli W3110 for the conversion of sugar to redox-neutral and oxidized products: Homoacetate production
-
USA
-
Causey TB, Zhou S, Shanmugam KT, Ingram LO. Engineering the metabolism of Escherichia coli W3110 for the conversion of sugar to redox-neutral and oxidized products: homoacetate production. Proc Natl Acad Sci USA 2003; 100:825-32.
-
(2003)
Proc Natl Acad Sci
, vol.100
, pp. 825-832
-
-
Causey, T.B.1
Zhou, S.2
Shanmugam, K.T.3
Ingram, L.O.4
-
69
-
-
0028210599
-
High concentrations of acetate with a mutant strain of C. thermoaceticum
-
Parekh SR, Cheryan M. High concentrations of acetate with a mutant strain of C. thermoaceticum. Biotechnol Lett 1994; 16:139-42.
-
(1994)
Biotechnol Lett
, vol.16
, pp. 139-142
-
-
Parekh, S.R.1
Cheryan, M.2
-
70
-
-
0024586192
-
Cloning of the membrane-bound aldehyde dehydrogenase gene of Acetobacter polyoxogenes and improvement of acetic acid production by use of the cloned gene
-
Fukaya M, Tayama K, Tamaki T, Tagami H, Okumura H, Kawamura Y, et al. Cloning of the membrane-bound aldehyde dehydrogenase gene of Acetobacter polyoxogenes and improvement of acetic acid production by use of the cloned gene. Appl Environ Microbiol 1989; 55:171-6.
-
(1989)
Appl Environ Microbiol
, vol.55
, pp. 171-176
-
-
Fukaya, M.1
Tayama, K.2
Tamaki, T.3
Tagami, H.4
Okumura, H.5
Kawamura, Y.6
-
71
-
-
18444393083
-
Genetically engineered wine yeast produces a high concentration of L-lactic acid of extremely high optical purity
-
Saitoh S, Ishida N, Onishi T, Tokuhiro K, Nagamori E, Kitamoto K, et al. Genetically engineered wine yeast produces a high concentration of L-lactic acid of extremely high optical purity. Appl Environ Microbiol 2005; 71:2789-92.
-
(2005)
Appl Environ Microbiol
, vol.71
, pp. 2789-2792
-
-
Saitoh, S.1
Ishida, N.2
Onishi, T.3
Tokuhiro, K.4
Nagamori, E.5
Kitamoto, K.6
-
72
-
-
0035989644
-
Genome shuffling of Lactobacillus for improved acid tolerance
-
Patnaik R, Louie S, Gavrilovic V, Perry K, Stemmer WPC, Ryan CM, et al. Genome shuffling of Lactobacillus for improved acid tolerance. Nat Biotechnol 2002; 20:707-12.
-
(2002)
Nat Biotechnol
, vol.20
, pp. 707-712
-
-
Patnaik, R.1
Louie, S.2
Gavrilovic, V.3
Perry, K.4
Stemmer, W.P.C.5
Ryan, C.M.6
-
73
-
-
47749114582
-
Genome shuffling of Lactobacillus delbrueckii mutant and Bacillus amyloliquuefaciens through protoplastic fusion for L-latic acid production from starchy wastes
-
John RP, Gangadharan D, Madhavan Nampoothiri K. Genome shuffling of Lactobacillus delbrueckii mutant and Bacillus amyloliquuefaciens through protoplastic fusion for L-latic acid production from starchy wastes. Bioresour Technol 2008; 99:8008-15.
-
(2008)
Bioresour Technol
, vol.99
, pp. 8008-8015
-
-
John, R.P.1
Gangadharan, D.2
Madhavan Nampoothiri, K.3
-
74
-
-
28444472789
-
Fermentation of 10% (w/v) sugar to D(-)-lactate by engineered Escherichia coli B
-
Zhou S, Yomano LP, Shanmugam KT, Ingram LO. Fermentation of 10% (w/v) sugar to D(-)-lactate by engineered Escherichia coli B. Biotechnol Lett 2003; 27:1891-6.
-
(2003)
Biotechnol Lett
, vol.27
, pp. 1891-1896
-
-
Zhou, S.1
Yomano, L.P.2
Shanmugam, K.T.3
Ingram, L.O.4
-
75
-
-
33745642526
-
D-Lactic acid production by metabolically engineered Saccharomyces cerevisiae
-
Ishida N, Suzuki T, Tokuhiro K, Nagamori E, Onishi T, Saitoh S, et al. D-Lactic acid production by metabolically engineered Saccharomyces cerevisiae. J Biosci Bioeng 2006; 101:172-7.
-
(2006)
J Biosci Bioeng
, vol.101
, pp. 172-177
-
-
Ishida, N.1
Suzuki, T.2
Tokuhiro, K.3
Nagamori, E.4
Onishi, T.5
Saitoh, S.6
-
76
-
-
2142811523
-
Lactic acid production by Rhizopus oryzae transformants with modified lactate dehydrogenase activity
-
Skory CD. Lactic acid production by Rhizopus oryzae transformants with modified lactate dehydrogenase activity. Appl Microbiol Biotechnol 2004; 64:237-42.
-
(2004)
Appl Microbiol Biotechnol
, vol.64
, pp. 237-242
-
-
Skory, C.D.1
-
77
-
-
18444393083
-
Genetically engineered wine yeast produces a high concentration of L-lactic acid of extremely high optical purity
-
Saito S, Ishida N, Onishi T, Tokuhiro K, Nagamori E, Kitamoto K, et al. Genetically engineered wine yeast produces a high concentration of L-lactic acid of extremely high optical purity. Appl Environ Microbiol 2005; 71:2789-92.
-
(2005)
Appl Environ Microbiol
, vol.71
, pp. 2789-2792
-
-
Saito, S.1
Ishida, N.2
Onishi, T.3
Tokuhiro, K.4
Nagamori, E.5
Kitamoto, K.6
-
78
-
-
0032825184
-
Replacement of a metabolic pathway for large scale production of lactic acid from engineered yeasts
-
Porro D, Bianchi MM, Brambilla L, Menghini R, Bolzani D, Carrera V, et al. Replacement of a metabolic pathway for large scale production of lactic acid from engineered yeasts. Appl Environ Microbiol 1999; 65:4211-5.
-
(1999)
Appl Environ Microbiol
, vol.65
, pp. 4211-4215
-
-
Porro, D.1
Bianchi, M.M.2
Brambilla, L.3
Menghini, R.4
Bolzani, D.5
Carrera, V.6
-
79
-
-
33645029734
-
Genome-based metabolic engineering of Mannheimia succiniciproducens for succinic acid production
-
Lee SJ, Song H, Lee SY. Genome-based metabolic engineering of Mannheimia succiniciproducens for succinic acid production. Appl Environ Microbiol 2006; 72:1939-48.
-
(2006)
Appl Environ Microbiol
, vol.72
, pp. 1939-1948
-
-
Lee, S.J.1
Song, H.2
Lee, S.Y.3
-
80
-
-
19744367895
-
Fed-batch culture of a metabolically engineered Escherichia coli strain designed for high-level succinate production and yield under aerobic conditions
-
Lin H, Bennett GN, San KY. Fed-batch culture of a metabolically engineered Escherichia coli strain designed for high-level succinate production and yield under aerobic conditions. Biotechnol Bioeng 2005; 90:775-9.
-
(2005)
Biotechnol Bioeng
, vol.90
, pp. 775-779
-
-
Lin, H.1
Bennett, G.N.2
San, K.Y.3
-
81
-
-
18944378749
-
Novel pathway engineering design of the anaerobic central metabolic pathway in Escherichia coli
-
Sanchez AM, Bennett GN, San KY. Novel pathway engineering design of the anaerobic central metabolic pathway in Escherichia coli. Metab Eng 2005; 7:229-39.
-
(2005)
Metab Eng
, vol.7
, pp. 229-239
-
-
Sanchez, A.M.1
Bennett, G.N.2
San, K.Y.3
-
82
-
-
0036309458
-
Succinate production in dual-phase Escherichia coli fermentations depends on the time of transition from aerobic to anaerobic conditions
-
Vemuri GN, Eiteman MA, Altman E. Succinate production in dual-phase Escherichia coli fermentations depends on the time of transition from aerobic to anaerobic conditions. J Ind Microbiol Biotechnol 2002; 28:325-32.
-
(2002)
J Ind Microbiol Biotechnol
, vol.28
, pp. 325-332
-
-
Vemuri, G.N.1
Eiteman, M.A.2
Altman, E.3
-
83
-
-
0038119755
-
Phosphoenolpyruvate availability and the biosynthesis of shikimic acid
-
Chandran SS, Yi J, Draths KM, Von Daeniken R, Weber W, Frost JW. Phosphoenolpyruvate availability and the biosynthesis of shikimic acid. Biotechnol Prog 2003; 19:808-14.
-
(2003)
Biotechnol Prog
, vol.19
, pp. 808-814
-
-
Chandran, S.S.1
Yi, J.2
Draths, K.M.3
Von Daeniken, R.4
Weber, W.5
Frost, J.W.6
-
84
-
-
1642457254
-
Metabolic engineering for microbial production of shikimic acid
-
Kraemer M, Bongaerts J, Bovenberg R, Kremer S, Mueller U, Orf S, et al. Metabolic engineering for microbial production of shikimic acid. Metab Eng 2003; 5:277-83.
-
(2003)
Metab Eng
, vol.5
, pp. 277-283
-
-
Kraemer, M.1
Bongaerts, J.2
Bovenberg, R.3
Kremer, S.4
Mueller, U.5
Orf, S.6
-
85
-
-
77957583526
-
Metabolic engineering of Clostridium tyrobutyricum for butyric acid fermentation
-
San Diego, Abstract 70
-
Liu X, Yang ST. Metabolic engineering of Clostridium tyrobutyricum for butyric acid fermentation. Proc 229th ACS National Meeting San Diego 2005; Abstract 70.
-
(2005)
Proc 229th ACS National Meeting
-
-
Liu, X.1
Yang, S.T.2
-
86
-
-
0026410778
-
L-Malic acid formation by immobilized Saccharomyces cerevisiae amplified for fumarase
-
Neufeld RJ, Peleg Y, Rokem JS, Pines O, Goldberg I. L-Malic acid formation by immobilized Saccharomyces cerevisiae amplified for fumarase. Enzyme Microb Technol 1991; 13:991-6.
-
(1991)
Enzyme Microb Technol
, vol.13
, pp. 991-996
-
-
Neufeld, R.J.1
Peleg, Y.2
Rokem, J.S.3
Pines, O.4
Goldberg, I.5
-
87
-
-
0026636011
-
Metabolic engineering of Candida tropicalis for the production of long-chain dicarboxylic acids
-
Picataggio S, Rohver T, Deander K, Lanning D, Reynolds R, Mielenz J, et al. Metabolic engineering of Candida tropicalis for the production of long-chain dicarboxylic acids. Nat Biotechnol 1992; 10:894-8.
-
(1992)
Nat Biotechnol
, vol.10
, pp. 894-898
-
-
Picataggio, S.1
Rohver, T.2
Deander, K.3
Lanning, D.4
Reynolds, R.5
Mielenz, J.6
-
88
-
-
0023431472
-
Genetic engineering of ethanol production in Escherichia coli
-
Ingram LO, Conway T, Clark DP, Sewell GW, Preston JF. Genetic engineering of ethanol production in Escherichia coli. Appl Environ Microbiol 1987; 53:2420-5.
-
(1987)
Appl Environ Microbiol
, vol.53
, pp. 2420-2425
-
-
Ingram, L.O.1
Conway, T.2
Clark, D.P.3
Sewell, G.W.4
Preston, J.F.5
-
89
-
-
0001574949
-
Fermentation of crystalline cellulose to ethanol by Klebsiella oxytoca containing chromosomally integrated Zymomonas mobilis genes
-
Doran JB, Ingram LO. Fermentation of crystalline cellulose to ethanol by Klebsiella oxytoca containing chromosomally integrated Zymomonas mobilis genes. Biotechnol Prog 1993; 9:533-8.
-
(1993)
Biotechnol Prog
, vol.9
, pp. 533-538
-
-
Doran, J.B.1
Ingram, L.O.2
-
90
-
-
0034040510
-
Development of new ethanologenic Escherichia coli strains for fermentation of lignocellulosic biomass
-
Dien BS, Nichols NN, O'Bryan PJ, Bothast RJ. Development of new ethanologenic Escherichia coli strains for fermentation of lignocellulosic biomass. Appl Biochem Biotechnol 2000; 84-86:181-96.
-
(2000)
Appl Biochem Biotechnol
, vol.84-86
, pp. 181-196
-
-
Dien, B.S.1
Nichols, N.N.2
O'Bryan, P.J.3
Bothast, R.J.4
-
91
-
-
57649149334
-
Genome shuffling to improve thermotolerance, ethanol tolerance and ethanol productivity of Saccharomyces cerevisiae
-
Shi DJ, Wang CL, Wang KM. Genome shuffling to improve thermotolerance, ethanol tolerance and ethanol productivity of Saccharomyces cerevisiae. J Ind Microbiol Biotechnol 2009; 36:139-47.
-
(2009)
J Ind Microbiol Biotechnol
, vol.36
, pp. 139-147
-
-
Shi, D.J.1
Wang, C.L.2
Wang, K.M.3
-
92
-
-
77949306818
-
Improved production of ethanol by novel gene shuffling in Saccharomyces cerevisiae
-
Hou L. Improved production of ethanol by novel gene shuffling in Saccharomyces cerevisiae. Appl Biochem Biotechnol 2010; 160:1084-93.
-
(2010)
Appl Biochem Biotechnol
, vol.160
, pp. 1084-1093
-
-
Hou, L.1
-
93
-
-
38749088716
-
Genome shuffling in the ethanologenic yeast Candida krusei to improve acetic acid tolerance
-
Wei P, Li Z, He P, Lin Y, Jiang N. Genome shuffling in the ethanologenic yeast Candida krusei to improve acetic acid tolerance. Biotechnol Appl Biochem 2008; 49:113-20.
-
(2008)
Biotechnol Appl Biochem
, vol.49
, pp. 113-120
-
-
Wei, P.1
Li, Z.2
He, P.3
Lin, Y.4
Jiang, N.5
-
94
-
-
0033967647
-
High production of 1,3-propanediol from industrial glycerol by a newly isolated Clostridium butyricum strain
-
Papanikolaou S, Ruiz-Sanchez P, Pariset B, Blanchard F, Fick M. High production of 1,3-propanediol from industrial glycerol by a newly isolated Clostridium butyricum strain. J Biotechnol 2000; 77:191-208.
-
(2000)
J Biotechnol
, vol.77
, pp. 191-208
-
-
Papanikolaou, S.1
Ruiz-Sanchez, P.2
Pariset, B.3
Blanchard, F.4
Fick, M.5
-
95
-
-
0742286881
-
Pathway engineering through rational design. Tutorial: Designing and building cell factories for biobased production
-
Sanford K, Valle F, Ghirnikar R. Pathway engineering through rational design. Tutorial: Designing and building cell factories for biobased production. Gen Eng News 2004; 24:44-5.
-
(2004)
Gen Eng News
, vol.24
, pp. 44-45
-
-
Sanford, K.1
Valle, F.2
Ghirnikar, R.3
-
96
-
-
0142027026
-
Metabolic engineering for the microbial production of 1,3 propanediol
-
Nakamura C, Whited G. Metabolic engineering for the microbial production of 1,3 propanediol. Curr Opin Biotechnol 2003; 14:454-9.
-
(2003)
Curr Opin Biotechnol
, vol.14
, pp. 454-459
-
-
Nakamura, C.1
Whited, G.2
-
97
-
-
2442587515
-
Metabolic engineering of Escherichia coli: Construction of an efficient biocatalyst for D-mannitol formation in a whole-cell biotransformation
-
Kaup B, Bringer-Meyer S, Sahm H. Metabolic engineering of Escherichia coli: construction of an efficient biocatalyst for D-mannitol formation in a whole-cell biotransformation. Appl Microbiol Biotechnol 2004; 64:333-9.
-
(2004)
Appl Microbiol Biotechnol
, vol.64
, pp. 333-339
-
-
Kaup, B.1
Bringer-Meyer, S.2
Sahm, H.3
-
98
-
-
28444455948
-
D-Mannitol formation from D-glucose in a whole-cell biotransformation with recombinant Escherichia coli
-
Kaup B, Bringer-Meyer S, Sahm H. D-Mannitol formation from D-glucose in a whole-cell biotransformation with recombinant Escherichia coli. Appl Microbiol Biotechnol 2005; 69:397-403.
-
(2005)
Appl Microbiol Biotechnol
, vol.69
, pp. 397-403
-
-
Kaup, B.1
Bringer-Meyer, S.2
Sahm, H.3
-
99
-
-
33947431635
-
High-level; production of the low-calorie sugar sorbitol by Lactobacillus plantarum through metyabolic engineering
-
Ladero V, Ramos A, Wiersma A, Goffin P, Schanck A, Kleerbezem M. High-level; production of the low-calorie sugar sorbitol by Lactobacillus plantarum through metyabolic engineering. Appl Environ Microbiol 2007; 73:1864-72.
-
(2007)
Appl Environ Microbiol
, vol.73
, pp. 1864-1872
-
-
Ladero, V.1
Ramos, A.2
Wiersma, A.3
Goffin, P.4
Schanck, A.5
Kleerbezem, M.6
-
100
-
-
84966188821
-
Cloning of the Bacillus subtilis IMP dehydrogenase gene and its application to increased production of guanosine
-
Miyagawa K, Kimura H, Nakahama K, Kikuchi M, Doi M, Akiyama S, et al. Cloning of the Bacillus subtilis IMP dehydrogenase gene and its application to increased production of guanosine. Nat Biotechnol 1986; 4:225-8.
-
(1986)
Nat Biotechnol
, vol.4
, pp. 225-228
-
-
Miyagawa, K.1
Kimura, H.2
Nakahama, K.3
Kikuchi, M.4
Doi, M.5
Akiyama, S.6
-
101
-
-
0034105938
-
Metabolic engineering of carotenoid accumulation in Escherichia coli by modulation of the isoprenoid precursor pool with expression of deoxyxylulose phosphate synthase
-
Matthews PD, Wurtzel ET. Metabolic engineering of carotenoid accumulation in Escherichia coli by modulation of the isoprenoid precursor pool with expression of deoxyxylulose phosphate synthase. Appl Microbiol Biotechnol 2000; 53:396-400.
-
(2000)
Appl Microbiol Biotechnol
, vol.53
, pp. 396-400
-
-
Matthews, P.D.1
Wurtzel, E.T.2
-
102
-
-
21044439802
-
Metabolic engineering of Escherichia coli for industrial production of glucosamine and N-acetylglucosamine
-
Deng M-D, Severson DK, Grund AD, Wassink SL, Burlingame RP, Berry A, et al. Metabolic engineering of Escherichia coli for industrial production of glucosamine and N-acetylglucosamine. Metab Eng 2005; 7:201-14.
-
(2005)
Metab Eng
, vol.7
, pp. 201-214
-
-
Deng, M-D.1
Severson, D.K.2
Grund, A.D.3
Wassink, S.L.4
Burlingame, R.P.5
Berry, A.6
-
103
-
-
0027910069
-
Metabolic engineering of Clostridium acetobutylicum ATCC 824 for increased solvent production by enhancement of acetone formation enzyme activities using a synthetic operon
-
Mermelstein LD, Papoutsakis ET, Petersen DJ, Bennett GN. Metabolic engineering of Clostridium acetobutylicum ATCC 824 for increased solvent production by enhancement of acetone formation enzyme activities using a synthetic operon. Biotechnol Bioeng 1993; 42:1053-60.
-
(1993)
Biotechnol Bioeng
, vol.42
, pp. 1053-1060
-
-
Mermelstein, L.D.1
Papoutsakis, E.T.2
Petersen, D.J.3
Bennett, G.N.4
-
104
-
-
0031886572
-
Expression of Clostridium acetobutylicum ATCC 824 genes in Escherichia coli for acetone production and acetate detoxification
-
Bermejo LL, Welker NE, Papoutsakis ET. Expression of Clostridium acetobutylicum ATCC 824 genes in Escherichia coli for acetone production and acetate detoxification. Appl Environ Microbiol 1998; 64:1079-85.
-
(1998)
Appl Environ Microbiol
, vol.64
, pp. 1079-1085
-
-
Bermejo, L.L.1
Welker, N.E.2
Papoutsakis, E.T.3
-
106
-
-
0029995755
-
γ-(L-α-aminoadipyl)-L-cysteinyl-D-valine synthetase is a rate limiting enzyme for penicillin production in Aspergillus nidulans
-
Kennedy J, Turner G. γ-(L-α-aminoadipyl)-L-cysteinyl-D-valine synthetase is a rate limiting enzyme for penicillin production in Aspergillus nidulans. Mol Gen Genet 1996; 253:189-97.
-
(1996)
Mol Gen Genet
, vol.253
, pp. 189-197
-
-
Kennedy, J.1
Turner, G.2
-
107
-
-
0013543369
-
Recombination studies with Cephalosporium acremonium
-
In: Sebek OK, Laskin AI, eds., Washington, DC: American Society for Microbiology
-
Hamlyn PF, Ball C. Recombination studies with Cephalosporium acremonium. In: Sebek OK, Laskin AI, eds. Genetics of Industrial Microorganisms. Washington, DC: American Society for Microbiology 1979; 185-91.
-
(1979)
Genetics of Industrial Microorganisms
, pp. 185-191
-
-
Hamlyn, P.F.1
Ball, C.2
-
108
-
-
33644966417
-
Improved transformation of Cephalosporium acremonium
-
In: Alacevic M, Hranueli D, Toman Z, eds., Zagreb: Pliva
-
Skatrud PL, Fisher DL, Ingolia TD, Queener SW. Improved transformation of Cephalosporium acremonium. In: Alacevic M, Hranueli D, Toman Z, eds. Genetics of Industrial Microorganisms, Part B. Zagreb: Pliva 1987; 111-9.
-
(1987)
Genetics of Industrial Microorganisms, Part B
, pp. 111-119
-
-
Skatrud, P.L.1
Fisher, D.L.2
Ingolia, T.D.3
Queener, S.W.4
-
109
-
-
0024513339
-
Use of recombinant DNA to improve production of cephalosporin C by Cephalosporium acremonium
-
Skatrud PL, Tietz AJ, Ingolia TD, Cantwell CA, Fisher DL, Chapman JL, et al. Use of recombinant DNA to improve production of cephalosporin C by Cephalosporium acremonium. Nat Biotechnol 1989; 7:477-85.
-
(1989)
Nat Biotechnol
, vol.7
, pp. 477-485
-
-
Skatrud, P.L.1
Tietz, A.J.2
Ingolia, T.D.3
Cantwell, C.A.4
Fisher, D.L.5
Chapman, J.L.6
-
110
-
-
0342967062
-
Strain improvement by genetic recombination of cephamycin producers, Nocardia lactamdurans and Streptomyces griseus
-
Wesseling AC, Lago B. Strain improvement by genetic recombination of cephamycin producers, Nocardia lactamdurans and Streptomyces griseus. Devel Indust Microbiol 1981; 22:641-51.
-
(1981)
Devel Indust Microbiol
, vol.22
, pp. 641-651
-
-
Wesseling, A.C.1
Lago, B.2
-
111
-
-
16244415184
-
Expression of ccaR, encoding the positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus, is dependent on bldG
-
Bignell DRD, Tahlan K, Colvin KR, Jensen SE, Leskiw BK. Expression of ccaR, encoding the positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus, is dependent on bldG. Antimicrob Agents Chemother 2005; 49:1529-41.
-
(2005)
Antimicrob Agents Chemother
, vol.49
, pp. 1529-1541
-
-
Bignell, D.R.D.1
Tahlan, K.2
Colvin, K.R.3
Jensen, S.E.4
Leskiw, B.K.5
-
112
-
-
0034108566
-
Overexpression of the lat gene in Nocardia lactamdurans from strong heterologous promoters results in very high levels of lysine-6-aminotransferase and up two-fold increase in cephamycin C production
-
Chary VK, de la Fuente JL, Leitao AL, Liras P, Martin JF. Overexpression of the lat gene in Nocardia lactamdurans from strong heterologous promoters results in very high levels of lysine-6-aminotransferase and up two-fold increase in cephamycin C production. Appl Microbiol Biotechnol 2000; 53:282-8.
-
(2000)
Appl Microbiol Biotechnol
, vol.53
, pp. 282-288
-
-
Chary, V.K.1
de la Fuente, J.L.2
Leitao, A.L.3
Liras, P.4
Martin, J.F.5
-
113
-
-
0026710635
-
Isolation of deacetoxycephalosporin C from fermentation broths of Penicillium chrysogenum transformants: Construction of a new fungal biosynthetic pathway
-
Cantwell C, Beckmann R, Whiteman P, Queener SW, Abraham EP. Isolation of deacetoxycephalosporin C from fermentation broths of Penicillium chrysogenum transformants: construction of a new fungal biosynthetic pathway. Proc R Soc Lond (Biol) 1992; 248:283-9.
-
(1992)
Proc R Soc Lond (Biol)
, vol.248
, pp. 283-289
-
-
Cantwell, C.1
Beckmann, R.2
Whiteman, P.3
Queener, S.W.4
Abraham, E.P.5
-
114
-
-
0028835709
-
Production of cephalosporin intermediates by feeding adipic acid to recombinant Penicillium chrysogenum strains expressing ring expansion activity
-
Crawford L, Stepan AM, Mcada PC, Rambosek JA, Conder MJ, Vinci VA, et al. Production of cephalosporin intermediates by feeding adipic acid to recombinant Penicillium chrysogenum strains expressing ring expansion activity. Nat Biotechnol 1995; 13:58-62.
-
(1995)
Nat Biotechnol
, vol.13
, pp. 58-62
-
-
Crawford, L.1
Stepan, A.M.2
McAda, P.C.3
Rambosek, J.A.4
Conder, M.J.5
Vinci, V.A.6
-
115
-
-
0033898359
-
Environmentally safe production of 7-aminodeacetoxycephalosporanic acid (7ADCA) using recombinant strains of Acremonium chrysogenum
-
Velasco J, Adrio JL, Moreno MA, Diez B, Soler G, Barredo JL. Environmentally safe production of 7-aminodeacetoxycephalosporanic acid (7ADCA) using recombinant strains of Acremonium chrysogenum. Nat Biotechnol 2000; 18:857-61.
-
(2000)
Nat Biotechnol
, vol.18
, pp. 857-861
-
-
Velasco, J.1
Adrio, J.L.2
Moreno, M.A.3
Diez, B.4
Soler, G.5
Barredo, J.L.6
-
116
-
-
7544240471
-
Cloning and co-expression of D-amino acid oxidase and glutaryl-7-aminocephalosporanic acid acylase genes in Escherichia coli Enzyme
-
Luo H, Yu H, Qiang L, Shen Z. Cloning and co-expression of D-amino acid oxidase and glutaryl-7-aminocephalosporanic acid acylase genes in Escherichia coli Enzyme Microb Technol 2004; 35:514-8.
-
(2004)
Microb Technol
, vol.35
, pp. 514-518
-
-
Luo, H.1
Yu, H.2
Qiang, L.3
Shen, Z.4
-
118
-
-
33646082272
-
Rational strain improvement for enhanced clavulanic acid production by genetic engineering of the glycolytic pathway in Streptomyces clavuligerus
-
Li R, Townsend CA. Rational strain improvement for enhanced clavulanic acid production by genetic engineering of the glycolytic pathway in Streptomyces clavuligerus. Metab Eng 2006; 8:240-52.
-
(2006)
Metab Eng
, vol.8
, pp. 240-252
-
-
Li, R.1
Townsend, C.A.2
-
119
-
-
0345440126
-
Deletion of the pyc gene blocks clavulanic acid biosynthesis except in glycerol-containing medium: Evidence for two different genes in formation of the C3 unit
-
Perez-Redondo RA, Rodriguez-Garcia A, Martin JF, Liras P. Deletion of the pyc gene blocks clavulanic acid biosynthesis except in glycerol-containing medium: evidence for two different genes in formation of the C3 unit. J Bacteriol 1999; 181:6922-8.
-
(1999)
J Bacteriol
, vol.181
, pp. 6922-6928
-
-
Perez-Redondo, R.A.1
Rodriguez-Garcia, A.2
Martin, J.F.3
Liras, P.4
-
120
-
-
0031891879
-
A pathway-specific transcriptional activator regulates late steps of clavuklanic acid biosynthesis in Streptomyces clavuligerus
-
Paradkar AS, Aiodoo KA, Jensen SE. A pathway-specific transcriptional activator regulates late steps of clavuklanic acid biosynthesis in Streptomyces clavuligerus. Mol Microbiol 1998; 27:831-43.
-
(1998)
Mol Microbiol
, vol.27
, pp. 831-843
-
-
Paradkar, A.S.1
Aiodoo, K.A.2
Jensen, S.E.3
-
121
-
-
0030954966
-
A regulatory gene (ccaR) required for cephamycin and clavulanic acid production in Streptomyces clavuligerus: Amplification results overproduction of both β-lactam compounds
-
Perez-Llarena FJ, Liras P, Rodriguez-Garcia A, Martin JF. A regulatory gene (ccaR) required for cephamycin and clavulanic acid production in Streptomyces clavuligerus: amplification results overproduction of both β-lactam compounds. J Bacteriol 1997; 179:2053-9.
-
(1997)
J Bacteriol
, vol.179
, pp. 2053-2059
-
-
Perez-Llarena, F.J.1
Liras, P.2
Rodriguez-Garcia, A.3
Martin, J.F.4
-
122
-
-
0031038018
-
Applications of transposition mutagenesis in antibiotic producing streptomyces
-
Baltz RH, McHenney MA, Cantwell CA, Queener SW, Solenberg PJ. Applications of transposition mutagenesis in antibiotic producing streptomyces. Ant v Leeuwenhoek 1997; 71:179-87.
-
(1997)
Ant v Leeuwenhoek
, vol.71
, pp. 179-187
-
-
Baltz, R.H.1
McHenney, M.A.2
Cantwell, C.A.3
Queener, S.W.4
Solenberg, P.J.5
-
123
-
-
0030039759
-
Transposition mutagenesis in Streptomyces fradiae: Identification of a neutral site for the stable insertion of DNA by transposon exchange
-
Solenberg PJ, Cantwell CA, Tietz AJ, McGilvray D, Queener SW, Baltz RH. Transposition mutagenesis in Streptomyces fradiae: identification of a neutral site for the stable insertion of DNA by transposon exchange. Gene 1996; 16:67-72.
-
(1996)
Gene
, vol.16
, pp. 67-72
-
-
Solenberg, P.J.1
Cantwell, C.A.2
Tietz, A.J.3
McGilvray, D.4
Queener, S.W.5
Baltz, R.H.6
-
124
-
-
53349166080
-
Antibiotic formation by interspecific protoplast fusion in streptomycetes and emergence of drug resistance by protoplast regeneration
-
(Kyoto)
-
Yamashita F, Hotta K, Kurasawa S, Okami Y, Umezawa H. Antibiotic formation by interspecific protoplast fusion in streptomycetes and emergence of drug resistance by protoplast regeneration. Proc 4th Internat Symp Genet Indust Microorgs (Kyoto) 1982; 20:108.
-
(1982)
Proc. 4th Internat Symp Genet Indust Microorgs
, vol.20
, pp. 108
-
-
Yamashita, F.1
Hotta, K.2
Kurasawa, S.3
Okami, Y.4
Umezawa, H.5
-
125
-
-
0021744397
-
Isolation and structure of a new antibiotic, indolizomycin, produced by a strain SK2-52 obtained by interspecies fusion treatment
-
Gomi S, Ikeda D, Nakamura H, Naganawa H, Yamashita F, Hotta K, et al. Isolation and structure of a new antibiotic, indolizomycin, produced by a strain SK2-52 obtained by interspecies fusion treatment. J Antibiot 1984; 37:1491-4.
-
(1984)
J Antibiot
, vol.37
, pp. 1491-1494
-
-
Gomi, S.1
Ikeda, D.2
Nakamura, H.3
Naganawa, H.4
Yamashita, F.5
Hotta, K.6
-
126
-
-
0019989586
-
16,17-dihydrorifamycin S and 16,17-dihydro-17-hydroxyrifamycin S, two novel rifamycins from a recombinant strain C5/42 of Nocardia mediterranei
-
Traxler P, Schupp T, Wehrli W. 16,17-dihydrorifamycin S and 16,17-dihydro-17-hydroxyrifamycin S, two novel rifamycins from a recombinant strain C5/42 of Nocardia mediterranei. J Antibiot 1982; 35:594-601.
-
(1982)
J Antibiot
, vol.35
, pp. 594-601
-
-
Traxler, P.1
Schupp, T.2
Wehrli, W.3
-
127
-
-
0029913557
-
Variety of hybrid characters among recombinants obtained by interspecific protoplast fusion in streptomycetes
-
Okanishi M, Suzuki N, Furuta T. Variety of hybrid characters among recombinants obtained by interspecific protoplast fusion in streptomycetes. Biosci Biotechnol Biochem 1996; 60:1233-8.
-
(1996)
Biosci Biotechnol Biochem
, vol.60
, pp. 1233-1238
-
-
Okanishi, M.1
Suzuki, N.2
Furuta, T.3
-
128
-
-
34447524208
-
Expressionof biosynthetic gene clusters in heterologous hosts for natural product production and combinatorial biosynthesis
-
Galm U, Shen B. Expressionof biosynthetic gene clusters in heterologous hosts for natural product production and combinatorial biosynthesis. Exp Opin Drug Disc 2006; 1:409-37.
-
(2006)
Exp Opin Drug Disc
, vol.1
, pp. 409-437
-
-
Galm, U.1
Shen, B.2
-
129
-
-
0141513836
-
On the generation of novel anticancer drugs by recombinant DNA technology: The use of combinatorial biosynthesis to produce novel drugs
-
Mendez C, Salas JA. On the generation of novel anticancer drugs by recombinant DNA technology: the use of combinatorial biosynthesis to produce novel drugs. Comb Chem High Throughput Screen 2003; 6:513-26.
-
(2003)
Comb Chem High Throughput Screen
, vol.6
, pp. 513-526
-
-
Mendez, C.1
Salas, J.A.2
-
130
-
-
0034788156
-
Combinatorial biosynthesis of antimicrobials and other natural products
-
Rodriguez E, McDaniel R. Combinatorial biosynthesis of antimicrobials and other natural products. Curr Opin Microbiol 2001; 4:526-34.
-
(2001)
Curr Opin Microbiol
, vol.4
, pp. 526-534
-
-
Rodriguez, E.1
McDaniel, R.2
-
131
-
-
0037140766
-
Rationally designed glycosylated premithramycins: Hybrid aromatic polyketides using genes from three different biosynthetic pathways
-
Trefzer A, Blanco G, Remsing L, Kunzel E, Rix U, Lipata F, et al. Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways. J Amer Chem Soc 2002; 124:6056-62.
-
(2002)
J Amer Chem Soc
, vol.124
, pp. 6056-6062
-
-
Trefzer, A.1
Blanco, G.2
Remsing, L.3
Kunzel, E.4
Rix, U.5
Lipata, F.6
-
132
-
-
0023638046
-
New antibiotics from genetically engineered actinomycetes. 1.2-Norerythromycins, isolation and structural determination
-
McAlpine JB, Yuan JS, Brown DP, Grebner KD, Whittern DN, Buko A, et al. New antibiotics from genetically engineered actinomycetes. 1.2-Norerythromycins, isolation and structural determination. J Antibiot 1987; 40:1115-22.
-
(1987)
J Antibiot
, vol.40
, pp. 1115-1122
-
-
McAlpine, J.B.1
Yuan, J.S.2
Brown, D.P.3
Grebner, K.D.4
Whittern, D.N.5
Buko, A.6
-
133
-
-
0025859219
-
An erythromycin derivative produced by targeted gene disruption in Saccharopolyspora erythrea
-
Weber JM, Leung JO, Swanson SJ, Idler KB, McAlpine JB. An erythromycin derivative produced by targeted gene disruption in Saccharopolyspora erythrea. Science 1991; 252:114-7.
-
(1991)
Science
, vol.252
, pp. 114-117
-
-
Weber, J.M.1
Leung, J.O.2
Swanson, S.J.3
Idler, K.B.4
McAlpine, J.B.5
-
134
-
-
0027234764
-
An erythromycin analog produced by reprogramming of polyketide synthesis
-
USA
-
Donadio S, McAlpine JB, Sheldon PJ, Jackson M, Katz L. An erythromycin analog produced by reprogramming of polyketide synthesis. Proc Natl Acad Sci USA 1993; 90:7119-23.
-
(1993)
Proc Natl Acad Sci
, vol.90
, pp. 7119-7123
-
-
Donadio, S.1
McAlpine, J.B.2
Sheldon, P.J.3
Jackson, M.4
Katz, L.5
-
135
-
-
0026415106
-
Modular organization of genes required for complex polyketide biosynthesis
-
Donadio S, Staver MJ, McAlpine JB, Swanson SJ, Katz L. Modular organization of genes required for complex polyketide biosynthesis. Science 1991; 252:675-9.
-
(1991)
Science
, vol.252
, pp. 675-679
-
-
Donadio, S.1
Staver, M.J.2
McAlpine, J.B.3
Swanson, S.J.4
Katz, L.5
-
136
-
-
0033515090
-
Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products
-
USA
-
McDaniel R, Thamchaipenet A, Gustafsson C, Fu H, Betlach M, Betlach M, et al. Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products. Proc Natl Acad Sci USA 1999; 96:1846-51.
-
(1999)
Proc Natl Acad Sci
, vol.96
, pp. 1846-1851
-
-
McDaniel, R.1
Thamchaipenet, A.2
Gustafsson, C.3
Fu, H.4
Betlach, M.5
Betlach, M.6
-
137
-
-
0013033285
-
Novel erythromycins from a recombinant Saccharopolyspora erythraea strain NRRL 23338 pIGI I. Fermentation, isolation and biological activity
-
Pacey MS, Dirlam JP, Geldart RW, Leadlay PF, McArthur HAI, McCormick EL, et al. Novel erythromycins from a recombinant Saccharopolyspora erythraea strain NRRL 23338 pIGI I. Fermentation, isolation and biological activity. J Antibiot 1998; 51:1029-34.
-
(1998)
J Antibiot
, vol.51
, pp. 1029-1034
-
-
Pacey, M.S.1
Dirlam, J.P.2
Geldart, R.W.3
Leadlay, P.F.4
McArthur, H.A.I.5
McCormick, E.L.6
-
138
-
-
0032738419
-
A multi-plasmid approach to preparing large libraries of polyketides
-
Xue Q, Ashley G, Hutchinson CR, Santi DV. A multi-plasmid approach to preparing large libraries of polyketides. Proc Natl Acad Sci 1999; 96:11740-5.
-
(1999)
Proc Natl Acad Sci
, vol.96
, pp. 11740-11745
-
-
Xue, Q.1
Ashley, G.2
Hutchinson, C.R.3
Santi, D.V.4
-
139
-
-
0033610483
-
Engineering a methymycin/pikromycin-calicheamicin hybrid: Construction of two new macrolides carrying a designed sugar moiety
-
Zhou L, Ahlert J, Xue Y, Thorson JS, Sherman DH, Liu H-W. Engineering a methymycin/pikromycin-calicheamicin hybrid: construction of two new macrolides carrying a designed sugar moiety. J Amer Chem Soc 1999; 121:9881-2.
-
(1999)
J Amer Chem Soc
, vol.121
, pp. 9881-9882
-
-
Zhou, L.1
Ahlert, J.2
Xue, Y.3
Thorson, J.S.4
Sherman, D.H.5
Liu, H-W.6
-
140
-
-
0035501490
-
Altering the glycosylation pattwern of bioactive compounds
-
Mendez C, Salas JA. Altering the glycosylation pattwern of bioactive compounds. Trends Biotechnol 2001; 19:449-56.
-
(2001)
Trends Biotechnol
, vol.19
, pp. 449-456
-
-
Mendez, C.1
Salas, J.A.2
-
141
-
-
0029965386
-
Direct fermentative production of acyltylosins by genetically-engineered strains of Streptomyces fradiae
-
Arisawa A, Kawamura N, Narita T, Kojima I, Okamura K, Tsunekawa H, et al. Direct fermentative production of acyltylosins by genetically-engineered strains of Streptomyces fradiae. J Antibiot 1996; 49:349-54.
-
(1996)
J Antibiot
, vol.49
, pp. 349-354
-
-
Arisawa, A.1
Kawamura, N.2
Narita, T.3
Kojima, I.4
Okamura, K.5
Tsunekawa, H.6
-
142
-
-
0024796844
-
Production of a hybrid macrolide in Streptomyces ambofaciens and Streptomyces lividans by introduction of a cloned carbomycin biosynthetic gene from Streptomyces thermotolerans
-
Epp JK, Huber MLB, Turner JR, Goodson T, Schoner BE. Production of a hybrid macrolide in Streptomyces ambofaciens and Streptomyces lividans by introduction of a cloned carbomycin biosynthetic gene from Streptomyces thermotolerans. Gene 1989; 85:293-301.
-
(1989)
Gene
, vol.85
, pp. 293-301
-
-
Epp, J.K.1
Huber, M.L.B.2
Turner, J.R.3
Goodson, T.4
Schoner, B.E.5
-
143
-
-
0026741927
-
A macrolide 3-O-acyltransferase gene from the midecamycin-producing species Streptomyces mycarofaciens
-
Hara O, Hutchinson CR. A macrolide 3-O-acyltransferase gene from the midecamycin-producing species Streptomyces mycarofaciens. J Bacteriol 1992; 174:5141-4.
-
(1992)
J Bacteriol
, vol.174
, pp. 5141-5144
-
-
Hara, O.1
Hutchinson, C.R.2
-
144
-
-
0026141803
-
Expression of polyketide biosynthesis and regulatory genes in heterologous streptomycetes
-
Strohl WR, Bartel PL, Connors NC, Woodman RH. Expression of polyketide biosynthesis and regulatory genes in heterologous streptomycetes. J Indust Microbiol 1991; 7:163-74.
-
(1991)
J Indust Microbiol
, vol.7
, pp. 163-174
-
-
Strohl, W.R.1
Bartel, P.L.2
Connors, N.C.3
Woodman, R.H.4
-
145
-
-
0024996111
-
Biosynthesis of anthraquinones by interspecies cloning of actinorhodin biosynthesis genes in streptomycetes: Clarification of actinorhodin gene functions
-
Bartel PL, Zhu CB, Lampel JS, Dosch DC, Connors NC, Strohl WR, et al. Biosynthesis of anthraquinones by interspecies cloning of actinorhodin biosynthesis genes in streptomycetes: clarification of actinorhodin gene functions. J Bacteriol 1990; 172:4816-26.
-
(1990)
J Bacteriol
, vol.172
, pp. 4816-4826
-
-
Bartel, P.L.1
Zhu, C.B.2
Lampel, J.S.3
Dosch, D.C.4
Connors, N.C.5
Strohl, W.R.6
-
146
-
-
0029034197
-
Rational design of peptide antibiotics by targeted replacement of bacterial and fungal domains
-
Stachelhaus T, Schneider A, Marahiel M. Rational design of peptide antibiotics by targeted replacement of bacterial and fungal domains. Science 1995; 269:69-72.
-
(1995)
Science
, vol.269
, pp. 69-72
-
-
Stachelhaus, T.1
Schneider, A.2
Marahiel, M.3
-
147
-
-
33744533954
-
Microbial genomics for the improvement of natural product discovery
-
Van Lanen SG, Shen B. Microbial genomics for the improvement of natural product discovery. Curr Opin Microbiol 2006; 9:252-60.
-
(2006)
Curr Opin Microbiol
, vol.9
, pp. 252-260
-
-
Van Lanen, S.G.1
Shen, B.2
-
149
-
-
33644557421
-
When will the genomics investment pay off for antibacterial discovery?
-
Mills SD. When will the genomics investment pay off for antibacterial discovery? Biochem Pharmacol 2006; 71:1096-102.
-
(2006)
Biochem Pharmacol
, vol.71
, pp. 1096-1102
-
-
Mills, S.D.1
-
150
-
-
0037264608
-
Target selection in drug discovery
-
Knowles J, Gromo G. Target selection in drug discovery. Nat Revs/Drug Disc 2003; 2:63-9.
-
(2003)
Nat Revs/Drug Disc
, vol.2
, pp. 63-69
-
-
Knowles, J.1
Gromo, G.2
-
151
-
-
0037318402
-
A genomics-guided approach for discovering and expressing cryptic metabolic pathways
-
Zazopoulos E, Hwang K, Staffa A, Liu W, Bachmann BO, Nonaka K, et al. A genomics-guided approach for discovering and expressing cryptic metabolic pathways. Nat Biotechnol 2003; 21:187-90.
-
(2003)
Nat Biotechnol
, vol.21
, pp. 187-190
-
-
Zazopoulos, E.1
Hwang, K.2
Staffa, A.3
Liu, W.4
Bachmann, B.O.5
Nonaka, K.6
-
152
-
-
0036276191
-
Streptococcus pneumonia as a genomics platform for broad spectrum antibiotic discovery
-
Glass JI, Belanger AE, Robertson GT. Streptococcus pneumonia as a genomics platform for broad spectrum antibiotic discovery. Curr Opin Microbiol 2002; 5:338-42.
-
(2002)
Curr Opin Microbiol
, vol.5
, pp. 338-342
-
-
Glass, J.I.1
Belanger, A.E.2
Robertson, G.T.3
-
154
-
-
0032502899
-
Differential genome analysis applied to the species-specific features of Helicobacter pylori
-
Huynen M, Dandekar T, Bork P. Differential genome analysis applied to the species-specific features of Helicobacter pylori. FEBS Lett 1998; 426:1-5.
-
(1998)
FEBS Lett
, vol.426
, pp. 1-5
-
-
Huynen, M.1
Dandekar, T.2
Bork, P.3
-
155
-
-
64249144646
-
Microbial prescreens for anticancer activity
-
Newman DJ, Shapiro S. Microbial prescreens for anticancer activity. SIM News 2008; 58:132-50.
-
(2008)
SIM News
, vol.58
, pp. 132-150
-
-
Newman, D.J.1
Shapiro, S.2
-
156
-
-
34547654448
-
Mutation and high-throughput screening method for improving the production of epothilones of Sorangium
-
Gong GL, Sun X, Liu XL, Hu W, Cao WR, Liu H, et al. Mutation and high-throughput screening method for improving the production of epothilones of Sorangium. J Ind Microbiol Biotechnol 2007; 34:615-23.
-
(2007)
J Ind Microbiol Biotechnol
, vol.34
, pp. 615-623
-
-
Gong, G.L.1
Sun, X.2
Liu, X.L.3
Hu, W.4
Cao, W.R.5
Liu, H.6
-
157
-
-
0037316031
-
Integrating transcriptional and metabolite profiles to direct the engineering of lovastatin-producing fungal strains
-
Askenazi M, Driggers EM, Holtzman DA, Norman TC, Iverson S, Zimmer DP, et al. Integrating transcriptional and metabolite profiles to direct the engineering of lovastatin-producing fungal strains. Nat Biotechnol 2003; 21:150-6.
-
(2003)
Nat Biotechnol
, vol.21
, pp. 150-156
-
-
Askenazi, M.1
Driggers, E.M.2
Holtzman, D.A.3
Norman, T.C.4
Iverson, S.5
Zimmer, D.P.6
-
158
-
-
0034210940
-
Effect of a global regulatory gene, afsR2, from Streptomyces lividans on avermectin production in Streptomyces avermitilis
-
Lee JY, Hwang YS, Kim SS, Kim ES, Choi CY. Effect of a global regulatory gene, afsR2, from Streptomyces lividans on avermectin production in Streptomyces avermitilis. Biosci Bioeng 2000; 89:606-8.
-
(2000)
Biosci Bioeng
, vol.89
, pp. 606-608
-
-
Lee, J.Y.1
Hwang, Y.S.2
Kim, S.S.3
Kim, E.S.4
Choi, C.Y.5
-
159
-
-
0347297588
-
Cloning and analysis of a DNA fragment stimulating avermectin production in various Streptomyces avermitilis strains
-
Hwang YS, Kim E-S, Biró S, Choi C-Y. Cloning and analysis of a DNA fragment stimulating avermectin production in various Streptomyces avermitilis strains. Appl Environ Microbiol 2003; 69:1263-9.
-
(2003)
Appl Environ Microbiol
, vol.69
, pp. 1263-1269
-
-
Hwang, Y.S.1
Kim, E-S.2
Biró, S.3
Choi, C-Y.4
-
160
-
-
0027410919
-
Transposon mutagenesis by Tn4560 and applications with avermectin-producing Streptomyces avermitilis
-
Ikeda H, Takada Y, Pang C-H, Tanaka H, Omura S. Transposon mutagenesis by Tn4560 and applications with avermectin-producing Streptomyces avermitilis. J Bacteriol 1993; 175:2077-82.
-
(1993)
J Bacteriol
, vol.175
, pp. 2077-2082
-
-
Ikeda, H.1
Takada, Y.2
Pang, C-H.3
Tanaka, H.4
Omura, S.5
-
161
-
-
33749177715
-
Construction of ivermectin producer by domain swaps of avermectin polyketide synthase in Streptomyces avermitilis
-
Zhang X, Chen Z, Li M, Wen Y, Song Y, Li J. Construction of ivermectin producer by domain swaps of avermectin polyketide synthase in Streptomyces avermitilis. Appl Microbiol Biotechnol 2006; 72:986-94.
-
(2006)
Appl Microbiol Biotechnol
, vol.72
, pp. 986-994
-
-
Zhang, X.1
Chen, Z.2
Li, M.3
Wen, Y.4
Song, Y.5
Li, J.6
-
162
-
-
61349178501
-
Production of recombinant proteins by microbes and higher organisms
-
Demain AL, Vaishnav P. Production of recombinant proteins by microbes and higher organisms. Biotechnol Adv 2009; 27:297-306.
-
(2009)
Biotechnol Adv
, vol.27
, pp. 297-306
-
-
Demain, A.L.1
Vaishnav, P.2
-
163
-
-
61349165045
-
Expression systems for process and product improvement
-
Rayder RA. Expression systems for process and product improvement. BioProc Internat 2008; 6:4-9.
-
(2008)
BioProc Internat
, vol.6
, pp. 4-9
-
-
Rayder, R.A.1
-
164
-
-
0038753800
-
Use of combinatorial genetic libraries to humanize N-linked glycosylation in the yeast Pichia pastoris
-
USA
-
Choi BK, Bobrowicz P, Davidson RC, Hamilton SR, Kung DH, Li H, et al. Use of combinatorial genetic libraries to humanize N-linked glycosylation in the yeast Pichia pastoris. Proc Natl Acad Sci USA 2003; 100:5022-7.
-
(2003)
Proc Natl Acad Sci
, vol.100
, pp. 5022-5027
-
-
Choi, B.K.1
Bobrowicz, P.2
Davidson, R.C.3
Hamilton, S.R.4
Kung, D.H.5
Li, H.6
-
165
-
-
62549137028
-
Grappling with biologic manufacturing concerns
-
Morrow KJ Jr. Grappling with biologic manufacturing concerns. Gen Eng Biotechnol News 2009; 29:54-5.
-
(2009)
Gen Eng Biotechnol News
, vol.29
, pp. 54-55
-
-
Morrow Jr., K.J.1
-
166
-
-
8844262654
-
High level recombinant protein expression in Ralstonia eutropha using T7 RNA polymerase based amplification
-
Barnard GC, Henderson GE, Srinivasan S, Gerngross TU. High level recombinant protein expression in Ralstonia eutropha using T7 RNA polymerase based amplification. Protein Expr Purif 2004; 38:264-71.
-
(2004)
Protein Expr Purif
, vol.38
, pp. 264-271
-
-
Barnard, G.C.1
Henderson, G.E.2
Srinivasan, S.3
Gerngross, T.U.4
-
167
-
-
0032790856
-
High-yield secretion of recombinant gelatins by Pichia pastoris
-
Werten MWT, van den Bosch TJ, Wind RD, Mooibroek H, De Wolf FA. High-yield secretion of recombinant gelatins by Pichia pastoris. Yeast 1999; 15:1087-96.
-
(1999)
Yeast
, vol.15
, pp. 1087-1096
-
-
Werten, M.W.T.1
van den Bosch, T.J.2
Wind, R.D.3
Mooibroek, H.4
De Wolf, F.A.5
-
169
-
-
0036535753
-
Recombinant protein expression for therapeutic applications
-
Andersen DC, Krummen L, Recombinant protein expression for therapeutic applications. Curr Opin Biotechnol 2002; 13:117-23.
-
(2002)
Curr Opin Biotechnol
, vol.13
, pp. 117-123
-
-
Andersen, D.C.1
Krummen, L.2
-
170
-
-
61349176665
-
Animal cell culture; novel systems for research and production
-
Wrotnowski C. Animal cell culture; novel systems for research and production. Gen Eng News 1998; 18:13-37.
-
(1998)
Gen Eng News
, vol.18
, pp. 13-37
-
-
Wrotnowski, C.1
-
171
-
-
28644437357
-
Development of animal-free, protein-free and chemically-defined media for NS0 cell culture
-
Zhang J, Robinson D. Development of animal-free, protein-free and chemically-defined media for NS0 cell culture. Cytotechnology 2005; 48:59-74.
-
(2005)
Cytotechnology
, vol.48
, pp. 59-74
-
-
Zhang, J.1
Robinson, D.2
-
172
-
-
77953469156
-
Many considerations in selecting bioproduction culture media
-
Decaria P, Smith A, Whitford W. Many considerations in selecting bioproduction culture media. BioProc Internat 2009; 7:44-51.
-
(2009)
BioProc Internat
, vol.7
, pp. 44-51
-
-
Decaria, P.1
Smith, A.2
Whitford, W.3
-
173
-
-
77957589343
-
Genetic engineering leads to microbial, animal cell and transgenic expression systems
-
Scott C, Montgomery SA, Rosin LJ. Genetic engineering leads to microbial, animal cell and transgenic expression systems. BIO Internat Conv 2007; 27-34.
-
(2007)
BIO Internat Conv
, pp. 27-34
-
-
Scott, C.1
Montgomery, S.A.2
Rosin, L.J.3
-
174
-
-
37349024048
-
Improving protein production processes
-
Morrow KJ Jr. Improving protein production processes. Gen Eng & Biotechnol News 2007; 27:44-7.
-
(2007)
Gen Eng & Biotechnol News
, vol.27
, pp. 44-47
-
-
Morrow Jr., K.J.1
-
175
-
-
85012852409
-
Antibody production using mammalian cell culture-How high can we push productivity?
-
San Diego
-
Ryll T. Antibody production using mammalian cell culture-How high can we push productivity? Proc SIM Ann Mtg Prog Abstr, San Diego 2008; 146:101.
-
(2008)
Proc SIM Ann Mtg Prog Abstr
, vol.146
, pp. 101
-
-
Ryll, T.1
-
176
-
-
70350113998
-
An emerging star for therapeutic and catalytic protein production
-
Meyer HP, Biass J, Jungo C, Klein J, Wenger J, Mommers R. An emerging star for therapeutic and catalytic protein production. BioProc Internat 2008; 6:10-21.
-
(2008)
BioProc Internat
, vol.6
, pp. 10-21
-
-
Meyer, H.P.1
Biass, J.2
Jungo, C.3
Klein, J.4
Wenger, J.5
Mommers, R.6
-
177
-
-
61349131530
-
A review of therapeutic protein expression by mammalian cells
-
Coco Martin JM, Harmsen MM. A review of therapeutic protein expression by mammalian cells. BioProcess Internat 2008; 6:28-33.
-
(2008)
BioProcess Internat
, vol.6
, pp. 28-33
-
-
Coco Martin, J.M.1
Harmsen, M.M.2
-
178
-
-
43249118744
-
A technology bet. DSM's pharma product unit leverages its biotech strength to survive in a tough environment
-
Jarvis LM. A technology bet. DSM's pharma product unit leverages its biotech strength to survive in a tough environment. Chem Eng News 2008; 86:30-1.
-
(2008)
Chem Eng News
, vol.86
, pp. 30-31
-
-
Jarvis, L.M.1
-
179
-
-
0025792409
-
Production scale insect cell culture
-
Agathos SN. Production scale insect cell culture. Biotechnol Adv 1991; 9:51-68.
-
(1991)
Biotechnol Adv
, vol.9
, pp. 51-68
-
-
Agathos, S.N.1
-
180
-
-
61349160645
-
Baculovirus vectors for making proteins in insect cells
-
Knight P. Baculovirus vectors for making proteins in insect cells. ASM News 1991; 57:567-70.
-
(1991)
ASM News
, vol.57
, pp. 567-570
-
-
Knight, P.1
-
181
-
-
0000434975
-
Industrial enzyme technology
-
Cowan D. Industrial enzyme technology. Trends Biotechnol 1996; 14:177-8.
-
(1996)
Trends Biotechnol
, vol.14
, pp. 177-178
-
-
Cowan, D.1
-
182
-
-
0026371479
-
Industrial enzymes-developments in production and application
-
Falch E. Industrial enzymes-developments in production and application. Biotech Adv 1991; 9:643-58.
-
(1991)
Biotech Adv
, vol.9
, pp. 643-658
-
-
Falch, E.1
-
183
-
-
84974560892
-
Industrial biotechnology overview
-
In: Schaechter M, Lederberg J, eds., 3rd edition, Oxford: Elsevier
-
Vaishnav P, Demain AL. Industrial biotechnology overview. In: Schaechter M, Lederberg J, eds. Encyclopedia of Microbiology, 3rd edition, Oxford: Elsevier 2009; 335-48.
-
(2009)
Encyclopedia of Microbiology
, pp. 335-348
-
-
Vaishnav, P.1
Demain, A.L.2
-
184
-
-
0031132511
-
Bacterial biocatalysis: Stealing a page from nature's book
-
Wackett LP. Bacterial biocatalysis: stealing a page from nature's book. Nat Biotechnol 1997; 15:415-6.
-
(1997)
Nat Biotechnol
, vol.15
, pp. 415-416
-
-
Wackett, L.P.1
-
185
-
-
0020438726
-
Molecular cloning of α-amylase gene from Bacillus amyloliquefaciens and its expression in Bacillus subtilis
-
Palva I. Molecular cloning of α-amylase gene from Bacillus amyloliquefaciens and its expression in Bacillus subtilis. Gene 1982; 19:81-7.
-
(1982)
Gene
, vol.19
, pp. 81-87
-
-
Palva, I.1
-
186
-
-
0022444645
-
Overproduction from a cellulase gene with a high guanosine-plus-cytosine content in Escherichia coli
-
O'Neill GP, Kilburn DG, Warren RAJ, Miller RC Jr. Overproduction from a cellulase gene with a high guanosine-plus-cytosine content in Escherichia coli. Appl Environ Microbiol 1986; 52:737-43.
-
(1986)
Appl Environ Microbiol
, vol.52
, pp. 737-743
-
-
O'Neill, G.P.1
Kilburn, D.G.2
Warren, R.A.J.3
Miller Jr., R.C.4
-
187
-
-
0021052116
-
Molecular cloning of exo-cellobiohydrolase I derived from Trichoderma reesei strain L27
-
Shoemaker S, Schweickart V, Ladner M, Gelfand D, Kwok S, Myambo K, et al. Molecular cloning of exo-cellobiohydrolase I derived from Trichoderma reesei strain L27. Bio/Technology 1983; 1:691-6.
-
(1983)
Bio/Technology
, vol.1
, pp. 691-696
-
-
Shoemaker, S.1
Schweickart, V.2
Ladner, M.3
Gelfand, D.4
Kwok, S.5
Myambo, K.6
-
188
-
-
84936285575
-
Fungi: The perfect hosts?
-
Van Brunt J. Fungi: the perfect hosts? Bio/Technology 1986; 4:1057-62.
-
(1986)
Bio/Technology
, vol.4
, pp. 1057-1062
-
-
Van Brunt, J.1
-
189
-
-
0022885127
-
Cloning of the xylanase gene of Streptomyces lividans
-
Mondou F, Shareck F, Morosoli R, Kleupfel D. Cloning of the xylanase gene of Streptomyces lividans. Gene 1986; 49:323-9.
-
(1986)
Gene
, vol.49
, pp. 323-329
-
-
Mondou, F.1
Shareck, F.2
Morosoli, R.3
Kleupfel, D.4
-
190
-
-
0022620114
-
Overproduction of aspartase of Escherichia coli K-12 by molecular cloning
-
Komatsubara S, Taniguchi T, Kisumi M. Overproduction of aspartase of Escherichia coli K-12 by molecular cloning. J Biotechnol 1986; 3:281-91.
-
(1986)
J Biotechnol
, vol.3
, pp. 281-291
-
-
Komatsubara, S.1
Taniguchi, T.2
Kisumi, M.3
-
191
-
-
33644942025
-
Genetic engineering applications in the development of selected industrial enzymes and therapeutic proteins
-
In: Sankaran R, Manja KS, eds., Mysore, India: Defense Food Research Laboratory
-
Elander RP. Genetic engineering applications in the development of selected industrial enzymes and therapeutic proteins. In: Sankaran R, Manja KS, eds. Microbes for Better Living. Mysore, India: Defense Food Research Laboratory 1995; 619-28.
-
(1995)
Microbes for Better Living
, pp. 619-628
-
-
Elander, R.P.1
-
192
-
-
0027232825
-
Cloning, characterization and overexpression of the phytase-encoding gene (phyA) of Aspergillus niger
-
Van Hartinsveldt W, van Zeijl CM, Harteeld GM, Gouka RJ, Suykerbuyk M, Luiten RG, et al. Cloning, characterization and overexpression of the phytase-encoding gene (phyA) of Aspergillus niger. Gene 1993; 127:87-94.
-
(1993)
Gene
, vol.127
, pp. 87-94
-
-
Van Hartinsveldt, W.1
van Zeijl, C.M.2
Harteeld, G.M.3
Gouka, R.J.4
Suykerbuyk, M.5
Luiten, R.G.6
-
193
-
-
0002333495
-
Cloning of the penicillin G-acylase gene of Escherichia coli ATCC 11105 on multicopy plasmids
-
In: Weetall HH, Royer GP, eds., New York: Plenum
-
Mayer H, Collins J, Wagner F. Cloning of the penicillin G-acylase gene of Escherichia coli ATCC 11105 on multicopy plasmids. In: Weetall HH, Royer GP, eds. Enzyme Engineering, vol. 5. New York: Plenum 1980; 61-9.
-
(1980)
Enzyme Engineering
, vol.5
, pp. 61-69
-
-
Mayer, H.1
Collins, J.2
Wagner, F.3
-
194
-
-
0032478082
-
Engineering an enzyme to resist boiling
-
USA
-
Van den Burg B, Vriend G, Veltman O, Venema G, Eijsink VGH. Engineering an enzyme to resist boiling. Proc Natl Acad Sci USA 1998; 95:2056-60.
-
(1998)
Proc Natl Acad Sci
, vol.95
, pp. 2056-2060
-
-
Van den Burg, B.1
Vriend, G.2
Veltman, O.3
Venema, G.4
Eijsink, V.G.H.5
-
195
-
-
0032885231
-
DNA shuffling of subgenomic sequences of subtilisin
-
Ness JE, Welch M, Giver L, Bueno M, Cherry JR, Borchert TV, et al. DNA shuffling of subgenomic sequences of subtilisin. Nat Biotechnol 1999; 17:893-6.
-
(1999)
Nat Biotechnol
, vol.17
, pp. 893-896
-
-
Ness, J.E.1
Welch, M.2
Giver, L.3
Bueno, M.4
Cherry, J.R.5
Borchert, T.V.6
-
196
-
-
0033976143
-
Directed evolution of enantioselective enzymes for organic chemistry
-
Jaeger KE, Reetz MT. Directed evolution of enantioselective enzymes for organic chemistry. Curr Opin Chem Biol 2000; 4:68-73.
-
(2000)
Curr Opin Chem Biol
, vol.4
, pp. 68-73
-
-
Jaeger, K.E.1
Reetz, M.T.2
-
197
-
-
0034878844
-
Directed evolution of biphenyl dioxygenase: Emergence of enhanced degradation capacity for benzene, toluene and alkylbenzenes
-
Suenaga H, Mitsokua M, Ura Y, Watanabe T, Furukawa K. Directed evolution of biphenyl dioxygenase: emergence of enhanced degradation capacity for benzene, toluene and alkylbenzenes. J Bacteriol 2001; 183:5441-4.
-
(2001)
J Bacteriol
, vol.183
, pp. 5441-5444
-
-
Suenaga, H.1
Mitsokua, M.2
Ura, Y.3
Watanabe, T.4
Furukawa, K.5
-
198
-
-
0035844691
-
Enhancement of stability and activity of phospholipase A(1) in organic solvents by directed evolution
-
Song JK, Rhee JS. Enhancement of stability and activity of phospholipase A(1) in organic solvents by directed evolution. Biochim Biophys Acta 2001; 1547:370-8.
-
(2001)
Biochim Biophys Acta
, vol.1547
, pp. 370-378
-
-
Song, J.K.1
Rhee, J.S.2
-
199
-
-
0034833072
-
Novel enzyme activities and functional plasticity revealed by recombining highly homologous enzymes
-
Raillard S, Krebber A, Chen Y, Ness JE, Bermudez E, Trinidad R, et al. Novel enzyme activities and functional plasticity revealed by recombining highly homologous enzymes. Chem Biol 2001; 8:891-8.
-
(2001)
Chem Biol
, vol.8
, pp. 891-898
-
-
Raillard, S.1
Krebber, A.2
Chen, Y.3
Ness, J.E.4
Bermudez, E.5
Trinidad, R.6
-
200
-
-
0035424404
-
Advances in directed protein evolution by recursive genetic recombination: Applications to therapeutic proteins
-
Kurtzman AL, Govindarajan S, Vahle K, Jones JT, Heinrichs V, Patten PA. Advances in directed protein evolution by recursive genetic recombination: applications to therapeutic proteins. Curr Opin Biotechnol 2001; 12:361-70.
-
(2001)
Curr Opin Biotechnol
, vol.12
, pp. 361-370
-
-
Kurtzman, A.L.1
Govindarajan, S.2
Vahle, K.3
Jones, J.T.4
Heinrichs, V.5
Patten, P.A.6
-
201
-
-
0036845827
-
DNA shuffling: Induced molecular breeding to produce new generation long-lasting vaccines
-
Marshall SH. DNA shuffling: induced molecular breeding to produce new generation long-lasting vaccines. Biotechnol Adv 2002; 20:229-38.
-
(2002)
Biotechnol Adv
, vol.20
, pp. 229-238
-
-
Marshall, S.H.1
-
203
-
-
0033928844
-
Directed evolution: The 'rational' basis for 'irrational' design
-
Tobin MB, Gustafsson C, Huisman GW. Directed evolution: the 'rational' basis for 'irrational' design. Curr Opin Struct Biol 2000; 10:421-7.
-
(2000)
Curr Opin Struct Biol
, vol.10
, pp. 421-427
-
-
Tobin, M.B.1
Gustafsson, C.2
Huisman, G.W.3
-
204
-
-
0029670330
-
Improved green fluorescent protein by molecular evolution using DNA shuffling
-
Crameri A, Whitehorn A, Stemmer WPC. Improved green fluorescent protein by molecular evolution using DNA shuffling. Nat Biotechnol 1996; 14:315-9.
-
(1996)
Nat Biotechnol
, vol.14
, pp. 315-319
-
-
Crameri, A.1
Whitehorn, A.2
Stemmer, W.P.C.3
-
205
-
-
67349098201
-
Generation of high-yield rapamycin-producing strains through protoplast-related techniques
-
Chen X, Wei P, Fan L, Yang D, Zhu X, Shen W, et al. Generation of high-yield rapamycin-producing strains through protoplast-related techniques. Appl Microbiol Biotechnol 2009; 83:507-12.
-
(2009)
Appl Microbiol Biotechnol
, vol.83
, pp. 507-512
-
-
Chen, X.1
Wei, P.2
Fan, L.3
Yang, D.4
Zhu, X.5
Shen, W.6
-
206
-
-
33749049315
-
Artemisinin: The biosynthetic pathway and its regulation in Artemisia annua, a terpenoid-rich species
-
Weathers PJ, Elkholy S, Wobbe KK. Artemisinin: the biosynthetic pathway and its regulation in Artemisia annua, a terpenoid-rich species. In Vitro Cell & Devel Biol Plant 2006; 42:309-17.
-
(2006)
In Vitro Cell & Devel Biol Plant
, vol.42
, pp. 309-317
-
-
Weathers, P.J.1
Elkholy, S.2
Wobbe, K.K.3
-
207
-
-
0038391517
-
Engineering a metabolic pathway in Escherichia coli for production of terpenoids
-
Martin VJJ, Pitera DJ, Withers ST, Newman JD, Keasling JD. Engineering a metabolic pathway in Escherichia coli for production of terpenoids. Nat Biotechnol 2003; 21:796-802.
-
(2003)
Nat Biotechnol
, vol.21
, pp. 796-802
-
-
Martin, V.J.J.1
Pitera, D.J.2
Withers, S.T.3
Newman, J.D.4
Keasling, J.D.5
-
208
-
-
33645870422
-
Production of the antimalarial drug precursor artemisinic acid in engineered yeast
-
Ro D-K, Paradise EM, Ouellet M, Fisher KJ, Newman KL, Ndubgu JM, et al. Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature 2006; 440:940-3.
-
(2006)
Nature
, vol.440
, pp. 940-943
-
-
Ro, D-K.1
Paradise, E.M.2
Ouellet, M.3
Fisher, K.J.4
Newman, K.L.5
Ndubgu, J.M.6
-
209
-
-
56249130054
-
Developing an industrial artemisinic acid fermentation process to support the cost-effective production of antimalarial artemisinin-based combination therapies
-
Lenihan JR, Tsuruta H, Diola D, Renninger NS, Regentin R. Developing an industrial artemisinic acid fermentation process to support the cost-effective production of antimalarial artemisinin-based combination therapies. Biotechnol Prog 2008; 24:1026-32.
-
(2008)
Biotechnol Prog
, vol.24
, pp. 1026-1032
-
-
Lenihan, J.R.1
Tsuruta, H.2
Diola, D.3
Renninger, N.S.4
Regentin, R.5
-
210
-
-
70349937056
-
Enhanced production of spinosad in Saccharopolyspora spinosa by genome shuffling
-
(ahead of print)
-
Jin ZH, Xu B, Lin SZ, Jin QC, Cen PL. Enhanced production of spinosad in Saccharopolyspora spinosa by genome shuffling. Appl Biochem Biotechnol 2009; (ahead of print).
-
(2009)
Appl Biochem Biotechnol
-
-
Jin, Z.H.1
Xu, B.2
Lin, S.Z.3
Jin, Q.C.4
Cen, P.L.5
-
211
-
-
0001120822
-
Industrial products of biotechnology: Application of gene technology
-
In: Jacobson GK, Jolly SO, eds., Weinheim: VCH
-
Bigelas R. Industrial products of biotechnology: application of gene technology. In: Jacobson GK, Jolly SO, eds. Biotechnology, vol. 7b. Weinheim: VCH 1989; 230-59.
-
(1989)
Biotechnology
, vol.7 b
, pp. 230-259
-
-
Bigelas, R.1
-
212
-
-
0026526851
-
Increase of xanthan production by cloning xps genes into wild-type Xanthomonas campestris
-
Tseng YH, Ting WY, Chou HC, Yang BY, Chun CC. Increase of xanthan production by cloning xps genes into wild-type Xanthomonas campestris. Lett Appl Microbiol 1992; 14:43-6.
-
(1992)
Lett Appl Microbiol
, vol.14
, pp. 43-46
-
-
Tseng, Y.H.1
Ting, W.Y.2
Chou, H.C.3
Yang, B.Y.4
Chun, C.C.5
-
213
-
-
0035007045
-
Kinetic analysis of growth and xanthan gum production with Xanthomonas campestris on sucrose, using sequentially consumed nitrogen sources
-
Letisse F, Chevallereau P, Simon JL, Lindley ND. Kinetic analysis of growth and xanthan gum production with Xanthomonas campestris on sucrose, using sequentially consumed nitrogen sources. Appl Microbiol Biotechnol 2001; 55:417-22.
-
(2001)
Appl Microbiol Biotechnol
, vol.55
, pp. 417-422
-
-
Letisse, F.1
Chevallereau, P.2
Simon, J.L.3
Lindley, N.D.4
-
214
-
-
0031688984
-
Xanthan gum biosynthesis and application: A biochemical/genetic perspective
-
Becker A, Katzen F, Puehler A, Ielpi L. Xanthan gum biosynthesis and application: a biochemical/genetic perspective. Appl Microbiol Biotechnol 1998; 50:145-52.
-
(1998)
Appl Microbiol Biotechnol
, vol.50
, pp. 145-152
-
-
Becker, A.1
Katzen, F.2
Puehler, A.3
Ielpi, L.4
|