Chronic and delayed mustard gas keratopathy: A histopathologic and immunohistochemical study

European Journal of Ophthalmology

Volumn 20, Issue 5, 2010, Pages 839-843

  Kanavi, Mozhgan Rezaei ^a   Javadi, Atefeh ^a   Javadi, Mohammad Ali ^a  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Histopathology; Immunohistochemistry; Keratopathy; Mustard gas

Indexed keywords

CD31 ANTIGEN; CD68 ANTIGEN; BIOLOGICAL MARKER; CD38 ANTIGEN; CD38 PROTEIN, HUMAN; CHEMICAL WARFARE AGENT; MEMBRANE PROTEIN; MUSTARD GAS;

ADULT; ARTICLE; BASEMENT MEMBRANE; BOWMAN MEMBRANE; CASE STUDY; CHRONIC DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CORNEA DYSTROPHY; CORNEA EPITHELIUM; CORNEA THICKNESS; CORNEAL ENDOTHELIAL CELL LOSS; DELAYED MUSTARD GAS KERATOPATHY; DISEASE SEVERITY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; KERATOPATHY; MALE; OBSERVATIONAL STUDY; PRIORITY JOURNAL; CHEMICAL BURN; CHEMICALLY INDUCED DISORDER; CORNEA DISEASE; ENZYME IMMUNOASSAY; EYE BURN; METABOLISM; MIDDLE AGED; PATHOLOGY; PENETRATING KERATOPLASTY; WAR;

ADULT; ANTIGENS, CD31; ANTIGENS, CD38; BIOLOGICAL MARKERS; BURNS, CHEMICAL; CHEMICAL WARFARE AGENTS; CHRONIC DISEASE; CORNEAL DISEASES; EYE BURNS; HUMANS; IMMUNOENZYME TECHNIQUES; KERATOPLASTY, PENETRATING; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; MUSTARD GAS; WAR;

EID: 77957560017     PISSN: 11206721     EISSN: None     Source Type: Journal    
DOI: 10.1177/112067211002000505     Document Type: Article

References (17)

1. Safarinejad MR, Moosavi SA, Montazeri B. Ocular injuries caused by mustard gas: diagnosis, treatment and medical defense. Mil Med 2001; 166: 67-70.
2. Duke-Elder S, MacFaul PA. Injuries. Part 2. Non-mechanical injuries. In: Duke-Elder S, ed. System of Ophthalmology. Vol. 14. London: Henry Kimpton; 1972: 1133-58.
3. Solberg Y, Alcalay M, Belkin M. Ocular injury by mustard gas. Surv Ophthalmol 1997; 41: 461-6.
4. Javadi MA, Yazdani S, Sajjadi H, et al. Chronic and delayed-onset mustard gas keratitis. Report of 48 patients and review of literature. Ophthalmology 2005; 112: 617-25.
5. Pfister R. Ocular effects of mustard agents and lewisite. In: Pechura CM, Rall DP, eds. Veterans at Risk: The Health Effect of Mustard Gas and Lewisite. Washington, DC: Academic Press, 1993; 131-47.
6. Javadi MA, Yazdani S, Rezaei Kanavi M, et al. Long term outcomes of penetrating keratoplasty in chronic and delayed mustard gas keratitis. Cornea 2007; 26: 1074-8.
7. Javadi MA, Baradaran-Rafii A. Living-related conjunctival-limbal allograft for chronic or delayed-onset mustard gas keratopathy. Cornea 2009; 28: 51-7.
8. Richter MN, Watchlin J, Bechrakis NE, Hoffmann F. Keratoplasty after mustard gas injury, clinical outcome and histology. Cornea 2006; 25: 467-9.
9. Petrali JP, Oglesby-Megee SB. Toxicity of mustard gas skin lesions. Microsc Res Tech 1997; 37: 221.
10. Wilson SE, Mohan RR, Mohan RR, Ambrósio R Jr, Hong J, Lee J. The corneal wound healing response: cytokine-mediated interaction of the epithelium, stroma, and inflammatory cells. Prog Retin Eye Res 2001; 20: 625-37.
11. Livingston PC, Walker HM. A study of the effects of liquid mustard gas upon the eyes of rabbits and of certain methods of treatment. Br J Ophthalmol 1940; 24: 67-97.
12. Borak J, Sidell FR. Agents of chemical warfare: sulfur mustard. Ann Emerg Med 1992; 21: 303-8.
13. Helena MC, Baerveldt F, Kim WJ, Wilson SE. Keratocyte apoptosis after corneal surgery. Invest Ophthalmol Vis Sci 1998; 39: 276-83.
14. Friedlaender MH. Principles of general immunity and mechanisms of immune reactivity. In: Foundations of Duane's Clinical Ophthalmology. Philadelphia: Lippincott Williams & Wilkins, 1998; 1-23.
15. Sangwan VS. Limbal stem cells in health and disease. Biosci Rep 2001; 21: 385-405.
16. Baradaran-Rafii AR, Javadi MA, Rezaei Kanavi M, Eslani M, Jamali H, Karimian F. Limbal stem cell deficiency in chronic and delayed-onset mustard gas keratopathy. Ophthalmology 2010; 117: 246-52.
17. IARC. Overall evaluation of carcinogenicity. In: IARC Monographs on the evaluation of carcinogenic risk of chemicals to humans. Lyon, France: International Agency of Research on Cancer, 1987; 7(Suppl). PMID: 3482203.