Rapid urine drug screens: Diphenhydramine and methadone cross-reactivity

Pediatric Emergency Care

Volumn 26, Issue 9, 2010, Pages 665-666

  Rogers, Steven C ^a   Pruitt, Charles W ^b   Crouch, Dennis J ^c   Caravati, E Martin ^b  

^a UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c Aegis Sciences Corporation   (United States)

Author keywords

cross reactants; diphenhydramine; methadone; pediatric toxicology; urine drug screen

Indexed keywords

DINORDIPHENHYDRAMINE; DIPHENHYDRAMINE; DRUG METABOLITE; METHADONE; NORDIPHENHYDRAMINE; TRICYCLIC ANTIDEPRESSANT AGENT; UNCLASSIFIED DRUG;

ARTICLE; CASE REPORT; CHILD; CONFUSION; CONSCIOUSNESS LEVEL; DRUG CROSS REACTIVITY; DRUG SCREENING; DRUG URINE LEVEL; EQUIPMENT; FALSE POSITIVE RESULT; FLUORESCENCE POLARIZATION IMMUNOASSAY; HOSPITAL ADMISSION; HUMAN; IN VITRO STUDY; LABORATORY TEST; MALE; MUCOSAL DRYNESS; MULTI LINE SCREEN TEST DEVICE; MYDRIASIS; NOSE CONGESTION; SCHOOL CHILD; SLEEP DISORDER; URINALYSIS; URINE DRUG SCREENING; VISUAL HALLUCINATION;

ANALGESICS, OPIOID; CHILD; DIPHENHYDRAMINE; HUMANS; HYPNOTICS AND SEDATIVES; IMMUNOASSAY; MALE; METHADONE; REPRODUCIBILITY OF RESULTS; SUBSTANCE ABUSE DETECTION; SUBSTANCE-RELATED DISORDERS; URINALYSIS;

EID: 77957370476     PISSN: 07495161     EISSN: None     Source Type: Journal    
DOI: 10.1097/PEC.0b013e3181f05443     Document Type: Article

References (4)

1. Sorisky A, Watson DC. Positive diphenhydramine interference in the EMIT-st Assay for tricyclic antidepressants in serum [letter to the editor]. Clin Chem. 1986;32(4):715.
2. Schneider S, Wennig R. Interference of diphenhydramine with EMIT II immunoassay for propoxyphene. J Anal Toxicol. 1999;23:637-638.
3. Baselt RC. Disposition of Toxic Drugs and Chemicals in Man. 8th ed. Foster City, CA: Biomedical Publications; 2008:489-492, 941-945.
4. One Step Multi-Drug, Multi-Line Screen Test Device [package insert]. San Diego, CA: ACON Laboratories; 2005.