Synthesis and evaluation of 2-hydroxymethylene cross-linked dextrins as tablet superdisintegrants

International Journal of ChemTech Research

Volumn 2, Issue 3, 2010, Pages 1786-1798

  Satyanarayana, K ^a   Arpana, G ^b   Raveendranadh, P ^b   Rambhau, D ^a   Reddy, B Madhava ^b  

^a NATCO   (India)

^b G Pulla Reddy College of Pharmacy   (India)

Author keywords

2 Hydroxymethylene cross linked dextrin; Degree of cross linking; Disintegration time; Flow properties; Superdisintegrant; Swelling capacity

Indexed keywords

2 HYDROXYMETHYLENE CROSSLINKED DEXTRIN; CROSCARMELLOSE SODIUM; CROSPOVIDONE; DEXTRIN; DISINTEGRATING AGENT; EPICHLOROHYDRIN; FOLIC ACID; PARACETAMOL; STARCH; STARCH GLYCOLATE SODIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG GRANULATION; DRUG SYNTHESIS; MOUSE; NONHUMAN; TABLET COMPRESSION; TABLET DISINTEGRATION; TABLET FORMULATION; TABLET HARDNESS;

EID: 77957369622     PISSN: None     EISSN: 09744290     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. J. Lopez-Solis and L. Villafuerte-Robles, Effect of disintegrants with different hygroscopicity on dissolution of Norfloxacin / Pharmatose DCL 11 tablets, International Journal of Pharmaceutics, 2001, 216, 127-135.
2. Bredenberg. S, New Concepts in Administration of Drugs in Tablet Form: Formulation and Evaluation of a Sublingual Tablet for Rapid Absorption, and Presentation of an Individualised Dose Administration System, Doctoral Thesis, Uppsala University, 2003.
3. Rong-Kun Chang, Mirwais Shinwari, Michael Leonzio, Lei-Shu Wu, Josephine Pang, and Munir A. Hussain, Evaluation of the disintegrant properties for an experimental, crosslinked polyalkylammonium polymer, International Journal of Pharmaceutics 1998, 173, 87-92
4. Sandipan Kundu and P. K. Sahoo, Recent Trends In The Developments of Orally Disintegrating Tablet Technology, Pharma Times, 2008, 40, 11-15.
5. Mrudula H Bele and Dilip V Derle, Analysis of Patents Pertaining to Superdisintegrants used in Tablet manufacturing, Journal of Intellectual Property Rights, 2008, 13, 601-604.
6. Majumdar Shivprasad and Nikam Dhiraj, Formulation and evaluation of fast dispersible tablets of aceclofenac, Journal of Pharmacy Research 2009, 2, 1296-1298
7. DMV Fonterra Excipients, Superdisintegrants: an introduction to chemistry and performance, [online] Available from: http://www.dmv-fonterraexcipients.com/products/~/media/DFEA18D0FB9945A984F16949D2B56B95.ashx
8. Eugene S. Barabas and Christianah M. Adeyeye, Crospovidone, Analytical Profiles of Drug Substances and Excipients, Academic press, 1996, 24, 87-163
9. Ray C Rowe, Paul J Sheskey, and Paul J Weller, Sodiumstarchglycolate, Handbook of Pharmaceutical Excipients. 4th edition, APhA publications, Pharmaceutical press, 2003, 581-584.
10. Na Zhao, Larry L and Augsburger, Functionality Comparison of 3 Classes of Superdisintegrants in Promoting Aspirin Tablet Disintegration and Dissolution, AAPS PharmSciTech. 2005, 6, E634-E640.
11. Chemicalland21, Dextrin, [online], Available from: http://chemicalland21.com/lifescience/foco/DEXTRIN.htm
12. G.M. Flodin Perstorp, Johan A.O. Johansson, Uppsala and Stig A.I. Carisson, Cation-Exchangers from cross-linked Polyhydroxy Materials, 1966, US Patent 3, 275, 576.
13. Johan A. Olof. Johansson, Disinfectants containing Iodine complexed to a hydrophilic organic carrier, 1975, US Patent 4, 010, 259.
14. Kota Satyanarayana, Adibhatla Kali Satya Bhujanga Rao, and Venkaiah Chowdary Nannapaneni, Improved process for the preparation of Cadexomer Iodine, 2008, WO 2008/117300 A2.
15. Chebli. C and Cartilier. L, Cross-linked cellulose as a tablet excipient: A binding /disintegrating agent, International Journal of Pharmaceutics, 1998, 171, 101-110.