UvrB gene deletion enhances SOS chromotest sensitivity for nitroreductases that preferentially generate the 4-hydroxylamine metabolite of the anti-cancer prodrug CB1954

Journal of Biotechnology

Volumn 150, Issue 1, 2010, Pages 190-194

  Prosser, G A ^a   Patterson, A V ^b,c   Ackerley, D F ^a,c  

^a VICTORIA UNIVERSITY OF WELLINGTON   (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Cancer gene therapy; CB1954; Nitroaromatic prodrug; Nitroreductase; SOS chromotest; UvrB

Indexed keywords

CANCER GENE THERAPY; CB1954; NITROREDUCTASES; PRODRUGS; SOS CHROMOTEST; UVRB;

ACTIVATION ANALYSIS; AROMATIC COMPOUNDS; BACTERIOLOGY; ESCHERICHIA COLI; GENETIC ENGINEERING; METABOLISM; METABOLITES; NUCLEOTIDES; REPAIR; SYSTEMS ENGINEERING;

GENE THERAPY;

5 (1 AZIRIDINYL) 2,4 DINITROBENZAMIDE; ANTINEOPLASTIC AGENT; BACTERIAL ENZYME; DRUG METABOLITE; HYDROXYLAMINE; METHYLTRANSFERASE; NITROREDUCTASE; NUCLEOTIDE; PRODRUG; PROTEIN NFSA; PROTEIN YFKO; UNCLASSIFIED DRUG;

ARTICLE; BACILLUS SUBTILIS; CYTOTOXICITY; DNA DAMAGE; ESCHERICHIA COLI; EXCISION REPAIR; GENE; GENE DELETION; GENE THERAPY; KLEBSIELLA PNEUMONIAE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SOS CHROMOTEST; UVRB GENE; WILD TYPE;

ANTINEOPLASTIC AGENTS; AZIRIDINES; BACILLUS SUBTILIS; BACTERIAL PROTEINS; DNA HELICASES; ESCHERICHIA COLI PROTEINS; GENE DELETION; KINETICS; KLEBSIELLA PNEUMONIAE; METRONIDAZOLE; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; NITROFURAZONE; NITROREDUCTASES; SOS RESPONSE (GENETICS);

BACILLUS SUBTILIS; ESCHERICHIA COLI; KLEBSIELLA PNEUMONIAE;

EID: 77957352023     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2010.08.007     Document Type: Article

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