Pulmonary tumor thrombotic microangiopathy in patients with gastric carcinoma: An analysis of 6 autopsy cases and review of the literature

Pathology Research and Practice

Volumn 206, Issue 10, 2010, Pages 682-689

  Chinen, Katsuya ^a,b   Tokuda, Yasuharu ^c   Fujiwara, Masachika ^a   Fujioka, Yasunori ^a  

^a KYORIN UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b OFUNA CHUO HOSPITAL   (Japan)

^c UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Autopsy; Gastric carcinoma; Pulmonary tumor thrombotic microangiopathy

Indexed keywords

ANTICOAGULANT AGENT; ANTINEOPLASTIC AGENT; ENDOTHELIAL CELL GROWTH FACTOR; THROMBOPLASTIN;

ADENOCARCINOMA; ADULT; AGED; ARTICLE; AUTOPSY; CANCER PALLIATIVE THERAPY; CARCINOMATOSIS; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INCIDENCE; INCIDENTAL FINDING; LUNG EMBOLISM; LUNG EMPHYSEMA; MALE; MALNUTRITION; MORTALITY; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; PULMONARY TUMOR THROMBOTIC MICROANGIOPATHY; SIGNET RING CARCINOMA; STOMACH CARCINOMA; TUMOR CELL;

ADENOCARCINOMA; AGED; AGED, 80 AND OVER; AUTOPSY; CARCINOMA, SIGNET RING CELL; CELL DIFFERENTIATION; FEMALE; HUMANS; HYPERTENSION, PULMONARY; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASTIC CELLS, CIRCULATING; STOMACH NEOPLASMS; THROMBOPLASTIN; THROMBOTIC MICROANGIOPATHIES; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 77957341762     PISSN: 03440338     EISSN: 16180631     Source Type: Journal    
DOI: 10.1016/j.prp.2010.05.002     Document Type: Article

References (48)

1. Babu R.V., Romero A., Sharma G. A 39-year-old man with epigastric pain, intermittent chest pain, and progressive dyspnea. Chest 2007, 132:2012-2015.
2. Bennett J.S., Chan C., Vilaire G., Mousa S.A., DeGrado W.F. Agonist-activated alphavbeta3 on platelets and lymphocytes binds to matrix protein osteopontin. J. Biol. Chem. 1997, 272:8137-8140.
3. Bläker H., Daum R., Tröger J., Mechtersheimer G., Otto H.F. Adenocarcinoma of the stomach with tumor-thrombotic microangiopathy in an 11-year-old male patient. Eur. J. Pediatr. Surg. 2000, 10:45-49.
4. Canova C.R., Kuhn M., Allemann J., Reinhart W.H. Lethal pulmonary hypertension in a young woman caused by unrecognized haemangiosis carcinomatosa. J. Intern. Med. 1998, 243:255-257.
5. Cheuk W., Chan J.K.C. Unusual pulmonary vascular pathology in a young dyspnoeic woman. Pathology 2001, 33:504-507.
6. Cheung T.-C., Ng F.-H., Chow K.-C., Maw C.K.-C., Ng W.-F. Occult gastric cancer presenting as cor pulmonale resulting from tumor cell microembolism. Am. J. Gastroenterol. 1997, 92:1057-1059.
7. Chinen K., Fujino T., Horita A., Sakamoto A., Fujioka Y. Pulmonary tumor thrombotic microangiopathy caused by an ovarian cancer expressing tissue factor and vascular endothelial growth factor. Pathol. Res. Pract. 2009, 205:63-68.
8. Chinen K., Kazumoto T., Ohkura Y., Matsubara O., Tsuchiya E. Pulmonary tumor thrombotic microangiopathy caused by a gastric carcinoma expressing vascular endothelial growth factor and tissue factor. Pathol. Int. 2005, 55:27-31.
9. Farber H.W., Loscalzo J. Pulmonary arterial hypertension. N. Engl. J. Med. 2004, 351:1655-1665.
10. Franquet T., Gimenez A., Prats R., Rodriquez-Arias J.M., Rodriguez C. Thrombotic microangiopathy of pulmonary tumors: a vascular cause of tree-in bud pattern on CT. AJR Am. J. Roentgenol. 2002, 179:897-899.
11. Geiger R., Berger R.M.F., Hess J., Bogers A.J.J.C., Sharma H.S., Mooi W.J. Enhanced expression of vascular endothelial growth factor in pulmonary plexogenic arteriopathy due to congenital heart disease. J. Pathol. 2000, 191:202-207.
12. Hara A., Ichinoe M., Ogawa T., Shiraishi H., Okayasu I. A microscopic adenocarcinoma of the stomach with pulmonary tumor thrombotic microangiopathy in a 17-year-old male. Pathol. Res. Pract. 2005, 201:457-461.
13. Hirata K., Miyagi S., Tome M., Asato H., Uechi N., Kunishima N. Cor pulmonale due to tumor cell microemboli: report of a case with occult gastric carcinoma. Arch. Intern. Med. 1988, 148:2287-2289.
14. Hoshikawa Y., Matsuda Y., Suzuki S., Okada Y., Tabata T., Matsumura Y., Kondo T. Osteopontin may be responsible for pulmonary vascular remodeling. Chest 2005, 128:621S.
15. Hsu L.-H., Izumi T., Sugiyama Y., Kitamura S., Takaku F., Yamaguchi K. An autopsied case of pulmonary tumor embolization presenting a clinical picture of subacute cor pulmonale. Nihon Kyobu Shikkan Gakkai Zasshi 1983, 21:886-889. (in Japanese with English abstract).
16. Igarashi S., Kawaguchi T., Hoshi N. Early gastric carcinoma with widespread metastasis and pulmonary tumor thrombotic microangiopathy (PTTM): report of an autopsy case. I to Cho (Stomach and Intestine) 1997, 32:861-865. (in Japanese with English abstract).
17. Isoda K., Nishikawa K., Kamezawa Y., Yoshida M., Kusuhara M., Moroi M., Tada N., Ohsuzu F. Osteopontin plays an important role in the development of medial thickening and neointimal formation. Circ. Res. 2002, 91:77-82.
18. Japanese classification of gastric carcinoma (2nd English edition). Gastric Cancer 1998, 1:10-24. Japanese Gastric Cancer Association.
19. Kane R.D., Hawkins H.K., Miller J.A., Noce P.S. Microscopic pulmonary tumor emboli associated with dyspnea. Cancer 1975, 36:1473-1482.
20. Kanzaki Y., Joh K., Yokoyama K., Kashima K., Daa T., Miyamoto S., Hamamoto H., Tsuji K., Yamasaki T., Yokoyama S. Two autopsy cases of pulmonary tumor thrombotic microangiopathy. Jpn. J. Diagn. Pathol. 2005, 22:21-24. (in Japanese).
21. Keenan N.G., Nicholson A.G., Oldershaw P.J. Fatal acute pulmonary hypertension caused by pulmonary tumour thrombotic microangiopathy. Int. J. Cardiol. 2008, 124:e11-e13.
22. Kinuya K., Yamanouchi K., Terahara S. Diagnosis: pulmonary tumor thrombotic microangiopathy developing cor pulmonale. Ann. Nucl. Med. 2002, 16. Frontpage, 220.
23. Kuraki T., Kobayashi H., Nagata N., Kawai T. Pulmonary tumor embolism caused by asymptomatic gastric cancer. Nihon Kyobu Shikkan Gakkai Zasshi 1997, 35:641-644. (in Japanese with English abstract).
24. Lesprit P., Godeau B., Authier F.-J., Soubrier M., Zuber M., Larroche C., Viard J.P., Wechsler B., Gheradi R. Pulmonary hypertension in POEMS syndrome: a new feature mediated by cytokines. Am. J. Respir. Crit. Care Med. 1998, 157:907-911.
25. Miyano S., Izumi S., Takeda Y., Tokuhara M., Mochizuki M., Matsubara O., Kuwata H., Kobayashi N., Kudo K. Pulmonary tumor thrombotic microangiopathy. J. Clin. Oncol. 2007, 25:597-599.
26. Noguchi S., Imanaga T., Shimizu M., Nakano T., Miyazaki N. A case of pulmonary tumor thrombotic microangiopathy diagnosed by transbronchial lung biopsy. Nihon Kokyuki Gakkai Zasshi 2008, 46:493-496. (in Japanese with English abstract).
27. Onoda N., Okamoto H. An autopsy case of gastric carcinoma associated with pulmonary hypertension due to pulmonary tumor thrombotic microangiopathy. Jpn. J. Diagn. Pathol. 2000, 17:153-155. (in Japanese).
28. Parkin D.M., Bray F., Ferlay J., Pisani P. Global cancer statistics, 2002. CA Cancer J. Clin. 2005, 55:74-108.
29. Pinckard J.K., Wick M.R. Tumor-related thrombotic pulmonary microangiopathy: review of pathologic findings and pathophysiologic mechanisms. Ann. Diagn. Pathol. 2000, 4:154-157.
30. Roder D.M. The epidemiology of gastric cancer. Gastric Cancer 2002, 5(Suppl. 1):5-11.
31. Saito I., Taki K., Yasui H., Fujioka Y. An autopsy case of pulmonary tumor thrombotic microangiopathy (PTTM) in the background of idiopathic portal hypertension. Jpn. J. Diagn. Pathol. 2004, 21:58-61. (in Japanese).
32. Saito K., Ishida A., Oosugi N. Pulmonary tumor thrombotic microangiopathy (PTTM) in a case with gastric adenocarcinoma. Nihon Kyobu Rinsho 2000, 59:632-635. (in Japanese with English abstract).
33. Sakashita N., Yokose C., Fujii K., Matsumoto M., Ohnishi K., Takeya M. Pulmonary tumor thrombotic microangiopathy resulting from metastatic signet ring cell carcinoma of the stomach. Pathol. Int. 2007, 57:383-387.
34. Sato Y., Marutsuka K., Asada Y., Yamada M., Setoguchi T., Sumiyoshi A. Pulmonary tumor thrombotic microangiopathy. Pathol. Int. 1995, 45:436-440.
35. Sekizawa K., Ohrui T., Nakayama K., Yanai M., Sasaki H. Cor pulmonale and tumour cell microemboli. Lancet 1998, 352:822.
36. Seppala N., Cala A., Klebe S. Unusual presentation of pulmonary tumor thrombotic microangiopathy with no detectable primary tumor. J. Postgrad. Med. 2009, 55:38-40.
37. Shoji M., Hancock W.W., Abe K., Micko C., Casper K.A., Baine R.M., Wilcox J.N., Danave I., Dillehay D.L., Matthews E., Contrino J., Morrissey J.H., Gordon S., Edgington T.S., Kudryk B., Kreutzer D.L., Rickles F.R. Activation of coagulation and angiogenesis in cancer: immunohistochemical localization in situ of clotting proteins and vascular endothelial growth factor in human cancer. Am. J. Pathol. 1998, 152:399-411.
38. Suzuki M., Kida K., Ito E., Nomura K. Pulmonary tumor thrombotic microangiopathy caused by signet ring cell carcinoma in gastric cancer. Nihon Kokyuki Gakkai Zasshi 2007, 45:560-565. (in Japanese with English abstract).
39. Suzuki M., Ochi S., Suzuki Y. A case of pulmonary tumor thrombotic microangiopathy revealed by autopsy. Naika 2003, 92:593-595. (in Japanese).
40. Takahashi F., Kumasaka T., Nagaoka T., Wakiya M., Fujii H., Shimizu K., Uchida K., Morio Y., Seyama K., Hino O., Takahashi K., Fukuchi Y. Osteopontin expression in pulmonary tumor thrombotic microangiopathy caused by gastric carcinoma. Pathol. Int. 2009, 59:752-756.
41. Tamura A., Matsubara O. Pulmonary tumor embolism: relationship between clinical manifestations and pathologic findings. Nihon Kyobu Shikkan Gakkai Zasshi 1993, 31:1269-1278. (in Japanese with English abstract).
42. Tamura H., Mikuniya A., Mikami M., Higashiyama A., Sasaki N., Fujino Y., Narita T., Onodera K., Oike Y. A case of young man with subacute pulmonary hypertension due to tumor cell embolization from gastric cancer. Junkankika 1991, 30:81-86. (in Japanese with English abstract).
43. Tashima Y., Abe K., Matsuo Y., Baba S., Kaneko K., Isoda T., Yabuuchi H., Sasaki M., Honda H. Pulmonary tumor thrombotic microangiopathy: FDG-PET/CT findings. Clin. Nucl. Med. 2009, 34:175-177.
44. Thompson W.P., White P.D. The commonest cause of hypertrophy of the right ventricle: left ventricular strain and failure. Am. Heart J. 1936, 12:641-649.
45. Tuder R.M., Chacon M., Alger L., Wang J., Taraseviciene-Stewart L., Kasahara Y., Cool C.D., Bishop A.E., Geraci M., Semenza G.L., Yacoub M., Polak J.M., Voelkel N.F. Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis. J. Pathol. 2001, 195:367-374.
46. von Herbay A., Illes A., Waldherr R., Otto H.F. Pulmonary tumor thrombotic microangiopathy with pulmonary hypertension. Cancer 1990, 66:587-592.
47. Wang X., Louden C., Ohlstein E.H., Stadel J.M., Gu J.L., Yue T.L. Osteopontin expression in platelet-derived growth factor-stimulated vascular smooth muscle cells and carotid artery after balloon angioplasty. Arterioscler. Thromb. Vasc. Biol. 1996, 16:1365-1372.
48. Zhang Y., Deng Y., Luther T., Müller M., Ziegler R., Waldherr R., Stern D.M., Nawroth P.P. Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice. J. Clin. Invest. 1994, 94:1320-1327.