Are second-trimester minor sonographic markers for Down syndrome useful in patients who have undergone first-trimester combined screening?

American Journal of Obstetrics and Gynecology

Volumn 203, Issue 4, 2010, Pages 408.e1-408.e4

  Sood, Monica ^a   Rochelson, Burton ^a   Krantz, David ^b   Ravens, Rachel ^b   Tam Tam, Hima ^a   Vohra, Nidhi ^a   Lewis, Dawnette ^a   Ray, Bidisha ^a  

^a Northwell Health   (United States)

^b PERKINELMER INC   (United States)

Author keywords

Down syndrome screening; first trimester; genetic sonogram; minor markers; trisomy 21

Indexed keywords

ADULT; ARTICLE; DIAGNOSTIC ACCURACY; DOWN SYNDROME; FEMALE; FETUS; FETUS ECHOGRAPHY; FIRST TRIMESTER PREGNANCY; HUMAN; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; PRENATAL DIAGNOSIS; PRIORITY JOURNAL; RISK FACTOR; SCREENING; SECOND TRIMESTER PREGNANCY; COHORT ANALYSIS; ECHOCARDIOGRAPHY; ECHOGRAPHY; FEMUR; HUMERUS; INTESTINE; KIDNEY PELVIS; MASS SCREENING; NUCHAL TRANSLUCENCY MEASUREMENT; PREDICTIVE VALUE; PREGNANCY; RETROSPECTIVE STUDY; STATISTICAL MODEL;

ADULT; COHORT STUDIES; DOWN SYNDROME; ECHOCARDIOGRAPHY; FEMALE; FEMUR; HUMANS; HUMERUS; INTESTINES; KIDNEY PELVIS; LIKELIHOOD FUNCTIONS; MASS SCREENING; NUCHAL TRANSLUCENCY MEASUREMENT; PREDICTIVE VALUE OF TESTS; PREGNANCY; PREGNANCY TRIMESTER, FIRST; PREGNANCY TRIMESTER, SECOND; RETROSPECTIVE STUDIES;

EID: 77957341468     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajog.2010.05.030     Document Type: Article

References (20)

1. A.M. Vintzileos, and J.F. Egan Adjusting the risk for trisomy 21 on the basis of second-trimester ultrasonography Am J Obstet Gynecol 172 1995 837 844
2. American College of Obstetricians and Gynecologists ACOG practice bulletin no. 77: screening for fetal chromosomal abnormalities Obstet Gynecol 109 2007 217 227
3. Y.M. Fang, P. Benn, and J.F. Egan Use of the genetic sonogram in the United States in 2001 and 2007 J Ultrasound Med 27 2008 1543 1548
4. Y.M.V. Fang, P. Benn, and W. Campbell Down syndrome screening in the United States in 2001 and 2007: a survey of maternal-fetal medicine specialists Am J Obstet Gynecol 201 2009 97.e1 97.e5
5. B.R. Benacerraf, R. Gelman, and F.D. Frigoletto Jr Sonographic identification of second-trimester fetuses with Down's syndrome N Engl J Med 317 1987 1371
6. R. Perella, A.J. Duerinckx, and E.G. Grant Second-trimester sonographic diagnosis of Down syndrome: role of femur-length shortening and nuchal-fold thickening AJR Am J Roentgenol 151 1988 981
7. B.R. Benacerraf, J. Mandell, J.A. Estroff, B.L. Harlow, and F. Frigoletto Fetal pyelectasis: a possible association with Down syndrome Obstet Gynecol 76 1990 58 60
8. B. Bromley, E. Leiberman, L. Laboba, and B.R. Benacerraf Echogenic intracardiac focus: a sonographic sign for fetal Down syndrome Obstet Gynecol 86 1995 998 1001
9. B. Bromley, E. Lieberman, T. Shipp, M. Richardson, and B.R. Benacerraf Significance of an echogenic intracardiac focus in fetuses at high and low risk for aneuploidy J Ultrasound Med 17 1998 127 131
10. D.A. Nyberg, R.G. Resta, and D.A. Luthy Echogenic bowel and Down's syndrome Ultrasound Obstet Gynecol 3 1993 330 333
11. R.N. Slotnick, and A.Z. Abuhamad Prognostic implications of fetal echogenic bowel Lancet 347 1996 85 87
12. D.A. Nyberg, R.G. Resta, D.A. Luthy, D.E. Hickok, and M.A. Williams Humerus and femur length shortening in the detection of Down's syndrome Am J Obstet Gynecol 168 1993 534 539
13. B.R. Benacerraf, D. Neuberg, and F.D. Frigoletto Jr Humeral shortening in second trimester fetuses with Down syndrome Obstet Gynecol 77 1991 223 227
14. D.A. Nyberg, V.L. Souter, A. El-Bastawissi, S. Young, F. Luthhardt, and D.A. Luthy Isolated sonographic markers for detection of fetal Down syndrome in the second trimester of pregnancy J Ultrasound Med 20 2001 1053 1063
15. D.A. Krantz, T.W. Hallahan, V.J. Macri, and J.N. Macri Genetic sonography after first trimester Down syndrome screening Ultrasound Obstet Gynecol 29 2007 666 670
16. P. Rozenberg, L. Bussires, and S. Chevret Screening for Down syndrome using first-trimester combined screening followed by second-trimester ultrasound examination in an unselected population Am J Obstet Gynecol 195 2006 1379 1387
17. D.A. Nyberg, D.A. Luthy, R.G. Resta, B.C. Nyberg, and M.A. Williams Age-adjusted ultrasound risk assessment for fetal Down's syndrome during the second trimester: description of the method and analysis of 142 cases Ultrasound Obstet Gynecol 12 1998 8 14
18. C.H. Comstock, F.D. Malone, and R.H. Ball Is there a nuchal translucency millimeter measurement above which there is no added benefit from first trimester serum screening? Am J Obstet Gynecol 195 2006 843 847
19. K.M. Aagaard-Tillery, F.D. Malone, D.A. Nyberg First and Second Trimester Evaluation of Risk Research Consortium Role of second-trimester genetic sonography after Down syndrome screening Obstet Gynecol 114 2009 1189 1196
20. J.R. Wax, M.G. Pinette, A. Cartin, and J. Blackstone Second-trimester genetic sonography after first-trimester combined screening for trisomy 21 J Ultrasound Med 28 2009 321 325