Proposal of new uncertainty factor application to derive tolerable daily intake

Regulatory Toxicology and Pharmacology

Volumn 58, Issue 2, 2010, Pages 237-242

  Hasegawa, Ryuichi ^a   Hirata Koizumi, Mutsuko ^a   Dourson, Michael L ^b   Parker, Ann ^b   Sweeney, Lisa M ^b   Nishikawa, Akiyoshi ^a   Yoshida, Midori ^a   Ono, Atsushi ^a   Hirose, Akihiko ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b Toxicology Excellence for Risk Assessment   (United States)

Author keywords

Chemical risk assessment; Probabilistic approach; Subdivision of UF; Uncertainty factor

Indexed keywords

ANTINEOPLASTIC AGENT;

ARTICLE; DOG; DRUG SURVEILLANCE PROGRAM; DRUG TOLERABILITY; HAMSTER; HUMAN; MONKEY; MONTE CARLO METHOD; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROBABILITY; RABBIT; RAT; RISK ASSESSMENT; RISK MANAGEMENT; SPECIES DIFFERENCE; TOXICOKINETICS; TOXICOLOGY;

ANIMALS; ANTINEOPLASTIC AGENTS; CRICETINAE; DOGS; HAPLORHINI; HUMANS; MICE; MODELS, STATISTICAL; NO-OBSERVED-ADVERSE-EFFECT LEVEL; RABBITS; RATS; RISK ASSESSMENT; SPECIES SPECIFICITY; UNCERTAINTY;

ANIMALIA; CANIS FAMILIARIS; CRICETINAE; MUS; ORYCTOLAGUS CUNICULUS; RATTUS;

EID: 77957338946     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2010.06.006     Document Type: Article

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