Ocular surface reconstruction with cultivated limbal epithelium in a patient with unilateral stem cell deficiency caused by epidermolysis bullosa dystrophica hallopeau-siemens

Cornea

Volumn 29, Issue 4, 2010, Pages 462-464

  Thanos, Melissa ^a   Pauklin, Mikk ^a,b   Steuhl, Klaus P ^a   Meller, Daniel ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b UNIVERSITY OF TARTU   (Estonia)

Author keywords

corneal epithelium; epidermolysis bullosa dystrophica; ex vivo expansion; limbal stem cells; ocular surface reconstruction

Indexed keywords

BEVACIZUMAB; BOTULINUM TOXIN A; CORNEREGEL EDO; DEXAMETHASONE; DEXPANTHENOL; EYE DROPS; FLUORESCEIN; HYALURONIC ACID; NYLON; OFLOXACIN; STEROID; UNCLASSIFIED DRUG;

AMNION; ANTERIOR EYE CHAMBER; ARTICLE; AUTOTRANSPLANTATION; BLISTER; CASE REPORT; CELL EXPANSION; CHILD; CLINICAL EFFECTIVENESS; CONJUNCTIVA; CONTRACTURE; CORNEA DISEASE; CORNEA EPITHELIUM; CORNEA LIMBUS; CORNEA NEOVASCULARIZATION; CORNEA STROMA; CORNEA SURGERY; CORNEAL BIOPSY; DISEASE COURSE; ELBOW; EPIDERMOLYSIS BULLOSA DYSTROPHICA; EPITHELIUM CELL; EVENING DOSAGE; EX VIVO STUDY; EYE; EYE EXAMINATION; EYELID; FOLLOW UP; FOREARM; GOBLET CELL; HAND MOVEMENT; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; IMPRESSION CYTOLOGY; INTRAOCULAR PRESSURE; LIMBAL STEM CELL DEFICIENCY; MALE; OFF LABEL DRUG USE; PANNUS; PATIENT SAFETY; PHOTOGRAPHY; PHYSICAL EXAMINATION; POSTERIOR EYE CHAMBER; POSTOPERATIVE CARE; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PTOSIS; RECURRENT DISEASE; RELAPSE; SCAR FORMATION; SCHOOL CHILD; SCLERA; SLIT LAMP; SUTURE; SYMBLEPHARON; SYNDACTYLY; TIBIA; VISUAL ACUITY;

CELL CULTURE TECHNIQUES; CHILD; CORNEAL DISEASES; EPIDERMOLYSIS BULLOSA DYSTROPHICA; EPITHELIAL CELLS; EPITHELIUM, CORNEAL; HUMANS; LIMBUS CORNEAE; MALE; RECOVERY OF FUNCTION; STEM CELL TRANSPLANTATION; STEM CELLS; TRANSPLANTATION, AUTOLOGOUS;

EID: 77957333806     PISSN: 02773740     EISSN: None     Source Type: Journal    
DOI: 10.1097/ICO.0b013e3181b442ea     Document Type: Article

References (17)

1. Hovnanian A, Duquesnoy P, Blanchet-Bardon C, et al. Genetic linkage of recessive dystrophic epidermolysis bullosa to the type VII collagen gene. J Clin Invest. 1992;90:1032-1036
2. Uitto J, Christiano AM. Molecular basis for the dystrophic forms of epidermolysis bullosa: mutations in the type VII collagen gene. Arch Dermatol Res. 1994;287:16-22
3. McDonnell PJ, Spalton DJ. The ocular signs and complications of epidermolysis bullosa. J R Soc Med. 1988;81:576-578
4. Steuhl KP, Anton-Lamprecht I, Arnold ML, et al. Recurrent bilateral corneal erosions due to an association of epidermolysis bullosa simplex Köbner and X-linked ichthyosis with steroid sulfatase deficiency. Graefes Arch Clin Exp Ophthalmol. 1988;226:216-223
5. Tong L, Hodgkins PR, Denyer J, et al. The eye in epidermolysis bullosa. Br J Ophthalmol. 1999;83:323-326
6. Lin AN, Murphy F, Brodie SE, et al. Review of ophthalmic findings in 204 patients with epidermolysis bullosa. Am J Ophthalmol. 1994;118: 384-390
7. Matsumoto Y, Dogru M, Tsubota K. Ocular surface findings in Hallopeau-Siemens subtype of dystrophic epidermolysis bullosa: report of a case and literature review. Cornea. 2005;24:474-479
8. Meller D, Pires RT, Tseng SC. Ex vivo preservation and expansion of human limbal epithelial stem cells on amniotic membrane cultures. Br J Ophthalmol. 2002;86:463-471
9. Pauklin M, Steuhl KP, Meller D. Characterization of the corneal surface in limbal stem cell deficiency and after transplantation of cultivated limbal epithelium. Ophthalmology. 2009;116:1048-1056
10. Altan-Yaycioglu R, Akova YA, Oto S. Amniotic membrane transplantation for treatment of symblepharon in a patient with recessive dystrophic epidermolysis bullosa. Cornea. 2006;25:971-973
11. Goyal R, Jones SM, Espinosa M, et al. Amniotic membrane transplantation in children with symblepharon and massive pannus. Arch Ophthalmol. 2006;124:1435-1440
12. Kim SW, Ha BJ, Kim EK, et al. The effect of topical bevacizumab on corneal neovascularization. Ophthalmology. 2008;115:e33-38
13. Pauklin M, Kakkassery V, Steuhl KP, et al. Expression of membraneassociated mucins in limbal stem cell deficiency and after transplantation of cultivated limbal epithelium. Curr Eye Res. 2009;34:221-230
14. Hernandez Galindo EE, Theiss C, Pauklin M, et al. Correlation of cell cycle kinetics with p63 expression in human limbal epithelial cells expanded on intact human amniotic membrane. Ophthalmic Res. 2009;41:83-90
15. Endo K, Nakamura T, Kawasaki S, et al. Human amniotic membrane, like corneal epithelial basement membrane, manifests the alpha5 chain of type IV collagen. Invest Ophthalmol Vis Sci. 2004;45:1771-1774
16. Fukuda K, Chikama T, Nakamura M, et al. Differential distribution of subchains of the basement membrane components type IV collagen and laminin among the amniotic membrane, cornea, and conjunctiva. Cornea. 1999;18:73-79
17. Seitz B, Resch MD, Schlotzer-Schrehardt U, et al. Histopathology and ultrastructure of human corneas after amniotic membrane transplantation. Arch Ophthalmol. 2006;124:1487-1490.