Using thermally stimulated current (TSC) to investigate disorder in micronized drug substance produced at different milling energies

Pharmaceutical Research

Volumn 27, Issue 10, 2010, Pages 2234-2241

  Forcino, Rachel ^a   Brum, Jeffrey ^a   Galop, Marc ^a   Sun, Yan ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

annealing of surface disorder; crystal defects; micronization energy; non crystalline content; thermally stimulated current (TSC)

Indexed keywords

HYDROCHLORIC ACID;

ARTICLE; CONTROLLED STUDY; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG MANUFACTURE; DRUG STORAGE; ELECTRIC CURRENT; ENERGY; INTERMETHOD COMPARISON; MEASUREMENT; MICRONIZATION; MOLECULAR MECHANICS; PARTICLE SIZE; PHASE SEPARATION; PRIORITY JOURNAL; THERMALLY STIMULATED CURRENT; THERMODYNAMICS;

CALORIMETRY, DIFFERENTIAL SCANNING; CRYSTALLIZATION; HOT TEMPERATURE; HYDROCHLORIC ACID; PHARMACEUTICAL PREPARATIONS; TECHNOLOGY, PHARMACEUTICAL; VOLATILIZATION; X-RAY DIFFRACTION;

EID: 77957330184     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0230-7     Document Type: Article

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