Electron-microscopic examination of effects of yokukansan, a traditional Japanese medicine, on degeneration of cerebral cells in thiamine-deficient rats

Neuropathology

Volumn 30, Issue 5, 2010, Pages 524-536

  Iizuka, Seiichi ^a   Kawakami, Zenji ^a   Imamura, Sachiko ^a   Yamaguchi, Takuji ^a   Sekiguchi, Kyoji ^a   Kanno, Hitomi ^a   Ueki, Toshiyuki ^a   Kase, Yoshio ^a   Ikarashi, Yasushi ^a  

^a TSUMURA AND CO   (Japan)

Author keywords

aggressiveness; neurological symptoms; neurons; thiamine deficiency; yokukansan

Indexed keywords

NEUROPROTECTIVE AGENT; UNCLASSIFIED DRUG; YOKUKANSAN; HERBACEOUS AGENT; YI-GAN SAN;

AGGRESSION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BODY WEIGHT; BRAIN BLOOD VESSEL; CONTROLLED STUDY; DIETARY INTAKE; DRUG EFFECT; ELECTRON MICROSCOPY; MALE; MICROSCOPY; MYELIN SHEATH; NERVE DEGENERATION; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; RAT; SYMPTOM; THIAMINE DEFICIENCY; TRADITIONAL MEDICINE; ANIMAL; BRAIN STEM; CHINESE MEDICINE; DRUG EFFECTS; NERVE CELL; PATHOLOGY; ULTRASTRUCTURE; WISTAR RAT;

AGGRESSION; ANIMALS; ASTROCYTES; BODY WEIGHT; BRAIN STEM; DRUGS, CHINESE HERBAL; MALE; MEDICINE, KAMPO; MICROSCOPY, ELECTRON; NEURONS; RATS; RATS, WISTAR; THIAMINE DEFICIENCY;

EID: 77957322358     PISSN: 09196544     EISSN: 14401789     Source Type: Journal    
DOI: 10.1111/j.1440-1789.2010.01101.x     Document Type: Article

References (54)

1. Iwasaki K, Satoh-Nakagawa T, Maruyama M et al. A randomized, observer-blind, controlled trial of the traditional Chinese medicine yi-gan san for improvement of behavioral and psychological symptoms and activities of daily living in dementia patients. J Clin Psychiatry 2005 66 : 248 252.
2. Iwasaki K, Maruyama M, Tomita N et al. Effects of the traditional Chinese herbal medicine yi-gan san for cholinesterase inhibitor-resistant visual hallucinations and neuropsychiatric symptoms in patients with dementia with Lewy bodies. Clin Psychiatry 2005 66 : 1612 1613.
3. Ikarashi Y, Iizuka S, Imamura S et al. Effects of yokukansan, a traditional Japanese medicine, on memory disturbance and behavioral and psychological symptoms of dementia in thiamine-deficient rats. Biol Pharm Bull 2009 32 : 1701 1709.
4. Nakagawasai O, Yamadera F, Sato S et al. Alterations in cognitive function in prepubertal mice with protein malnutrition: relationship to changes in choline acetyltransferase. Behav Brain Res 2006 15 : 111 117.
5. Onodera K, Ogura Y, Kisara K. Characteristics of muricide induced by thiamine deficiency and its suppression by antidepressants or intraventricular serotonPhysiol Behav 1981 27 : 847 853.
6. Onodera K. Aggressive behavior in thiamine-deficient rats and the histaminergic system. Ann Psychiatry 1992 3 : 31 40.
7. Cheeta S, Irvine E, File SE. Social isolation modifies nicotine's effects in tests of anxiety. Br J Pharmacol 2001 132 : 1389 1395.
8. Lumley LA, Robinson CL, Slusher BS et al. Reduced isolation-induced aggressiveness in mice following NAALADase inhibition. Psychopharmacol 2004 171 : 375 381.
9. Butterworth RF, Giguere JF, Bernard AM. Activities of thiamine-dependent enzymes in two experimental models of thiamine-deficiency encephalopathy. Neurochem Res 1986 11 : 567 577.
10. Collins GH. Glial cell changes in the brain stem of thiamine-deficient rats. Am J Pathol 1967 50 : 791 814.
11. Mulholland PJ. Susceptibility of the cerebellum to thiamine deficiency. The Cerebellum 2006 5 : 55 63.
12. Sheu KF, Calingasan NY, Lindsay JG et al. Immunochemical characterization of the deficiency of the alpha-ketoglutarate dehydrogenase complex in thiamine-deficient rat braJ Neurochem 1998 70 : 1143 1150.
13. Carvalho FM, Pereira SR, Pires RG et al. Thiamine deficiency decreases glutamate uptake in the prefrontal cortex and impairs spatial memory performance in a water maze test. Pharmacol Biochem Behav 2006 83 : 481 489.
14. Nakagawasai O, Yamadera F, Iwasaki K et al. Effect of kami-untan-to on the impairment of learning and memory induced by thiamine-deficient feeding in mice. Neurosci 2004 125 : 233 241.
15. Hazell AS, Todd KG, Butterworth RF. Mechanism of neuronal cell death in Wernicke's encephalopathy. Metab Brain Dis 1998 13 : 97 122.
16. Nakagawasai O, Tadano T, Hozumi S et al. Characteristics of depressive behavior induced by feeding thiamine-deficient diet in mice. Life Sci 2001 69 : 1181 1191.
17. Onodera K. Effect of decarboxylase inhibitor on muricide suppression by l-dopa in thiamine deficient rats. Arch Int Pharmacodyn Ther 1987 285 : 263 276.
18. Wasman M, Flynn JP. Directed attack elicited from hypothalamus. Arch Neurol 1962 6 : 220 227.
19. Maeda H. Emotional behavior: aggressive behavior. In : Kubota K, Ono T, eds. Physiology of Behavior in Handbook of Physiological Science, Chapter 7, Vol. 11. Tokyo : Igaku-Shoin, Ltd, 2001 209 221.
20. Murata A, Nakagawasai O, Yamadera F et al. Dysfunction of serotonergic system in thiamine-deficient diet fed mice: effects of SSRI on abnormality induced by thiamine deficiency. Jpn J Neuropsychopharmacol 2004 24 : 93 99.
21. Matsushita H, Takeuchi Y, Kosaka S et al. Changes in serotonergic neurons in the brain of pyrithiamine-induced acute thiamine-deficient mice. Acta Neuropathol (Berl) 1999 98 : 614 621.
22. Barclay LL, Gibson GE, Blass JP. Cholinergic therapy of abnormal open-field behavior in thiamine-deficient rats. J Nutr 1982 112 : 1906 1913.
23. Goto I, Nagara H, Tateishi J et al. Thiamine-deficient encephalopathy in rats: effects of deficiencies of thiamine and magnesium. Brain Res 1986 372 : 31 36.
24. Jodar L, Takahashi M, Kaneto H. FS stress induces long-lasting memory facilitation: involvement of cholinergic pathways. Pharmacol Biochem Behaiv 1996 53 : 735 740.
25. Langlais PJ, Savage LM. Thiamine deficiency in rat produces cognitive and memory deficits on spatial tasks that correlate with tissue loss in diencephalon, cortex and white matter. Behav Brain Res 1995 68 : 75 89.
26. Robertson DM, Wasan SM, Skinner DB. Ultrastructural features of early brain stem lesions of thiamine-deficient rats. Am J Pathol 1968 52 : 1081 1097.
27. O'Shea RD. Roles and regulation of glutamate transporters in the central nervous system. Clin Exp Pharmacol Physiol 2002 29 : 1018 1023.
28. Rothstein JD, Martin L, Levey AL et al. Localization of neuronal and glial glutamate transporters. Neuron 1994 13 : 713 725.
29. Schousboe A, Sonnewald U, Civenni G et al. Role of astrocytes in glutamate homeostasis: implications for excitotoxicity. Adv Exp Med Biol 1997 429 : 195 206.
30. Langlais PJ, Zhang SX. Extracellular glutamate is increased in thalamus during thiamine deficiency-induced lesions and is blocked by MK-801. J Neurochem 1993 61 : 2175 2182.
31. Todd KG, Butterworth RF. In vivo microdialysis in an animal model of neurological disease: thiamine deficiency (Wernicke) encephalopathy. Methods 2001 23 : 55 61.
32. Hazell AS, Rao KVR, Danbort NC et al. Selective down-regulation of the astrocyte glutamate transporters GLT-1 and GLAST within the medial thalamus in experimental Wernicke's encephalopathy. J Neurochem 2001 78 : 560 568.
33. Langlais PJ, Mair RG. Protective effects of glutamate antagonist MK801 on pyrithiamine-induced lesions and amino acid changes in rat braJ Neurosci 1990 10 : 1664 1674.
34. Todd KG, Butterworth RF. Evaluation of the role of NMDA-mediated exitotoxicity in the selective neuronal loss in experimental Wernicke encephalopathy. Exp Neurol 1998 149 : 130 138.
35. Meldrum B, Garthwaite J. Excitatory amino acid neurotoxicity and neurodegenerative disease. Trends Pharmacol Sci 1990 11 : 379 387.
36. Kawakami Z, Kanno H, Terawaki K et al. Neuroprotective effects of yokukansan, a traditional Japanese medicine, on glutamate-mediated excitotoxicity in cultured cells. Neurosci 2009 159 : 1397 1407.
37. Parker WD, Haas R, Stumpf DA et al. Brain mitochondrial metabolism in experimental thiamine deficiency. Neurol 1984 34 : 1477 1481.
38. Wang X, Wang B, Fan Z et al. Thiamine deficiency induces endoplasmic reticulum stress in neurons. Neurosci 2007 144 : 1045 1056.
39. Tateno M, Ukai W, Ono T et al. Neuroprotective effects of yi-gan san against beta amyloid-induced cytotoxicity on rat cortical neurons. Prog Neuropsychopharmacol Biol Psychiatry 2008 32 : 1704 1707.
40. Calingasan NY, Baker H, Sheu KFR et al. Blood-brain barrier abnormalities in vulnerable brain regions during thiamine deficiency. Exp Neurol 1995 134 : 64 72.
41. Harata N, Iwasaki Y. Evidence for early blood-brain barrier breakdown in experimental thiamine deficiency in the mouse. Metab Brain Dis 1995 10 : 159 174.
42. Martin PR, Singleton CK, Hiller-Sturmhöfel S. The role of thiamine deficiency in alcoholic brain disease. Alcohol Res Health 2003 27 : 134 142.
43. Watanabe I, Iwasaki Y, Aikawa H et al. Hemorrhage of thiamine-deficient encephalopathy. J Neuropathol Exp Neurol 1981 40 : 566 580.
44. Moncada S, Palmer RM, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991 43 : 109 142.
45. Murphy S, Minor RL, Welk G et al. Evidence for an astrocyte-derived vasorelaxing factor with properties similar to nitric oxide. J Neurochem 1990 55 : 349 351.
46. Chan PH, Schmidley JW, Fishman RA et al. Brain injury, edema, and vascular permeability changes induced by oxygen-derived free radical. Neurology 1984 34 : 315 320.
47. Claus D, Eggers R, Warecka K et al. Thiamine deficiency and nervous system function disturbances. Eur Arch Psychiatr Nerrol Sci 1985 234 : 390 394.
48. Eftekharpour E, Karimi-Abdolrezaee S, Sinha K et al. Structural and functional alterations of spinal cord axons in adult Long Evans Shaker (LES) dysmyelinated rats. Exp Neurol 2005 193 : 334 349.
49. Franssen H. Electrophysiology in demyelinating polyneuropathies. Expert Rev Neurother 2008 8 : 417 431.
50. Tankisi H, Pugdahl K, Johnsen B et al. Correlations of nerve conduction measures in axonal and demyelinating polyneuropathies. 2008 119 : 1694 1695.
51. Lee J, Son D, Lee P et al. Protective effect of methanol extract of Uncaria rhynchophylla against excitotoxicity induced by N-methyl-D-aspartate in rat hippocampus. J Pharmacol Sci 2003 92 : 70 73.
52. Sun X, Chan LN, Gong X et al. N-methyl-D-aspartate receptor antagonist activity in traditional Chinese stroke medicines. Neurosignals 2003 12 : 31 38.
53. Shimada Y, Goto H, Itoh T et al. Evaluation of the protective effects of alkaloids from the hooks and stems of Uncaria sinensis on glutamate-induced neuronal death in cultured cerebellar granule cells from rats. J Pharm Pharmacol 1999 51 : 715 722.
54. Mahakunakorn P, Tohda M, Murakami Y et al. Antioxidant and free radical-scavenging activity of choto-san and its related constituents. Biol Pharm Bull 2004 27 : 38 46.