Expression of the ACTH receptor, steroidogenic acute regulatory protein, and steroidogenic enzymes in canine cortisol-secreting adrenocortical tumors

Domestic Animal Endocrinology

Volumn 39, Issue 4, 2010, Pages 259-267

  Galac, S ^a   Kool, M M J ^a   Naan, E C ^a   Daminet, S ^b   Mol, J A ^a   Kooistra, H S ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

Adrenal cortex; Cushing's syndrome; Dog; Hypercortisolism; Tumorigenesis

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CORTICOTROPIN RECEPTOR; HYDROCORTISONE; MESSENGER RNA; PHOSPHOPROTEIN; STEROID; STEROID 11BETA MONOOXYGENASE; STEROID 17ALPHA MONOOXYGENASE; STEROID 21 MONOOXYGENASE; STEROIDOGENIC ACUTE REGULATORY PROTEIN;

ADRENAL CORTEX TUMOR; ANIMAL; ANIMAL DISEASE; ARTICLE; BIOSYNTHESIS; DOG; DOG DISEASE; FEMALE; GENE EXPRESSION; GENETICS; MALE; METABOLISM; POLYMERASE CHAIN REACTION; SECRETION;

3-HYDROXYSTEROID DEHYDROGENASES; ADRENAL CORTEX NEOPLASMS; ANIMALS; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; DOG DISEASES; DOGS; FEMALE; GENE EXPRESSION; HYDROCORTISONE; MALE; PHOSPHOPROTEINS; POLYMERASE CHAIN REACTION; RECEPTORS, CORTICOTROPIN; RNA, MESSENGER; STEROID 11-BETA-HYDROXYLASE; STEROID 17-ALPHA-HYDROXYLASE; STEROID 21-HYDROXYLASE; STEROIDS;

CANIS FAMILIARIS;

EID: 77957319878     PISSN: 07397240     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.domaniend.2010.07.001     Document Type: Article

References (48)

1. Galac S., Reusch C.E., Kooistra H.S., Rijnberk A. Adrenals. Clinical Endocrinology of Dogs and Cats 2010, 93-154. Schlütersche, Hannover, Germany. 2nd ed. A. Rijnberk, H.S. Kooistra (Eds.).
2. Mountyoj K.G., Bird I.M., Rainey W.E., Cone R.D. ACTH induces upregulation of ACTH receptor mRNA in mouse and human adrenocortical cell lines. Mol Cell Endocrinol 1994, 99:R17-R20.
3. Mountyoj K.G., Robbins L.S., Mortrud M.T., Cone R.D. The cloning of a family of genes that encode the melanocortin receptors. Science 1992, 275:1248-1251.
4. Siegrist W., Eberle A.N. Melanocortins and their implications in melanoma. Trends Endocrinol Metab 1995, 6:115-120.
5. Cone R.D., Mountjoy K.G., Robbins L.S., Nadeau J.H., Johnson K.R., Roselli-Rehfuss L., Mortrud M.T. Cloning and functional characterization of a family of receptors for the melanotropic peptides. Ann N Y Acad Sci 1993, 31:342-363.
6. Miller W.L. StAR search-what we know about how the steroidogenic acute regulatory protein mediates mitochondrial cholesterol import. Mol Endocrinol 2007, 21:589-601.
7. Manna P., Dyson M.T., Stocco D.M. Regulation of the steroidogenic acute regulatory protein gene expression: present and future perspectives. Mol Hum Reprod 2009, 15:321-333.
8. Miller W.L. Molecular biology of steroid hormone synthesis. Endocr Rev 1988, 9:295-318.
9. Reincke M., Mora P., Beuschlein F., Arlt W., Chrousos G., Allolio B. Deletion of the adrenocorticotropin gene in human adrenocortical tumors: implications for tumorigenesis. J Clin Endocrinol Metab 1997, 82:3054-3058.
10. Zwerman O., Beuschlein F., Klink A., Stahl M., Reincke M. The role of ACTH receptor in adrenal tumors: identification of a novel microsatellite marker. Horm Metab Res 2004, 36:406-410.
11. Reincke M., Beuschlein F., Latronico A.C., Arlt W., Chrousos G., Allolio B. Expression of adrenocorticotropic hormone receptor mRNA in human adrenocortical neoplasms: correlation with P450scc expression. Clin Endocrinol 1997, 46:619-626.
12. Imai T., Sarkar D., Shibata A., Funahashi H., Morita-Matsuyama T., Kikomori T., Ohmori S., Seo H. Expression of adrenocorticotropin receptor gene in adrenocortical adenomas from patients with Cushing syndrome: possible contribution for the autonomous production of cortisol. Ann Surg 2001, 234:85-91.
13. Bassett M.H., Mayhew B., Rehman K., White P.C., Mantero F., Arnaldo G., Stewart P.M., Bujalska I., Rainey W.E. Expression profiles for steroidogenic enzymes in adrenocortical disease. J Clin Endocrinol Metab 2005, 90:5446-5455.
14. Peterson M.E., Gilbertson S.R., Druckner W.D. Plasma cortisol response to exogenous ACTH in 22 dogs with hyperadrenocorticism caused by an adrenocortical neoplasia. J Am Vet Med Assoc 1982, 180:542-544.
15. Van Vonderen I.K., Kooistra H.S., Rijnberk A. Influence of veterinary care on the urinary corticoid:creatinine ratio in dogs. J Vet Intern Med 1998, 12:431-435.
16. Labelle P., Kyles E., Farver T.B., de Cock H.E.V. Indicators of malignancy of canine adrenocortical tumors: histopathology and proliferation index. Vet Pathol 2004, 41:490-497.
17. Mcgavin M.D., Zachary J.F., Mcgavin M. Endocrine system. Pathologic Basis of Veterinary Disease 2006, 1067-1154. Mosby, Philadelphia. 5th ed.
18. Zucker M. Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res 2003, 31:3406-3415.
19. Brinkhof B., Spee B., Rothuizen J., Penning L.C. Development and evaluation of canine reference genes for accurate quantification of gene expression. Anal Biochem 2006, 356:36-43.
20. Javadi S., Galac S., Boer P., Robben J.H., Teske E., Kooistra H.S. Aldosterone to renin ratio and cortisol to adrenocorticotropic hormone ratio in healthy dogs and dogs with primary hypoadrenocorticism. J Vet Intern Med 2006, 20:556-561.
21. Rijnberk A., van Wees A., Mol J.A. Assessment of two tests for the diagnosis of canine hyperadrenocorticism. Vet Rec 1988, 122:178-180.
22. Stolp R., Rijnberk A., Meijer J.C., Croughs R.J. Urinary corticoids in the diagnosis of canine hyperadrenocorticism. Res Vet Sci 1983, 34:141-144.
23. REST 2008, http://www.REST.de.com.
24. Estivariz F.E., Carino M., Lowry P.J., Jackson S. Further evidence that N-terminal pro-opiomelanocortin peptides are involved in adrenal mitogenesis. J Endocrinol 1988, 116:201-206.
25. Fassnacht M., Hahner S., Hansen I.A., Kreutzberger T., Zink M., Adermann K., Jakob F., Troppmair J., Allolio B. N-terminal proopiomelanocortin acts as mitogen in adrenocortical tumor cells and decreases adrenal steroidogenesis. J Clin Endocrinol Metab 2003, 88:2171-2179.
26. Reincke M., Beuschlein F., Menig G., Hofmockel G., Arlt W., Lehman R., Karl M., Allolio B. Localisation and expression of adrenocorticotropic hormone receptor mRNA in normal and neoplastic human adrenal cortex. J Endocrinol 1998, 156:415-423.
27. Beuschlein T., Fassnacht M., Klink A., Allolio B., Reincke M. ACTH receptor expression, regulation and role in adrenocortical tumor formation. Eur J Endocrinol 2001, 144:199-206.
28. Lebrethon M.C., Naville D., Begeot M., Saez J.M. Regulation of corticotropin receptor gene number and messenger RNA in cultured human adrenocortical cells by corticotropin and angiotensin II. J Clin Investig 1994, 93:1828-1833.
29. Penhoat A., Lebrethon M.C., Begeot M., Saez J.M. Regulation of ACTH receptor mRNA and binding sites by ACTH and angiotensin II in cultured human and bovine adrenal fasciculata cells. Endocr Res 1995, 2:157-168.
30. Morita T., Imai T., Murata Y., Kambe F., Funahashi H., Takagi H., Seo H. Adrenocorticotropic hormone (ACTH) increases the expression of its own receptors gene. Endocr J 1995, 42:475-480.
31. Lefebvre H., Duparc C., Chartrel N., Jegou S., Pellerin A., Laquerriere A., Ivell R., Vaudry H., Kuhn J.M. Intraadrenal adrenocorticotropin production in a case of bilateral macronodular adrenal hyperplasia causing Cushing's syndrome. J Clin Endocrinol Metab 2003, 88:3035-3042.
32. Feldman E.C. Distinguishing dogs with functioning adrenocortical tumors from dogs with pituitary-dependent hyperadrenocorticism. J Am Vet Med Assoc 1985, 187:49-53.
33. Weiss L.M., Medeiross L.J., Vickery A.L. Pathologic features of prognostic significance in adrenocortical carcinoma. Am J Surg Pathol 1989, 13:202-206.
34. Manna P., Dyson M.T., Stocco D.M. Regulation of the steroidogenic acute regulatory protein gene expression: present and future perspectives. Mol Hum Reprod 2009, 15:321-333.
35. Zenkert S., Schubert B., Fassnack M., Beuschlein F., Allolio B., Rreincke M. Steroidogenic acute regulatory protein mRNA expression in adrenal tumors. Eur J Endocrinol 2000, 142:294-299.
36. Sewer M.B., Dammer E.B., Jagarlapudi S. Transcriptional regulation of adrenocortical steroid expression. Drug Metab Rev 2007, 39:371-388.
37. Lavoie H.A., King S.R. Transcriptional regulation of steroidogenic genes: STARD1, CYP11A1, and HSD3B. Exp Biol Med (Maywood) 2009, 234:880-907.
38. Mason J.I., Keeney D.S., Bird I.M., Rainey W.E., Morohashi K.I., Leers-Sucheta S., Melner M. The regulation of 3β-hydroxysteroid dehydrogenase expression. Steroids 1997, 62:164-168.
39. 4 isomerase gene family. Endocr Rev 2005, 26:525-582.
40. Ristić J., Ramsey I.K., Heats F.M., Evans H.J., Herrtage M.E. The use of 17-hydroxyprogesterone in the diagnosis of canine hyperadrenocorticism. J Vet Intern Med 2002, 16:433-439.
41. Benitah N., Feldman E.C., Kass P.H., Nelson R.W. Evaluation of serum 17-hydroxyprogesterone concentration after administration of ACTH in dogs with hyperadrenocorticism. J Am Vet Med Assoc 2005, 227:1095-1101.
42. Chapman P.S., Mooney C.E., Ede J., Evans H., O'Connor J., Pfeiffer D.U., Neiger R. Evaluation of the basal and post-adrenocorticotrophic hormone serum concentrations of 17-hydroxyprogesterone for the diagnosis of hyperadrenocorticism in dogs. Vet Rec 2003, 153:771-775.
43. Eastwood J.M., Elwood C.M., Hurley K.J. Trilostane treatment of a dog with functional adrenocortical neoplasia. J Small Anim Pract 2003, 44:126-131.
44. Benchekroun G., de Fornel-Thibaud P., Lafarge S., Gomes E., Begon D., Delisle F., Moraillon R., Heripet D., Maurey C., Rosenberg D. Trilostane therapy for hyperadrenocorticism in three dogs with adrenocortical metastasis. Vet Rec 2008, 163:190-192.
45. Javadi S., Kooistra H.S., Mol J.A., Boer P., Boer W.H., Rijnberk A. Plasma aldosterone concentration and plasma renin activity in healthy dogs and in dogs with hypercortisolism. Vet Rec 2003, 153:521-525.
46. Mendonca B.B., Lucon A.M., Menezes C.A.V., Saldanha L.B., Latronico A.C., Zerbini C., Maduireira G., Domenice S., Albergaria M.A., Camargo M.H. Clinical, hormonal and pathological findings in a comparative study of adrenal cortical neoplasms in childhood and adulthood. J Urol 1995, 154:2004-2009.
47. Kikuchi E., Yanaihara H., Nakashima J., Homma K., Ohigashi T., Asakura H., Tachibana M., Shibata H., Saruta T., Murai M. Urinary steroid profile in adrenocortical tumors. Biomed Pharmacother 2000, 54:194s-197s.
48. Thomas C.M.G., Otten B.J. De waarde van het steroidprofiel in urine bij de diagnostiek en behandeling van endocriene stoornissen van gonaden en bijnier. Ned Tijdschr Klin Chem 2000, 25:37-43.