Pyrenocine I, a new pyrenocine analog produced by Paecilomyces sp. FKI-3573

Journal of Antibiotics

Volumn 63, Issue 9, 2010, Pages 559-561

  Hashida, Junko ^a   Niitsuma, Megumi ^a   Iwatsuki, Masato ^a   Mori, Mihoko ^a   Ishiyama, Aki ^a   Namatame, Miyuki ^a   Nishihara Tsukashima, Aki ^a   Nonaka, Kenichi ^a   Ui, Hideaki ^a   Masuma, Rokuro ^a   Otoguro, Kazuhiko ^a   Yamada, Haruki ^a   Shiomi, Kazuro ^a   Ömura, Satoshi ^a  

^a KITASATO UNIVERSITY   (Japan)

Author keywords

antitrypanosomal activity; citreoviridin; Paecilomyces; pyrenocine

Indexed keywords

ANTITRYPANOSOMAL AGENT; CITREOVIRIDIN; PYRENOCINE 1; PYRENOCINE A; PYRENOCINE B; SURAMIN; UNCLASSIFIED DRUG; ANTIPROTOZOAL AGENT; FUNGAL DNA; PYRONE DERIVATIVE; RIBOSOMAL SPACER DNA;

AFRICAN TRYPANOSOMIASIS; ARTICLE; COLUMN CHROMATOGRAPHY; CYTOTOXICITY; DRUG ACTIVITY; DRUG ISOLATION; DRUG MECHANISM; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; FUNGUS CULTURE; IC 50; IN VITRO STUDY; NUCLEOTIDE SEQUENCE; PAECILOMYCES; PRIORITY JOURNAL; TRYPANOSOMA BRUCEI; CHEMICAL STRUCTURE; CHEMISTRY; CLASSIFICATION; DNA SEQUENCE; DRUG EFFECTS; DRUG SENSITIVITY; GENETICS; HUMAN; IC50; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TRYPANOSOMA;

PAECILOMYCES SP.;

ANTIPROTOZOAL AGENTS; DNA, FUNGAL; DNA, RIBOSOMAL SPACER; HUMANS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PAECILOMYCES; PARASITIC SENSITIVITY TESTS; PYRONES; SEQUENCE ANALYSIS, DNA; SOIL MICROBIOLOGY; TRYPANOSOMA;

EID: 77957317511     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2010.65     Document Type: Article

References (14)

1. World Health Organization. The Global Burden of Disease: 2004 Update, WHO, Geneva, (2008).
2. Brun, R., Blum, J., Chappuis, F. & Burri, C. Human African Trypanosomiasis. Lancet 375, 148-159 (2010).
3. Otoguro, K. et al. Selective and potent in vitro antitrypanosomal activities of ten microbial metabolites. J. Antibiot. 61, 372-378 (2008).
4. Ishiyama, A. et al. In vitro and in vivo antitrypanosomal activities of two microbial metabolites, KS-505a and alazopeptin. J. Antibiot. 61, 627-632 (2008).
5. Ishiyama, A. et al. In vitro and in vivo antitrypanosomal activities of three peptide antibiotics: leucinostatin A and B, alamethicin I and tsushimycin. J. Antibiot. 62, 303-308 (2009).
6. Sato, H. et al. X-ray crystal structure of pyrenocine A, a phytotoxin from Pyrenochaeta terrestris. Agric. Biol. Chem. 45, 795-797 (1981).
7. Sakabe, N., Goto, T. & Hirata, Y. The structure of citreoviridin, a toxic compound produced by Penicillium citreoviride molded on rice. Tetrahedron Lett. 27, 1825-1830 (1964).
8. von Arx, J. A. The Genera of Fungi Sporulating in Pure Culture. 3rd edn. 263 (J. Cramer, Vaduz, 1981).
9. Whang, K., Venkataraman, H., Kim, Y. G. & Cha, J. K. Total synthesis of (-)-citreoviridin and (+)-citreoviral. J. Org. Chem. 56, 7174-7177 (1991).
10. Krohn, K., Sohrab, M. H., Draeger, S. & Schulz, B. New pyrenocines from an endophytic fungus. Nat. Prod. Commun. 3, 1689-1692 (2008).
11. Sparace, S. A., Reeder, R. D. & Khanizadeh, S. Antibiotic activity of the pyrenocines. Can. J. Microbiol. 33, 327-330 (1987).
12. Amagata, T., Minoura, K. & Numata, A. Cytotoxic metabolites produced by a fungal strain from a Sargassum alga. J. Antibiot. 51, 432-434 (1998).
13. Nilanonta, C. et al. New diketopiperazines from the entomopathogenic fungus Verticillium hemipterigenum BCC 1449. J. Antibiot. 56, 647-651 (2003).
14. Cataldi de Flombaum, M. A. & Stoppani, A. O. M. Influence of efrapeptin, aurovertin and citreoviridin on the mitochondrial adenosine triphosphatase from Trypanosoma cruzi. Mol. Biochem. Parasitol. 3, 143-155 (1981).