The role of angiotensin receptor blocker and calcium channel blocker combination therapy in treating hypertension: Focus on recent studies

American Journal of Cardiovascular Drugs

Volumn 10, Issue 5, 2010, Pages 315-320

  Chrysant, Steven G ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

amlodipinevalsartan, therapeutic use; angiotensin type 1 receptor antagonists, general; calcium channel antagonists, general; hypertension, treatment; olmesartan medoxomilamlodipine, therapeutic use; telmisartanamlodipine, therapeutic use.

Indexed keywords

AMLODIPINE; AMLODIPINE PLUS OLMESARTAN; AMLODIPINE PLUS VALSARTAN; ANGIOTENSIN RECEPTOR ANTAGONIST; CALCIUM CHANNEL BLOCKING AGENT; DIHYDROPYRIDINE; OLMESARTAN; PLACEBO; TELMISARTAN; TELMISARTAN PLUS AMLODIPINE; UNCLASSIFIED DRUG; VALSARTAN;

ADD ON THERAPY; ANGIONEUROTIC EDEMA; ANTIHYPERTENSIVE THERAPY; ARTERY DILATATION; BLOOD PRESSURE REGULATION; CLINICAL TRIAL; COUGHING; DRUG EFFICACY; DRUG SAFETY; EDEMA; FACTORIAL DESIGN; FOOT EDEMA; HUMAN; HYPERTENSION; MEDLINE; MONOTHERAPY; NATRIURESIS; PERIPHERAL EDEMA; PRIORITY JOURNAL; REVIEW;

ANGIOTENSIN RECEPTOR ANTAGONISTS; CALCIUM CHANNEL BLOCKERS; DRUG THERAPY, COMBINATION; HUMANS; HYPERTENSION;

EID: 77957314718     PISSN: 11753277     EISSN: 1179187X     Source Type: Journal    
DOI: 10.2165/11538850-000000000-00000     Document Type: Review

References (25)

1. Rosamond W, Flegal K, Friday G, et al., for the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics - 2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2007;115: e69-171 (Pubitemid 46226160)
2. Ong KL, Cheung BM, Man YB, et al. Prevalence, awareness, treatment, and control of hypertension among United States adults 1999-2004. Hypertension 2007;49:69-75 (Pubitemid 46360343)
3. Chobanian AV, Bakris GL, Black HR, et al. The seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. JAMA 2003;289:2560-72 (Pubitemid 37430158)
4. Tocci G, Sciarretta S, Volpe M. Development of heart failure in recent hypertension trials. J Hypertens 2008;26:1477-86
5. Padwal R, Straus SE, McAlister FA. Evidence based management of hypertension: cardiovascular risk factors and their effects on the decision to treat hypertension. Evidence based review. BMJ 2001;322:977-80 (Pubitemid 32374691)
6. Lewington S, Clarke R, Qizilbash N, et al., Prospective Studies Collaboration. Age-specific relevance of usual blood pressure to vascular mortality: a metaanalysis of individual data for one million adults in 61 prospective studies. Lancet 2002;360:1903-13 (Pubitemid 35472129)
7. Chrysant SG. Using fixed-dose combination therapies to achieve blood pressure goals. Clin Drug Investig 2008;28:713-34
8. Epstein M, Bakris G. Newer approaches to antihypertensive therapy: use of fixed-dose combination therapy. Arch Intern Med 1996;156:1969-78 (Pubitemid 26318104)
9. Chrysant SG. Amlodipine/ARB fixed-dose combinations for the treatment of hypertension: focus on amlodipine/olmesartan combination. Drugs Today 2008;44:443-53
10. Chrysant SG. Proactive compared with passive adverse event recognition: calcium channel blocker-associated edema. J Clin Hypertens (Greenwich) 2008;10:716-22
11. Fogari R, Zoppi A, Derosa G, et al. Effect of valsartan addition to amlodipine on ankle oedema and subcutaneous tissue pressure in hypertensive patients. J Hum Hypertens 2007;21:220-4 (Pubitemid 46267738)
12. Messerli FH. Vasodilatory edema: a common side effect of antihypertensive therapy. Am J Hypertens 2001;14:978-9
13. Lacourcière Y. The incidence of cough: a comparison of lisinopril, placebo and telmisartan, a novel angiotensin II antagonist. Telmisartan Cough Study Group. Int J Clin Pract 1999;53:99-103 (Pubitemid 29131365)
14. Dicpinigaitis P. Angiotensin-converting enzyme inhibitor-induced cough. Chest 2006;129 Suppl. 1:1695-735
15. Philipp T, Smith TR, Glazer R, et al. Two multicenter, 8-week, randomized, double-blind, placebo-controlled, parallel-group studies evaluating the efficacy and tolerability of amlodipine and valsartan in combination and as monotherapy in adult patients with mild to moderate essential hypertension. Clin Ther 2007;29:563-80 (Pubitemid 47028551)
16. Chrysant SG, Melino M, Karki S, et al. The combination of olmesartan medoxomil and amlodipine besylate in controlling high blood pressure: COACH, a randomized, double-blind, placebo-controlled, 8-week factorial efficacy and safety study. Clin Ther 2008;30:587-604 (Pubitemid 351680489)
17. Ichihara A, Kaneshiro Y, Sakoda Littlejohn III TW, et al. Add-on amlodipine improves arterial function and structure in hypertensive patients treated with an angiotensin receptor blocker. J Cardiovasc Pharmacol 2007;49:161-6 (Pubitemid 46579950)
18. Sharma A, Bagchi A, Kinagi SB, et al. Results of a comparative, phase III, 12-week, multicenter, prospective, randomized, double-blind assessment of the efficacy and tolerability of a fixed-dose combination of telmisartan and amlodipine versus amlodipine monotherapy in Indian adults with stage II hypertension. Clin Ther 2007;29:2667-76
19. Littlejohn III TW, Majul CR, Olvera R, et al., on behalf of the study investigators. Results of treatment with telmisartan-amlodipine in hypertensive patients. J Clin Hypertens (Greenwich) 2009;11:1-7
20. Littlejohn III TW, Majul CR, Olvera R, et al. Telmisartan plus amlodipine in patients with moderate or severe hypertension: results from a subgroup analysis of a randomized, placebo-controlled, parallel-group, 4×4 fac torial study. Postgrad Med 2009;121:5-14
21. Littlejohn III T, Majul CR, Oigman W, et al. Combination therapies of telmisartan and amlodipine are effective at lowering 24 hour BP: findings on an ABPM substudy in hypertensive patients [abstract P-50]. J Clin Hypertens (Greenwich) 2008;10 Suppl. A: A26
22. Chrysant SG, Chrysant GS, Desai A. Current status of angiotensin receptor blockers for the treatment of cardiovascular diseases: focus on telmisartan. J Hum Hypertens 2005;19:173-83 (Pubitemid 40360933)
23. Bakris G, Molitch M, Hewkin A, et al. Differences in glucose tolerance between fixed-dose antihypertensive drug combinations in people with metabolic syndrome. Diabetes Care 2006;29:2592-7 (Pubitemid 44912184)
24. ONTARGET Investigators. Telmisartan, ramipril or both in patients at high risk for vascular events. N Engl J Med 2008;358:1547-59 (Pubitemid 351522739)
25. Williams B, Lacy PS, Thom SM, et al. Differential impact of blood pressurelowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFÉ) Study. Circulation 2006;113:1213-25 (Pubitemid 43754247)