Identification of ilaprazole metabolites in human urine by HPLC-ESI-MS/MS and HPLC-NMR experiments

Biomedical Chromatography

Volumn 24, Issue 10, 2010, Pages 1130-1135

  Zhou, Gan ^a   Shi, Shuyun ^a   Zhang, Wei ^a   Tan, Zhirong ^a   Chen, Yao ^a   Guo, Dong ^a   Zhou, Honghao ^a   Hu, Haitang ^b   Tan, Jin ^b  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b Liyzon Pharmaceutical Group Inc   (China)

Author keywords

HPLC ESI MS MS; HPLC NMR; Human urine; Ilaprazole; Metabolites

Indexed keywords

BIOMOLECULES; BODY FLUIDS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SODIUM BICARBONATE; SODIUM CARBONATE; SULFUR COMPOUNDS;

ACETATE BUFFER SOLUTIONS; AMMONIUM ACETATE; GASTRIC ULCERS; HPLC-ESI-MS/MS; HPLC-NMR; HPLC/ESI-MS/MS; HUMAN URINE; ILAPRAZOLE; LIMITED DATA; NMR EXPERIMENTS;

METABOLITES;

11,12 DIHYDROXYILAPRAZOLE SULFIDE; 12 HYDROXYILAPRAZOLE SULFIDE; ACETONITRILE; AMMONIUM ACETATE; DRUG METABOLITE; ILAPRAZOLE; ILAPRAZOLE SULFIDE; ILAPRAZOLE SULFIDE A; SODIUM CARBONATE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG STRUCTURE; DRUG TRANSFORMATION; DRUG URINE LEVEL; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; HYDROXYLATION; LIQUID LIQUID EXTRACTION; MALE; NORMAL HUMAN; PRECIPITATION; PROTON NUCLEAR MAGNETIC RESONANCE; REDUCTION; SINGLE DRUG DOSE;

EID: 77957314160     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1416     Document Type: Article

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