Application of one-step liquid chromatography-electrospray tandem MS/MS and collision-induced dissociation to quantification of ezetimibe and identification of its glucuronated metabolite in human serum: A pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 28, 2010, Pages 2789-2795

  Bahrami, Gholamreza ^a,b   Mohammadi, Bahareh ^a   Khatabi, Pyman Malek ^b   Farzaei, Mohammad Hosein ^b   Majnooni, Mohammad Bagher ^b   Bahoosh, Saba Rahimi ^b  

^a KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Ezetimibe; Ezetimibe glucuronide; HPLC; LC MS MS bioequivalence study; MRM

Indexed keywords

EZETIMIBE; EZETIMIBE GLUCURONIDE; HPLC; LC-MS/MS; MRM;

ACETONITRILE; BIOMOLECULES; BODY FLUIDS; DISSOCIATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUIDS; METABOLISM; METABOLITES; METHANOL;

CHROMATOGRAPHY;

EZETIMIBE; OMEPRAZOLE;

ARTICLE; COLLISIONALLY ACTIVATED DISSOCIATION; DRUG DETERMINATION; DRUG METABOLISM; DRUG SPECIFICITY; DRUG STABILITY; DRUG STRUCTURE; HUMAN; LIQUID CHROMATOGRAPHY; NEGATIVE ION ELECTROSPRAY; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

ADULT; AZETIDINES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROSS-OVER STUDIES; GLUCURONIDES; HUMANS; LEAST-SQUARES ANALYSIS; MALE; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; THERAPEUTIC EQUIVALENCY;

EID: 77957313192     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.08.023     Document Type: Article

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