Association of 2548 GA polymorphism in the leptin gene with preeclampsiapregnancy-induced hypertension

Hypertension in Pregnancy

Volumn 29, Issue 4, 2010, Pages 366-374

  Sugathadasa, B H K R ^a   Tennekoon, K H ^a   Karunanayake, E H ^a   Kumarasiri, J M ^b   Wijesundere, A P D S ^b  

^a UNIVERSITY OF COLOMBO   (Sri Lanka)

^b Castle Street Hospital for Women ^*  (Sri Lanka)

Author keywords

LEP gene polymorphism; Leptin; Preeclampsia; Pregnancy induced hypertension; Soluble leptin receptor

Indexed keywords

LEPTIN; LEPTIN RECEPTOR;

ADULT; ALLELE; ARTICLE; BODY MASS; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENETIC ASSOCIATION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MATERNAL HYPERTENSION; POLYMERASE CHAIN REACTION; PREECLAMPSIA; PROTEIN BLOOD LEVEL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM; ANALYSIS OF VARIANCE; BLOOD; GENE FREQUENCY; GENETICS; NONPARAMETRIC TEST;

ADULT; ALLELES; ANALYSIS OF VARIANCE; FEMALE; GENE FREQUENCY; HUMANS; HYPERTENSION, PREGNANCY-INDUCED; LEPTIN; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, LEPTIN; STATISTICS, NONPARAMETRIC;

EID: 77957308305     PISSN: 10641955     EISSN: 15256065     Source Type: Journal    
DOI: 10.3109/10641950903214617     Document Type: Article

References (39)

1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-432. [Pub Med:10509783]
2. Considine RV, Caro JF. Leptin: genes, concepts and clinical perspective. Horm Res 1996a; 46:249-256. [Pub Med:8982834]
3. Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Med 1995;1:1155-1161. [Pub Med:7584987]
4. Masuzaki H, Ogawa Y, Sagawa HK, Matsumoto T, Mise HY, et al. Non adipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans. Nature Med 1997;3:1029-1033. [Pub Med: 9288733]
5. Senaris R, Garcia-Cabbalaero T, Casabiell X, Gallegeo R, Castro R, Considine RV, et al. Synthesis of leptin in human placenta. Endocrinology 1997;138:4501-4504. [Pub Med: 9322972]
6. Bado A, Levasseur S, Attoub S, Kermorgant S, Laigneau JP, Bortoluzzi MN, et al. The stomach is a source of leptin. Nature 1998;394:790-793. [Pub Med: 9723619]
7. Smith-Kirwin S, O'Connor D, de Johnston J, Lancey ED, Hassink SG, Funanage VL. Leptin expression in human mammary epithelial cells and breast milk. J Clin Endocrinol Metab 1998;83:1810-1813. [Pub Med:9589698]
8. Wang J, Liu R, Hawkins M, Brazilai N, Rossetti L. A nutrient-sensing pathway regulates leptin gene in muscle and fat. Nature 1998;393:684-688. [Pub Med: 9641678]
9. Hoggard N, Hunter L, Duncan JS, Williams LM, Trayhurn P, Mercer JG. Leptin and leptin receptor mRNA and protein expression in the murine fetus and placenta. Proc Natl Acad Sci USA 1997;94:11073-11078. [Pub Med: 9380761]
10. Green ED, Maffei M, Braden VV, Proenca R, De Silva U, Zhang Y, et al. The human obese (OB) gene: RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome 7. Genome Res 1995;5:5-12. [Pub Med: 8717050]
11. Bi S, Govrilova O, Gang DW. Identification of a placental enhancer for the human leptin gene. J Biol Chem 1997;48:30583-30588. [Pub Med: 9374555]
12. Lain KY, Roberts JM. Contemporary concepts of the pathogenesis and management of preeclampsia. JAMA 2002;287:3183-3186 [Pub Med: 12076198]
13. Roberts JM, Lain KY. Recent insights into the pathogenesis of preeclampsia. Placenta 2002:29: 359-372. [Pub Med: 1206185]
14. Meekins JW, Pijnenborg R, Hanssens M, McFadyen IR, van Asshe A. A study of placental bed spiral arteries and trophoblast invasion in normal and severe preeclamptic pregnancies. Br J Obstet Gynecol 1994;101:669-674. [Pub Med: 7947500]
15. Shore VH, Wang TH, Wang CL, Torry RJ, Caudle MR, Torry DS. Vascular endothelial growth factor, placental growth factor and their receptors in isolated human trophoblast. Placenta 1997;18:657-665. [Pub Med: 9364601]
16. Polliotti DM, Fry AG, Saller DN, Mooney RA, Cox C, Miller RK. Second-trimester maternal serum placental growth factor and vascular endothelial growth factor for predicting severe, early onset preeclampsia. Obstet Gynecol 2003;101:1266-1274. [Pub Med: 12798535]
17. Levine RJ, Maynard SE, Qian C, Lim K-H, England LJ, Yu KF, et al. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med 2004;350:672-683 [Pub Med: 14764923]
18. Levine RJ, Lam C, Qian C, Yu KF, Maynard SE, Sachs BP, et al. Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med 2006;355:992-1005. [Pub Med: 16957146]
19. Williams MA, Havel PJ, Schwartz MW, Leisenring WM, King IB, Zingheim RW, et al. Preeclampsia disrupts the normal relationship between serum leptin concentration and adiposity in pregnancy. Paediatr Perinat Epidemiol 1999;13:190-204.
20. Poston L. Leptin and pre-eclampsia. Semin Reprod Med Med 2002;20:131-138. [Pub Med: 12087498]
21. Vasku JAB, Vasku A, Dostalova Z, Bienert P. Association of leptin genetic polymorphism-2548 G/A with gestational diabetes mellitus. Genes Nutr 2006;1:117-124. [Pub Med: 18850205]
22. McCarthy JF, Misra DN, Roberts JM. Maternal plasma leptin level is increased in preeclampsia and positively correlates with fetal cord concentration. Am J Obstet Gynecol 1999;180:731-736. [Pub Med: 10076153]
23. Muy-rivera M, Ning Y, Frederick IO, Vadachkoria S, Luthy DA, Williams MA. Leptin, soluble leptin and leptin gene polymorphism in relation to preeclampsia. Physiol Res 2005;54:167-174. [Pub Med: 1554442]
24. Huang L, Wang Z, Li C. Modulation of circulating leptin levels by its soluble receptor. J Biol Chem 2001;276:6343-6634. [Pub Med: 11102451]
25. Friedman, JM, Halaas, JL. Leptin and the regulation of body weight in mammals. Nature 1998;395:763-769. [Pub Med: 9796811]
26. Grosfeld A, Andre J, Hauguel-De MS, Berra E, Pouyssegur J, Guerre-Millo M. Hypoxiainducible factor-1 trans-activates the human leptin gene promoter. J Biol Chem 2002;277:42953-42957. [Pub Med: 12215445]
27. Ambrosoni G, Nath AK, Sierra-Honigmann MR, Flores-Riveros J. Transcriptional activity of the human leptin gene in response to hypoxia. J Biol Chem 2002;277:34601-34609. [Pub Med: 2084725]
28. Laivuori H, Gallaher MJ, Collura L, Crombleholme WR, Markovic N, Rajakumar A, et al. Expression, ontogeny, and regulation of hypoxia-inducible transcription factors in the human placenta. Biol Reprod 2006;12:551-556. [Pub Med: 16870954]
29. Jaquet D, Leger J, Levy-Marchal C, Oury JF Czernichow P. Ontogeny of leptin in human fetuses and newborns: effect of intrauterine growth retardation on serum leptin concentrations. J Clin Endocrinol Metab 1998;4:1243-1246. [Pub Med: 9543149]
30. Hoffstedt L, Eriksson P, Mottuagui-tabar S, Arner P. A polymorphism in the leptin promoter region (-2548 G/A) influences gene expression and adipose tissue secretion of leptin. Horm Metab Res 2002;7:355-359. [Pub Med: 12189581]
31. Chappell S, Morgan L. Searching for genetic clues to the causes of pre-eclampsia. Clin Sci (Lond) 2006;110:443-458. [Pub Med 16526948:]
32. Bienertova-vasku J, Dostalova Z, Kaskova K, Bienert P, Vasku A, Unzevtig V. Is there any link between severe preeclampsia and defined polymorphism in leptin and adiponectin genes? J Obstet Gynaecol Res 2008;34:858-864. [Pub Med: 18958929]
33. Snoussi K, Strosberg AD, Noureddine B, Slim BA, Noureddine AH, Lotfi C. Leptin and leptin receptor polymorphisms are associated with increased risk and poor prognosis of breast carcinoma. BMC Cancer 2006;6:38. [Pub Med: 16504019]
34. Ribeiro R, Araujo AP, Coelho A, Catarino R, Pinto D, Araujo A, et al. Over expressing leptin genetic polymorphism (-2548 G/A) is associated with susceptibility to prostate cancer and risk of advanced disease. Prostate 2004;59:268-274. [Pub Med: 15042602]
35. Ribeiro R, Araujo AP, Coelho A, Catarino R, Pinto D, Araujo A, et al. A functional polymorphism in the promoter region of leptin gene increase susceptibility for non-small cell lung cancer. Eur J Cancer 2006;42:1188-1193. [Pub Med: 16630717]
36. Bienertova-Vasku JA, Hlinomaz O, Vasku A. Are common leptin promoter polymorphisms associated with restenosis after coronary stenting? Heart Vessels 2007;22:310-315. [Pub Med: 17879022]
37. Lu D, Yang X, Wu Y, Wang H, Huang H, Dong M. Serum adiponectin, leptin and soluble leptin receptor in preeclampsia. Int J Gynaecol Obstet 2006;95:121-126. [Pub Med: 16919629]
38. Mise H, Sagawa N, Matsumoto T, Yura S. Nanno H, Itoh H, et al. Augmented placental production of leptin in pre-eclampsia: possible involvement of placental hypoxia. J Clin Endocrinol Metab 1998;83:3223-3229. [Pub Med: 9745432]
39. Haugen F, Ranheim T, Harsem NK, Lips E, Staff AC, Drevon CA. Increased plasma levels of adiponectin in preeclampsia: a relationship to placenta and adipose tissue gene expression. Am J Physol Endocrinol Metab 2006;290: E326-E333. [Pub Med: 16144822]