Medical and surgical approaches to vulvar intraepithelial neoplasia

Dermatologic Therapy

Volumn 23, Issue 5, 2010, Pages 477-484

  Lai, Kimberly W ^a   Mercurio, Mary Gail ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

HPV; human papillomavirus; photodynamic therapy; surgical excision; topical therapy; treatment; VIN; vulva; vulvar carcinoma; vulvar dysplasia; vulvar intraepithelial neoplasia

Indexed keywords

CIDOFOVIR; FLUOROURACIL; IMIQUIMOD;

BURN; CANCER DIAGNOSIS; CANCER GROWTH; CANCER INCIDENCE; CANCER SURGERY; CARBON DIOXIDE LASER; CLINICAL FEATURE; HUMAN; LASER SURGERY; NOMENCLATURE; PHOTODYNAMIC THERAPY; REVIEW; SKIN IRRITATION; SKINNING VULVECTOMY; SORENESS; TUMOR BIOPSY; ULCER; VAPORIZATION; VULVA CANCER; VULVAR INTRAEPITHELIAL NEOPLASIA; VULVECTOMY;

ADJUVANTS, IMMUNOLOGIC; AMINOQUINOLINES; ANTIMETABOLITES, ANTINEOPLASTIC; ANTIVIRAL AGENTS; CARCINOMA IN SITU; CYTOSINE; FEMALE; FLUOROURACIL; GYNECOLOGIC SURGICAL PROCEDURES; HUMANS; LASER THERAPY; PHOSPHONIC ACIDS; PHOTOCHEMOTHERAPY; VULVAR NEOPLASMS;

EID: 77957298290     PISSN: 13960296     EISSN: 15298019     Source Type: Journal    
DOI: 10.1111/j.1529-8019.2010.01351.x     Document Type: Review

References (28)

1. Sideri M, Jones RW, Wilkinson EJ, et al. Squamous vulvar intraepithelial neoplasia: 2004 modified terminology, ISSVD vulvar oncology subcommittee. J Reprod Med 2005 : 50 (11 807 810.
2. Judson PL, Habermann EB, Baxter NN, Durham SB, Virnig BA. Trends in the incidence of invasive and in situ vulvar carcinoma. Obstet Gynecol 2006 : 107 (5 1018 1022.
3. Preti M, Van Seters M, Sideri M, Van Beurden M. Squamous vulvar intraepithelial neoplasia. Clin Obstet Gynecol 2005 : 48 (4 845 861.
4. Hart WR. Vulvar intraepithelial neoplasia: historical aspects and current status. Int J Gynecol Pathol 2001 : 20 (1 16 30.
5. Joura EA. Epidemiology, diagnosis and treatment of vulvar intraepithelial neoplasia. Curr Opin Obstet Gynecol 2002 : 14 (1 39 43.
6. Pinto AP, Miron A, Yassin Y, et al. Differentiated vulvar intraepithelial neoplasia contains Tp53 mutations and is genetically linked to vulvar squamous cell carcinoma. Mod Pathol 2010 : 23 (3 404 412.
7. Yang B, Hart WR. Vulvar intraepithelial neoplasia of the simplex (differentiated) type: a clinicopathologic study including analysis of HPV and p53 expression. Am J Surg Pathol 2000 : 24 (3 429 441.
8. Kennedy CM, Boardman LA. New approaches to external genital warts and vulvar intraepithelial neoplasia. Clin Obstet Gynecol 2008 : 51 (3 518 526.
9. Cardosi RJ, Bomalaski JJ, Hoffman MS. Diagnosis and management of vulvar and vaginal intraepithelial neoplasia. Obstet Gynecol Clin North Am 2001 : 28 (4 685 702.
10. van de Nieuwenhof HP, van der Avoort IA, de Hullu JA. Review of squamous premalignant vulvar lesions. Crit Rev Oncol Hematol 2008 : 68 (2 131 156.
11. Sillman FH, Sedlis A, Boyce JG. A review of lower genital intraepithelial neoplasia and the use of topical 5-fluorouracil. Obstet Gynecol Surv 1985 : 40 (4 190 220.
12. Tristram A, Fiander A. Clinical responses to Cidofovir applied topically to women with high grade vulval intraepithelial neoplasia. Gynecol Oncol 2005 : 99 (3 652 655.
13. Iavazzo C, Pitsouni E, Athanasiou S, Falagas ME. Imiquimod for treatment of vulvar and vaginal intraepithelial neoplasia. Int J Gynaecol Obstet 2008 : 101 (1 3 10.
14. Le T, Menard C, Hicks-Boucher W, et al. Final results of a phase 2 study using continuous 5% imiquimod cream application in the primary treatment of high-grade vulva intraepithelial neoplasia. Gynecol Oncol 2007 : 106 (3 579 584.
15. van Seters M, van Beurden M, ten Kate FJ, et al. Treatment of vulvar intraepithelial neoplasia with topical imiquimod. N Engl J Med 2008 : 358 (14 1465 1473.
16. Raspagliesi F, Fontanelli R, Rossi G, et al. Photodynamic therapy using a methyl ester of 5-aminolevulinic acid in recurrent Paget's disease of the vulva: a pilot study. Gynecol Oncol 2006 : 103 (2 581 586.
17. Soergel P, Hillemanns P. Photodynamic therapy for intraepithelial neoplasia of the lower genital tract. Photodiagnosis Photodyn Ther 2010 : 7 (1 10 14.
18. Hillemanns P, Wang X, Staehle S, Michels W, Dannecker C. Evaluation of different treatment modalities for vulvar intraepithelial neoplasia (VIN): CO(2) laser vaporization, photodynamic therapy, excision and vulvectomy. Gynecol Oncol 2006 : 100 (2 271 275.
19. Fehr MK, Hornung R, Degen A, et al. Photodynamic therapy of vulvar and vaginal condyloma and intraepithelial neoplasia using topically applied 5-aminolevulinic acid. Lasers Surg Med 2002 : 30 (4 273 279.
20. Martin-Hirsch PL, Whitehurst C, Buckley CH, Moore JV, Kitchener HC. Photodynamic treatment for lower genital tract intraepithelial neoplasia. Lancet 1998 : 351 (9113 1403.
21. Baggish M. Wide Excision with or without Skin Graft. In : Baggish M, Karram M, eds. Atlas of pelvic anatomy and gynecologic surgery. Philadelphia, PA : Elsevier Sanders, 2006 : 867 874.
22. Modesitt SC, Waters AB, Walton L, Fowler WC Jr., Van Le L. Vulvar intraepithelial neoplasia III: occult cancer and the impact of margin status on recurrence. Obstet Gynecol 1998 : 92 (6 962 966.
23. Baggish M. Vulvectomy. In : Baggish M, Karram M, eds. Atlas of pelvic anatomy and gynecologic surgery. Philadelphia, PA : Elsevier Sanders, 2006 : 889 908.
24. Di Saia PJ, Rich WM. Surgical approach to multifocal carcinoma in situ of the vulva. Am J Obstet Gynecol 1981 : 140 (2 136 145.
25. Rettenmaier MA, Berman ML, DiSaia PJ. Skinning vulvectomy for the treatment of multifocal vulvar intraepithelial neoplasia. Obstet Gynecol 1987 : 69 (2 247 250.
26. Baggish M. Laser Excision and Vaporization. In : Baggish M, Karram M, eds. Atlas of pelvic anatomy and gynecologic surgery. Philadelphia, PA : Elsevier Sanders, 2006 : 875 882.
27. Sideri M, Spinaci L, Spolti N, Schettino F. Evaluation of CO(2) laser excision or vaporization for the treatment of vulvar intraepithelial neoplasia. Gynecol Oncol 1999 : 75 (2 277 281.
28. 2 laser surgery for vulvar intraepithelial neoplasia. Excisional, destructive and combined techniques. J Reprod Med 2002 : 47 (11 913 918.