Determination of the unstable drug otilonium bromide in human plasma by LC-ESI-MS and its application to a pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 28, 2010, Pages 2896-2900

  Zhao, Yan rong ^a   Ding, Li ^a   Fan, Hong wei ^b   Yu, Yong ^a   Qi, Xie min ^a   Leng, Ye ^a   Rao, Ya kun ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

LC ESI MS; Otilonium bromide; Pharmacokinetics; Sample preparation; Stability

Indexed keywords

CONCENTRATION RANGES; EXTRACTION RECOVERY; HUMAN PLASMAS; INTERNAL STANDARDS; LC-ESI-MS; MATRIX EFFECTS; OTILONIUM BROMIDE; PHARMACOKINETIC STUDIES; POTASSIUM FLUORIDES; RAPID DEGRADATION; SAMPLE PREPARATION;

ACETONITRILE; BROMINE COMPOUNDS; ENZYMES; PHARMACOKINETICS; PLASMA (HUMAN); POTASSIUM;

PLASMAS;

2 CHLOROBENZYLIDENEMALONONITRILE; ACETONITRILE; OTILONIUM BROMIDE; POTASSIUM FLUORIDE;

ACCURACY; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; DRUG DEGRADATION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG HYDROLYSIS; DRUG ISOLATION; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; OUTCOME ASSESSMENT; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION;

ACETONITRILES; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; FLUORIDES; HUMANS; LINEAR MODELS; MALE; POTASSIUM COMPOUNDS; QUATERNARY AMMONIUM COMPOUNDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 77957297917     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.08.003     Document Type: Article

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