Failure to replicate an association of rs5984894 SNP in the PCDH11X gene in a collection of 1,222 Alzheimer's disease affected patients

Journal of Alzheimer's Disease

Volumn 21, Issue 2, 2010, Pages 385-388

  Lescai, Francesco ^a,b   Pirazzini, Chiara ^b   D'Agostino, Giuseppe ^b   Santoro, Aurelia ^b   Ghidoni, Roberta ^c   Benussi, Luisa ^c   Galimberti, Daniela ^d   Federica, Esposito ^e   Marchegiani, Francesca ^f   Cardelli, Maurizio ^f   Olivieri, Fabiola ^f   Nacmias, Benedetta ^g   Sorbi, Sandro ^g   Bagnoli, Silvia ^g   Tagliavini, Fabrizio ^h   Albani, Diego ⁱ   Boneschi, Filippo Martinelli ^e   Binetti, Giuliano ^c   Forloni, Gianluigi ⁱ   Quadri, Pierluigi ^j   Scarpini, Elio ^d   Franceschi, Claudio ^b   more..

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c IRCCS ISTITUTO CENTRO SAN GIOVANNI DI DIO FATEBENEFRATELLI   (Italy)

^d UNIVERSITY OF MILAN   (Italy)

^e SAN RAFFAELE HOSPITAL   (Italy)

^f INRCA   (Italy)

^g UNIVERSITY OF FLORENCE   (Italy)

^h DEPARTMENT OF NEUROSURGERY   (Italy)

ⁱ MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^j Ospedali Regionali of Mendrisio and Lugano   (Switzerland)

more..

Author keywords

Alzheimer's disease; APOE; genetics; replication

Indexed keywords

APOLIPOPROTEIN E4;

AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; CHROMOSOME XQ; DISEASE ASSOCIATION; FEMALE; GENDER; GENOME; HUMAN; ITALY; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED STATES;

EID: 77957287436     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2010-091516     Document Type: Article

References (17)

1. von Strauss E, Viitanen M, De Ronchi D, Winblad B and Fratiglioni L (1999) Aging and the occurrence of dementia: Findings from a populationbased cohort with a large sample of nonagenarians. Arch Neurol 56, 587592.
2. Brouwers N, Sleegers K and Van Broeckhoven C (2008) Molecular genetics of Alzheimer's disease: An update. Ann Med 40, 562583.
3. Coon KD,MyersAJ,CraigDW,Webster JA, Pearson JV, Lince DH, Zismann VL, Beach TG, Leung D, Bryden L, Halperin RF, Marlowe L, Kaleem M, Walker DG, Ravid R, Heward CB, Rogers J, Papassotiropoulos A, Reiman EM, Hardy J and Stephan DA (2007) A highdensity wholegenome association study reveals that APOE is the major susceptibility gene for sporadic lateonset Alzheimer's disease. J Clin Psychiatry 68, 613618.
4. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL and PericakVance MA (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261, 921923.
5. Saunders AM, Trowers MK, Shimkets RA, Blakemore S, Crowther DJ,Mansfield TA,Wallace DM, Strittmatter WJ and Roses AD (2000) The role of apolipoprotein E in Alzheimer's disease: Pharmacogenomic target selection. Biochim Biophys Acta 1502, 8594.
6. Poduslo SE, Huang R, Huang J and Smith S (2009) Genome screen of lateonset Alzheimer's extended pedigrees identifies TRPC4AP by haplotype analysis. Am J Med Genet B Neuropsychiatr Genet 150B, 5055.
7. Reiman EM (2007) Linking brain imaging and genomics in the study of Alzheimer's disease and aging. Ann N Y Acad Sci 1097, 94113.
8. Waring SC and Rosenberg RN (2008) Genomewide association studies in Alzheimer disease. Arch Neurol 65, 329334.
9. Carrasquillo MM, Zou F, Pankratz VS, Wilcox SL, Ma L, Walker-LP, Younkin SG, Younkin CS, Younkin LH, Bisceglio GD, ErtekinTaner N, Crook JE, Dickson DW, Petersen RC and GraffRadford NR (2009) Genetic variation in PCDH11X is associated with susceptibility to lateonset Alzheimer's disease. Nat Genet 41, 192198.
10. Balding DJ (2006) A tutorial on statistical methods for population association studies. Nat Rev Genet 7, 781791.
11. Gabriel S, Ziaugra L and Tabbaa D (2009) SNP genotyping using the Sequenom MassARRAY iPLEX platform.Curr Protoc Hum Genet Chapter 2, Unit 2 12.
12. Purcell S, Neale B, ToddBrown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ and Sham PC (2007) PLINK: A tool set for wholegenome association and populationbased linkage analyses. Am J Hum Genet 81, 559575.
13. Venables WNaR BD (2002) Modern Applied Statistics with S, Springer, New York.
14. CedazoMinguez A (2007) Apolipoprotein E and Alzheimer's disease: Molecular mechanisms and therapeutic opportunities. J Cell Mol Med 11, 12271238.
15. Zintzaras E (2008) Variance estimation of allelebased odds ratio in the absence of HardyWeinberg equilibrium. Eur J Epidemiol 23, 323326.
16. Lambert JC, Heath S, Even G, Campion D, Sleegers K, Hiltunen M, Combarros O, Zelenika D, Bullido MJ, Tavernier B, Letenneur-L, Bettens K, Berr C, Pasquier F, Fievet N, Barberger Gateau P, Engelborghs S, De Deyn P, Mateo I, Franck A, Helisalmi S, Porcellini E, Hanon O, de Pancorbo MM, Lendon C, Dufouil C, Jaillard C, Leveillard T,Alvarez V, Bosco P, Mancuso M, Panza F, Nacmias B, Bossu P, Piccardi P, Annoni G, Seripa D, Galimberti D, Hannequin D, Licastro F, Soininen H, Ritchie K, Blanche H, Dartigues JF, Tzourio C, Gut I, Van Broeckhoven C, Alperovitch A, Lathrop M and Amouyel P (2009) Genomewide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat Genet 41, 10941099.
17. Greene CS, Penrod NM, Williams SM and Moore JH (2009) Failure to replicate a genetic association may provide important clues about genetic architecture. PLoS One 4, e5639.