A new and weakly antispasmodic protoberberine alkaloid from rhizoma coptidis

Phytotherapy Research

Volumn 24, Issue 9, 2010, Pages 1414-1416

  Zhao, Ming ^a   Xian, Yan Fang ^a   Ip, Siu Po ^a   Fong, Harry H S ^b   Che, Chun Tao ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Antispasmodic activity; Coptis chinensis; Protoberberine; Rhizoma coptidis

Indexed keywords

3 HYDROXY 2 METHOXY 9,10 METHYLENEDIOXY 8 OXO PROTOBERBERINE; 3 METHOXYCINNAMIC ACID; 8 OXO COPTISINE; 8 OXO EPIBERBERINE; PROTOBERBERINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHINESE HERB; DRUG ACTIVITY; DRUG ISOLATION; DRUG STRUCTURE; FRACTIONATION; GUINEA PIG; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; ILEUM; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; RHIZOMA COPTIDIS;

ACETYLCHOLINE; ANIMALS; BERBERINE ALKALOIDS; COPTIS; DRUGS, CHINESE HERBAL; GUINEA PIGS; ILEUM; INHIBITORY CONCENTRATION 50; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PARASYMPATHOLYTICS; RHIZOME;

CAVIA; COPTIS CHINENSIS;

EID: 77957281277     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3154     Document Type: Article

References (5)

1. Chan SS, Zhao M, Lao L, Fong HH, Che CT. 2008. Magnolol and honokiol account for the anti-spasmodic effect of Magnolia officinalis in isolated guinea pig ileum. Planta Med 74: 381-384.
2. Fukutake M, Yokota S, Kawamura H et al. 1998. Inhibitory effect of Coptidis rhizoma and Scutellariae radix on azoxymethane-induced aberrant crypt foci formation in rat colon. Biol Pharm Bull 21: 814-817. (Pubitemid 28407226)
3. Ivanovska N, Philipov S. 1996. Study on the anti-inflammatory action of Berberis vulgaris root extract, alkaloid fractions and pure alkaloids. Int J Immunopharmacol 18: 553-561.
4. Pharmacopoeia of The People's Republic of China, 2005 Edition, Vol. 1. Chemical Industry Press: Beijing, 213-214.
5. Wang W, Zahng QW, Ye WC, Wang YT. 2007. Isoquinoline alkaloids from the Rhizoma of Coptis chinensis. Chin J Nat Med 5: 348-350.