Obstructive sleep apnoea is associated with risk factors comprising the metabolic syndrome

Respirology

Volumn 15, Issue 7, 2010, Pages 1122-1126

  Akahoshi, Toshiki ^a   Uematsu, Akihito ^a   Akashiba, Tsuneto ^a,b   Nagaoka, Kenichi ^a   Kiyofuji, Kouji ^a   Kawahara, Seiji ^a   Hattori, Tomohiro ^a   Kaneita, Yoshitaka ^c   Yoshizawa, Takayuki ^a   Takahashi, Noriaki ^a   Uchiyama, Makoto ^a   Hashimoto, Shu ^a  

^a NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Department of Internal Medicine   (Japan)

^c Division of Public Health   (Japan)

Author keywords

hypoxaemia; insulin resistance; metabolic syndrome; obesity; obstructive sleep apnoea

Indexed keywords

CHOLESTEROL; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; ARTICLE; CAUCASIAN; CHOLESTEROL BLOOD LEVEL; DIASTOLIC BLOOD PRESSURE; DISEASE SEVERITY; DYSLIPIDEMIA; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; HUMAN; HYPERTENSION; JAPANESE; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; OBESITY; PATIENT SELECTION; POLYSOMNOGRAPHY; PRIORITY JOURNAL; RISK FACTOR; SLEEP APNEA SYNDROME; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE;

ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; COMORBIDITY; CROSS-SECTIONAL STUDIES; DYSLIPIDEMIAS; GLUCOSE INTOLERANCE; HUMANS; HYPERTENSION; JAPAN; MALE; METABOLIC SYNDROME X; MIDDLE AGED; OBESITY; PREVALENCE; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SLEEP APNEA, OBSTRUCTIVE;

EID: 77957277793     PISSN: 13237799     EISSN: 14401843     Source Type: Journal    
DOI: 10.1111/j.1440-1843.2010.01818.x     Document Type: Article

References (35)

1. Young T, Palta M, Dempsey J et al. The occurrence of sleep-disordered breathing among middle-aged adults. N. Engl. J. Med. 1993 328 : 1230 5. (Pubitemid 23115702)
2. Marin JM, Carrizo SJ, Vicente E et al. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet 2005 365 : 1046 53. (Pubitemid 40386782)
3. Young T, Shahar E, Nieto FJ et al. Predictors of sleep-disordered breathing in community-dwelling adults: the Sleep Heart Health Study. Arch. Intern. Med. 2002 162 : 893 900. (Pubitemid 34299121)
4. Alberti KG, Zimmet P, Shaw J. Metabolic syndrome - a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet. Med. 2006 23 : 469 80.
5. American Academy of Sleep Medicine. Obstructive sleep apnea syndrome. In : Sateia MJ (ed.) The International Classification of Sleep Disorders, 2nd edn. American Academy of Sleep Medicine
6. Kushida CA, Littner MR, Morgenthaler T et al. Practice parameters for the indications for polysomnography and related procedures: an update for 2005. Sleep 2005 28 : 499 521. (Pubitemid 40489844)
7. Committee on Evaluation of Diagnostic Standards for Metabolic Syndrome. Definition and diagnostic standards for metabolic syndrome. Nippon Naika Gakkai Zasshi 2005 94 : 794 809.
8. World Health Organization. Definition, Diagnosis and Classification of Diabetes and Its Complications: Report of a WHO Consultation. Part 1: Diagnosis and Classification of Diabetes Mellitus. World Health Organization
9. National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 2002 106 : 3143 421.
10. Young T, Peppard PE, Gottlieb DJ. Epidemiology of obstructive sleep apnea: a population health perspective. Am. J. Respir. Crit. Care Med. 2002 165 : 1217 39. (Pubitemid 34461732)
11. Young T, Peppard PE, Taheri S. Excess weight and sleep-disordered breathing. J. Appl. Physiol. 2005 99 : 1592 9. (Pubitemid 43014371)
12. Vgontzas AN, Bixler EO, Chrousos GP. Metabolic disturbances in obesity versus sleep apnoea: the importance of visceral obesity and insulin resistance. J. Intern. Med. 2003 254 : 32 44.
13. Chin K, Shimizu K, Nakamura T et al. Changes in intra-abdominal visceral fat and serum leptin levels in patients with obstructive sleep apnea syndrome following nasal continuous positive airway pressure therapy. Circulation 1999 100 : 706 12. (Pubitemid 29383639)
14. Coughlin SR, Mawdsley L, Mugarza JA et al. Obstructive sleep apnoea is independently associated with an increased prevalence of metabolic syndrome. Eur. Heart J. 2004 25 : 735 41. (Pubitemid 38647933)
15. Sasanabe R, Banno K, Otake K et al. Metabolic syndrome in Japanese patients with obstructive sleep apnea syndrome. Hypertens. Res. 2006 29 : 315 22. (Pubitemid 43965112)
16. Ip MS, Lam B, Ng MM et al. Obstructive sleep apnea is independently associated with insulin resistance. Am. J. Respir. Crit. Care Med. 2002 165 : 670 6. (Pubitemid 34194755)
17. Punjabi NM, Sorkin JD, Katzel LI et al. Sleep-disordered breathing and insulin resistance in middle-aged and overweight men. Am. J. Respir. Crit. Care Med. 2002 165 : 677 82.
18. Punjabi NM, Shahar E, Redline S et al. Sleep-disordered breathing, glucose intolerance, and insulin resistance: the Sleep Heart Health Study. Am. J. Epidemiol. 2004 160 : 521 30. (Pubitemid 39215628)
19. Newman AB, Nieto FJ, Guidry U et al. Relation of sleep-disordered breathing to cardiovascular disease risk factors: the Sleep Heart Health Study. Am. J. Epidemiol. 2001 154 : 50 9. (Pubitemid 32565686)
20. Reichmuth KJ, Austin D, Skatrud JB et al. Association of sleep apnea and type II diabetes: a population-based study. Am. J. Respir. Crit. Care Med. 2005 172 : 1590 5. (Pubitemid 43076551)
21. Harsch IA, Schahin SP, Radespiel-Troger M et al. Continuous positive airway pressure treatment rapidly improves insulin sensitivity in patients with obstructive sleep apnea syndrome. Am. J. Respir. Crit. Care Med. 2004 169 : 156 62. (Pubitemid 38114528)
22. Babu AR, Herdegen J, Fogelfeld L et al. Type 2 diabetes, glycemic control, and continuous positive airway pressure in obstructive sleep apnea. Arch. Intern. Med. 2005 165 : 447 52. (Pubitemid 40280202)
23. Robinson GV, Pepperell JC, Segal HC et al. Circulating cardiovascular risk factors in obstructive sleep apnoea: data from randomised controlled trials. Thorax 2004 59 : 777 82.
24. Faccenda J, Boon NA, Mackay TW et al. Randomized placebo-controlled trial of continuous positive airway pressure on blood pressure in the sleep apnea-hypopnea syndrome. Am. J. Respir. Crit. Care Med. 2001 163 : 344 8. (Pubitemid 32158510)
25. Pepperell JC, Ramdassingh-Dow S, Crosthwaite N et al. Ambulatory blood pressure after therapeutic and subtherapeutic nasal continuous positive airway pressure for obstructive sleep apnoea: a randomized parallel trial. Lancet 2002 359 : 204 10. (Pubitemid 34113817)
26. Becker HF, Jerrentrup A, Ploch T et al. Effects of nasal continuous positive airway pressure treatment on blood pressure in patients with obstructive sleep apnea. Circulation 2003 107 : 68 73. (Pubitemid 36070935)
27. Logan AG, Tkacova R, Perlikowski SM et al. Refractory hypertension and sleep apnoea: effect of CPAP on blood pressure and baroreflex. Eur. Respir. J. 2003 21 : 241 7. (Pubitemid 36204537)
28. Parish JM, Adam T, Facchiano L. Relationship of metabolic syndrome and obstructive sleep apnea. J. Clin. Sleep Med. 2007 3 : 467 72. (Pubitemid 47378249)
29. Punjabi NM, Polotsky VY. Disorders of glucose metabolism in sleep apnea. J. Appl. Physiol. 2005 99 : 1998 2007. (Pubitemid 41547203)
30. Iiyori N, Alonso LC, Li J et al. Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity. Am. J. Respir. Crit. Care Med. 2007 175 : 851 7. (Pubitemid 46631798)
31. Li J, Thorne LN, Punjabi NM et al. Intermittent hypoxia induces hyperlipidemia in lean mice. Circ. Res. 2005 97 : 698 706. (Pubitemid 41416339)
32. Savransky V, Nanayakkara A, Li J et al. Chronic intermittent hypoxia induces atherosclerosis. Am. J. Respir. Crit. Care Med. 2007 175 : 1290 7. (Pubitemid 46905755)
33. Spiegel K, Leproult R, Van Cauter E. Impact of sleep debt on metabolic and endocrine function. Lancet 1999 354 : 1435 9. (Pubitemid 29494756)
34. Tasali E, Leproult R, Ehrmann DA et al. Slow-wave sleep and the risk of type 2 diabetes in humans. Proc. Natl. Acad. Sci. U.S.A. 2008 105 : 1044 9. (Pubitemid 351272411)
35. Spiegel K, Tasali E, Penev P et al. Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Ann. Intern. Med. 2004 141 : 846 50. (Pubitemid 39601178)