GPI-1046 increases presenilin-1 expression and restores NMDA channel activity.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

Volumn 37, Issue 4, 2010, Pages 457-467

  Steiner, Joseph P ^a   Payne, Kathryn B ^b   Main, Christopher Drummond ^b   D'Alfonso, Sabrina ^b   Jacobsen, Kirsten X ^b   Hicks, T Philip ^b   Staines, William A ^b   Poulter, Michael O ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

1 (3,3 DIMETHYL 1,2 DIOXOPENTYL) 2 PYRROLIDINECARBOXYLIC ACID 3 (3 PYRIDYL)PROPYL ESTER; 2 AMINO 5 PHOSPHOPENTANOIC ACID; 2-AMINO-5-PHOSPHOPENTANOIC ACID; ADRENERGIC RECEPTOR STIMULATING AGENT; AMINO ACID RECEPTOR BLOCKING AGENT; DRUG DERIVATIVE; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NR1 NMDA RECEPTOR; OXIDOPAMINE; PRESENILIN 1; PYRROLIDINE DERIVATIVE; TYROSINE 3 MONOOXYGENASE; VALINE;

ANIMAL; ARTICLE; CELL MEMBRANE POTENTIAL; CORPUS STRIATUM; DISEASE MODEL; DRUG EFFECT; GENETICS; HEMISPHERIC DOMINANCE; IN VITRO STUDY; LONG EVANS RAT; MALE; METABOLISM; METHODOLOGY; NERVE CELL; PARKINSON DISEASE; PATCH CLAMP; PATHOLOGY; PHYSIOLOGY; RAT; UPREGULATION;

ADRENERGIC AGENTS; ANIMALS; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; EXCITATORY AMINO ACID ANTAGONISTS; FUNCTIONAL LATERALITY; MALE; MEMBRANE POTENTIALS; NEURONS; OXIDOPAMINE; PARKINSON DISEASE; PATCH-CLAMP TECHNIQUES; PRESENILIN-1; PYRROLIDINES; RATS; RATS, LONG-EVANS; RECEPTORS, N-METHYL-D-ASPARTATE; RNA, MESSENGER; TYROSINE 3-MONOOXYGENASE; UP-REGULATION; VALINE;

EID: 77957277443     PISSN: 03171671     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0317167100010465     Document Type: Article

References (0)