Preconceptional oral vaccination prevents experimental biliary atresia in newborn mice

European Journal of Pediatric Surgery

Volumn 20, Issue 3, 2010, Pages 158-163

  Turowski, C ^a   Leonhardt, J ^b   Teichmann, B ^a   Heim, A ^a   Baumann, U ^a   Kuebler, J F ^a   Petersen, C ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b St Bernward Hospital   (Germany)

Author keywords

biliary atresia; mouse model; prevention; rhesus rotavirus; vaccination

Indexed keywords

ROTAVIRUS VACCINE; SIMIAN ROTAVIRUS VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT ATRESIA; CHOLESTASIS; CONTROLLED STUDY; FEMALE; LIGAMENT DISEASE; LIVER BIOPSY; MARE; MATERNAL CARE; MATING; MICROSCOPIC ANATOMY; MOUSE; NEWBORN; NONHUMAN; PLAQUE FORMING CELL; REAL TIME POLYMERASE CHAIN REACTION; VACCINATION; VIRUS LOAD; ANIMAL; BAGG ALBINO MOUSE; DISEASE MODEL; IMMUNOLOGY; ORAL DRUG ADMINISTRATION; PREGNANCY; ROTAVIRUS INFECTION; VIROLOGY; VIRUS REPLICATION;

ADMINISTRATION, ORAL; ANIMALS; ANIMALS, NEWBORN; BILIARY ATRESIA; DISEASE MODELS, ANIMAL; FEMALE; MICE; MICE, INBRED BALB C; PRECONCEPTION CARE; PREGNANCY; ROTAVIRUS INFECTIONS; ROTAVIRUS VACCINES; VACCINATION; VIRUS REPLICATION;

EID: 77957272064     PISSN: 09397248     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0030-1249700     Document Type: Article

References (32)

1. Balistreri WF, Grand R, Hoofnagle JH, etal. Biliary atresia: current concepts and research directions. Summary of a symposium. Hepatology 1996 23 1682-1692
2. Sokol RJ, Mack C, Narkewicz MR, etal. Pathogenesis and outcome of biliary atresia: current concepts. J Pediatr Gastroenterol Nutr 2003 37 4-21
3. Petersen C. Pathogenesis and treatment opportunities for biliary atresia. Clin Liver Dis 2006 10 73-88, vi [Review]
4. Perlmutter DH, Shepherd RW. Extrahepatic biliary atresia: a disease or a phenotype? Hepatology 2002 35 1297-1304
5. Petersen C, Kuske M, Bruns E, etal. Progress in developing animal models for biliary atresia. Eur J Pediatr Surg 1998 8 137-141 (Pubitemid 28312048)
6. Crawford SE, Patel DG, Cheng E, etal. Rotavirus viremia and extraintestinal viral infection in the neonatal rat model. J Virol 2006 80 4820-4832
7. Petersen C, Biermanns D, Kuske M, etal. New aspects in a murine model for extrahepatic biliary atresia. J Pediatr Surg 1997 32 1190-1195
8. Czech-Schmidt G, Verhagen W, Szavay P, etal. Immunological gap in the infectious animal model for biliary atresia. J Surg Res 2001 1011 62-67
9. Bezerra JA. The next challenge in pediatric cholestasis: deciphering the pathogenesis of biliary atresia. J Pediatr Gastroenterol Nutr 2006 1 S23-29
10. Landing BH. Considerations of the pathogenesis of neonatal hepatitis, biliary atresia and choledochal cyst-the concept of infantile obstructive cholangiopathy. Prog Pediatr Surg 1974 6 113-139
11. Mack CL. The pathogenesis of biliary atresia: evidence for a virus-induced autoimmune disease. Semin Liver Dis 2007 27 233-242
12. Kuebler JF, Czech-Schmidt G, Leonhardt J, etal. Type-I but not type-II interferon receptor knockout mice are susceptible to biliary atresia. Pediatr Res 2006 59 790-794
13. Vesikari T, Matson DO, Dennehy P, etal. Rotavirus Efficacy and Safety Trial (REST) Study. Team Safety and efficacy of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine. N Engl J Med 2006 354 23-33
14. Ruiz-Palacios GM, Prez-Schael I, Velzquez FR, etal. Human Rotavirus Vaccine Study Group. Safety and efficacy of an attenuated vaccine against severe rotavirus gastroenteritis. N Engl J Med 2006 354 11-22
15. Glass RI, Parashar UD. The promise of new rotavirus vaccines. N Engl J Med 2006 354 75-77
16. Riepenhoff-Talty M, Schaekel K, Clark HF, etal. Group A rotaviruses produce extrahepatic biliary obstruction in orally inoculated newborn mice. Pediatr Res 1993 33 394-399
17. Mack CL, Tucker RM, Lu BR, etal. Cellular and humoral autoimmunity directed at bile duct epithelia in murine biliary atresia. Hepatology 2006 44 1231-1239
18. Bezerra JA, Tiao G, Ryckman FC, etal. Genetic induction of proinflammatory immunity in children with biliary atresia. Lancet 2002 360 1653-1659
19. Shivakumar P, Campbell KM, Sabla GE, etal. Obstruction of extrahepatic bile ducts by lymphocytes is regulated by IFN-gamma in experimental biliary atresia. J Clin Invest 2004 114 322-329
20. Petersen C, Bruns E, Kuske M, etal. Treatment of extrahepatic biliary atresia with interferon-alpha in a murine infectious model. Pediatr Res 1997 42 623-628
21. Leonhardt J, Stanulla M, von Wasielewski R, etal. Gene expression profile of the infective murine model for biliary atresia. Pediatr Surg Int 2006 22 84-89
22. Mohanty SK, Shivakumar P, Sabla G, etal. Loss of interleukin-12 modifies the pro-inflammatory response but does not prevent duct obstruction in experimental biliary atresia. BMC Gastroenterol 2006 6 14
23. Carvalho E, Liu C, Shivakumar P, etal. Analysis of the biliary transcriptome in experimental biliary atresia. Gastroenterology 2005 129 713-717
24. Mack CL, Tucker RM, Sokol RJ, etal. Armed CD4+ Th1 effector cells and macrophages participate in bile duct injury in murine biliary atresia. Clin Immunol 2005 115 200-209
25. Mack CL, Tucker RM, Sokol RJ, etal. Biliary atresia is associated with CD4+ Th1 cell-mediated portal-tract inflammation. Pediatr Res 2004 56 9-10
26. Mack CL, Falta MT, Sullivan AK, etal. Oligoclonal expansions of CD4+ and CD8+ T-cells in the target organ of patients with biliary atresia. Gastroenterology 2007 133 278-287
27. Oldstone MB. Molecular and cellular mechanisms, pathogenesis, and treatment of insulin-dependent diabetes obtained through study of transgenic model of molecular mimicry. Curr Top Microbiol Immunol 2005 296 65-87
28. Bondoc AJ, Jafri MA, Donnelly B, etal. Prevention of the murine model of biliary atresia after live rotavirus vaccination of dams. J Pediatr Surg 2009 44 1479-1490
29. Martin D, Rioux S, Gagnon E, etal. Protection from group B streptococcal infection in neonatal mice by maternal immunization with recombinant sip protein. Infect Immun 2002 70 4897-4901
30. Ward RL. Rotavirus vaccines: how they work or don't work. Expert Rev Mol Med 2008 12 10: e5
31. Ward RL. Possible mechanisms of protection elicited by candidate rotavirus vaccines as determined with the adult mouse model. Viral Immunol 2003 16 17-24
32. Shivakumar P, Sabla G, Mohanty S, etal. Effector role of neonatal hepatic CD8+ lymphocytes in epithelial injury and autoimmunity in experimental biliary atresia. Gastroenterology. 2007 133 268-277