Antiarthritic activity of carissa spinarum root extract in freund's adjuvant induced polyarthritis in rats

Pharmacologyonline

Volumn 2, Issue , 2010, Pages 713-718

  Hegde, Karunakar ^a   Issac, Cijo ^a   Joshi, Arun B ^b  

^a SRINIVAS COLLEGE OF PHARMACY   (India)

^b GOA COLLEGE OF PHARMACY   (India)

Author keywords

Carissa spinarum; Freund's adjuvant induced arthritis; Phenylbutazone; Root extract

Indexed keywords

ALCOHOL; ANTIRHEUMATIC AGENT; CARISSA SPINARUM EXTRACT; FLAVONOID; FREUND ADJUVANT; PHENYLBUTAZONE; PLANT EXTRACT; TANNIN DERIVATIVE; TRITERPENOID; UNCLASSIFIED DRUG;

ADJUVANT ARTHRITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARISSA SPINARUM; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG SAFETY; DRUG SCREENING; FEMALE; MALE; MEDICINAL PLANT; NONHUMAN; PHYTOCHEMISTRY; PLANT ROOT; POLYARTHRITIS; RAT; TOXICITY TESTING; WISTAR ALBINO GLAXO RAT;

EID: 77957269936     PISSN: None     EISSN: 18278620     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Butler SH, Godefroy F, Besson JM, Weil-Fugazza J. A limited arthritic model for chronic pain studies in the rat. Pain 1992; 48: 73-81.
2. Behar SM, Porcelli SA. Mechanisms of autoimmune disease induction. The role of the immune response to microbial pathogens. Arthritis and Rheumatism 1995; 38: 458-476.
3. Kapoor M, Shaw O, Appleton I. Possible anti-inflammatory role of COX-2 derived prostaglandins: Implications for inflammation research. Current Opinion in Investigational Drugs 2005; 6: 461-466.
4. Kirtikar KR, Basu BD. Indian Medicinal Plants, Vol.2, (Lalit Mohan Basu, Allahabad), 2003, 1548-1549.
5. Chopra RN, Nayar SL, Chopra IC. Glossary of Indian Medicinal Plants, (CSIR, New Delhi), 1956; 52.
6. Flora of China, Vol. 16, Page 146. Available at http: //www.efloras.org/florataxon.aspx?flora_id=2&taxon_id=200018364.
7. Raina MK, Bhatnagar JK, Atal CK. Isolation of caffeic acid from the roots of Carissa spinarum Linn. The Indian Journal of Pharmacy 1971; 33: 76-77.
8. Mathuram V, Brahmadhayalaselvam A, Hussain AJ, Rao RB, Patra A. Chemical constituents of Carissa spinarum and their antibacterial activity. Journal of the Indian Chemical Society 1998; 75: 262-264.
9. Rastogi RC, Kulshreshtha DK, Rastogi RP. Cardioactive constituents from Carissa spinarum Linn. Indian Journal of Chemistry 1969; 7: 1102-1104.
10. Rao RJ, Kumar US, Reddy SV, Tiwari AK, Rao JM. Antioxidants and a new germacrane sesquiterpene from Carissa spinarum. Natural Product Research 2005; 19: 763-769.
11. Vohra MM, De NN. Comparative cardiotonic activity of Carissa carandas and Carissa spinarum. Indian Journal of Medical Research 1963; 51: 937-940.
12. Karunakar Hegde, Arun B Joshi. Preliminary phytochemical screening and antipyretic activity of Carissa spinarum root extract. Der Pharmacia Lettre 2010; 2: 255-260.
13. OECD, Guidelines for testing of chemicals, Acute oral toxicity, Environmental Health and Safety Monograph Series on Testing and Adjustment No. 425, 2001, 1.
14. nd ed. (Chapman and Hall, London) 1984, 84.
15. Newbound BB. Chemotherapy of arthritis induced in rats by mycobacterial adjuvants. British Journal of Pharmacology and Chemotherapy 1963; 21: 127-136.
16. Rao CS, Singh PP, Junnarkar AY, Muralidhar N, Trivedi BS Rao BE. IDPH-8261-a new non-steroidal anti-inflammatory agent. Indian Journal of Experimental Biology 1995; 33: 28-33.
17. Colpaert FC, Meert T, Witte P, Schmitt P. Further evidence validating adjuvant arthritis as an experimental model of chronic pain in the rat. Life Sciences, 1982; 31: 67-75.
18. Calvino B, Crepon-Bernard MA, Le Bars D. Parallel clinical and behavioral studies of adjuvant-induced arthritis in the rat: possible relationship with "chronic pain". Behavior and Brain Research 1987; 24: 11-29.
19. Clatworthy AL, Illich PA, Castro GA, Walters ET. Role of peri-axonal inflammation in the development of thermal hyperalgesia and guarding behavior in a rat model of neuropathic pain. Neuroscience Letters 1995; 184: 5-8.
20. Kupeli E, Yesilada E. Flavonoids with anti-inflammatory and antinociceptive activity from cistus laurifolius L. leaves through bioassay-guided procedures. Journal of Ethnopharmacology 2007; 112: 524-530.
21. Mohammad Sayyah, Naghmeh Hadidi, Mohammad Kamalinejad. Analgesic and anti-inflammatory activity of Lactuca sativa seed extract on rats. Journal of Ethnopharmacology 2004; 92: 325-329.