Enhancement of dissolution rate and oral absorption of a poorly water-soluble drug, K-832, by adsorption onto porous silica using supercritical carbon dioxide

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 76, Issue 2, 2010, Pages 215-221

  Miura, Hiroshi ^a   Kanebako, Makoto ^a   Shirai, Hiroyuki ^a   Nakao, Hiroshi ^a   Inagi, Toshio ^a   Terada, Katsuhide ^b  

^a KOWA COMPANY LTD   (Japan)

^b TOHO UNIVERSITY   (Japan)

Author keywords

Absorption; Amorphous; Dissolution; Porous silica; Supercritical carbon dioxide

Indexed keywords

2 BENZYL 5 (4 CHLOROPHENYL) 6 [4 (METHYLTHIO)PHENYL] 2H PYRIDAZIN 3 ONE; CARBON DIOXIDE; CYTOKINE; INTERLEUKIN 1BETA; K 832; PYRIDAZINE DERIVATIVE; SILICON DIOXIDE; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ARTICLE; CRYSTAL STRUCTURE; DOG; DRUG ABSORPTION; DRUG FORMULATION; DRUG SOLUBILITY; INFLAMMATION; ISCHEMIA; MALE; NONHUMAN; SCANNING ELECTRON MICROSCOPY; X RAY POWDER DIFFRACTION;

ADMINISTRATION, ORAL; ADSORPTION; ANIMALS; AREA UNDER CURVE; CALORIMETRY, DIFFERENTIAL SCANNING; CARBON DIOXIDE; DOGS; DRUG CARRIERS; MALE; METHYLENE CHLORIDE; MICROSCOPY; PYRIDAZINES; SILICON DIOXIDE; SOLUBILITY; SOLVENTS; SULFIDES; X-RAY DIFFRACTION;

EID: 77957255299     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2010.06.016     Document Type: Article

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